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Fulltext Investigation of Surface Plasmon Resonance (SPR) in MoS2- and WS2-Protected Titanium Side-Polished Optical Fiber as a Humidity Sensor

Zakaria R, Zainuddin NAM, Leong TC, Rosli R, Rusdi MF, Harun SW, et al.

Micromachines (Basel), 2019 Jul 11;10(7).
PMID: 31336745 DOI: 10.3390/mi10070465

In this paper, we report the effects of a side-polished fiber (SPF) coated with titanium (Ti) films in different thicknesses, namely 5 nm, 13 nm, and 36 nm, protected by a thin layer of transition metal dichalcogenides (TMDCs) such as molybdenum disulfide (MoS2) and tungsten disulfide (WS2), which provide ultra-sensitive sensor-based surface plasmon resonance (SPR) covering from the visible to mid-infrared region. The SPF deposited with Ti exhibits strong evanescent field interaction with the MoS2 and WS2, and good optical absorption, hence resulting in high-sensitivity performance. Incremental increases in the thickness of the Ti layer contribute to the enhancement of the intensity of transmission with redshift and broad spectra. The findings show that the optimum thickness of Ti with 36 nm combined with MoS2 causes weak redshifts of the longitudinal localized surface plasmon resonance (LSPR) mode, while the same thickness of Ti with WS2 causes large blueshifts. The redshifts are possibly due to a reduced plasmon-coupling effect with the excitonic region of MoS2. The observed blueshifts of the LSPR peak position are possibly due to surface modification between WS2 and Ti. Changing the relative humidity from 58% to 88% only elicited a response in Ti/MoS2. Thus, MoS2 shows more sensitivity on 36-nm thickness of Ti compared with WS2. Therefore, the proposed fiber-optic sensor with integration of 2D materials is capable of measuring humidity in any environment.

Matched MeSH terms: Fiber Optic Technology
Fulltext Improved classification of Orthosiphon stamineus by data fusion of electronic nose and tongue sensors

Zakaria A, Shakaff AY, Adom AH, Ahmad MN, Masnan MJ, Aziz AH, et al.

Sensors (Basel), 2010;10(10):8782-96.
PMID: 22163381 DOI: 10.3390/s101008782

An improved classification of Orthosiphon stamineus using a data fusion technique is presented. Five different commercial sources along with freshly prepared samples were discriminated using an electronic nose (e-nose) and an electronic tongue (e-tongue). Samples from the different commercial brands were evaluated by the e-tongue and then followed by the e-nose. Applying Principal Component Analysis (PCA) separately on the respective e-tongue and e-nose data, only five distinct groups were projected. However, by employing a low level data fusion technique, six distinct groupings were achieved. Hence, this technique can enhance the ability of PCA to analyze the complex samples of Orthosiphon stamineus. Linear Discriminant Analysis (LDA) was then used to further validate and classify the samples. It was found that the LDA performance was also improved when the responses from the e-nose and e-tongue were fused together.

Matched MeSH terms: Food Technology/methods*
Fulltext Evaluation of inverter reliability performance due to negative bias temperature instability (NBTI) effects in advance CMOS technology nodes

Zainudin, M.F., Hussin, H., Halim, A.K.

Pertanika Journal of Science & Technology, 2017;25(101):295-304.
MyJurnal

Negative bias temperature instability (NBTI) is the most concern issue CMOS devices with the scaling
down of the CMOS technologies. NBTI effect contributes to P-MOSFET device degradation which later
reduce the performance and reliability of CMOS circuits. This paper presents a reliability simulation study
based on R-D model on CMOS inverter circuit. HSPICE MOSRA model together with the Predictive
Technology Model (PTM) was used as to incorporate the NBTI model in the circuit reliability simulation
study for different technology nodes. PTM of High Performance (HP) models of 16nm, 22nm, 32nm
and 45nm were used in this simulation study. The atomic hydrogen based model was integrated in the
simulation. The results show that in a CMOS inverter circuit, the threshold voltage shift of p-MOSFET
under NBTI stressing increased as the year progressed.. The threshold voltage shift was observed to
increase up to 45.1% after 10 years of operation. The time exponent, n ~ 0.232 of the threshold voltage
shift observed indicates that the defect mechanism contributed to the degradation is atomic hydrogen.
The propagation delay increased to 19.5% over a 10-year period. s up to 19.5% from the zero year
of operation until 10 years of the operation. In addition, the time propagation delay increased as year
increased when the technology nodes smaller. The finding is important for understanding reliability
issues related to advanced technology nodes in CMOS circuits study.

