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Fulltext Therapeutic Effects of Vitamin D on Vaginal, Sexual, and Urological Functions in Postmenopausal Women

Hassanein MM, Huri HZ, Abduelkarem AR, Baig K

Nutrients, 2023 Aug 30;15(17).
PMID: 37686835 DOI: 10.3390/nu15173804

Recent years have witnessed the emergence of growing evidence concerning vitamin D's potential role in women's health, specifically in postmenopausal women. This evidence also includes its connection to various genitourinary disorders and symptoms. Numerous clinical studies have observed improvements in vulvovaginal symptoms linked to the genitourinary syndrome of menopause (GSM) with vitamin D supplementation. These studies have reported positive effects on various aspects, such as vaginal pH, dryness, sexual functioning, reduced libido, and decreased urinary tract infections. Many mechanisms underlying these pharmacological effects have since been proposed. Vitamin D receptors (VDRs) have been identified as a major contributor to its effects. It is now well known that VDRs are expressed in the superficial layers of the urogenital organs. Additionally, vitamin D plays a crucial role in supporting immune function and modulating the body's defense mechanisms. However, the characterization of these effects requires more investigation. Reviewing existing evidence regarding vitamin D's impact on postmenopausal women's vaginal, sexual, and urological health is the purpose of this article. As research in this area continues, there is a potential for vitamin D to support women's urogenital and sexual health during the menopausal transition and postmenopausal periods.

Matched MeSH terms: Vitamins
Effect of antioxidants and nutrients in patients with allergy and asthma

Das S

J Allergy Clin Immunol, 2014 Sep;134(3):763.
PMID: 25065724 DOI: 10.1016/j.jaci.2014.06.011
Matched MeSH terms: Vitamins/therapeutic use*
Fulltext Palm vitamin eprotects bone against dexamethasone-induced osteoporosis in male rats

Ima Nirwana S, Fakhrurazi H

Med J Malaysia, 2002 Jun;57(2):136-44.
PMID: 24326643

The aim of this study was to determine the effects of palm oil-derived vitamin E on glucocorticoid-induced osteoporosis. Three-month old male Wistar rats were adrenalectomised to remove circulating glucocorticoids. The animals were then administered with Dexamethasone 120 µg/kg body weight/day. Treatment with palm vitamin E 60 mg/kg body weight/day was given simultaneously. The results showed that palm vitamin E prevented the loss in regional and whole body bone mineral density seen in the Dexamethasone treated animals. Palm vitamin E improved femoral length and calcium content in the Dexamethasone treated animals. The results confirmed that palm oil-derived vitamin E was effective in preventing glucocorticoid-induced osteoporosis.

Matched MeSH terms: Vitamins*
Vitamin use and beliefs among students at a Malaysian university

Mazlan Bin Yong

J R Soc Health, 1990 Aug;110(4):132-4.
PMID: 2121980

A questionnaire was administered in class to a sample of physical education students at a Malaysian University in order to determine their beliefs and use patterns regarding vitamin supplementation. About a quarter of the subjects (24.6%) had practised vitamin supplementation for the past two years prior to the study, 14.9% of them being females as opposed to only 9.7% males. The most frequently used vitamin supplements, in rank order, were multivitamins (used by 57.6%), vitamin C (24.2%), the B-Complex vitamins (9.1%), and vitamin E (6.1%). Among vitamin supplementeers, the most frequently cited reasons for using vitamin supplements, in rank order, were 'to supplement the daily diet' (33.3%), 'to prevent colds' (27.3%), and 'to prevent fatigue or lethargy' (21.2%). Among non-supplementeers, the three reasons most frequently mentioned for not using vitamin supplements were 'vitamin needs are adequately supplied by daily meals' (50.5%), 'I am healthy enough and therefore I do not need extra vitamins' (27.2%), and 'fear of insidious side effects' (9.9%). In general, both supplementeers and non-supplementeers tended to believe in the purported health benefits of vitamin supplementation. However, on the whole, supplementeers were willing to change their supplementation habits.

