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Fulltext Experimental and theoretical investigation of the mechanisms of drying during CO2 injection into saline reservoirs

Sokama-Neuyam YA, Yusof MAM, Owusu SK, Darkwah-Owusu V, Turkson JN, Otchere AS, et al.

Sci Rep, 2023 Jun 06;13(1):9155.
PMID: 37280365 DOI: 10.1038/s41598-023-36419-3

A viable CO2 storage resource must have sufficient storage capacity, reliable containment efficiency and adequate well injectivity. Deep saline formations stand out in terms of storage capacity and containment efficiency. However, formation brine dry-out and salt precipitation in the near well region could impair CO2 injectivity in deep saline reservoirs, thus reducing their potential for CO2 storage. Core-flood experiments and analytical modelling were used to investigate various mechanisms of external and internal salt precipitation. Particularly, the impact of the extension of the dry-out region on CO2 injectivity was investigated. It was found that, for high permeability rocks, injection of CO2 at relatively low injection rates could result in salt cake deposition at the injection inlet especially under high salinity conditions. It was also found that extension of the dry-out region does not have significant impact on CO2 injectivity. Although the magnitude of CO2 injectivity impairment increased more than two-fold when initial brine salinity was doubled, real-time changes in CO2 injectivity during the drying process was found to be independent of initial brine salinity. We have shown that the bundle-of-tubes model could provide useful insight into the process of brine vaporization and salt deposition in the dry-out region during CO2 injection. This work provides vital understanding of the effect of salt precipitation on CO2 injectivity.
Fulltext Recent Advances of Triglyceride Catalytic Pyrolysis via Heterogenous Dolomite Catalyst for Upgrading Biofuel Quality: A Review

Zamri MFMA, Shamsuddin AH, Ali S, Bahru R, Milano J, Tiong SK, et al.

Nanomaterials (Basel), 2023 Jun 27;13(13).
PMID: 37446463 DOI: 10.3390/nano13131947

This review provides the recent advances in triglyceride catalytic pyrolysis using heterogeneous dolomite catalysts for upgrading biofuel quality. The production of high-quality renewable biofuels through catalytic cracking pyrolysis has gained significant attention due to their high hydrocarbon and volatile matter content. Unlike conventional applications that require high operational costs, long process times, hazardous material pollution, and enormous energy demand, catalytic cracking pyrolysis has overcome these challenges. The use of CaO, MgO, and activated dolomite catalysts has greatly improved the yield and quality of biofuel, reducing the acid value of bio-oil. Modifications of the activated dolomite surface through bifunctional acid-base properties also positively influenced bio-oil production and quality. Dolomite catalysts have been found to be effective in catalyzing the pyrolysis of triglycerides, which are a major component of vegetable oils and animal fats, to produce biofuels. Recent advances in the field include the use of modified dolomite catalysts to improve the activity and selectivity of the catalytic pyrolysis process. Moreover, there is also research enhancement of the synthesis and modification of dolomite catalysts in improving the performance of biofuel yield conversion. Interestingly, this synergy contribution has significantly improved the physicochemical properties of the catalysts such as the structure, surface area, porosity, stability, and bifunctional acid-base properties, which contribute to the catalytic reaction's performance.
Fulltext Prevalence, antimicrobial susceptibility and plasmid profiling of Vibrio spp. isolated from cultured groupers in Peninsular Malaysia

Amalina NZ, Santha S, Zulperi D, Amal MNA, Yusof MT, Zamri-Saad M, et al.

BMC Microbiol, 2019 11 11;19(1):251.
PMID: 31711432 DOI: 10.1186/s12866-019-1624-2