Matched MeSH terms: Technology
Fulltext Topical nasal anaesthesia for fibreoptic bronchoscopy: lignocaine spray or gel?

Zainudin BM, Rafia MH, Sufarlan AW

Singapore Med J, 1993 Apr;34(2):148-9.
PMID: 8266157

Lignocaine spray for anaesthetising the nasal mucosa for fibreoptic bronchoscopy often causes discomfort to the patient. We compared two techniques of applying nasal topical anaesthesia using either lignocaine spray (group A: 25 patients) or gel (group B: 30 patients) to assess patients' tolerance to the procedure. Both groups received 100 mg of lignocaine in the nostril, 40-50 mg to oropharynx, 120 mg to vocal cords and 40-100 mg to trachea and bronchi. Throat anaesthesia was the most common unpleasant part experienced by both groups of patients (34.5%), followed by examination of bronchi (30.6%) and nasal anaesthesia (21.8%). Significantly more patients in group A experienced discomfort or pain during nasal anaesthesia as compared to group B (p < 0.001). Patients' tolerance to the bronchoscopy was similar in both groups and the examination was performed satisfactorily in all patients. Thus, lignocaine gel is a simple technique, effective and less irritating as compared to lignocaine spray for topical nasal anaesthesia.

Matched MeSH terms: Fiber Optic Technology
Frequency-controlled wireless shape memory polymer microactuator for drug delivery application

Zainal MA, Ahmad A, Mohamed Ali MS

Biomed Microdevices, 2017 Mar;19(1):8.
PMID: 28124762 DOI: 10.1007/s10544-017-0148-5

This paper reports the wireless Shape-Memory-Polymer actuator operated by external radio frequency magnetic fields and its application in a drug delivery device. The actuator is driven by a frequency-sensitive wireless resonant heater which is bonded directly to the Shape-Memory-Polymer and is activated only when the field frequency is tuned to the resonant frequency of heater. The heater is fabricated using a double-sided Cu-clad Polyimide with much simpler fabrication steps compared to previously reported methods. The actuation range of 140 μm as the tip opening distance is achieved at device temperature 44 °C in 30 s using 0.05 W RF power. A repeatability test shows that the actuator's average maximum displacement is 110 μm and standard deviation of 12 μm. An experiment is conducted to demonstrate drug release with 5 μL of an acidic solution loaded in the reservoir and the device is immersed in DI water. The actuator is successfully operated in water through wireless activation. The acidic solution is released and diffused in water with an average release rate of 0.172 μL/min.

Matched MeSH terms: Wireless Technology*
Optimization of a greener method for removal phenol species by cloud point extraction and spectrophotometry

Zain NN, Abu Bakar NK, Mohamad S, Saleh NM

Spectrochim Acta A Mol Biomol Spectrosc, 2014 Jan 24;118:1121-8.
PMID: 24161875 DOI: 10.1016/j.saa.2013.09.129

A greener method based on cloud point extraction was developed for removing phenol species including 2,4-dichlorophenol (2,4-DCP), 2,4,6-trichlorophenol (2,4,6-TCP) and 4-nitrophenol (4-NP) in water samples by using the UV-Vis spectrophotometric method. The non-ionic surfactant DC193C was chosen as an extraction solvent due to its low water content in a surfactant rich phase and it is well-known as an environmentally-friendly solvent. The parameters affecting the extraction efficiency such as pH, temperature and incubation time, concentration of surfactant and salt, amount of surfactant and water content were evaluated and optimized. The proposed method was successfully applied for removing phenol species in real water samples.

