Displaying publications 21 - 40 of 112 in total

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  1. Kalanjati VP, Hasanatuludhhiyah N, d'Arqom A, Muhammad A, Marchianti ACN, Arsyi DH, et al.
    F1000Res, 2022;11:1296.
    PMID: 36636472 DOI: 10.12688/f1000research.125551.2
    Introduction: Health literacy on the coronavirus disease 2019 (COVID-19) affects people's capability to ascertain their health and health care quality during the pandemic. The objective of this study was to determine the levels of health literacy about COVID-19 vaccines and vaccinations (Vaccines and Vaccinations literacy-VL) in the Indonesian adult general population, assessing the perceptions of the respondents about current adult immunization and beliefs about vaccinations in general, and analyzing correlations of these variables with the VL levels. Methods: A cross-sectional study using a rapid survey was administered via the Internet. Data were analyzed using descriptive and inferential statistics; the internal consistency of the VL scales was evaluated using Cronbach's alpha coefficient; the inter-correlation between the functional and interactive-critical VL questions, the underlying components (factors) and each question's load on the components were identified using a Principal Component Analysis (PCA). An alpha level lesser than 0.05 was considered significant. Results: Responses to functional- and interactive/ critical- VL questions were acceptable and showed internal consistency (Cronbach's alpha = 0.817 and 0.699, respectively), lowest values observed were 0.806 for functional scale and 0.640 for the interactive-critical scale. The PCA demonstrated that there were two components accounting for 52.45% of the total variability. Approximately 60% of respondents were females (n=686). Almost all respondents used the internet to seek information regarding COVID-19 and COVID-19 vaccinations. Many used at least one social media actively with 74.4% of respondents sometimes believing the validity of this information. Conclusions: High scores were observed in both functional- and interactive/ critical-VL, and were quite in a balance between sexes in the prior VL and higher in females for the latter; these were also closely related to the educational level and age group. It is crucial to increase public health literacy in managing the pandemic.
    Matched MeSH terms: Indonesia/epidemiology
  2. Nur FM, Batubara AS, Fadli N, Rizal S, Siti-Azizah MN, Wilkes M, et al.
    Rev Bras Parasitol Vet, 2022;31(1):e020421.
    PMID: 35293430 DOI: 10.1590/S1984-29612022015
    Betta rubra is an ornamental freshwater fish endemic to northern Sumatra, Indonesia. The B. rubra population has decreased in recent decades, and is classified as an endangered species in the IUCN Red List. This study aims to report for the first time infection by L. cyprinacea in B. rubra harvested from the Aceh Besar region of Indonesia. The fish samples were obtained from the Cot Bira tributaries, Aceh Besar District, Indonesia from January to December 2020. The results showed that the parasite infected 6 out of 499 samples in August and September, with a prevalence and intensity rate of 1% and 2 parasites/fish, respectively. The eyes and pectoral fins were the common infection sites. Despite B. rubra is not an optimal host (small size) for the parasite, this parasite might serve as additional threatening factors for the endangered B. rubra fish population.
    Matched MeSH terms: Indonesia/epidemiology
  3. Pattanakuhar S, Ahmedy F, Setiono S, Engkasan JP, Strøm V, Kovindha A
    Am J Phys Med Rehabil, 2023 Mar 01;102(3):214-221.
    PMID: 35700141 DOI: 10.1097/PHM.0000000000002066
    BACKGROUND: The impact of bladder care and urinary complications on quality of life in persons with spinal cord injury who have neurogenic lower urinary tract dysfunction has not been elucidated, especially in those living in low-resource countries.

    METHODS: This multinational cross-sectional survey was conducted in rehabilitation facilities in Malaysia, Indonesia, and Thailand. Community-dwelling adults with traumatic or nontraumatic spinal cord injury participating in the International Spinal Cord Injury Community Survey from 2017 to 2018 were enrolled. Data regarding bladder management/care, presence of bladder dysfunction, urinary tract infection, and quality of life score were extracted from the International Spinal Cord Injury Community Survey questionnaire. The impact of bladder care and urinary complications on quality of life was determined using univariable and multivariable regression analysis.

