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Find the Missing Millions: Malaysia's experience with nationwide hepatitis C screening campaign in the general population

Md Said R, Mohd Zain R, Chan HK, Soelar SA, Rusli N, Nasir NH, et al.

J Viral Hepat, 2020 06;27(6):638-643.
PMID: 31997563 DOI: 10.1111/jvh.13267

Approximately 2.5% of the Malaysian population is currently living with hepatitis C virus (HCV) infection. Yet, the public awareness of the disease is limited and under-screening remains a major challenge. With the support of international non-for-profit organizations, the Ministry of Health in Malaysia recently launched a one-week nationwide hepatitis C screening campaign in conjunction with the World Hepatitis Day. For the first time, the rapid diagnostic test (RDT) for HCV screening was introduced in public health institutions. This campaign involved 49 hospitals and 38 health clinics across the country, targeting the adult general population with unknown HCV infection status. Of the 11 382 participants undergoing the RDT, 1.9% were found to be positive for hepatitis C antibody (anti-HCV) and were referred to on-site medical departments or nearby hospitals for confirmatory testing and treatment. Men, the Malay ethnic group, intranasal and injection drug users and ex-prisoners were shown to have higher odds of being positive for anti-HCV. In addition to serving as a model to educate the general population about the disease, this campaign demonstrates the feasibility of decentralizing HCV screening, particularly by promoting the use of RDT, and linking the HCV-infected patients to care in Malaysia.

Matched MeSH terms: Ethnic Groups
Ocular surface disease in psoriatic patients in a developing country

Goh Y, Kwan Z, Han WH, Iqbal T, Yahya F, Khang TF, et al.

Int Ophthalmol, 2021 Jun;41(6):2139-2147.
PMID: 33788072 DOI: 10.1007/s10792-021-01771-8

PURPOSE: To evaluate ocular surface changes among patients with psoriasis in Malaysia, a developing country in Southeast Asia.
METHODS: An interdisciplinary case-control study (60 psoriasis patients and 40 control subjects) to look at the differences in ocular surface manifestations between patients with psoriasis and a group of age-, gender- and ethnicity-matched healthy controls.
RESULTS: One hundred and twenty eyes of 60 patients with psoriasis and 80 eyes of 40 healthy controls without psoriasis were included in the study. Mild-to-moderate psoriasis was found in 42 patients (70%), while 18 patients (30%) had severe psoriasis. Psoriatic arthritis was found in 19 patients (32%). Of the 60 psoriatic patients, the prevalence of ocular involvement was 65% (39/60), in which 32% (19/60) had dry eyes, 27% (16/60) had lid margin abnormalities, 33% (20/60) had cataract, and one had history of anterior uveitis. Compared to controls, ocular surface of psoriatic patients showed more eyelid margin abnormalities, higher meibomian gland loss and lower tear film break-up time. The estimated odds ratio for dry eyes in the psoriasis group was 2.2 (95% CI: 0.8-6.9).
CONCLUSION: Ocular surface disorders encompassing eyelid margin abnormalities, meibomian gland loss and tear dysfunction occur at an earlier and higher rate among psoriatic patients.

Matched MeSH terms: Ethnic Groups
Fulltext Knowledge, attitude and practice of evidence-based medicine among primary care practitioners in Malaysia: a cross-sectional study

Zanaridah MN, Norhayati MN, Rosnani Z

BMJ Open, 2021 Jun 01;11(6):e044372.
PMID: 34078635 DOI: 10.1136/bmjopen-2020-044372

OBJECTIVES: To determine the level of knowledge and practice of evidence-based medicine (EBM) and the attitudes towards it and to identify the factors associated with its practice among primary care practitioners in Selangor, Malaysia.
SETTING: This cross-sectional study was conducted in randomly selected health clinics in Selangor. Data were collected from primary care physicians using self-administered questionnaires on knowledge, practice and attitudes regarding EBM.
PARTICIPANTS: The study included 225 respondents working in either government or private clinics. It excluded house officers and those working in public and private universities or who were retired from practice.
RESULTS: A total of 32.9% had a high level of EBM knowledge, 12% had a positive attitude towards EBM and 0.4% had a good level of its practice. The factors significantly associated with EBM practice were ethnicity, attitude, length of work experience as a primary care practitioner and quick access to online reference applications on mobile phones.
CONCLUSIONS: Although many physicians have suboptimal knowledge of EBM and low levels of practising it, majority of them have a neutral attitude towards EBM practice. Extensive experience as a primary care practitioner, quick access to online references on a mobile phone and good attitude towards EBM were associated with its practice.

