Displaying publications 21 - 40 of 59 in total

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  1. Respiratory symptoms and asthma in primary school children in Kuala Lumpur
    Omar AH
    Acta Paediatr Jpn, 1990 Apr;32(2):183-7.
    PMID: 2116069
    In a cross-sectional study of 7 to 12-year-old primary school children in Kuala Lumpur, the prevalence of chronic cough and/or phlegm, persistent wheeze, and doctor-diagnosed asthma were 8.0%, 8.0% and 8.7%, respectively. The prevalence of asthma (defined as persistent wheeze and/or doctor-diagnosed asthma) was 13.8%. 4.3% experienced at least one episode of chest illness that resulted in inactivity for at least 3 days in the previous year. The mean age of commencement of symptoms in the doctor-diagnosed asthma group was 2.75 years. The prevalence of chronic cough and/or phlegm and persistent wheeze were highest among Indian children (p less than 0.05). More Malays had been diagnosed as having asthma than the other ethnic groups but the differences were not statistically significant. The patients' fathers' low levels of education were associated with chronic cough and/or phlegm (p less than 0.05) but not with other complaints. Asthma was significantly more common among boys than girls. No age differences were noted. Further analysis showed that persistent wheeze and doctor-diagnosed asthma were associated with increased likelihood of other respiratory illnesses or doctor-diagnosed allergy before the age of 2 years.
    Matched MeSH terms: Respiratory Tract Diseases/epidemiology
  2. Fulltext Association between occupational stress and respiratory symptoms among lecturers in Universiti Putra Malaysia
    Nur Aqilah MY, Juliana J
    Glob J Health Sci, 2012 Nov;4(6):160-9.
    PMID: 23121752 DOI: 10.5539/gjhs.v4n6p160
    There was considerable evidence that a subject's psychological status may influence respiratory sensations and that some subjects may experience respiratory symptoms regardless of the presence of a respiratory disease. The objective of this study was to determine the association between occupational stress and respiratory symptoms among lecturers. This cross sectional study was conducted in Universiti Putra Malaysia, involved 61 lecturers from various faculties. Job Content Questionnaire (JCQ) and questionnaires based on American Thoracic Society were used to collect the data on socio-demography, stress level and respiratory symptoms. High level of occupational stress (high strain) was determined among 16 of the respondents (26.2%). Breathlessness was the common symptom experienced by the respondents. Female lecturers were significantly experienced high stress level compared to male (p=0.035). They were also significantly having more breathlessness symptom compared to male lecturer (p=0.011). Study highlighted in study population, gender plays a significant role that influenced level of occupational stress and also gender has role in resulting occupational stress level and respiratory symptoms. There was no significant association between occupational stress and respiratory symptoms. It can be concluded that this group of lecturers of Universiti Putra Malaysia did not experienced high occupational stress level. Occupational stress level was not statistically significantly associated with all respiratory symptoms being studied.
    Matched MeSH terms: Respiratory Tract Diseases/epidemiology*
  3. Fulltext Local experience in paediatric flexible bronchoscopy
    Norzila MZ, Norrashidah AW, Rusanida A, Sushila S, Azizi BHO
    Med J Malaysia, 2003 Aug;58(3):350-5.
    PMID: 14750374
    All children who underwent flexible bronchoscopy in the respiratory unit at Paediatric Institute, Hospital Kuala Lumpur from June 1997 to June 2002 were reviewed. A hundred and ten children underwent the procedure under sedation or general anaesthesia. The median age of these children was eight months. (Q1 3, Q3 30) The commonest indication for performing flexible bronchoscopy was for chronic stridor (50 cases) followed by persistent or recurrent changes such as lung infiltrates, atelectasis and consolidation on the chest radiographs (22). Laryngomalacia was found to be the commonest cause of stridor in 29 children. Two patients were diagnosed with pulmonary tuberculosis. With regard to safety, three procedures were abandoned due to recurrent desaturation below 85%. One of these patients had severe laryngospasm that required ventilation for 48 hours but recovered fully. Two neonates developed pneumonia requiring antibiotics following bronchoscopy. No patients developed pneumothorax or bleeding following the procedure. Bronchoscopy is a safe procedure when performed by well-trained personnel. Since it is an invasive procedure the benefits must outweigh the risks before it is performed.