    RESULTS: Questionnaires from 770 adults were recruited for analysis. After adjusting for all demographic and spinal cord injury-related data, secondary conditions, as well as activity and participation factors, urinary tract infection was an independent negative predictive factor of quality of life score ( P = 0.007, unstandardized coefficients = -4.563, multivariable linear regression analysis, enter method).

    CONCLUSIONS: Among bladder care and urinary complication factors, urinary tract infection is the only factor negatively impacting quality of life. These results address the importance of proper bladder management and urinary tract infection prevention in persons with spinal cord injury to improve their quality of life.

    Matched MeSH terms: Indonesia/epidemiology
  4. Seran JM, Untari T, Kusumawati A, Salsabila RAI
    Open Vet J, 2025 Jun;15(6):2903-2908.
    PMID: 40989634 DOI: 10.5455/OVJ.2025.v15.i6.60
    BACKGROUND: One disease that interferes with reproductive performance is brucellosis, which causes significant economic losses.

    AIM: This study aimed to identify the reactor and evaluate the results of a Brucella abortus vaccination in the Malaka Regency.

    METHODS: This research method involves the first stage, which involves sampling serum from 100 cattle. Serum specimens are derived from blood taken from the jugular or coccygeal vein using a Vacutainer tube filled with silicone and left at room temperature until the blood is separated into serum and clot. Then, for serological tests in the form of the Rose Bengal test (RBT), if the RBT test is positive, followed by the complement fixation test (CFT) test, and the CFT test is also positive, the patient is designated as a brucellosis reactor. At the same time, if the CFT is positive in vaccinated cattle, the vaccination is considered successful, and if it is negative, it is necessary to reevaluate the immunization.

    RESULT: The results of 100 samples showed that the RBT and CFT tests yielded two distinct outcomes: a positive RBT and a negative CFT test, indicating that no B. abortus reactors were detected.

    CONCLUSION: Cattle in Malacca Regency were not found to be positive for the B. abortus reactor. Vaccination results against Brucella are not optimal, as indicated by the absence of an antibody response, as determined by RBT and CFT tests.

    Matched MeSH terms: Indonesia/epidemiology
  5. Ismail M, Alsalahi A, Khaza'ai H, Imam MU, Ooi J, Samsudin MN, et al.
    PMID: 32731336 DOI: 10.3390/ijerph17155410
    BACKGROUND: Cerebrovascular diseases (CBVDs) and diabetes mellitus (DM) are interrelated and cumbersome global health burdens. However, the relationship between edible oils consumption and mortality burdens of CBVDs and DM has not yet been evaluated. This review aims to explore correlations between per capita mortality burdens of CBVDs and DM, as well as food consumption of palm or soya oils in 11 randomly selected countries in 2005, 2010, and 2016.

    METHODS: After obtaining data on food consumption of palm and soya oils and mortality burdens of CBVDs and DM, correlations between the consumption of oils and mortality burdens of diseases were explored.

    RESULTS: There was a positive correlation between the consumption of soya oil with the mortality burden of CBVDs in Australia, Switzerland, and Indonesia, as well as the mortality burden of DM in the USA. The consumption of palm oil had a positive correlation with the mortality burden of DM in Jordan only.

    CONCLUSIONS: Food consumption of soya oil in several countries possibly contributes to the mortality burden of CBVDs or DM more than food consumption of palm oil, which could be a possible risk factor in the mortality burdens of CBVDs and DM.