Matched MeSH terms: Ethnic Groups
Fulltext Obesity among schoolchildren in Kuala Selangor: a cross-sectional study

Sumarni Mohd G, Muhammad Amir K, Ibrahim Md S, Mohd Rodi I, Izzuna Mudla MG, Nurziyana I

Trop Biomed, 2006 Dec;23(2):148-54.
PMID: 17322816

Childhood obesity is an established problem in many countries and emerging in others. Epidemiological data on obesity in children is essential in order to plan public health policy and services. A study was conducted to determine the prevalence of obesity in schoolchildren in the fifth grade of elementary school (10-12 years old) in the district of Kuala Selangor. Ten schools of which five are in urban and five in rural areas were selected consisting of 699 eleven year old schoolchildren from the three major ethnic groups. Using international cut-off points for obesity, we report an overall prevalence of obesity of 7.2%. Prevalence of obesity in urban children is 7.2% whereas in rural children it is 7.0 %. Analysed by gender, there were 8.9% obese boys and 5.3% obese girls. Among the 3 major ethnic groups, the Malays had the highest prevalence of obesity at 9.3% followed by the Chinese with 6.6% while among Indians 3.0%. The data obtained from this study suggests that obesity in Kuala Selangor children is a cause for concern in urban and rural areas.

Matched MeSH terms: Ethnic Groups
Fulltext Self-care behaviour among type 2 diabetes patients

Siti Khuzaimah AS, Aini A, Surindar Kaur SS, Hayati Adilin MAM, Padma AR

Pertanika Journal of Science & Technology, 2014;22(2):471-488.
MyJurnal

Self-care behaviour involves all activities type 2 diabetes patients engage in to care for their disease. In our local population, however, most patients do not manage their disease appropriately. This study aimed to determine the level of self-care behaviour and to examine the differences in self-care behaviour according to type 2 diabetes patients’ demographic data and health condition at University Malaya Medical Centre. Sample of this study comprised 388 patients (respondents) and data were collected from December 2010 to February 2011 using self-administered questionnaires. Results showed that the level of self-care behaviour was moderately high (mean = 38.94, SD=11.93). There were significant differences between self-care behaviour and ethnicity [Wilk’s Lambda = 0.92, F(12, 1008) = 2.70, p < 0.05], age group [Wilk’s Lambda = 0.96, F(4, 383) = 4.39, p < 0.05], education level [Wilk’s Lambda = 0.94, F(12, 1008) = 1.85, p < 0.05], type of treatment [Wilk’s Lambda = 0.92, F(12, 1008) = 2.84, p < 0.05], health education [Wilk’s Lambda = 0.97, F(4, 383) = 3.33, p< 0.05]. Respondents who are Indian, elderly, had lower level of education, on insulin treatment, had received health education on diabetes and not smoking had better self-care behaviour scores. It can be concluded that high risk type 2 diabetes patients should be taught individually so as to help them improve physical and psychological outcome.
Study site: diabetic clinic; medical, nephrology, orthopedic, and surgery wards, University Malaya Medical Centre (UMMC)

Matched MeSH terms: Ethnic Groups
Fulltext Loss-of-function HSD17B13 variants, non-alcoholic steatohepatitis and adverse liver outcomes: Results from a multi-ethnic Asian cohort

Ting YW, Kong AS, Zain SM, Chan WK, Tan HL, Mohamed Z, et al.

