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Clinical investigation of the protective effects of palm vitamin E tocotrienols on brain white matter

Gopalan Y 1 , Shuaib IL , Magosso E , Ansari MA , Abu Bakar MR , Wong JW Show all authors , Khan NA , Liong WC , Sundram K , Ng BH , Karuthan C , Yuen KH

Affiliations 

  • 1 From the Faculty of Pharmacy, Universiti Teknologi Mara, Selangor, Malaysia (Y.G.); Advanced Medical and Dental Institute, Penang, Malaysia (I.L.S., E.M., M.A.A., M.R.A.B.); School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia (N.A.K.K., K.H.Y.); Hovid Research Sdn Bhd, Ipoh, Malaysia (J.W.W., B.H.N.); Malaysian Palm Oil Council (K.S.); Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia (C.K.); Buckinghamshire Healthcare, NHS Trust, Buckinghamshire, United Kingdom (W.C.L.)
Stroke, 2014 May;45(5):1422-8.
PMID: 24699052 DOI: 10.1161/STROKEAHA.113.004449

Abstract

Previous cell-based and animal studies showed mixed tocotrienols are neuroprotective, but the effect is yet to be proven in humans. Thus, the present study aimed to evaluate the protective activity of mixed tocotrienols in humans with white matter lesions (WMLs). WMLs are regarded as manifestations of cerebral small vessel disease, reflecting varying degrees of neurodegeneration and tissue damage with potential as a surrogate end point in clinical trials.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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