BACKGROUND: Numerous prevalence studies of Vibrio spp. infection in fish have been extensively reported worldwide, including Malaysia. Unfortunately, information on the prevalence of Vibrio spp. in groupers (Epinephelus spp.) is limited. In this study, groupers obtained from nine farms located at different geographical regions in Malaysia were sampled for the presence of pathogenic Vibrio spp. and their susceptibility profiles against seven antibiotics.
RESULTS: Out of 270 grouper samples, 195 (72%) were detected with the presence of Vibrio spp. Vibrio communis showed highest prevalence in grouper (28%), followed by V. parahaemolyticus (25%), V. alginolyticus (19%), V. vulnificus (14%), V. rotiferianus (3%), Vibrio sp. (3%), V. campbellii (2%), V. mytili (2%), V. furnissii (2%), V. harveyi (1%), V. tubiashii (1%), V. fluvialis (0.3%) and V. diabolicus (0.3%). Assessment on the antibiotic susceptibility profiles of the Vibrio spp. revealed that majority of the isolates were susceptible to tetracycline, streptomycin, erythromycin and bacitracin, but resistance to ampicillin, penicillin G and vancomycin. The mean MAR index of the Vibrio isolates was 0.51, with 85% of the isolates showed MAR index value of higher than 0.2. Results indicate that the Vibrio spp. were continuously exposed to antibiotics. Furthermore, the plasmid profiles of Vibrio spp. showed that 38.7% of the isolates harbored plasmid with molecular weight of more than 10 kb, while 61.3% were without plasmid. During curing process, Vibrio spp. lost their plasmid, but remained resistant to ampicillin, penicillin G, bacitracin and vancomycin while a few isolates remained resistant to erythromycin, streptomycin and tetracycline. The results suggested that the resistance to antibiotics in isolated Vibrio spp. might be due to chromosomal and plasmid borne.
CONCLUSIONS: This study demonstrates the prevalence of Vibrio spp. in groupers and the distribution of multidrug resistance strains that could be of concern to the farmers in Malaysia. In addition, data from this study can be further used in fish disease management plan.
Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics

Sumaira S, Vijayarathna S, Hemagirri M, Adnan M, Hassan MI, Patel M, et al.

Noncoding RNA Res, 2024 Dec;9(4):1140-1158.
PMID: 39022680 DOI: 10.1016/j.ncrna.2024.06.003

Irrespective of medical technology improvements, cancer ranks among the leading causes of mortality worldwide. Although numerous cures and treatments exist, creating alternative cancer therapies with fewer adverse side effects is vital. Since ancient times, plant bioactive compounds have already been used as a remedy to heal cancer. These plant bioactive compounds and their anticancer activity can also deregulate the microRNAs (miRNAs) in the cancerous cells. Therefore, the deregulation of miRNAs in cancer cells by plant bioactive compounds and the usage of the related miRNA could be a promising approach for cancer cure, mainly to prevent cancer and overcome chemotherapeutic side effect problems. Hence, this review highlights the function of plant bioactive compounds as an anticancer agent through the underlying mechanism that alters the miRNA expression in cancer cells, ultimately leading to apoptosis. Moreover, this review provides insight into using plant bioactive compounds -driven miRNAs as an anticancer agent to develop miRNA-based cancer gene therapy. They can be the potential resource for gene therapy and novel strategies targeting cancer therapeutics.
Fulltext In Vitro Antiplasmodium and Chloroquine Resistance Reversal Effects of Andrographolide

Ibraheem ZO, Majid RA, Sidek HM, Noor SM, Yam MF, Abd Rachman Isnadi MF, et al.

Evid Based Complement Alternat Med, 2019;2019:7967980.
PMID: 31915453 DOI: 10.1155/2019/7967980

The emergence of drug-resistant strains of Plasmodium falciparum is the worst catastrophe that has ever confronted the dedicated efforts to eradicate malaria. This urged for searching other alternatives or sensitizers that reverse chloroquine resistance. In this experiment, the potential of andrographolide to inhibit plasmodial growth and reverse CQ resistance was tested in vitro using the SYBRE green-1-based drug sensitivity assay and isobologram technique, respectively. Its safety level toward mammalian cells was screened as well against Vero cells and RBCs using MTT-based drug sensitivity and RBC hemolysis assays, respectively. Its effect against hemozoin formation was screened using β-hematin formation and heme fractionation assays. Its molecular characters were determined using the conventional tests for the antioxidant effect measurement and the in silico molecular characterization using the online free chemi-informatic Molinspiration software. Results showed that andrographolide has a moderate antiplasmodium effect that does not entitle it to be a substituent for chloroquine. Furthermore, andrographolide ameliorated the sensitivity of the parasite to chloroquine. Besides, it showed an indirect inhibitory effect against hemozoin formation within the parasite and augmented the chloroquine-induced inhibition of hemozoin formation. The study suggests that its chloroquine resistance reversal effect may be due to inhibition of chloroquine accumulation or due to its impact on the biological activity of the parasite. Overall, this in vitro study is a clue for the reliability of andrographolide to be added with chloroquine for reversal of chloroquine resistance and tolerance, but further in vivo studies are recommended to confirm this notion. In spite of its prominent and safe in vitro and in vivo growth inhibitory effect and its in vitro chloroquine resistance reversing effect, it is inapplicable to implement it in malaria chemotherapy to substitute chloroquine or to reverse its resistance.
Fulltext The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned?