Clin Mol Hepatol, 2021 Jul;27(3):486-498.
PMID: 33618508 DOI: 10.3350/cmh.2020.0162

BACKGROUND/AIMS: 17β-hydroxysteroid dehydrogenase 13 (HSD17B13) variants were recently reported to have significantly lower odds of non-alcoholic fatty liver disease (NAFLD). This is a two-part study that aimed to evaluate the association of HSD17B13 variants with NAFLD and its histological severity, and to identify the association of the variants with clinical outcomes in a cohort of biopsy-proven NAFLD patients.
METHODS: Consecutive biopsy-proven NAFLD patients and controls without fatty liver were recruited for this study between 2009 and 2014. Genotyping for HSD17B13 variants was performed using rhAmp assays. A total of 165 patients with NAFLD were monitored up until August 2019. Clinical outcomes were recorded.
RESULTS: HSD17B13 rs72613567 TA allele and rs6834314 G allele were associated with lower odds of non-alcoholic steatohepatitis (NASH) in the overall cohort and among ethnic Chinese, but not among ethnic Malays or Indians (P<0.05). During a mean follow-up of 89 months, 32 patients (19.4%) experienced at least one clinical outcome (cardiovascular events, n=22; liver-related complications, n=6; extra-hepatic malignancy, n=5; and mortality, n=6). The rs72613567 homozygous TA allele and the rs6834314 homozygous G allele were independently associated with a lower incidence of liver-related complications (hazard ratio [HR], 0.004; 95% confidence interval [CI], 0.00-0.64; P=0.033 and HR, 0.01; 95% CI, 0.00-0.97; P=0.048, respectively) and were associated with lower grade of hepatocyte ballooning among the ethnic Chinese.
CONCLUSION: HSD17B13 rs72613567 and rs6834314 variants were inversely associated with NAFLD and NASH, and were associated with lower incidence of adverse liver outcomes in a cohort of multi-ethnic Asian patients with NAFLD.

Matched MeSH terms: Ethnic Groups
Fulltext Effect of mycophenolate mofetil in steroid dependent and steroid resistant nephrotic syndrome patients in Pakistan

Iftikhar, E., Khan, Humayun I., Rabia, T., Sheikh, Shabbir A., Malik, Aaqil, Nor Iza A. Rahman

Malaysian Journal of Paediatrics and Child Health, 2011;17(1):0-0.
MyJurnal

Objective: To describe the effect of mycophenolate mofetil in Pakistani children with steroid dependent and steroid resistant nephrotic syndrome. Methods: This is cross sectional retrospective review of 16 patients; 9 boys and 7 girls (11 SD/FRNS and 5 SRNS) for a period of 4.8 years. This study was conducted in Mayo hospital and Fatima Memorial hospital specialist care centre, Lahore involving urban and suburban population. Results: The median age of the group was 4 years (1.6 to 12.6 years). Seven patients had histological diagnosis of MCN, 3 had diffuse mesangial proliferation, one of membranoproliferative glomerulonephritis and 4 had FSGS. Out of 5 SRNS 4 were found to have FSGS and 1 had membranoproliferative glomerulonephritis (MPGN). A total of three patients were completely off steroids and in two patients MMF was also successfully stopped. Number of relapses /patient /year calculated by applying Wilcoxan signed rank test was found to be 4.31 + 0.87(3.00-6.00 /patient/year) before starting MMF, which dropped to 1.12 + 0.718 (0.00- 2.000 /patient/year) after starting MMF, p=0.0001. Reduction in steroid dose from mean of 0.85 + 0.18 mg/kg/day to 0.3mg/kg/day + 1.56 was achieved in 12 months, p

Matched MeSH terms: Ethnic Groups
Fulltext Reliability and validity of child posttraumatic stress-revised instrument in malay language among Malaysian adolescents

Elklit, A., Ghazali, S.R

Malaysian Journal of Psychiatry, 2015;24(1):59-67.
MyJurnal

Background: Most PTSD screening tools for children and adolescents have been validated in Western contexts which is not necessarily generalizable to non-western cultures. Therefore, the objective of this cross-sectional study was to determine the psychometric properties of the Child Posttraumatic Stress Disorder Reaction Index (CPTS-RI) within a Malaysian population. Methods: Eighty-five adolescents aged 13- to 14-years-old completed the CPTS-RI, Harvard Trauma Questionnaire (HTQ) and Hopkins Symptom Checklist scale (HSCL). Results: Results showed a good internal consistency for the overall scale (α =.92), for the subscale -re-experience, avoidance and arousal subscales (α = .89, α = .73, α = .56 respectively) and for different gender groups and ethnicity. CPTS-RI demonstrated good construct and divergent validity, and showed good concurrent validity with the use of HTQ and HSCL as the criterion measure. Conclusion: Findings suggest that CPTS-RI is a valid and reliable instrument to assess PTSD symptoms among Malaysian adolescents.