Matched MeSH terms: Green Chemistry Technology/methods*
Green synthesis of silver and copper nanoparticles using ascorbic acid and chitosan for antimicrobial applications

Zain NM, Stapley AG, Shama G

Carbohydr Polym, 2014 Nov 4;112:195-202.
PMID: 25129735 DOI: 10.1016/j.carbpol.2014.05.081

Silver and copper nanoparticles were produced by chemical reduction of their respective nitrates by ascorbic acid in the presence of chitosan using microwave heating. Particle size was shown to increase by increasing the concentration of nitrate and reducing the chitosan concentration. Surface zeta potentials were positive for all nanoparticles produced and these varied from 27.8 to 33.8 mV. Antibacterial activities of Ag, Cu, mixtures of Ag and Cu, and Ag/Cu bimetallic nanoparticles were tested using Bacillus subtilis and Escherichia coli. Of the two, B. subtilis proved more susceptible under all conditions investigated. Silver nanoparticles displayed higher activity than copper nanoparticles and mixtures of nanoparticles of the same mean particle size. However when compared on an equal concentration basis Cu nanoparticles proved more lethal to the bacteria due to a higher surface area. The highest antibacterial activity was obtained with bimetallic Ag/Cu nanoparticles with minimum inhibitory concentrations (MIC) of 0.054 and 0.076 mg/L against B. subtilis and E. coli, respectively.

Matched MeSH terms: Green Chemistry Technology
Fulltext Drone for medical products transportation in maternal healthcare: A systematic review and framework for future research

Zailani MAH, Sabudin RZAR, Rahman RA, Saiboon IM, Ismail A, Mahdy ZA

Medicine (Baltimore), 2020 Sep 04;99(36):e21967.
PMID: 32899033 DOI: 10.1097/MD.0000000000021967

INTRODUCTION: Medical products transportation has become an important research topic requiring multidisciplinary collaboration among experts in medicine, engineering, and health economics. Current modes of transportation are unable to overcome the limited settings in maternal healthcare, particularly during the event of obstetric emergencies. The drone is a promising medical product aerial transportation (MedART) that holds an enormous potential for delivery of medical supplies in the healthcare system. We conducted a systematic review to examine scientific evidence of positive impact of drone transportation on maternal health.
METHODS: The following electronic databases were searched from inception to July 2019: ScienceDirect, PubMed, and EMBASE. The report was made in accordance with the principles of PRISMA guidelines. The search terms used were related to drones including unmanned aerial vehicle (UAV) and unmanned aerial system (UAS), and related to obstetric/maternal including obstetric emergencies and postpartum hemorrhage. Studies were selected if the intervention used were drones, and if any direct or indirect maternal health indicators were reported. Meta-analysis was not done throughout the study in view of the anticipated heterogeneity of each study.
RESULTS: Our initial search yielded a total of 244 relevant publications, from which 236 were carried forward for a title and abstract screening. After careful examination, only two were included for systematic synthesis. Among the reasons for exclusion were irrelevance to maternal health purpose, and irrelevance to drone applications in healthcare. An updated search yielded one additional study that was also included. Overall, two studies assessed drones for blood products delivery, and one study used drones to transport blood samples.
CONCLUSION: A significant deficiency was found in the number of reported studies analyzing mode of medical products transportation and adaptation of drones in maternal healthcare. Future drone research framework should focus on maternal healthcare-specific drone applications in order to reap benefits in this area.

Matched MeSH terms: Remote Sensing Technology/instrumentation*; Remote Sensing Technology/trends
Drone technology in maternal healthcare in Malaysia: A narrative review

Zailani MAH, Raja Sabudin RZA, Abdul Rahman R, Mohd Saiboon I, Ismail A, Mahdy ZA