    Matched MeSH terms: Respiratory Tract Diseases/pathology*; Respiratory Tract Diseases/surgery*
  4. Fulltext The fundamental of hajj demand for health care services within congestion in Makkah
    Nor Radhiah, M.N., Rosminah, M., Suhaimi, A.W., Omar, O.
    Malaysian Journal of Public Health Medicine, 2017;17(1):0-0.
    MyJurnal
    The large population of human congestion in Makkah during Hajj would promote contagious diseases. Thus, the pilgrims require health care services that are efficient, effective, and high quality. The aim of this study is to determine the type of health-related problems among Malaysian pilgrims and to identify the health care services required by them during Hajj in Makkah. A cross-sectional study was conducted in which involved 379 Malaysian pilgrims in 2013/14234H. The survey was conducted after the pilgrims completed their Hajj ritual. A total of 400 sets of questionnaires were distributed at Abraj Janadriyah Hotel, which was occupied by more than 3000 Malaysian pilgrims. The response rate for this survey was 93%. Male respondents were constituted of 49.6% and female respondents were 50.4% with the mean age 52 years old. The underlying disease among Malaysian pilgrims during Hajj was respiratory disease (77.5%). The demands for health personnel (36.1%) and quality medication (34.7%) are among the important healthcare services required by the Malaysian pilgrims in Makkah. Respiratory disease is a common disease experienced by Malaysian pilgrims in Makkah. A certain types of services such as health personnel and quality medicine are strongly demanded by the Malaysian pilgrims to overcome their health problem during Hajj. This research provides a fundamental input to the health care providers, and also benefited the Hajj management authority to improve the quality of hajj management in future.
    Matched MeSH terms: Respiratory Tract Diseases
  5. Fulltext The fundamental of hajj demand for health care services within congestion in Makkah
    Nor Radhiah M, Rosminah M, Suhaimi A, Omar O
    Malaysian Journal of Public Health Medicine, 2017;17(1):84-93.
    The large population of human congestion in Makkah during Hajj would promote contagious diseases. Thus, the pilgrims require health care services that are efficient, effective, and high quality. The aim of this study is to determine the type of health-related problems among Malaysian pilgrims and to identify the health care services required by them during Hajj in Makkah. A cross-sectional study was conducted in which involved 379 Malaysian pilgrims in 2013/14234H. The survey was conducted after the pilgrims completed their Hajj ritual. A total of 400 sets of questionnaires were distributed at Abraj Janadriyah Hotel, which was occupied by more than 3000 Malaysian pilgrims. The response rate for this survey was 93%. Male respondents were constituted of 49.6% and female respondents were 50.4% with the mean age 52 years old. The underlying disease among Malaysian pilgrims during Hajj was respiratory disease (77.5%). The demands for health personnel (36.1%) and quality medication (34.7%) are among the important healthcare services required by the Malaysian pilgrims in Makkah. Respiratory disease is a common disease experienced by Malaysian pilgrims in Makkah. A certain types of services such as health personnel and quality medicine are strongly demanded by the Malaysian pilgrims to overcome their health problem during Hajj. This research provides a fundamental input to the health care providers, and also benefited the Hajj management authority to improve the quality of hajj management in future.
    Matched MeSH terms: Respiratory Tract Diseases
  6. Fulltext Doctor hopping in general practice: a Malaysian survey
    Ngeow TF, Chia SF, Ong CB
    Aust Fam Physician, 1981 May;10(5):397-9, 401-3.
    PMID: 7283844
    In a survey of 5233 patients seen in the clinics of three general practitioners, 339 patients were found to be doctor hoppers (6.48 per cent). Respiratory symptoms and fever were the commonest presentation affecting mainly the paediatric age group. No improvement in the symptoms was quoted as the most common reason for switching to another doctor. Many factors contributed to doctor hopping and these were best considered in relation to the illness, the patient and the doctor: From the point of prevention, the doctor himself has a significant role to play, particularly in improving the doctor-patient relationship and patient compliance.