Matched MeSH terms: Ethnic Groups
Fulltext Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents

Hong JYH, Jalaludin MY, Mohamad Adam B, Fuziah MZ, Wu LL, Rasat R, et al.

Malays Fam Physician, 2015;10(3):11-18.
PMID: 27570603 MyJurnal

Background: Diabetic ketoacidosis (DKA) is a late presentation of newly diagnosed type 1 diabetes mellitus (DM) in children. The aim of this study was to determine the clinical characteristics of type 1 DM at presentation so that appropriate actions can be taken to promote early diagnosis.
Methods: This was a retrospective cohort review from a patient registry database. Data on all patients younger than 20 years old diagnosed with type 1 DM who had been registered with the Malaysian Diabetes in Children and Adolescents Registry (DiCARE) from its inception in 2006 until 2009 were analysed.
Results: The study included 490 children and adolescents, out of which 57.1% were female. The mean (SD) age at diagnosis was 7.5 (3.7) years, which increased from year 2000 to 2009 [6.6 (3.3) years to 9.6 (3.5) years; p = 0.001]. An increasing percentage of DKA at diagnosis was observed from year 2000 (54.5%) to year 2009 (66.7%), which remained high and leveled between 54.5% and 75.0%. DKA was more common in patients with normal weight (p = 0.002) with no significant association with age, gender, ethnicity and status of family history of diabetes mellitus.
Conclusion: An increasing trend of age at diagnosis of patients with type 1 DM was observed. Besides that, proportion of DKA at diagnosis had remained high over the past decade. This study found that normal weight was associated with status of DKA, thus more detailed investigations are required to determine the risk factors for DKA.

Matched MeSH terms: Ethnic Groups
Fulltext Demographic differences of preference, intake frequency and craving hedonic ratings of sweet foods among Malaysian subjects in Kuala Lumpur

Sia, B.T., Low, S.Y., Foong, W.C., Prmasivah, M., Khor, C.Z., Say, Y.H.

Malaysian Journal of Medicine and Health Sciences, 2013;9(1):55-64.
MyJurnal

As the sugar intake of Malaysians is one of the highest in the Asia Pacific region, we wanted to investigate how this high prevalence of ‘sweet tooth’ is influenced by biological determinants like age, gender, ethnicity and Body Mass Index (BMI). Therefore, this study was to determine the demographic and BMI differences of preference, intake frequency and craving of a list of sweet beverages and food among Malaysian subjects. Convenience sampling was performed around Kuala Lumpur, with informed consents, involving 367 multi-ethnic subjects (163 males, 204 females; 83 Malays, 201 Chinese, 83 Indians; 209 lean, 158 overweight). Demographics and anthropometric measurements were taken and questionnaire on the preference/frequency/craving of a list of 22 sweet food and beverages with a 7 point hedonic scale (from 1= very unpleasant/never/never crave to 7 = very pleasant/at least once a day/ always crave) was performed. Females significantly preferred more, took less frequently but had equal craving of sweet foods compared to males. Lean subjects and those

Matched MeSH terms: Ethnic Groups
Fulltext Traditional healers are causing treatment delay among patients with psychosis in Hospital Kuala Lumpur: fact or fallacy?