Matched MeSH terms: Vitamins*
Vitamin treatment of hemiplegia

Tweedie DR

Med J Malaysia, 1978 Dec;33(2):193-4.
PMID: 755175
Matched MeSH terms: Vitamins/therapeutic use*
Effect of vitamin E in non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomised controlled trials

Amanullah I, Khan YH, Anwar I, Gulzar A, Mallhi TH, Raja AA

Postgrad Med J, 2019 Nov;95(1129):601-611.
PMID: 31434683 DOI: 10.1136/postgradmedj-2018-136364

The efficacy of vitamin E among patients with non-alcoholic fatty liver disease (NAFLD) is unclear. The current qualitative and quantitative analyses aimed to ascertain the efficacy of vitamin E on clinical outcomes of patients with NAFLD. A systematic search of randomised controlled trials (RCTs) was performed using databases (PubMed, ProQuest, Scopus, EBSCOhost and Ovid) from inception to July 2018. Trials meeting the inclusion criteria were subjected to quality assessment using the Jadad Scoring. All trials meeting the prerequisites information for meta-analysis were subjected to quantitative synthesis of results. Nine RCTs (five in adults and four in children) were included. Four of the five RCTs on adults demonstrated significant improvements in alanine transaminase and other liver function surrogates in patients with NAFLD. On the other hand, only one of the four RCTs conducted on children showed significant improvements in liver functions with the use of vitamin E. Although quantitative synthesis of available data revealed insignificant differences between vitamin E and placebo, still the use of vitamin E improves the level of alanine transaminase and aspartate transaminase by -1.96 and -0.59, with heterogeneity of I2=67% and I2=0%, respectively. Adjuvant vitamin E therapy provides significant biochemical and histological improvements in adult patients with NAFLD, while paediatric patients showed insignificant efficacy compared with placebo. Lifestyle interventions along with vitamin E can provide much better results. Data, including the impact of vitamin E on hepatic histology, are still lacking. Moreover, the short duration of trials limits the conclusion on the safety and efficacy of proposed treatments.

Matched MeSH terms: Vitamins/pharmacology
Vitamin-B12 deficiency in the megaloblastic anaemias of Malaya

TASKER PW, MOLLIN DL, BERRIMAN H

Br J Haematol, 1958 Apr;4(2):167-76.
PMID: 13536254
Matched MeSH terms: Vitamin B 12 Deficiency/complications*; Vitamins*
Fulltext Establishing Relationship between Vitamins, Total Phenolic and Total Flavonoid Content and Antioxidant Activities in Various Honey Types

Zawawi N, Chong PJ, Mohd Tom NN, Saiful Anuar NS, Mohammad SM, Ismail N, et al.

Molecules, 2021 Jul 21;26(15).
PMID: 34361551 DOI: 10.3390/molecules26154399

Honey is a well-known natural sweetener and is rich in natural antioxidants that prevent the occurrence of oxidative stress, which is responsible for many human diseases. Some of the biochemical compounds in honey that contribute to this property are vitamins and phenolic compounds such as phenolic acids and flavonoids. However, the extent to which these molecules contribute towards the antioxidant capacity in vitro is inconsistently reported, especially with the different analytical methods used, as well as other extrinsic factors that influence these molecules' availability. Therefore, by reviewing recently published works correlating the vitamin, total phenolic, and flavonoid content in honey with its antioxidant activities in vitro, this paper will establish a relationship between these parameters. Based on the literature, vitamins do not contribute to honey's antioxidant capacity; however, the content of phenolic acids and flavonoids has an impact on honey's antioxidant activity.

Matched MeSH terms: Vitamins/analysis*
Fulltext A literature review on beneficial role of vitamins and trace elements: Evidence from published clinical studies

Taheri S, Asadi S, Nilashi M, Ali Abumalloh R, Ghabban NMA, Mohd Yusuf SY, et al.

J Trace Elem Med Biol, 2021 Sep;67:126789.
PMID: 34044222 DOI: 10.1016/j.jtemb.2021.126789

COVID-19 is a kind of SARS-CoV-2 viral infectious pneumonia. This research aims to perform a bibliometric analysis of the published studies of vitamins and trace elements in the Scopus database with a special focus on COVID-19 disease. To achieve the goal of the study, network and density visualizations were used to introduce an overall picture of the published literature. Following the bibliometric analysis, we discuss the potential benefits of vitamins and trace elements on immune system function and COVID-19, supporting the discussion with evidence from published clinical studies. The previous studies show that D and A vitamins demonstrated a higher potential benefit, while Selenium, Copper, and Zinc were found to have favorable effects on immune modulation in viral respiratory infections among trace elements. The principles of nutrition from the findings of this research could be useful in preventing and treating COVID-19.