Peeri NC, Shrestha N, Rahman MS, Zaki R, Tan Z, Bibi S, et al.

Int J Epidemiol, 2020 Jun 01;49(3):717-726.
PMID: 32086938 DOI: 10.1093/ije/dyaa033

OBJECTIVES: To provide an overview of the three major deadly coronaviruses and identify areas for improvement of future preparedness plans, as well as provide a critical assessment of the risk factors and actionable items for stopping their spread, utilizing lessons learned from the first two deadly coronavirus outbreaks, as well as initial reports from the current novel coronavirus (COVID-19) epidemic in Wuhan, China.
METHODS: Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a comprehensive review of PubMed literature, we obtained information regarding clinical signs and symptoms, treatment and diagnosis, transmission methods, protection methods and risk factors for Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS) and COVID-19. Comparisons between the viruses were made.
RESULTS: Inadequate risk assessment regarding the urgency of the situation, and limited reporting on the virus within China has, in part, led to the rapid spread of COVID-19 throughout mainland China and into proximal and distant countries. Compared with SARS and MERS, COVID-19 has spread more rapidly, due in part to increased globalization and the focus of the epidemic. Wuhan, China is a large hub connecting the North, South, East and West of China via railways and a major international airport. The availability of connecting flights, the timing of the outbreak during the Chinese (Lunar) New Year, and the massive rail transit hub located in Wuhan has enabled the virus to perforate throughout China, and eventually, globally.
CONCLUSIONS: We conclude that we did not learn from the two prior epidemics of coronavirus and were ill-prepared to deal with the challenges the COVID-19 epidemic has posed. Future research should attempt to address the uses and implications of internet of things (IoT) technologies for mapping the spread of infection.
Fulltext Erratum: The Impact of Pharmacist Medication Reviews on Geriatric Patients: A Scoping Review

Yaacob NLC, Loganathan M, Hisham NA, Kamaruzzaman H, Isa KAM, Ibrahim MIM, et al.

Korean J Fam Med, 2024 Jul;45(4):235.
PMID: 39054839 DOI: 10.4082/kjfm.23.0220.R
Fulltext Optimization of Thermal and Structural Design in Lithium-Ion Batteries to Obtain Energy Efficient Battery Thermal Management System (BTMS): A Critical Review

Fayaz H, Afzal A, Samee ADM, Soudagar MEM, Akram N, Mujtaba MA, et al.

Arch Comput Methods Eng, 2022;29(1):129-194.
PMID: 33935484 DOI: 10.1007/s11831-021-09571-0

Covid-19 has given one positive perspective to look at our planet earth in terms of reducing the air and noise pollution thus improving the environmental conditions globally. This positive outcome of pandemic has given the indication that the future of energy belong to green energy and one of the emerging source of green energy is Lithium-ion batteries (LIBs). LIBs are the backbone of the electric vehicles but there are some major issues faced by the them like poor thermal performance, thermal runaway, fire hazards and faster rate of discharge under low and high temperature environment,. Therefore to overcome these problems most of the researchers have come up with new methods of controlling and maintaining the overall thermal performance of the LIBs. The present review paper mainly is focused on optimization of thermal and structural design parameters of the LIBs under different BTMSs. The optimized BTMS generally demonstrated in this paper are maximum temperature of battery cell, battery pack or battery module, temperature uniformity, maximum or average temperature difference, inlet temperature of coolant, flow velocity, and pressure drop. Whereas the major structural design optimization parameters highlighted in this paper are type of flow channel, number of channels, length of channel, diameter of channel, cell to cell spacing, inlet and outlet plenum angle and arrangement of channels. These optimized parameters investigated under different BTMS heads such as air, PCM (phase change material), mini-channel, heat pipe, and water cooling are reported profoundly in this review article. The data are categorized and the results of the recent studies are summarized for each method. Critical review on use of various optimization algorithms (like ant colony, genetic, particle swarm, response surface, NSGA-II, etc.) for design parameter optimization are presented and categorized for different BTMS to boost their objectives. The single objective optimization techniques helps in obtaining the optimal value of important design parameters related to the thermal performance of battery cooling systems. Finally, multi-objective optimization technique is also discussed to get an idea of how to get the trade-off between the various conflicting parameters of interest such as energy, cost, pressure drop, size, arrangement, etc. which is related to minimization and thermal efficiency/performance of the battery system related to maximization. This review will be very helpful for researchers working with an objective of improving the thermal performance and life span of the LIBs.
Efficient Metabolic Pathway Modification in Various Strains of Lactic Acid Bacteria using CRISPR/Cas9 System for elevated synthesis of Antimicrobial Compounds

Haryani Y, Halid NA, Guat GS, Nor-Khaizura MAR, Hatta MAM, Sabri S, et al.