    Matched MeSH terms: Indonesia/epidemiology
  6. Efendie B, Abdullah I, Yusuf E
    Sr Care Pharm, 2020 Nov 01;35(11):484-486.
    PMID: 33121570 DOI: 10.4140/TCP.n.2020.484
    The pandemic has affected all walks of life and businesses, including education at all levels. Movement controls have forced the schools and universities to migrate the teaching and learning to be fully online. Some universities in large cities in Malyasia had already implemented blended learning and thus, were better prepared to adjust to the current situation. However, the universities, which practiced mainly traditional didactic courses, were struggling to suddenly change the mode of delivery. Many relied on the creativity of the lecturers and students.
    Matched MeSH terms: Indonesia/epidemiology
  7. Setiati S, Marsigit J
    Acta Med Indones, 2021 Jan;53(1):1-4.
    PMID: 33818400
    It has been a year since the Indonesian government announced its first COVID-19 identified in Jakarta. Since then, there have been more than 900,000 cases in Indonesia with case fatality rate (CFR) of 2.9%. The number of new cases per day is now ranging from 9,000 cases to almost 13,000 cases. Not only in Indonesia, but the number of new cases along with the mortality rate in other countries, such as Malaysia, Japan, United States, and Europe region also increased dramatically. COVID-19 vaccines are being investigated and the world hopes that vaccines will be the answer to tackle this pandemic. Is it really so? Immunization is an effort to induce immunity in individuals to prevent a disease or the complication related to the diseases that may be catastrophic. Immunization can be divided into passive, which is by giving certain type of antibody and active, which means that either we get the disease, or we get the antigen injected into our body.Having prior vaccination or past COVID-19 does not mean that someone is totally immune to COVID-19 as a recent study suggested that the antibody related to COVID-19 past infection is significantly decreasing after 3 months post-infection. Compliance to implementation of health protocol remained the most crucial strategy during this pandemic.
    Matched MeSH terms: Indonesia/epidemiology
  8. Ahsan A, Afin R, Amalia N, Hindriyani M, Jacinda AR, Kramer E
    Global Health, 2022 Feb 05;18(1):11.
    PMID: 35123526 DOI: 10.1186/s12992-022-00810-y
    BACKGROUND: Indonesia's stagnated progress towards tobacco control could be addressed through the implementation of a comprehensive national framework, such as the World Health Organization's (WHO) Framework Convention of Tobacco Control (FCTC). However, national tobacco industry supporters argue that accepting the FCTC will have negative economic implications for the country. These arguments have, thus far, discouraged the Indonesian government from ratifying the FCTC. Drawing from an analysis of the impact of the FCTC on other countries' smoking rates and Gross Domestic Product (GDP) per capita, this study offers empirical evidence against industry arguments concerning the potential negative economic impacts of FCTC adoption. This study applies a two stage least square estimation strategy to unbalanced panel data at country level. In the first stage we estimate the impact of FCTC ratification on smoking rates, and in the second step, we estimate the influence of smoking activity on macroeconomic performance.

    RESULTS: The result of this study shows that FCTC ratification has a negative impact on a country's smoking prevalence. While FCTC ratification positively correlates with reduced smoking prevalence, a decline in smoking prevalence is not related to a decline in GDP per capita.

    CONCLUSIONS: The results of this study shows that FCTC ratification, which can be an important driver for more effective tobacco control, does not necessarily have a negative impact on the economy. Instead, FCTC ratification may be beneficial for both health and economic outcomes, as it provides comprehensive guidance for reducing smoking prevalence that take into account social and economic factors.

    Matched MeSH terms: Indonesia/epidemiology
  9. Syafrawati S, Machmud R, Aljunid SM, Semiarty R
    Front Public Health, 2023;11:1147709.
    PMID: 37663851 DOI: 10.3389/fpubh.2023.1147709
    OBJECTIVE: To identify the incidence of moral hazards among health care providers and its determinant factors in the implementation of national health insurance in Indonesia.

    METHODS: Data were derived from 360 inpatient medical records from six types C public and private hospitals in an Indonesian rural province. These data were accumulated from inpatient medical records from four major disciplines: medicine, surgery, obstetrics and gynecology, and pediatrics. The dependent variable was provider moral hazards, which included indicators of up-coding, readmission, and unnecessary admission. The independent variables are Physicians' characteristics (age, gender, and specialization), coders' characteristics (age, gender, education level, number of training, and length of service), and patients' characteristics (age, birth weight, length of stay, the discharge status, and the severity of patient's illness). We use logistic regression to investigate the determinants of moral hazard.