Matched MeSH terms: Vitamins/pharmacology*
Fulltext Clinical investigation of the protective effects of palm vitamin E tocotrienols on brain white matter

Gopalan Y, Shuaib IL, Magosso E, Ansari MA, Abu Bakar MR, Wong JW, et al.

Stroke, 2014 May;45(5):1422-8.
PMID: 24699052 DOI: 10.1161/STROKEAHA.113.004449

Previous cell-based and animal studies showed mixed tocotrienols are neuroprotective, but the effect is yet to be proven in humans. Thus, the present study aimed to evaluate the protective activity of mixed tocotrienols in humans with white matter lesions (WMLs). WMLs are regarded as manifestations of cerebral small vessel disease, reflecting varying degrees of neurodegeneration and tissue damage with potential as a surrogate end point in clinical trials.

Matched MeSH terms: Vitamins/administration & dosage; Vitamins/adverse effects; Vitamins/pharmacology*
The influence of maternal vitamin D supplementation on infant vitamin D status: A systematic review and meta-analyses

Zhong X, Xiong Y, Wei D, Wang S, Xiao Z, Liu M, et al.

Complement Ther Med, 2020 Aug;52:102491.
PMID: 32951740 DOI: 10.1016/j.ctim.2020.102491

BACKGROUND: Inconsistencies exist with regard to effect of maternal vitamin D supplementation on infant vitamin D status. The inconsistencies could be attributed to numerous factors, such as duration of intervention and dosage, among others. In this work, we conducted a systematic review and meta-analysis to determine the influence of maternal vitamin D supplementation on infant vitamin D status.
METHODS: A comprehensive systematic search was performed in Scopus, EMBASE, Web of Science, and PubMed/MEDLINE, by investigators, from database inception until November 2019, without using any restrictions. Weighted mean difference (WMD) with the 95 % CI was used for assessing the effects of maternal vitamin D supplementation on 25(OH) D levels in infants.
RESULTS: Overall results from 14 studies revealed a non-significant effect of maternal vitamin D administration on the level of 25(OH) D in breastfeeding infants (WMD: -0.464 ng/mL, 95 % CI: -6.68 to 5.75, p = 0.884, I2 = 98 %). Subgroup analyses demonstrated that vitamin D supplementation dosage ≥2000 IU/day (WMD: 9 ng/mL, 95 % CI: 8.19, 9.82, I2 = 99 %) and intervention duration ≥20 weeks (WMD: 16.20 ng/mL, 95 % CI: 14.89, 17.50, I2 = 99 %) significantly increased 25(OH) D.
CONCLUSIONS: The main results indicate a non-significant increase in infant vitamin D following maternal vitamin D supplementation. Additionally, vitamin D supplementation dosage ≥2000 IU/day and intervention duration ≥20 weeks significantly increased infant 25(OH) D.

Matched MeSH terms: Vitamins
Fulltext UVC dosage effects on the physico-chemical properties of lime (Citrus aurantifolia) juice

Mohd-Hanif H, Shamsudin R, Adzahan NM

Food Sci Biotechnol, 2016;25(Suppl 1):63-67.
PMID: 30263487 DOI: 10.1007/s10068-016-0099-2

Lime juice is in high demand due to a sour taste. Commercial thermal pasteurization extends juice shelf-life; however, fruit juice subjected to thermal pasteurization tends to change color and lose vitamin content. Lime juice was irradiated with ultraviolet-C (UVC) at dosages of 22.76, 30.19, and 44.24 mJ/cm2 to investigate effects on the physicochemical properties of lime juice. pH values of lime juice did not change while total soluble solids, turbidity, titratable acidity, sweetness, and color values of lime juice did change after UV treatments. Changes in quality index indicators were prominent at the highest UV dosage of 44.24 mJ/cm2. A low UVC dosage was effective for treatment of lime juice with minimal changes in juice properties.