Marhani Midin, Salina Abdul Aziz, Phang, Cheng-Kar

ASEAN Journal of Psychiatry, 2010;11(2):206-215.
MyJurnal

Objective: Mental health services in Malaysia often face competition from traditional healers especially among patients with psychosis. The objective of the study is to determine whether patients who sought help earlier from traditional healers had longer duration of untreated psychosis (DUP), and more adverse experiences in pathways to psychiatric care. Methods: This is a hospital-based cross-sectional study of 50 inpatients with first-episode
psychosis in Hospital Kuala Lumpur. Structured Clinical Interview for DSM-IV (Diagnostic and statistical manual, 4th edition) Clinical Version for Axis I Disorders (SCID-CV) was used for establishing diagnosis. Onset of psychosis was defined as any one positive symptom with a score of >3 on the Positive and Negative Syndrome Scale (PANSS). Socio-demographic
data, information on pathways and treatment delaying factors were determined through face-to-face interview and semi-structured questionnaire. Results: Fifty-four percent of the patients had at least one contact with traditional healers prior to consulting psychiatric service, and it was the most popular first point of non-psychiatric help-seeking contact
(48%). Contact with traditional healers was not associated with age, gender, ethnic, education level, longer DUP or treatment delay, and admissions with violent behaviour or police assistance. Of those who had sought help from traditional healers, one third were recommended by at least one of their traditional healers to seek medical help. Conclusion:
Consultation involving traditional healers was a popular choice, and not associated with treatment delay. Traditional healers in an urban setting may be potential collaborators in managing patients with first-episode psychosis. Future research should explore the frontiers of such collaborative work.

Matched MeSH terms: Ethnic Groups
Fulltext Reliability of Bahasa Malaysia version of family environment scale and its measurement issues

Khairani Omar, Noor Azimah Muhammad, Farihna Mohamed Fadhlullah, Ramli Musa, Jamaiyah Hanif, Adam Bujang

ASEAN Journal of Psychiatry, 2010;11(1):44-55.
MyJurnal

Objective: Family Environment Scale (FES) is one of the most widely used instruments to measure many family aspects. Cross cultural adaptation of the original FES is essential prior to local utilization as different cultures percept their family environments differently. We attempted to translate the FES into the Bahasa Malaysia language for adolescents, evaluate its reliability using internal consistency and compare its results with the original
study. Methods: This is a cross-sectional study, involving adolescents aged 12-17 from four secondary schools. The adolescents were selected using quota sampling for different age, ethnic and academic performance. The study was divided into four phases, namely: i) translation of FES, ii) pilot test iii) internal consistency reliability test and iv) comparison of the study results with the original FES. Results: A total of 295 adolescents participated in this study. All of the reliability measurements generated (ranged between Cronbach’s alpha 0.10 - 0.70) were lower than those originally reported for this instrument (ranged between Cronbach’s alpha 0.61 -0.78). Five subscales in the Bahasa Malaysia version were found to be less than Cronbach’s alpha 0.5, which were below the acceptable level for practical or research use. There was considerable variation observed between the sample population of this study and that of the original study, which could be due to the social cultural differences. Conclusion: The Bahasa Malaysia version of FES requires further culturally
appropriate revision. A new measuring scale could also be devised to provide an accurate evaluation of the family environment as perceived by Malaysian adolescents, which has acceptable levels of reliability and validity.

Matched MeSH terms: Ethnic Groups
Fulltext Smoking and body mass index among malay adolescents in Kota Bharu, Kelantan

Norhayati, M.N.H., Zulkifli, A., Naing, L., Rohana, J., Jamil, B.Y.M.

Malaysian Journal of Public Health Medicine, 2006;6(1):44-50.
MyJurnal

Despite awareness of the detrimental effects of smoking, many adolescents initiate or continue to smoke. One possible explanation for smoking 13 the belief that it can control body weight. The objective of this study was to determine the association between Body Mass Index and smoking among Malay adolescents in Kota Bharu, Kelantan. A cross·sectional study was conducted between January to June 2005 among 1364 students selected from ten co»educational government secondary schools in Kota Bharu using stratified multistage cluster sampling. Guided self-administered questionnaire and anthropometric measurement were taken. Data was entered using SPSS 12.0 and analysed using STATA 8.0. The overall prevalence of smoking was 6. 7%. The prevalence of smoking among boys was 13.8% and among girls was 1.1%. There was no association between Body Mass Index and smoking. However, the findings may not be generalized to out-of·school youth and other ethnic groups in this country. The study was not conducted anonymously and the use of questionnaire to report smoking status can lead to measurement bias. Strategies aimed at correcting the belief that smoking can reduce weight should be included as one of the components in the prevention of smoking.