    RESULTS: We found that the incidences of possible unnecessary admissions, up-coding, and readmissions were 17.8%, 11.9%, and 2.8%, respectively. Senior physicians, medical specialists, coders with shorter lengths of service, and patients with longer lengths of stay had a significant relationship with the incidence of moral hazard.

    CONCLUSION: Unnecessary admission is the most common form of a provider's moral hazard. The characteristics of physicians and coders significantly contribute to the incidence of moral hazard. Hospitals should implement reward and punishment systems for doctors and coders in order to control moral hazards among the providers.

    Matched MeSH terms: Indonesia/epidemiology
  10. Corebima BIRV, Handono K, Barlianto W, Santosaningsih D, Rohsiswatmo R, Sulistijono E, et al.
    Med J Malaysia, 2023 Jul;78(4):458-465.
    PMID: 37518912
    INTRODUCTION: Necrotising enterocolitis (NEC) is a serious health problem primarily affects preterm and very low birthweight (VLBW) infants. However, the pathomechanism of NEC remains elusive. This study aimed to analyse the risk factors for NEC among preterm neonates in East Java, Indonesia.

    MATERIALS AND METHODS: A single-centre, prospective, casecontrol study involving 32 subjects of preterm neonates was conducted at a tertiary care hospital in Malang, East Java, Indonesia between January to June 2022. A total of 15 preterm neonates with NEC and 17 preterm neonates without NEC were enrolled in this study. Data on demographic, clinical and laboratory findings were collected. Multiple logistic regression test was performed to analyse the risk factors for NEC development. Further profiling within 15 subjects with NEC, i.e., NEC grade ≥ II, were conducted to collect systemic, abdominal, laboratory, abdominal x-ray (AXR) and blood culture findings.

    RESULTS: The risk factors related to NEC development in preterm infants were multi-morbidity (adjusted OR = 11.96; 95% CI 1.85 168.38; p = 0.046), antibiotic exposure (OR = 15.95; 95% CI 1.54 165.08; p = 0.020) and requiring advanced neonatal resuscitation at birth (OR = 10.04; 95% CI 1.09 92.11; p = 0.041). Further profiling within NEC cohorts highlighted respiratory distress (86.7%), (oro)gastric retention (80.0%), thrombocytopenia (53.3%), gastrointestinal dilatation in AXR (53.3%), and positive blood culture Klebsiella pneumoniae (40.0%) were most common findings.

    CONCLUSION: Preterm neonates with multimorbidity, prolonged antibiotic exposure, and requiring advanced resuscitation at birth were more likely to develop NEC. Early detection of the risk factors and determinant factors for survival may help to improve the clinical outcome.