Matched MeSH terms: Vitamins
Vitamin‐B12 Deficiency in the Megaloblastic Anaemias of Malaya

Tasker PWG, Mollin DL, Berriman H

Br J Haematol, 1958;4:167-176.
DOI: 10.1111/j.1365-2141.1958.tb03847.x
Matched MeSH terms: Vitamins
The nutritional composition of mayonnaise and salad dressing in the Malaysian market

Aswir Abd Rashed, Mohd Fairulnizal Md Noh, Norhayati Mustafa Khalid, Mohd Naeem Mohd Nawi, Mohd Azerulazree Jamilan, Nurul `Izzah Ab Rahman, et al.

Sains Malaysiana, 2017;46:139-147.

Mayonnaise and salad dressing are fast becoming popular condiments for Malaysian. The aim of this study was to
obtain the nutritional composition of mayonnaise and salad dressing commercially available in the Malaysian market.
The data will be used to update the Malaysian Food Composition Database which was last updated in 1997. A total of
six brands from each type of mayonnaise and salad dressing were sampled from local supermarkets in the Klang Valley
and analysed using standard methods. The validity of test data was monitored with the application of internal quality
controls in line with the requirements of ISO 17025. The energy contents of mayonnaise and salad dressings were up to
626.40 kcal/100 g. Our findings were also in agreement with the energy labelling on the packaging. Sodium was high in
mayonnaise and salad dressing because it is used in the final mixture of both condiments to improve their characteristics
for certain reasons. Mayonnaise and salad dressing have been identified as potent sources of vitamin A and vitamin
E and both condiments were found to contain high levels of these antioxidants. It can be concluded that this study are
useful not only in providing information on the nutritional content of several commercial types of mayonnaise and salad
dressing, but also in improving the public understanding of healthy food choices.

Matched MeSH terms: Vitamins
Fulltext Current Evidence on the Association of Micronutrient Malnutrition with Mild Cognitive Impairment, Frailty, and Cognitive Frailty among Older Adults: A Scoping Review

Mustafa Khalid N, Haron H, Shahar S, Fenech M

Int J Environ Res Public Health, 2022 Nov 25;19(23).
PMID: 36497797 DOI: 10.3390/ijerph192315722

Micronutrient malnutrition is thought to play an important role in the cause of cognitive impairment and physical frailty. The purpose of this scoping review was to map current evidence on the association between micronutrient deficiency in blood and mild cognitive impairment, frailty, and cognitive frailty among older adults. The scoping review was conducted based on the 2005 methodological framework by Arksey and O'Malley. The search strategy for potential literature on micronutrient concentration in blood and cognitive frailty was retrieved based on the keywords using electronic databases (PubMed, Cochrane Library, Google Scholar, Ovid, and Science Direct) from January 2010 to December 2021. Gray literature was also included in the searches. A total of 4310 articles were retrieved and 43 articles were incorporated in the review. Findings revealed a trend of significant association between low levels of B vitamins (folate and vitamin B12), vitamin D, vitamin A, vitamin E, omega 3 fatty acid, and albumin, and high homocysteine levels in blood with an increased risk of mild cognitive impairment among older adults. The results also indicated that low vitamin D levels, albumin, and antioxidants (lutein and zeaxanthin) in blood were significantly associated with frailty among older adults, while β-cryptoxanthin and zeaxanthin in blood were inversely associated with the risk of cognitive frailty. Vitamin D and antioxidants seemed to be targeted nutrients for the prevention of cognitive frailty. In conclusion, a wide range of micronutrient deficiency was associated with either mild cognitive impairment or frailty; however, little evidence exists on the dual impairment, i.e., cognitive frailty. This scoping review can serve as preliminary evidence for the association between micronutrient deficiency in blood and mild cognitive impairment, frailty, and cognitive frailty among older adults and prove the relevancy of the topic for future systematic reviews.