Malays J Pathol, 2021 Aug;43(2):251-259.
PMID: 34448789

INTRODUCTION: The vast advancement of technology and breakthrough in high-tech disciplines created multiple areas of research activities, including the emergence of the medical drone. Malaysia, a rapidly developing country in Southeast Asia is on track to achieving high-income status. However, the stagnant growth of Malaysian maternal healthcare does not run parallel with the aspiration. This review paper assessed and reported narratively the current condition of maternal healthcare in Malaysia, the possible application of drones in improving the sector, exploring in detail several challenges, and providing recommendations for experts in studying the rising technological phenomena.
MATERIALS AND METHODS: A literature search was done from June 2019 to November 2019 with restrictions to the English language. The search was performed in ScienceDirect, PubMed, and EMBASE databases, using a combination of search terms related to drones, Unmanned Aerial Vehicles (UAV), Unmanned Aerial Systems (UAS), maternal, obstetric, healthcare, medical products transportation and Malaysia. A discourse analysis followed and a narrative review was provided on this subject.
RESULTS AND DISCUSSION: The validated ability of drones in the delivery of blood products is highlighted as a possible application in improving maternal healthcare in Malaysia, particularly in the state of Sabah. Five key challenges are identified: infrastructure, technicalities, regulations, expertise, and social acceptance. Future predictions of drone technology in healthcare were outlined with the suggestion of three principle arms of application.
CONCLUSION: The usage of the medical drone in medical products transportation supports the objectives of WHO MDG 5 for Malaysian maternal health. A study on the impact of drones in reducing the maternal mortality ratio is recommended for further exploration.

Matched MeSH terms: Technology
An overview of sports engineering: history, impact and research

Zahari Taha, Mohd Hasnun Arif Hassan, Anwar P.P. Abdul Majeed, Mohd Azri Aris, Nina Nadia Sahim

Movement Health & Exercise, 2013;2(1):1-14.
MyJurnal

Sports engineering can be considered as a new engineering discipline. It bridges the gap between two distinctive fields: sport science and engineering. Sports engineers are responsible in designing and building new equipment based on athlete's demands, besides measuring the performance of the athlete, the equipment itself, as well as their interaction. It is without doubt that engineering and technology have played an important role not only in improving the performance of an athlete, but also in making sports more entertaining and safe. This article provides an insight into how engineering and technology have affected sports in many ways transforming it from just a past time to more exciting and competitive world events. Apart from the impact of engineering in sports, the history of the application of engineering and technology in sports is also elaborated. Furthermore, research conducted in related fields worldwide is highlighted. A brief overview of sports engineering research in Malaysia is also presented.

Matched MeSH terms: Technology
Fulltext Videolaryngoscope-assisted fibreoptic tracheal intubation in a young adolescent with hunter syndrome for posterior cervical fusion

Zabir, A.F., Frawley, G., Squire, P.

Journal of Surgical Academia, 2013;3(2):92-96.
MyJurnal

We here describe a videolaryngoscope assisted fibreoptic tracheal intubation in a 17-year-old patient with Hunter Syndrome (Mucopolysaccharidosis Type II) and known difficult intubation who required posterior cervical fusion surgery for cervical canal stenosis. The patient had a history of failed nasal and oral fibreoptic intubation. The use of a videolaryngoscope enabled continuous visualization of the tracheal inlet and allowed a straightforward nasal fibreoptic intubation attempt without complications. This report suggests a viable alternative for the management of a known difficult airway in children with mucopolysaccharidosis.

Matched MeSH terms: Fiber Optic Technology
Fulltext Acceptance of medical drone technology and its determinant factors among public and healthcare personnel in a Malaysian urban environment: knowledge, attitude, and perception

Za'im Sahul Hameed M, Nordin R, Ismail A, Zulkifley MA, Sham ASH, Sabudin RZAR, et al.

Front Public Health, 2023;11:1199234.
PMID: 38045974 DOI: 10.3389/fpubh.2023.1199234

INTRODUCTION: Unmanned aerial vehicles (UAVs) are used for commercial, medical, public safety, and scientific research purposes in various countries.
METHODS: This study aimed to explore the acceptance of medical delivery drones among medical practitioners as well as the public community in Malaysia using a knowledge, attitude, and perception (KAP) model and statistical analysis to decrease uncertainty. Bivariate and multivariate analyses of the results were performed in SPSS.
RESULTS: A total of 639 respondents took part in the survey, of which 557 complete responses were finally analyzed. The results showed that the overall acceptance rate for medical delivery drones was positive. The acceptance rate was significantly correlated with knowledge, attitude, and perception scores but not with sociodemographic factors.
DISCUSSION: Raising awareness and educating the medical as well as public communities regarding the potential role and benefits of drones are therefore important in garnering support for drone usage for medical purposes.