J Biotechnol, 2024 Sep 06.
PMID: 39245212 DOI: 10.1016/j.jbiotec.2024.09.002

Lactic acid bacteria (LAB) are known to exhibit various beneficial roles in fermentation, serving as probiotics, and producing a plethora of valuable compounds including compounds with antimicrobial activity including bacteriocin-like inhibitory substance (BLIS) that can be used as biopreservative to improve food safety and quality. However, the yield of BLIS is often limited, which poses a challenge to be commercially competitive with the current preservation practice. Therefore, the present work aimed to establish an optimised two-plasmid CRISPR/Cas9 system to redirect the carbon flux away from lactate towards compounds with antimicrobial activity by disrupting lactate dehydrogenase gene (ldh) on various strains of LAB. The lactic acid-deficient (ldhΔ) strains caused a metabolic shift resulting in increased inhibitory activity against selected foodborne pathogens up to 78% than the wild-type (WT) strain. The most significant effect was depicted by Enterococcus faecalis-ldh∆ which displayed prominent bactericidal effects against all foodborne pathogens as compared to the WT that showed no antimicrobial activity. The present work provided a framework model for economically important LAB and other beneficial bacteria to synthesise and increase the yield of valuable food and industrial compounds. The present work reported for the first time that the metabolism of selected LAB can be manipulated by modifying ldh to attain metabolites with higher antimicrobial activity.
Machine learning-based prognostic model for 30-day mortality prediction in Sepsis-3

Rahman MS, Islam KR, Prithula J, Kumar J, Mahmud M, Alam MF, et al.

BMC Med Inform Decis Mak, 2024 Sep 09;24(1):249.
PMID: 39251962 DOI: 10.1186/s12911-024-02655-4

BACKGROUND: Sepsis poses a critical threat to hospitalized patients, particularly those in the Intensive Care Unit (ICU). Rapid identification of Sepsis is crucial for improving survival rates. Machine learning techniques offer advantages over traditional methods for predicting outcomes. This study aimed to develop a prognostic model using a Stacking-based Meta-Classifier to predict 30-day mortality risks in Sepsis-3 patients from the MIMIC-III database.
METHODS: A cohort of 4,240 Sepsis-3 patients was analyzed, with 783 experiencing 30-day mortality and 3,457 surviving. Fifteen biomarkers were selected using feature ranking methods, including Extreme Gradient Boosting (XGBoost), Random Forest, and Extra Tree, and the Logistic Regression (LR) model was used to assess their individual predictability with a fivefold cross-validation approach for the validation of the prediction. The dataset was balanced using the SMOTE-TOMEK LINK technique, and a stacking-based meta-classifier was used for 30-day mortality prediction. The SHapley Additive explanations analysis was performed to explain the model's prediction.
RESULTS: Using the LR classifier, the model achieved an area under the curve or AUC score of 0.99. A nomogram provided clinical insights into the biomarkers' significance. The stacked meta-learner, LR classifier exhibited the best performance with 95.52% accuracy, 95.79% precision, 95.52% recall, 93.65% specificity, and a 95.60% F1-score.
CONCLUSIONS: In conjunction with the nomogram, the proposed stacking classifier model effectively predicted 30-day mortality in Sepsis patients. This approach holds promise for early intervention and improved outcomes in treating Sepsis cases.
Fulltext Spray Drying Encapsulation of Pediococcus acidilactici at Different Inlet Air Temperatures and Wall Material Ratios

Tirta GD, Martin L, Bani MD, Kho K, Pramanda IT, Pui LP, et al.