Matched MeSH terms: Ethnic Groups
Fulltext Prevalence of helicobacter pylori infection among patients attending gastroenterology endoscopy unit at Serdang Hospital

Chieng, Jin Yu, Pan, Yan, Loong, Yik Yee

Malaysian Journal of Medicine and Health Sciences, 2015;11(1):11-17.
MyJurnal

To study the prevalence of Helicobacter Pylori (H. pylori) infection, according to ethnicity, gender and endoscopic findings among the patients underwent the oesophago-gastro-duodenoscopes (OGDS) at gastroenterology endoscopy unit, Hospital Serdang, Selangor, Malaysia. The database of all whom underwent OGDS at the gastroenterology endoscopy unit, Hospital Serdang from 1st August 2010 to 31st July 2012 was collected and assessed, retrospectively. A total of 924 patients who underwent OGDS were analyzed for the H. pylori infection by using Campylobacter-like organism (CLO) test. 130 (14.07%) tested positive, and their data were further studied according to gender, ethnicity, age group, initial indication for OGDS and endoscopic finding. The prevalence rate among males was 15.15% (70/462), while it was 12.99% (60/462) among females. In terms of ethnics, H. pylori infection was commonly found among Indian and Chinese with prevalence rate of 25.13% (50/199) and 17.41% (51/293) respectively. These figures are significantly higher than the 6.01% (25/416) for Malays. The age group (31-50 years old) had the highest prevalence rate of H. Pylori infection, which is of 18.55% (41/221). No significant difference was observed among initial indications for OGDS. Erosions were the commonest finding in H. pylori positive group with rate of 51.54% (67/130). However, erosions were not uncommon in H. pylori negative group as well with the rate of 48.61% (386/794). H. pylori infection rate among Malaysians was generally low, with the highest rate in Indians, followed by Chinese and relatively low in Malays. No significant difference between the prevalence rate of H. pylori infection in male and that in female was found. Erosions were equally common in either H. pylori positive or H. pylori negative group.

Matched MeSH terms: Ethnic Groups
Fulltext Validity and Reliability of the Malay Version of Duke University Religion Index (DUREL-M) Among A Group of Nursing Student

Nurasikin, M.S., Aini, A., Aida Syarinaz, A.A., Ng, C.G.

Malaysian Journal of Psychiatry, 2010;19(2):1-5.
MyJurnal

Background: Duke University Religion Index (DUREL) is a brief and easy to use instrument for measurement of religious commitment. Objective: The aim of this study was to validate the Malay version of DUREL (DUREL-M) among a group of nursing students. Methods: This is a cross-sectional validation study conducted in a nursing school involved a group of year 1 nursing students. The students were given the Malay version of DUREL, Malay version of General Health Questionnaire (GHQ), Malay version of Brief COPE, Malay version of Depression Anxiety Stress Scale (DASS21), English version of DUREL. A week later, they were again given the Malay version of DUREL. Results: The instrument displayed good parallel reliability (0.70), test-retest reliability (0.68) (Spearman’s rho, p.

Matched MeSH terms: Ethnic Groups
Fulltext What do men want from a health screening mobile app? A qualitative study

Teo CH, Ng CJ, White A

PLoS One, 2017;12(1):e0169435.
PMID: 28060953 DOI: 10.1371/journal.pone.0169435

There is a lack of mobile app which aims to improve health screening uptake developed for men. As part of the study to develop an effective mobile app to increase health screening uptake in men, we conducted a needs assessment to find out what do men want from a health screening mobile app. In-depth interviews and focus group discussions were conducted with 31 men from a banking institution in Kuala Lumpur. The participants were purposely sampled according to their job position, age, ethnicity and screening status. The recruitment was stopped once data saturation was achieved. The audio-recorded interviews were transcribed verbatim and analyzed using thematic approach. Three themes emerged from the analysis and they were: content, feature and dissemination. In terms of the content, men wanted the app to provide information regarding health screening and functions that can assess their health; which must be personalized to them and are trustable. The app must have user-friendly features in terms of information delivery, ease of use, attention allocation and social connectivity. For dissemination, men proposed that advertisements, recommendations by health professionals, providing incentive and integrating the app as into existing systems may help to increase the dissemination of the app. This study identified important factors that need to be considered when developing a mobile app to improve health screening uptake. Future studies on mobile app development should elicit users' preference and need in terms of its content, features and dissemination strategies to improve the acceptability and the chance of successful implementation.