    Study site: Johor (Johor Bahru, Batu Pahat, Muar)
    Matched MeSH terms: Respiratory Tract Diseases/therapy
  7. Fulltext Cross cultural translation, adaptation and reliability of the Malay version of the Canadian Acute Respiratory Illness and Flu Scale (CARIFS)
    Nathan AM, Zaki R, Rozario R, Dhania N, Mohd Hamirudin SN, Eg KP, et al.
    Health Qual Life Outcomes, 2015;13:139.
    PMID: 26338016 DOI: 10.1186/s12955-015-0336-z
    The Canadian Acute Respiratory Illness and Flu Scale (CARIFS) is a parent-proxy questionnaire that assesses severity of acute respiratory infections in children. The aim was to (a) perform a cross-cultural adaptation and (b) prove that the Malay CARIFS is a reliable tool.
    Matched MeSH terms: Respiratory Tract Diseases/diagnosis*; Respiratory Tract Diseases/epidemiology
  8. Fulltext House dust mites, our intimate associates
    Nadchatram M
    Trop Biomed, 2005 Jun;22(1):23-37.
    PMID: 16880751
    House dust mites have lived in human contact from time immemorial. Human dander or dead skin constitutes the major organic component of the house dust ecosystem. Because the mites feed on dander, dust mites and human association will continue to co-exist as part of our environment. Efficient house-keeping practice is the best form of control to reduce infestation. However, special precautions are important when individuals are susceptible or sensitive to dust mites. House dust mites are responsible for causing asthma, rhinitis and contact dermatitis. The respiratory allergies are caused by the inhalation of dead or live mites, their faecal matter or other byproducts. Immune factors are of paramount importance in the development of dust related or mite induced respiratory diseases. House dust mites were found in some 1,000 samples of dust taken from approximately 330 dwellings in Peninsular Malaysia and Singapore. Mattresses, carpets, corners of a bedroom, and floor beneath the bed are favourable dust mite habitats. The incriminating species based on studies here and elsewhere, as well as many other species of dust mites of unknown etiological importance are widely distributed in Malaysian homes. Density of dust mites in Malaysia and Singapore is greater than in temperate countries. Prevention and control measures with reference to subjects sensitive to dust mite allergies, including chemical control described in studies conducted in Europe and America are discussed. However, a cost free and most practical way to remove mites, their faecal matter and other products is to resort to sunning the bedding and carpets to kill the living mites, and then beaten and brushed to remove the dust and other components.
    Matched MeSH terms: Respiratory Tract Diseases/etiology; Respiratory Tract Diseases/prevention & control*
  9. Respiratory health of rice millers in Kelantan, Malaysia
    Musa R, Naing L, Ahmad Z, Kamarul Y
    Southeast Asian J. Trop. Med. Public Health, 2000 Sep;31(3):575-8.
    PMID: 11289024
    A cross sectional study was carried out to evaluate the effect of rice husk dust in rice millers in Malaysia. Altogether 69 workers participated in this study. They were interviewed using standardized questionnaires and lung function tests were performed. Chest tightness was among the common symptoms (34.9%) complained by workers. Age, duration of employment and smoking status were among the factors associated with respiratory symptoms (p < 0.01). Lung function tests revealed some degree of impairment compared to the healthy population.
    Matched MeSH terms: Respiratory Tract Diseases/etiology*; Respiratory Tract Diseases/physiopathology
  10. Cardiorespiratory hospitalizations associated with smoke exposure during the 1997, Southeast Asian forest fires
    Mott JA, Mannino DM, Alverson CJ, Kiyu A, Hashim J, Lee T, et al.
    Int J Hyg Environ Health, 2005;208(1-2):75-85.