    Matched MeSH terms: Indonesia/epidemiology
  11. Lee HF, Hsu HC, Efendi F, Ramoo V, Susanti IA
    PLoS One, 2023;18(10):e0291073.
    PMID: 37816005 DOI: 10.1371/journal.pone.0291073
    The primary frontline healthcare providers who have frequent contact with COVID-19 patients are nurses. Many nurses have been infected with COVID-19 and have experienced severe emotional exhaustion and burnout. It is essential to assess nurses' psychological health during the COVID-19 pandemic. This study aimed to analyze the factors associated with burnout, resilience, and empowerment among Indonesian COVID-19 nurse survivors. In this cross-sectional study, 182 COVID-19 survivor nurses participated from September to November 2022 with convenience sampling. An online survey using the Copenhagen Burnout Inventory (CBI), the Connor-Davidson Resilience Scale (CD-RISC), and the Psychological Empowerment Scale (PES) were used to collect data. The data were analyzed using descriptive and binary logistic regression analyses. The majority of the nurses were aged between 30-45 years (61.6%), and females (67.4%) experienced burnout. Higher resilience was found among nurses contracting COVID-19 (83.1%). In the multivariate logistic regression analysis, the absence of psychological impact (OR = 0.44, 95% CI = 0.21-0.93) is significantly related to higher burnout experience. In addition, workplace, especially in hospital (OR = 4.32, 95% CI = 1.09-17.09) was associated with resilience, and a gap time after receiving negative COVID-19 result (OR = 3.90, 95% CI = 1.27-12.03) was correlated with psychological empowerment, in our results 4-6 month after had a negative result was at higher risk. To maintain a positive psychological aspect for COVID-19 nurse survivors, it needs to implement psychological support in the workplace and ensure an appropriate workload of nurse professionals.
    Matched MeSH terms: Indonesia/epidemiology
  12. Ling HN
    Lepr Rev, 2014 Dec;85(4):332-5.
    PMID: 25675658
    Matched MeSH terms: Indonesia/epidemiology
  13. Kapti RE, Arief YS, Triharini M, Corebima BIRV, Azizah N, Amaliya S
    Med J Malaysia, 2022 Nov;77(6):717-723.
    PMID: 36448390
    INTRODUCTION: Diarrhoea is one of the leading causes of infant mortality and morbidity. Infants with low-birth weight (LBW) have a higher risk of diarrhoea due to their low immunity and nutritional status issues.This study aimed to analyze the factors associated with diarrhoea in infants with LBW in Indonesia.

    MATERIALS AND METHODS: We used cross-sectional and secondary data from the 2017 Indonesia Demographic and Health Survey (IDHS). A total of 142 infants under 1 year were selected as the respondents. Chi-square test and binary logistic regression were used to examine factors associated with diarrhoea in infants with LBW in Indonesia.

    RESULTS: There are several factors more likely to increase the incidence of diarrhoea in infants with LBW, which are living in rural areas [OR = 5.65, 95% CI = 1.08-29.5] and having internet access less than the last 12 months (OR = 13.03, 95% CI = 1.48-114). Meanwhile, factors more likely to decrease the incidence of diarrhoea in infants with LBW, which are maternal age (20-24 years old) [odds ratio (OR) = 0.07, 95% CI = 0.01-0.98], cell phone ownership (OR = 0.08, 95% CI= 0.01-0.45), and the use of feeding bottles (OR = 0.22, 95% CI = 0.05-0.92).

    CONCLUSION: This study highlights that maternal age, cell phone ownership, internet access, area of residence, and use of feeding bottles are significant factors associated with diarrhoea in infants with LBW. Health workers must enhance health education related to those factors through the Community Integrated Child Health Service (Posyandu) programs.