Matched MeSH terms: Ethnic Groups
Fulltext Sybr Green Real-Time PCR is a useful method in screening for high risk human papilloma virus types 16 and 18 in neoplastic cervical cancer

Nor Rizan, K., Abdul Manaf ,A., Sabariah, A.R., Siti Aishah, M.A., Noorjahan Banu, M.A., Zubaidah, Z.

Medicine & Health, 2011;6(1):59-67.
MyJurnal

Human papillomavirus (HPV) plays an important role in the pathogenesis of cervical cancer. HPV has been found in 99.7% of cervical cancers worldwide. In Malaysia, it is the second most common cancer among women in all major ethnic groups. The main purpose of this study was to establish the method of SyBrGreen Real-Time PCR and apply it for identification of multiple infections of the two high risk HPV subtypes. In this study, 57 positive samples for HPV 16 and HPV 18 were used to establish a simple
and sensitive method to detect and identify HPV infection in the cervical neoplasia at different stages of the disease by using real-time ABICycler SyBrGreen 1 technology. The results showed 67 HPV genomes in 57 samples. HPV 16 genome was detected in 55/67 (82%) cases while HPV 18 was detected in 8/67 (12%) cases with 4 cases showing multiple infections of HPV 16 and HPV 18. HPV 16 was the most prevalent followed by HPV 18. Using SyBr Green Real-Time PCR techniques, the results
showed that DNA melting curve for HPV 16 had a peak around 80.2ºC and Ct value of 20 cycles whereas the DNA melting curve for HPV 18 around 79.2ºC and Ct value of 22 cycles. In conclusion, a SyBr Green Real-Time PCR method has the potential for clinical usage in detection and identification of HPV infection in cervical neoplasia at different stages of the disease.

Matched MeSH terms: Ethnic Groups
Fulltext Emotional intelligence of USM medical students

Khraisat, Adam Mahmoud Salameh, Ahmad Fuad Abdul Rahim, Muhamad Saiful Bahri Yusoff

Education in Medicine Journal, 2015;7(4):26-38.
MyJurnal

Introduction: Emotional intelligence (EI) refers to the ability to perceive, control and evaluates emotion. Research results found that EI is relevant to organizational development and manpower development. It is also important to academic success, emotional adaptability, stress management and other lifestyle issues. EI principles help one to understand and assess people's behaviors, interpersonal skills, attitudes and potentials. It also plays an important role in human resource planning, job placement and recruitment interviews and selection, business development, customer care services, and more. The study focused on exploring students’ EI, subscales of EI (i.e., personal competencies and social competencies) and its associated factors. Methods: A cross-sectional study was conducted on 571 medical students from year 1, 3 and 5. Years of study, gender, and ethnic groups were included as factor variables. USM Emotional Quotient Inventory (USMEQ-i) was used to measure EI, personal competence and social competence. Results: Years of study significantly associated with EI (F = 18.41, p < 0.001), personal competency (F = 16.93, p < 0.001) and social competency levels (F = 12.92, p < 0.001). There was a decreasing pattern of EI, personal competency and social competency level as medical training progresses. Male significantly had a higher EI (t = -1.99, p < 0.05) and personal competence (t = -1.99, p < 0.05) levels than female medical students. Nevertheless, male and female students had equal levels of social competence (t = -1.39, p = 0.730). Ethnic groups demonstrated no significant association with EI, personal competency and social competency level. Conclusion: This study found that years of study were the main associated factor, followed by gender. In addition, there is a cause of concern regarding the decreasing pattern of EI throughout medical training. Further research is required to investigate this concern, so that appropriate intervention can be taken to alleviate the concern.

Matched MeSH terms: Ethnic Groups
Fulltext Protective factors related to violence among adolescents: a cross sectional study in Terengganu

Nordiyanah, H., Khatijah, A.R., Mohd Aris, K., Mohd Jusoh, Anwa, S.