    PMID: 15881981 DOI: 10.1016/j.ijheh.2005.01.018
    We investigated the cardiorespiratory health effects of smoke exposure from the 1997 Southeast Asian Forest Fires among persons who were hospitalized in the region of Kuching, Malaysia. We selected admissions to seven hospitals in the Kuching region from a database of all hospital admissions in the state of Sarawak during January 1, 1995 and December 31, 1998. For several cardiorespiratory disease classifications we used Holt-Winters time-series analyses to determine whether the total number of monthly hospitalizations during the forest fire period (August 1 to October 31, 1997), or post-fire period (November 1, 1997 to December 31, 1997) exceeded forecasted estimates established from a historical baseline period of January 1, 1995 to July 31, 1997. We also identified age-specific cohorts of persons whose members were admitted for specific cardiorespiratory problems during January 1 to July 31 of each year (1995--1997). We compared Kaplan-Meier survival curves of time to first readmission for the 1997 cohorts (exposed to the forest fire smoke) with the survival curves for the 1995 and 1996 cohorts (not exposed, pre-fire cohorts). The time-series analyses indicated that statistically significant fire-related increases were observed in respiratory hospitalizations, specifically those for chronic obstructive pulmonary disease (COPD) and asthma. The survival analyses indicated that persons over age 65 years with previous hospital admissions for any cause (chi2(1df) = 5.98, p = 0.015), any cardiorespiratory disease (chi2(1df) = 5.3, p = 0.02), any respiratory disease (chi2(1df) = 7.8, p = 0.005), or COPD (chi2(1df) = 3.9, p = 0.047), were significantly more likely to be rehospitalized during the follow-up period in 1997 than during the follow-up periods in the pre-fire years of 1995 or 1996. The survival functions of the exposed cohorts resumed similar trajectories to unexposed cohorts during the post-fire period of November 1, 1997 to December 31, 1998. Communities exposed to forest fire smoke during the Southeast Asian forest fires of 1997 experienced short-term increases in cardiorespiratory hospitalizations. When an air quality emergency is anticipated, persons over age 65 with histories of respiratory hospitalizations should be preidentified from existing hospitalization records and given priority access to interventions.
    Matched MeSH terms: Respiratory Tract Diseases/etiology*; Respiratory Tract Diseases/epidemiology
  11. Fulltext Annual Southeast Asia haze increases respiratory admissions: A 2-year large single institution experience
    Ming CR, Ban Yu-Lin A, Abdul Hamid MF, Latif MT, Mohammad N, Hassan T
    Respirology, 2018 10;23(10):914-920.
    PMID: 29923364 DOI: 10.1111/resp.13325
    BACKGROUND AND OBJECTIVE: The Southeast Asia (SEA) haze is an annual problem and at its worst could produce respirable particles of concentrations up to 500 μg/m3 which is five times the level considered as 'unhealthy'. However, there are limited reports examining the direct clinical impact of the annual haze. This study examines the effects of the SEA haze on respiratory admissions.

    METHODS: Data from all respiratory admissions in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) from 1st January 2014 to 31st December 2015 were collected retrospectively from chart and electronic database. A total of 16 weeks of haze period had been formally dated by the Department of Environment using the definition of weather phenomenon leading to atmospheric visibility of less than 10 km. Multivariable regression analyses were performed to estimate rate ratios and 95% CI.

    RESULTS: There were 1968 subjects admitted for respiratory admissions in UKMMC during the study period. Incidence rates per week were significantly different between the two groups with 27.6 ± 9.2 cases per week during the haze versus 15.7 ± 6.7 cases per week during the non-haze period (P < 0.01). A total of 4% versus 2% was admitted to the intensive care unit in the haze and the non-haze groups, respectively (P = 0.02). The mean ± SD lengths of stay was 12.1 ± 5.2 days; the haze group had a longer stay (18.2 ± 9.7 days) compared to the non-haze groups (9.7 ± 3.9) (P < 0.001).

    CONCLUSION: The annual SEA haze is associated with increased respiratory admissions.

    Matched MeSH terms: Respiratory Tract Diseases/epidemiology*
  12. Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases
    Mehta M, Deeksha, Sharma N, Vyas M, Khurana N, Maurya PK, et al.
    Chem Biol Interact, 2019 May 01;304:10-19.