    Matched MeSH terms: Indonesia/epidemiology
  14. Karuniawati H, Sari N, Hossain MS, Ismail WI, Haq AHB, Yulianti T, et al.
    Int J Environ Res Public Health, 2022 Sep 22;19(19).
    PMID: 36231312 DOI: 10.3390/ijerph191912011
    The COVID-19 pandemic globally impacted physical, spiritual, and mental health (MH). The consequences significantly affected students' quality of life (QoL) too. This cross-sectional study assessed MH status and its relationship to the QoL of college students in Indonesia. This study collected data (September 2021-April 2022) online using the depression, anxiety, and stress scale-21 (DASS-21) to measure MH and the world health organization quality-of-life scale (WHOQoL-BREF) to measure the QoL. The data were analysed using SPSS with a bivariate and multivariate linear regression test. A total of 606 respondents participated in this study, with the majority being women (81.0%), aged 21-27 years (44.3%), and unmarried (98.5%) respondents. We observed 24.4% (n = 148) moderate depression, 18.3% (n = 111) very severe anxiety, and 21.1% (n = 128) moderate stress status. The QoL measurement determined that a moderate QoL in the physical and environmental health domains (>70%) and poor QoL in the psychological health domain (58.3%) were found. Gender, age, family support, history of COVID-19 diagnosis, family with COVID-19 diagnosis, vaccination status, and physical symptoms are significantly associated with MH status and QoL (p-value < 0.05). This study demonstrated that COVID-19 was negatively related to college students' MH and QoL. Targeted interventions may be needed to ameliorate both MH and QoL.
    Matched MeSH terms: Indonesia/epidemiology
  15. Ahsan A, Djutaharta T, Utami MG, Ayuning Pertiwi YB, Diniary A, Amalia N, et al.
    Soc Sci Med, 2025 May;372:117956.
    PMID: 40121696 DOI: 10.1016/j.socscimed.2025.117956
    Among the concerning commercial practices are those related to sugar-sweetened beverages (SSBs), which offer little nutritional value and contribute to energy-dense diets. Excessive SSB consumption is associated with obesity, a major risk factor for non-communicable diseases (NCDs), particularly Type 2 Diabetes Mellitus (T2DM). The rise in SSB consumption in Indonesia, driven by commercial factors, increases the risk of T2DM and related health burdens. This study aims to investigate SSB consumption patterns, caloric intake, and socio-demographic characteristics affecting T2DM prevalence, using probit regression estimates based on National Socioeconomic Survey (SUSENAS) 2018 and Basic Health Research (Riskesdas) 2018. The sample size comprises 699,959 individuals, with the unit of analysis focused on individual health outcomes. Our descriptive result implies that 76.49 % incurred expenses on at least one type of SSB in the past week. Ready-to-drink beverages were the most frequently consumed, while factory-produced liquid milk had the lowest average consumption. Probit regression analysis indicated that higher SSB caloric consumption significantly increased the probability of a T2DM diagnosis. This study underscores the need for targeted interventions to reduce SSB consumption and address T2DM risk factors, especially among higher-income households and specific regions.
    Matched MeSH terms: Indonesia/epidemiology
  16. Novita R, Suprayogi A, Agusta A, Nugraha AB, Darusman HS
    Acta Parasitol, 2025 Feb 10;70(1):59.
    PMID: 39928186 DOI: 10.1007/s11686-025-00995-3
    PURPOSE: Plasmodium inui is a type of malaria that is endemic in simian populations in Southeast Asia, primarily infecting nonhuman primates, one of which is Macaca fascicularis, or the long-tailed macaque. Plasmodium inui, a malaria parasite endemic to simian populations in Southeast Asia, predominantly targets non-human primates. The escalating rates of deforestation and urban expansion, which facilitate increased interactions between humans and primates, have intensified concerns regarding its zoonotic potential. Despite receiving comparatively less scholarly attention than P. knowlesi, P. inui is distinguished by its substantial strain diversity and capacity to infect various macaque species. This review investigates the potential for crossspecies transmission of P. inui to humans, concentrating on the regions of Indonesia and Southeast Asia.

    METHODS: We evaluate the ecological and epidemiological determinants influencing the distribution and transmission dynamics of P. inui among macaques while also considering the implications for human infection based on a literature review obtained from PubMed, Google Scholar, and Scopus.

    RESULTS: Although no documented human cases have emerged in Indonesia, cases in humans have only been detected in Malaysia and Thailand, the review underscores the zoonotic risk associated with P. inui, drawing comparisons to other simian malaria species that have successfully infiltrated human populations. The lack of systematic surveillance and detailed molecular investigations concerning P. inui in these regions accentuates the imperative for further scholarly inquiry.

    CONCLUSION: This review emphasizes the need for ongoing monitoring and research to enhance the understanding of zoonotic threats associated with P. inui, and informs future public health initiatives in Southeast Asia through a comprehensive evaluation of the genetic diversity of the parasite and its potential implications for public health.