Foods, 2022 Dec 28;12(1).
PMID: 36613381 DOI: 10.3390/foods12010165

Pediococcus acidilactici has gained research and commercial interest due to its outstanding probiotic properties, yet its survival during storage and consumption requires improvement. This study aims to enhance P. acidilactici survival using spray drying encapsulation. Different inlet air temperatures (120 °C, 150 °C, and 170 °C) and whey protein isolate (WPI):gum arabic (GA) ratios (1:1, 3:1, 1:3) were tested. Cell viability was significantly (p < 0.05) affected by the inlet temperature but not the WPI:GA ratio. Increasing the inlet temperature to 170 °C significantly decreased P. acidilactici viability by 1.36 log cycles, from 8.61 log CFU/g to 7.25 log CFU/g. The inlet temperature of 150 °C resulted in a powder yield (63.12%) higher than at 120 °C (58.97%), as well as significantly (p < 0.05) lower moisture content (5.71%) and water activity (aw 0.21). Viable cell counts in all encapsulated P. acidilactici were maintained at 5.24−6.75 log CFU/g after gastrointestinal tract (GIT) simulation, with WPI:GA of 3:1 and inlet temperature 150 °C having the smallest log reduction (0.3 log cycles). All samples containing different WPI:GA ratios maintained sufficient viability (>7 log CFU/g) during the first three weeks of storage at 25 °C. These results could provide insights for further developing P. acidilactici as commercial probiotic products.
Fulltext Ketamine Infusion in a Resistant Obsessive-Compulsive Disorder Patient in Bangladesh with Severe Suicidal Ideation: A Case Report

Algin S, Banik D, Rahman SA, Mahmud Tusher S, Tuj Johora F, Akter A, et al.

Cureus, 2024 Apr;16(4):e57877.
PMID: 38596207 DOI: 10.7759/cureus.57877

Treatment of resistant obsessive-compulsive disorder (OCD) typically results in insufficient symptom alleviation, and even long-term medication often fails to have the intended effect. Ketamine is a potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. Studies have shown that low-dose ketamine infusion results in a considerable reduction in obsessive-compulsive symptoms and a rapid resolution of suicidal ideation. This is a case report on the effect of intravenous ketamine infusion on a patient with resistant OCD and severe suicidal ideation. Intravenous (IV) ketamine was given once a week over consecutive three weeks with necessary precautions. Psychometric tools such as the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the Clinical Global Impressions Scale (CGI-S), the Beck Scale for Suicidal Ideations (BSSI), and Depression Anxiety and Stress Scale 21 (DASS-21) were applied before and after infusions. Obsessive-compulsive symptoms and suicidal severity started to decrease rapidly after the first infusion. However, after a transient improvement, these symptoms again began to increase after a stressful incident on the second day of the first infusion. All the symptoms measured by validated rating scales showed continued improvement after the following two infusions. The improvement was sustained until discharge (one week after the last infusion) and subsequent follow-up in the sixth and 12th weeks. The role of ketamine in reducing suicidal thoughts and behavior is already established. Very few studies emphasized its effectiveness in improving severe/resistant obsessive-compulsive symptoms. This pioneering work may offer scope for similar research in the relevant field.
Research note: Molecular subtyping of Salmonella enterica serovar Tshiongwe recently isolated in Malaysia during 2001-2002

Thong KL, Bakeri SA, Lai KS, Koh YT, Taib MZ, Lim VK, et al.

Southeast Asian J Trop Med Public Health, 2004 Mar;35(1):92-6.
PMID: 15272750

Pulsed field gel electrophoresis (PFGE) and antimicrobial susceptibility analysis were undertaken on twenty-three strains of Salmonella enterica serovar Tshiongwe, an unusual serovar, which recently emerged in Malaysia. Antimicrobial susceptibility analysis showed that all the strains were sensitive to ampicilin, chloramphenicol, cotrimoxazole, and kanamycin. Twenty (87%) and 8 (3.5%) strains had resistance to tetracycline and streptomycin respectively. PFGE analysis subtyped 23 strains into 10 profiles (Dice coefficient of similarity, F = 0.7-1.0). The predominant profile, X1 was found in both clinical and environmental isolates and was widely distributed in different parts of Malaysia during the study period. In addition, isolates recovered from food, a hand-towel, apron and the surface of a table-top in one particular location had unique, indistinguishable profiles (X4/4a) and identical antibiograms. Similarly, isolates from cooked meat and a chopping board had PFGE profiles similar to some human isolates. These probably indicated cross-contamination and poor hygiene in food practices, hence contributing to Salmonellosis. Factors causing the emergence of this rare Salmonella serovar being responsible for food poisoning episodes during the study period remained unclear. The study reiterated the usefulness and versatility of PFGE in the molecular subtyping of this rare Salmonella serovar in Malaysia.
Projections of future bioclimatic indicators using bias-corrected CMIP6 models: a case study in a tropical monsoon region

Kamruzzaman M, Shariot-Ullah M, Islam R, Amin MGM, Islam HMT, Ahmed S, et al.