    PMID: 30849336 DOI: 10.1016/j.cbi.2019.02.021
    Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so as to develop acquired immunity. Accounting to their involvement in pathogenesis, macrophages present a therapeutic target for the treatment of inflammatory respiratory diseases. This review focuses on novel drug delivery systems (NDDS) including nanoparticles, liposomes, dendrimers, microspheres etc that can target alveolar macrophage associated with inflammation, intracellular infection and lung cancer. The physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake. The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity. Further, the review also discuss about modified NDDS for specificity to the target and molecular targeting via anti-microbial peptides, kinases, NRF-2 and phosphodiesterase.
    Matched MeSH terms: Respiratory Tract Diseases/drug therapy*
  13. Management of respiratory insufficiency
    MANAVALAN AS
    Med J Malaya, 1961 Dec;16:125-35.
    PMID: 14469124
    Matched MeSH terms: Respiratory Tract Diseases*
  14. Fulltext Descriptive analysis of total medical admissions and common medical disorders in 1987 Kuantan General Hospital, using computerized in-patients' discharge record
    Lim TO, Looi HW, Harun K, Marzida
    Med J Malaysia, 1991 Sep;46(3):239-46.
    PMID: 1839919
    Using computerized in-patients' discharge records, a descriptive analysis was carried out of all medical admission in 1987 in a general hospital. The survey found that there were a total of 4053 admissions in 1987. A wide range of medical disorders were seen reflecting the lack of subspecialization. Cardiovascular disorders topped accounting for 25.6% of all admissions, followed by gastrointestinal and hepatobiliary disorders 12.8% and respiratory disorders 10.7%. The commonest specific medical disorders seen were hypertension 13.8%, diabetes mellitus 10.2%, ischaemic heart disease 7% and asthma 4.5%. The age, sex, ethnic and geographical distributions of the common medical disorders seen appear to conform to two broad pattern; hypertension, diabetes, ischaemic heart disease and cerebrovascular disease affected the older patients, had even ethic distribution and predominantly urban. Malaria, non-specific fever, viral hepatitis and acute gastroenteritis affected the younger patients, predominantly rural and Malay. Information from such surveys may be useful for planning and organization of medical services.
    Matched MeSH terms: Respiratory Tract Diseases/epidemiology*
  15. Fulltext Impact of chronic obstructive pulmonary disease (COPD) in the Asia-Pacific region: the EPIC Asia population-based survey
    Lim S, Lam DC, Muttalif AR, Yunus F, Wongtim S, Lan le TT, et al.
    Asia Pac Fam Med, 2015;14(1):4.
    PMID: 25937817 DOI: 10.1186/s12930-015-0020-9
    Chronic obstructive pulmonary disease (COPD) is a clinical syndrome encompassing a group of chronic, progressive, and debilitating respiratory conditions, that are characterized by incompletely reversible airflow limitation. Within the Asia-Pacific region, prevalence estimates have been derived using various protocols and study methods, and there is little data on the impact of COPD exacerbations. This study aimed to provide a comprehensive picture of the current prevalence and burden of COPD in this region.
    Matched MeSH terms: Respiratory Tract Diseases
  16. Fulltext Respiratory conditions in Malaysian asbestos cement workers
    Lim HH, Rampal KG, Joginder S, Abu Bakar CM, Chan KH, Vivek TN
    Med J Malaysia, 2002 Sep;57(3):340-7.
    PMID: 12440274 MyJurnal
    A cross-sectional study was conducted to determine the prevalence and type of respiratory conditions including asbestos-related diseases among Malaysian asbestos cement workers. The study population consisted of 1164 workers who had undergone medical surveillance from 1995 to 1997, including full history, physical examination, chest radiography and spirometry. More than half the male workers were smokers or ex-smokers, with smokers having more respiratory symptoms and signs, and reduced FEV1 compared with non smokers. The five most common respiratory conditions diagnosed were bronchial asthma, chronic bronchitis, pulmonary tuberculosis, upper respiratory tract infections and allergic rhinitis. On follow-up, there were also two cases of asbestosis and one case of bronchial carcinoma. The asbestosis cases were probably related to heavy occupational exposure to asbestos fibres in the past, before governmental regulations were gazetted in 1986. Further follow-up is essential for continued monitoring of the health status of asbestos workers.