    Matched MeSH terms: Indonesia/epidemiology
  17. Kariodimedjo PP, Fadila N, Fine SR, Trimarsanto H, Cotter C, Trianty L, et al.
    PLoS One, 2025;20(3):e0318608.
    PMID: 40067800 DOI: 10.1371/journal.pone.0318608
    As in other parts of Southeast Asia, efforts to achieve or sustain malaria elimination in Indonesia have been threatened by the emergence of human infection with the primate species P. knowlesi. To understand the transmission dynamics of this species, investigation of P. knowlesi genetic diversity and population structure is needed. A molecular surveillance study was conducted in two phases between June 2014 and September 2018 at five primary health facilities in Aceh Province, Indonesia, an area nearing malaria elimination. Dried blood spot samples were collected from patients presenting with suspected malaria and testing positive for malaria by microscopy. PCR was performed for molecular confirmation and species identification. Forty-six samples were confirmed to be P. knowlesi, of which 41 were amplified with genotyping targeting ten known P. knowlesi microsatellite markers. For samples within a site, nearly all (9 of 10 loci) or all loci were polymorphic. Across sites, multiple identical haplotypes were observed, though linkage distribution in the population was low (index of association (IAS) = 0.008). The parasite population was indicative of low diversity (expected heterozygosity [HE] =  0.63) and low complexity demonstrated by 92.7% monoclonal infections, a mean multiplicity of infection of 1.06, and a mean within-host infection fixation index (FST) of 0.05. Principal coordinate and neighbour-joining tree analyses indicated that P. knowlesi strains from Aceh were distinct from those reported in Malaysia. In a near-elimination setting in Indonesia, we demonstrate the first evidence that P. knowlesi strains were minimally diverse and were genetically distinct from Malaysian strains, suggesting highly localized transmission and limited connectivity to Malaysia. Ongoing genetic surveillance of P. knowlesi in Indonesia can inform tracking and planning of malaria control and elimination efforts.
    Matched MeSH terms: Indonesia/epidemiology
  18. Romadhon PZ, Ashariati A, Bintoro SUY, Suryantoro SD, Windradi C, Mahdi BA, et al.
    Hemoglobin, 2024 Sep;48(5):301-307.
    PMID: 39497272 DOI: 10.1080/03630269.2024.2414102
    Patients suffering from thalassemia are recipients of routine transfusions leading to hemosiderosis. Taking iron chelating agents is mandatory. Several studies have shown different results regarding the occurrence of kidney complications in thalassemia patients who received iron-chelating agents. In this study, we were looking for kidney complications by examining human NAG urine/serum and NGAL urine/serum in thalassemia community in East Java community. The study was conducted cross-sectionally in the thalassemia community in East Java with a total sample of 91 patients aged 13-48 years. All thalassemia patients filled in demographic data, transfusion routines, duration of taking iron chelating agents, and length of time diagnosed with thalassemia. Laboratory tests included routine blood tests for ferritin, ureum, serum creatinine, human NAG urine or serum, and human NGAL urine or serum. Comparison tests (t-test, Mann-Whitney, and ANOVA, Kruskal-Wallis) were conducted to see if there were significant differences in the levels of human NAG urine and human NGAL urine serum based on age, sex, blood group, duration of transfusion, routine of transfusion, duration of taking iron chelating agents, and types of iron chelating drugs. Multivariate analysis was conducted to see whether some of these categories were related to abnormalities in human NAG urine or serum and human NGAL urine or serum. All 91 patients had normal creatinine values, yet some had abnormal serum NAG. There is a significant difference in urine human NAG and urine human NGAL levels at ages over 23 years (p = 0.05 and p = 0.01). Significant differences in human NGAL serum were also found in working and student patients (p = 0.028). Serum NGAL also differed in those taking deferasirox (p = 0.030) and significantly different human NGAL urine was also found in iron overload status (Ferritin ≥ 1000 ng.ml) (p = 0.006). There is no difference between human NAG urine/serum and human NGAL urine/serum based on sex, body mass index, blood type, hemoglobin less than 10 g/dl, routine transfusion once a month, duration of using iron chelation for more than 10 years, or splenomegaly status (splenomegaly, splenectomy, or no splenomegaly). The multivariate logistic regression results showed that age above 23 was a factor associated with abnormal urine human NAG levels (aOR = 3.79, 95% CI = 1.08-13.28). Students (aOR = 4.89, 95% CI = 1.48-16.16) with ages above 23 years (aOR = 3.69, 95% CI = 1.09-12.43) showed higher risk for an abnormal serum human NGAL levels. Patients with beta-thalassemia major exhibit noticeable tubular damage. Further research is encouraged to determine other factors behind tubular damage in the thalassemia community, particularly in Indonesia.