Matched MeSH terms: Vitamins
Fulltext The Impact of Vitamin D Deficiency and Insufficiency on the Outcome of Type 2 Diabetes Mellitus Patients: A Systematic Review

Md Isa Z, Amsah N, Ahmad N

Nutrients, 2023 May 15;15(10).
PMID: 37242192 DOI: 10.3390/nu15102310

Vitamin D deficiency and insufficiency are public health concerns that have contributed to multiple negative health outcomes. Recent studies have revealed that vitamin D deficiency and insufficiency influence glycaemic control and the development of diabetes complications. The goal of this systematic review is to summarise the latest evidence on the impact of vitamin D deficiency and insufficiency on the outcome of Type 2 Diabetes Mellitus (T2DM) patients. In this PRISMA-guided systematic review, articles were sourced from three databases, namely, PubMed, Scopus, and Web of Science. The review only included literature published from 2012 until 2022, and 33 eligible studies met the inclusion criteria for this review. The included articles were critically appraised using the Mixed Method Appraisal Tool (MMAT). According to our findings, vitamin D deficiency or insufficiency is associated with mental health status, macrovascular and microvascular complications of T2DM, metabolic syndrome, increased risk of obesity, increased blood pressure, dyslipidaemia, glycaemic control, nerve-related disease, musculoskeletal-related complications, and reduced quality of life. Due to the diverse implications of vitamin D deficiency and insufficiency, screening for vitamin D levels in T2DM patients may be beneficial.

Matched MeSH terms: Vitamins
Fulltext Fish and Fish-Based Products for Nutrition and Health in the First 1000 Days: A Systematic Review of the Evidence from Low and Middle-Income Countries

Byrd KA, Shieh J, Mork S, Pincus L, O'Meara L, Atkins M, et al.

Adv Nutr, 2022 Dec 22;13(6):2458-2487.
PMID: 36166842 DOI: 10.1093/advances/nmac102

Fish provide essential nutrients for the critical window of growth and development in the first 1000 d of life and are thus an attractive option for inclusion in nutrition-sensitive and nutrition-specific programming. We conducted a systematic review of the evidence for fish and fish-based products for nutrition and health outcomes during the first 1000 d of life in low- and middle-income countries, searching the peer-reviewed and gray literature from 1999 to 2020. Databases included PubMed, Web of Science, Embase, ProQuest, and the Clinical Trials repository. Our search returned 1135 articles, 39 of which met the inclusion criteria. All studies were dual evaluated for risk of bias. Of the included studies, 18 measured maternal health and nutrition outcomes and 24 measured infant/child outcomes (3 measured both). Our search uncovered 10 impact evaluations, all of which measured consumption of fish or fish-based complementary food products in children aged 6-24 mo. We did not find strong evidence for fish consumption in children improving child growth from the impact evaluations; however, the studies were highly heterogeneous in their design and likely underpowered to detect an effect. Results from observational studies were mixed but provided evidence that adding fish to maternal and child diets is associated with improved nutrition outcomes, such as reducing the risk of anemia and improving vitamin D status. Given the nutrient richness of fish and the fact that production is often more environmentally friendly as compared with other animal source foods, more robust evidence is needed on the role of fish consumption in nutrition interventions to inform policy and programming recommendations in low- and middle-income countries.

Matched MeSH terms: Vitamins
Fulltext Breakfast Consumption and Quality of Macro- and Micronutrient Intake in Indonesia: A Study from the Indonesian Food Barometer

Khusun H, Anggraini R, Februhartanty J, Mognard E, Fauzia K, Maulida NR, et al.

Nutrients, 2023 Aug 30;15(17).
PMID: 37686824 DOI: 10.3390/nu15173792

Breakfast is an important meal that has been shown to have a positive effect on health. The current study aimed to assess the patterns of breakfast consumption among adult Indonesians and to estimate the contribution of breakfast to their nutrient intake and dietary quality. The study used 24-h recall data from the 2018 Indonesian Food Barometer study to assess breakfast intake among 1333 adults aged 18 and above from six provinces in Indonesia. Diet quality was measured using the Nutrient Rich Food index (NRF) 9.3, and the nutritional profile of breakfast was compared across tertiles of NRF 9.3. In total, 5.2% of adults in Indonesia skipped breakfast. Breakfast contributed 26% to daily energy intakes and 22-28% to intakes of all reported nutrients, except for total sugar (12%), vitamin C (8%) and vitamin D (7%). With respect to daily requirements, breakfast contributed approximately 20% to energy, protein, fat and sodium requirements, 26% to saturated fat but <15% to the requirements for most micronutrients and only 5% for fiber. Among breakfast consumers, a higher NRF score was associated with higher daily intakes of protein, dietary fiber and micronutrients and lower intakes of sodium from breakfast. This study suggests that a balanced breakfast in Indonesia should aim to lower fat and saturated fat intake while increasing fiber, potassium, calcium and vitamin C and D intake. These findings could inform the development of nutrient-based guidelines for breakfast consumption in Indonesia.