    Matched MeSH terms: Respiratory Tract Diseases/etiology*; Respiratory Tract Diseases/epidemiology*
  17. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
    Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A, Orlandini A, et al.
    Lancet, 2015 Jul 18;386(9990):266-73.
    PMID: 25982160 DOI: 10.1016/S0140-6736(14)62000-6
    Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However, the prognostic value of grip strength with respect to the number and range of populations and confounders is unknown. The aim of this study was to assess the independent prognostic importance of grip strength measurement in socioculturally and economically diverse countries.
    Matched MeSH terms: Respiratory Tract Diseases/mortality; Respiratory Tract Diseases/physiopathology
  18. Health status and the development of health services in colonial state: the case of British Malaya
    Leng CH
    Int J Health Serv, 1982;12(3):397-417.
    PMID: 7118330
    The health of a population and the development of health services in a country at a particular time in history are directly linked to the socioeconomic system. This paper discusses health and health services in Malay Peninsula during the time that it was a British colony. Economic production under British colonialism, which is basically a capitalist system, is organized primarily for the purpose of realizing profits. The health of the population is in direct conflict with and generally subordinated to this main objective. The pattern of health that emerges reflects this general framework. Moreover, health services under the colonialist system are developed primarily to serve the economic interests of the colonialists. Hence, the structure of health services is biased toward curative medicine and centered mainly in the urban areas.
    Matched MeSH terms: Respiratory Tract Diseases/epidemiology
  19. Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities
    Lee LY, Hew GSY, Mehta M, Shukla SD, Satija S, Khurana N, et al.
    Life Sci, 2021 Feb 15;267:118973.
    PMID: 33400932 DOI: 10.1016/j.lfs.2020.118973
    Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local immune and inflammatory responses. Several inflammatory and infectious diseases are triggered with their build up in the blood and tissues. The mobilization of eosinophils into the lungs is regulated by a cascade of processes guided by Th2 cytokine generating T-cells. Recruitment of eosinophils essentially leads to a characteristic immune response followed by airway hyperresponsiveness and remodeling, which are hallmarks of chronic respiratory diseases. By analysing the dynamic interactions of eosinophils with their extracellular environment, which also involve signaling molecules and tissues, various therapies have been invented and developed to target respiratory diseases. Having entered clinical testing, several eosinophil targeting therapeutic agents have shown much promise and have further bridged the gap between theory and practice. Moreover, researchers now have a clearer understanding of the roles and mechanisms of eosinophils. These factors have successfully assisted molecular biologists to block specific pathways in the growth, migration and activation of eosinophils. The primary purpose of this review is to provide an overview of the eosinophil biology with a special emphasis on potential pharmacotherapeutic targets. The review also summarizes promising eosinophil-targeting agents, along with their mechanisms and rationale for use, including those in developmental pipeline, in clinical trials, or approved for other respiratory disorders.
    Matched MeSH terms: Respiratory Tract Diseases/immunology*; Respiratory Tract Diseases/metabolism; Respiratory Tract Diseases/physiopathology
  20. Ethnobotanical uses of medicinal plants for respiratory disorders among the inhabitants of Gallies - Abbottabad, Northern Pakistan
    Kayani S, Ahmad M, Zafar M, Sultana S, Khan MP, Ashraf MA, et al.
    J Ethnopharmacol, 2014 Oct 28;156:47-60.
    PMID: 25153021 DOI: 10.1016/j.jep.2014.08.005
    Rich accessibility of medicinal plants in the study area provides low cost health care for respiratory disorders to local communities. This first report survey was commenced with an aim to document ethnic knowledge regarding the use of folk herbal medicine for respiratory diseases among the local communities of Gallies Abbottabad, Northern Pakistan using quantitative ethnobotanical approaches.
    Matched MeSH terms: Respiratory Tract Diseases/drug therapy*
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