Matched MeSH terms: Technology
Fulltext GRABCAR: OPPORTUNITIES AND CHALLENGES FOR TAXI OPERATORS

ZUHA ROSUFILA ABU HASAN, NINA MARLINI AHMAD, MOHANA DIVASINI JAYARAJ

UMT Journal of Undergraduate Research, 2019;1(3):46-55.
MyJurnal

Taxis, being a significant element of mobility, play a sufficiently great role in public transportation. However, the issues towards taxi services have gradually increaseddue tothe poor servicesgiven to passengers by taxi operators,leadingto the demand for otherride servicealternatives.With the developmentof technology, GrabCarwasdeveloped and launched asanonline taxi booking through smartphone application which can easily connectpassengers and drivers. The main purpose of this study is to find out the perception of taxi operators towards GrabCar service and vice versa sothatthere will be a clear point of view to identify opportunities andchallenges for taxi operators. Standardized open-endedinterviews were conducted with5taxi and 5 GrabCar operatorsin Kuala Terengganu and Kuala Nerus. Interview transcriptswere analyzed using content analysis. The findingsshowedthat there weremore challenges than opportunities for the taxi operators. This studycould help the government to improvetaxi services in general and GrabCar servicesin sharing economy.

Matched MeSH terms: Technology
An evaluation framework for Health Information Systems: human, organization and technology-fit factors (HOT-fit)

Yusof MM, Kuljis J, Papazafeiropoulou A, Stergioulas LK

Int J Med Inform, 2008 Jun;77(6):386-98.
PMID: 17964851

The realization of Health Information Systems (HIS) requires rigorous evaluation that addresses technology, human and organization issues. Our review indicates that current evaluation methods evaluate different aspects of HIS and they can be improved upon. A new evaluation framework, human, organization and technology-fit (HOT-fit) was developed after having conducted a critical appraisal of the findings of existing HIS evaluation studies. HOT-fit builds on previous models of IS evaluation--in particular, the IS Success Model and the IT-Organization Fit Model. This paper introduces the new framework for HIS evaluation that incorporates comprehensive dimensions and measures of HIS and provides a technological, human and organizational fit.

Matched MeSH terms: Technology Assessment, Biomedical/methods*; Technology Assessment, Biomedical/organization & administration*
Investigating evaluation frameworks for health information systems

Yusof MM, Papazafeiropoulou A, Paul RJ, Stergioulas LK

Int J Med Inform, 2008 Jun;77(6):377-85.
PMID: 17904898 DOI: 10.1016/j.ijmedinf.2007.08.004

BACKGROUND AND PURPOSE: Evaluation of health information systems (HIS) enables the assessment of the extent to which HIS are fulfilling their objectives in supporting the services of healthcare delivery. This paper presents an overview of evaluation in health informatics and information systems.
METHODS: Literature review on discourses, dimensions and methods of HIS and IS evaluation. A critical appraisal of selected HIS and IS evaluation frameworks is undertaken in order to identify HIS evaluation dimensions and measures. The frameworks are compared based on their inclusion of human, organizational and technological factors.
RESULTS: We found that an increasing number of evaluation studies deal with two distinct trends of HIS: one considers human and organizational issues and the other is concerned with the employment of a subjectivist approach. Our review indicates that current evaluation methods complement each other in that they evaluate different aspects of HIS and they can be improved upon.
CONCLUSIONS: Evaluation is complex; it is easy to measure many things but not necessarily the right ones. Nevertheless, it is possible to consider, a HIS evaluation framework with more comprehensive and specific measures that would incorporate technological, human and organizational issues to facilitate HIS evaluation.

Matched MeSH terms: Technology Assessment, Biomedical/methods*; Technology Assessment, Biomedical/organization & administration*
Fulltext Green Synthesis of Fe3O4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities

Yusefi M, Shameli K, Su Yee O, Teow SY, Hedayatnasab Z, Jahangirian H, et al.