Malaysian Journal of Public Health Medicine, 2002;2(1):36-41.
MyJurnal

A cross-sectional study was done to determine the prevalence of violence among 15-year-old adolescents and to identify associated protective or risk factors. The study involved 758 adolescents, 384 males and 3 74 females in the District of Kuala Terengganu and Besut, Terengganu. About 39.0% of adolescents under study were ever involved in violence. Percentage of girls were slightly higher 19.8% as compared to boys 19.2%. About 30% of the violent adolescents were from Kuala Terengganu and 9.1% from Besut. There was no significant relationship between violence and ethnic groups. Family total income above poverty line was significant protective towards violent behaviour < 0.01, OR 0.61, CI 0.45 - 0.82). Using univariate analysis, selected parental factors were protective against violence, such as good parental connection (p < 0.01), presence of parental regulation (p < 0.001), religious parents (p < 0.05) and parents who had dinner everyday with adolescents (p < 0.01, OR 0.59, CI 0.43 - 0.80). Adolescent who perceived to have interest in learning (p < 0.001, OR 0.32, CI 0.17 - 0.59) were less likely to involve in violence. Adolescent who felt well connected to their school (p < 0.01), and perceived themselves religious (P < 0.001) were more likely to be non-violent. Those who felt satisfied with day to day life were less likely to be involved in violence (p < 0.001, OR 0.52, CI 0.37 - 0.71). On the contrary, adolescents who ever had the feeling to run away from home (p < 0.001), had 3 times risk of violence, ever smoked cigarette had 2.4 times risk (p < 0.001, CI 1.55 - 3.69) ever been bullied by peers were 2.3 times risk (p < 0.001, CI 1.46 - 3.60) to violence. Same factors remained significant in multivariate analysis. Such factors were total family income below poverty line (p < 0.001, OR 1.82,CI 1.28 - 2.59), parental regulation (p < 0.05, OR 0.34, CI 0.13 - 0.89), had dinner every night and frequently (p < 0.01, OR 0. 62, CI 0.43 - 0.89), and adolescents' religiosity (p < 0.05, OR 0.81, CI 0.66 - 0.98) were protective, whereas ever· smoke cigarettes (12 < 0.01, OR 2.24,Cl 1.38 - 3.62), being bullied by peers (o < 0.01, OR 2. 09, C1 1.26 - 3.45), and frequently felt depressed previous one year (p < 0.001, OR 3.01,CI 1.79 - 5.07) were risk factors. The findings of the study will serve as baseline in planning adolescent health programme specifically to prevent violence behaviour from developing right from young, in the home and in the school environment.

Matched MeSH terms: Ethnic Groups
Fulltext Patient's Perceptions And Knowledge On Tooth Bleaching

Ahmad, R., Ariffin, E.H.Z.M., Vengrasalam, I., Kasim, N.H.A.

Ann Dent, 2005;12(1):-.
MyJurnal

The main objective of this study was to assess knowledge on tooth bleaching among patients visiting dental health care centres in Klang Valley. A total of 200 patients were conveniently selected and interviewed using structured questionnaires. Among the 200 respondents, 75.5% knew about bleaching. There was no statistically significant difference in knowledge of bleaching in relation to age, gender, ethnic group and income level of the patients interviewed (p>0.05) but the education level had a significant influence (p=0.049). Respondents with tertiary education had better knowledge about tooth bleaching as compared to those respondents without tertiary education. The sources of information about bleaching came from advertisements on electronic media (65.5%), articles in newspapers and magazines (14.7%), dentists (10.9%) and family and friends (8.8%). Out of the 75.5% of respondents who knew about bleaching, 18.2% had tried bleaching their teeth using either over-the-counter products or had undergone professional bleaching treatment. The commonest reasons cited for bleaching treatment were to remove coffee and tea stains (70%) and cigarette stains (16.7%). 73.3% of these patients were satisfied with the results achieved after bleaching. However, the majority of these patients (59.6%) were unsure of the safety of these bleaching products/procedures. In conclusion, 75.5% of patients interviewed in this study knew that bleaching is one of the treatment options available to improve dental aesthetics but only 18.2% have tried bleaching their teeth. Their main source of knowledge about bleaching came from advertisements on electronic media.

Matched MeSH terms: Ethnic Groups

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