    Matched MeSH terms: Indonesia/epidemiology
  19. Sahimin N, Lim YAL, Douadi B, Mohd Khalid MKN, Wilson JJ, Behnke JM, et al.
    Acta Trop, 2017 Sep;173:109-115.
    PMID: 28610937 DOI: 10.1016/j.actatropica.2017.06.011
    Ongoing urbanisation of the working population as well as cross-border migration of workers particularly into large cities has contributed to the development and growth of urban slums. These deprived areas are conducive for the transmission of intestinal pathogens including hookworm. The aim of this study was to determine both the prevalence and species identity of hookworm infections among the migrant worker community in Malaysia. A total of 388 faecal samples were collected from migrant workers between September 2014 and August 2015, representing workers from five employment sectors: construction, manufacturing, agriculture and plantations, food services and domestic services. Faecal samples were examined by microscopy and positive samples were subjected to molecular analysis. A total of 51 samples (13.1%) were positive by microscopy for hookworm infections. A two-step PCR based method amplifying a fragment of the 28S rRNA-ITS2 region was used to identify infections by Necator americanus and Ancylostoma spp. PCR products positive for Ancylostoma spp. were sequenced bidirectionally, and sequences analysed through BLAST and phylogenetic analysis. Samples containing Ancylostoma duodenale were further characterized by amplification and sequencing a fragment of cytochrome c oxidase subunit 1 (cox1) gene. PCR amplicons were successfully obtained from 42 (82.4%) of 51 samples, with 81.0% (34 of 42) identified as Necator americanus, 16.7% (7 of 42) as Ancylostoma spp. and 2.4% (1 of 42) as mixed infections of both species. All eight Ancylostoma spp. were confirmed to be Ancylostoma duodenale and this is the first time A. duodenale was reported in Malaysia. Samples containing A. duodenale from Nepalese and Indonesian workers shared high-similarity and were distinct compared to sequences from other countries. This study highlights the prevalence of hookworm infections among migrant workers living in Malaysia. Our findings underscore the necessity of screening migrant workers for hookworm infections, particularly those working in food-related services and industries.
    Matched MeSH terms: Indonesia/epidemiology
  20. Harahap H, Sandjaja S, Soekatri M, Khouw I, Deurenberg P
    Asia Pac J Clin Nutr, 2017 12 10;27(1):211-216.
    PMID: 29222901 DOI: 10.6133/apjcn.032017.05
    BACKGROUND AND OBJECTIVES: Indonesia is currently facing double burden malnutrition in children. As overweight and obesity are due to a disturbed energy balance, this study aimed to assess the association of total energy intake and physical activity with the prevalence of overweight among Indonesian children.

    METHODS AND STUDY DESIGN: The data used for this analysis were from 1143 children, 6-12 years old, that participated in the South East Asian Nutrition Survey (SEANUTS). Physical activity (PA) was measured using pedometers for 2 consecutive days and was categorized low, moderate and high. Child nutritional status was categorized based on body mass index for age z-scores (BAZ) into normal weight (-2 SD ≤BAZ≤1 SD) or overweight (BAZ >1 SD). Energy intake was calculated from a one day 24 hour recall and compared to the Indonesian recommended dietary allowance (RDA) for energy.

    RESULTS: Children with low PA had higher risk (ODDs 3.4, 95% CI: 2.0, 6.0) of being overweight compared to children who had high PA. Children with moderate PA and energy take >100% RDA had higher risk (ODDs 4.2, 95% CI 1.9, 9.3) of being overweight than children with high PA and energy intakes ≤100% RDA.

    CONCLUSIONS: Low physical activity independently or moderate physical activity and high energy intake are risk factors for Indonesian children to get overweight. Program intervention such as increasing physical activity at school and home is needed to reduce overweight among children.

    Matched MeSH terms: Indonesia/epidemiology
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