Int J Nanomedicine, 2021;16:2515-2532.
PMID: 33824589 DOI: 10.2147/IJN.S284134

INTRODUCTION: Fe3O4 nanoparticles (Fe3O4 NPs) with multiple functionalities are intriguing candidates for various biomedical applications.
MATERIALS AND METHODS: This study introduced a simple and green synthesis of Fe3O4 NPs using a low-cost stabilizer of plant waste extract rich in polyphenols content with a well-known antioxidant property as well as anticancer ability to eliminate colon cancer cells. Herein, Fe3O4 NPs were fabricated via a facile co-precipitation method using the crude extract of Garcinia mangostana fruit peel as a green stabilizer at different weight percentages (1, 2, 5, and 10 wt.%). The samples were analyzed for magnetic hyperthermia and then in vitro cytotoxicity assay was performed.
RESULTS: The XRD planes of the samples were corresponding to the standard magnetite Fe3O4 with high crystallinity. From TEM analysis, the green synthesized NPs were spherical with an average size of 13.42±1.58 nm and displayed diffraction rings of the Fe3O4 phase, which was in good agreement with the obtained XRD results. FESEM images showed that the extract covered the surface of the Fe3O4 NPs well. The magnetization values for the magnetite samples were ranging from 49.80 emu/g to 69.42 emu/g. FTIR analysis verified the functional groups of the extract compounds and their interactions with the NPs. Based on DLS results, the hydrodynamic sizes of the Fe3O4 nanofluids were below 177 nm. Furthermore, the nanofluids indicated the zeta potential values up to -34.92±1.26 mV and remained stable during four weeks of storage, showing that the extract favorably improved the colloidal stability of the Fe3O4 NPs. In the hyperthermia experiment, the magnetic nanofluids showed the acceptable specific absorption rate (SAR) values and thermosensitive performances under exposure of various alternating magnetic fields. From results of in vitro cytotoxicity assay, the killing effects of the synthesized samples against HCT116 colon cancer cells were mostly higher compared to those against CCD112 colon normal cells. Remarkably, the Fe3O4 NPs containing 10 wt.% of the extract showed a lower IC50 value (99.80 µg/mL) in HCT116 colon cancer cell line than in CCD112 colon normal cell line (140.80 µg/mL).
DISCUSSION: This research, therefore, introduced a new stabilizer of Garcinia mangostana fruit peel extract for the biosynthesis of Fe3O4 NPs with desirable physiochemical properties for potential magnetic hyperthermia and colon cancer treatment.

Matched MeSH terms: Green Chemistry Technology/methods*
Environmental hazards posed by mine dust, and monitoring method of mine dust pollution using remote sensing technologies: An overview

Yu H, Zahidi I

Sci Total Environ, 2023 Mar 15;864:161135.
PMID: 36566867 DOI: 10.1016/j.scitotenv.2022.161135

The over-exploitation of mineral resources has led to increasingly serious dust pollution in mines, resulting in a series of negative impacts on the environment, mine workers (occupational health) and nearby residents (public health). For the environment, mine dust pollution is considered a major threat on surface vegetation, landscapes, weather conditions and air quality, leading to serious environmental damage such as vegetation reduction and air pollution; for occupational health, mine dust from the mining process is also regarded as a major threat to mine workers' health, leading to occupational diseases such as pneumoconiosis and silicosis; for public health, the pollutants contained in mine dust may pollute surrounding rivers, farmlands and crops, which poses a serious risk to the domestic water and food security of nearby residents who are also susceptible to respiratory diseases from exposure to mine dust. Therefore, the second section of this paper combines literature research, statistical studies, and meta analysis to introduce the public mainly to the severity of mine dust pollution and its hazards to the environment, mine workers (occupational health), and residents (public health), as well as to present an outlook on the management of mine dust pollution. At the same time, in order to propose a method for monitoring mine dust pollution on a regional scale, based on the Dense Dark Vegetation (DDV) algorithm, the third section of this paper analysed the aerosol optical depth (AOD) change in Dexing City of China using the data of 2010, 2014, 2018 and 2021 from the NASA MCD19A2 Dataset to explore the mine dust pollution situation and the progress of pollution treatment in Dexing City from 2010 to 2021. As a discussion article, this paper aims to review the environmental and health risks caused by mine dust pollution, to remind the public to take mine dust pollution seriously, and to propose the use of remote sensing technologies to monitor mine dust pollution, providing suggestions for local governments as well as mines on mine dust monitoring measures.