Matched MeSH terms: Vitamins
Fulltext Safety of Vitamin K in mechanical heart valve patients with supratherapeutic INR: A systematic review and meta-analysis

Sapapsap B, Srisawat C, Suthumpoung P, Luengrungkiat O, Leelakanok N, Saokaew S, et al.

Medicine (Baltimore), 2022 Sep 09;101(36):e30388.
PMID: 36086772 DOI: 10.1097/MD.0000000000030388

BACKGROUND: Patients who had mechanical heart valves and an international normalized ratio (INR) of >5.0 should be managed by temporary cessation of vitamin K antagonist. This study aimed to investigate the safety of low-dose vitamin K1 in patients with mechanical heart valves who have supratherapeutic INR.
METHODS: CINAHL, Cochran Library, Clinical trial.gov, OpenGrey, PubMed, ScienceDirect, and Scopus were systematically searched from the inception up to October 2021 without language restriction. Studies comparing the safety of low-dose vitamin K1 treatment in patients with placebo or other anticoagulant reversal agents were included. We used a random-effect model for the meta-analysis. Publication bias was determined by a funnel plot with subsequent Begg's test and Egger's test.
RESULTS: From 7529 retrieved studies, 3 randomized control trials were included in the meta-analysis. Pooled data demonstrated that low-dose vitamin K was not associated with thromboembolism rate (risk ratio [RR] = 0.94; 95% CI: 0.19-4.55) major bleeding rate (RR = 0.58; 95% CI: 0.07-4.82), and minor bleeding rate (RR = 0.60; 95% CI: 0.07-5.09). Subgroup and sensitivity analysis demonstrated the nonsignificant effect of low-dose vitamin K on the risk of thromboembolism. Publication bias was not apparent, according to Begg's test and Egger's test (P = .090 and 0.134, respectively).
CONCLUSION: The current evidence does not support the role of low-dose vitamin K as a trigger of thromboembolism in supratherapeutic INR patients with mechanical heart valves. Nevertheless, more well-designed studies with larger sample sizes are required to justify this research question.

Matched MeSH terms: Vitamins
Fulltext A motley of possible therapies of the COVID-19: reminiscing the origin of the pandemic

Kaur I, Behl T, Sehgal A, Singh S, Sharma N, Subramanian V, et al.

Environ Sci Pollut Res Int, 2022 Sep;29(45):67685-67703.
PMID: 35933528 DOI: 10.1007/s11356-022-22345-w

The 2019 outbreak of corona virus disease began from Wuhan (China), transforming into a leading pandemic, posing an immense threat to the global population. The WHO coined the term nCOVID-19 for the disease on 11th February, 2020 and the International Committee of Taxonomy of Viruses named it SARS-CoV-2, on account of its similarity with SARS-CoV-1 of 2003. The infection is associated with fever, cough, pneumonia, lung damage, and ARDS along with clinical implications of lung opacities. Brief understanding of the entry target of virus, i.e., ACE2 receptors has enabled numerous treatment options as discussed in this review. The manuscript provides a holistic picture of treatment options in COVID-19, such as non-specific anti-viral drugs, immunosuppressive agents, anti-inflammatory candidates, anti-HCV, nucleotide inhibitors, antibodies and anti-parasitic, RNA-dependent RNA polymerase inhibitors, anti-retroviral, vitamins and hormones, JAK inhibitors, and blood plasma therapy. The text targets to enlist the investigations conducted on all the above categories of drugs, with respect to the COVID-19 pandemic, to accelerate their significance in hindering the disease progression. The data collected primarily targets recently published articles and most recent records of clinical trials, focusing on the last 10-year database. The current review provides a comprehensive view on the critical need of finding a suitable treatment for the currently prevalent COVID-19 disease, and an opportunity for the researchers to investigate the varying possibilities to find and optimized treatment approach to mitigate and ameliorate the chaos created by the pandemic worldwide.

Matched MeSH terms: Vitamins

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