Matched MeSH terms: Remote Sensing Technology
Fulltext Induced electron radiation effect on the performance of inter-satellite optical wireless communication

Youssouf AS, Hasbullah NF, Saidin N, Habaebi MH, Parthiban R, Bin Mohamed Zin MR, et al.

PLoS One, 2021;16(12):e0259649.
PMID: 34972119 DOI: 10.1371/journal.pone.0259649

This paper provides the details of a study on the effects of electron radiation on the Performance of Inters-satellite Optical Wireless Communication (IsOWC). Academia and industry focus on solutions that can improve performance and reduce the cost of IsWOC systems. Spacecraft, space stations, satellites, and astronauts are exposed to an increased level of radiation when in space, so it is essential to evaluate the risks and performance effects associated with extended radiation exposures in missions and space travel in general. This investigation focuses on LEO, especially in the near-equatorial radiation environment. Radiation experiments supported with simulations have made it possible to obtain and evaluate the electron radiation impact on optoelectronics at the device level and system level performances. The electron radiation has induced a system degradation of 70%. This result demonstrates the importance of such an investigation to predict and take necessary and suitable reliable quality service for future space missions.

Matched MeSH terms: Wireless Technology*
Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties

Yoon YK, Ali MA, Wei AC, Shirazi AN, Parang K, Choon TS

Eur J Med Chem, 2014 Aug 18;83:448-54.
PMID: 24992072 DOI: 10.1016/j.ejmech.2014.06.060

Two series of novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity. Among the newly synthesized compounds, compound 4j displayed the best inhibitory activity for SIRT1 (IC50 = 54.21 μM) as well as for SIRT2 (IC50 = 26.85 μM). Cell proliferation assay showed that compound 4j possessed good antitumor activity against three different types of cancer cells derived from colon (HCT-116), breast (MDA-MB-468) and blood-leukemia (CCRF-CEM) with cell viability of 40.0%, 53.2% and 27.2% respectively at 50 μM. Docking analysis of representative compound 4j into SIRT2 indicated that the interaction with receptor was primarily due to hydrogen bonding and π-π stacking interactions.

Matched MeSH terms: Green Chemistry Technology*
Development and Practical Application of a Multiple-Criteria Decision Analysis Framework on Respiratory Inhalers: Is It Always Useful in the MOH Malaysia Medicines Formulary Listing Context?

Yong YV, Mahamad Dom SH, Ahmad Sa'ad N, Lajis R, Md Yusof FA, Abdul Rahaman JA

MDM Policy Pract, 2021 03 30;6(1):2381468321994063.
PMID: 33855190 DOI: 10.1177/2381468321994063

Objectives. The current health technology assessment used to evaluate respiratory inhalers is associated with limitations that have necessitated the development of an explicit formulary decision-making framework to ensure balance between the accessibility, value, and affordability of medicines. This study aimed to develop a multiple-criteria decision analysis (MCDA) framework, apply the framework to potential and currently listed respiratory inhalers in the Ministry of Health Medicines Formulary (MOHMF), and analyze the impacts of applying the outputs, from the perspective of listing and delisting medicines in the formulary. Methods. The overall methodology of the framework development adhered to the recommendations of the ISPOR MCDA Emerging Good Practices Task Force. The MCDA framework was developed using Microsoft Excel 2010 and involved all relevant stakeholders. The framework was then applied to 27 medicines, based on data gathered from the highest levels of available published evidence, pharmaceutical companies, and professional opinions. The performance scores were analyzed using the additive model. The end values were then deliberated by an expert committee. Results. A total of eight main criteria and seven subcriteria were determined by the stakeholders. The economic criterion was weighted at 30%. Among the noneconomic criteria, "patient suitability" was weighted the highest. Based on the MCDA outputs, the expert committee recommended one potential medicine (out of three; 33%) be added to the MOHMF and one existing medicine (out of 24; 4%) be removed/delisted from the MOHMF. The other existing medicines remained unchanged. Conclusions. Although this framework was useful for deciding to add new medicines to the formulary, it appears to be less functional and impactful for the removal/delisting existing medicines from the MOHMF. The generalizability of this conclusion to other formulations remains to be confirmed.

Matched MeSH terms: Technology Assessment, Biomedical

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