Environ Sci Pollut Res Int, 2024 Nov 14.
PMID: 39541022 DOI: 10.1007/s11356-024-35487-w

This study evaluates the potential impacts of climate change on Bangladesh by analyzing 19 bioclimatic indicators based on temperature and precipitation. Data from 18 bias-corrected CMIP6 global climate models (GCMs) were used, covering four Shared Socioeconomic Pathways (SSPs)-SSP126, SSP245, SSP370, and SSP585-across three future timeframes: near-term (2015-2044), mid-term (2045-2074), and long-term (2075-2100). Under the high-emission SSP585 scenario, average temperatures are projected to rise by up to 3.76 °C, and annual precipitation could increase by 52.6%, reaching up to 3446.38 mm by the end of the century. The maximum temperature (Bio5) could reach 32.91 °C, while the minimum temperature (Bio6) might rise by 4.43 °C, particularly during winter. Precipitation seasonality (Bio15) is projected to increase by as much as 7.9% in the northwest, indicating heightened variability between wet and dry seasons. The diurnal temperature range (Bio2) is expected to decrease by up to - 1.3 °C, signifying reduced nighttime cooling, which could exacerbate heat stress. Significant reductions in temperature seasonality (Bio4) are forecast for the northeast, with notable declines in isothermality (Bio3) under SSP585, pointing to increased climatic extremes. These climatic shifts pose severe risks to agricultural productivity, water resource availability, and biodiversity, particularly in flood-prone regions. The findings highlight the need for urgent adaptation measures, including improved flood management systems, efficient water resource use, and climate-resilient agricultural practices. By providing robust region-specific projections, this study offers critical insights for policymakers and stakeholders to mitigate the adverse effects of climate change and safeguard environmental and economic sustainability in Bangladesh.
Leveraging machine learning algorithms in dynamic modeling of urban expansion, surface heat islands, and carbon storage for sustainable environmental management in coastal ecosystems

Kafy AA, Dey NN, Saha M, Altuwaijri HA, Fattah MA, Rahaman ZA, et al.

J Environ Manage, 2024 Nov;370:122427.
PMID: 39305877 DOI: 10.1016/j.jenvman.2024.122427

Climate change and rapid urbanization are dramatically altering coastal ecosystems worldwide, with significant implications for land surface temperatures (LST) and carbon stock concentration (CSC). This study investigates the impacts of day and night time LST dynamics on CSC in Cox's Bazar, Bangladesh, from 1996 to 2021, with future projections to 2041. Using Landsat and MODIS imagery, we found that mean daytime LST increased by 3.57 °C over the 25-year period, while nighttime LST showed a slight decrease of 0.05 °C. Concurrently, areas with no carbon storage increased by 355.78%, while high and very high CSC zones declined by 14.15% and 47.78%, respectively. The Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model estimated a 28.64 km2 reduction in high CSC areas from 1996 to 2021. Statistical analysis revealed strong negative correlations between LST and vegetation indices (R2 = -0.795 to -0.842, p 32 °C, while areas with LST <24 °C may decrease to 1.68%. These observations underscore the pressing necessity for sustainable strategies in urban planning and conservation in swiftly evolving coastal areas, especially considering the challenges posed by climate change and population growth.
Fulltext 3.3-4.3 GHz efficient continuous class-F gallium nitride power amplifier based on simplified real frequency technique and harmonic tuning

Sadeque MG, Yusoff Z, Roslee M, Hashim SJ, Mohd Marzuki AS, Lees J, et al.

PLoS One, 2024;19(8):e0306738.
PMID: 39141686 DOI: 10.1371/journal.pone.0306738

In order to implement the fifth generation (5G) communication system for a large number of users, the governments of many countries nominated the low 5G frequency band between 3.3 and 4.3 GHz. This paper proposes a wideband RFPA by designing the input matching network (MN) and output MN of the device using the simplified real frequency technique (SRFT) and the harmonic tuning network. The load-pull and source-pull is applied at multiple points for 100 MHz intervals over the bandwidth to obtain the optimum impedances at the output and input of the 10W Gallium Nitride (GaN) Cree CGH40010F device. To verify the design, the RFPA is simulated, and the performance is measured between 3.3 and 4.3 GHz. According to experimental findings, the measured drain efficiency (DE) throughout the whole bandwidth ranged from 57.5 to 67.5% at the output power of 40 dBm. Moreover, at the 1 dB compression point between 39.2 and 42.2 dBm output power, the drain efficiency (DE) achieves a high value of 81.2% with an output power of 42.2 dBm at a frequency of 3.3 GHz. The RFPA can obtain a maximum gain of 12.4 dB at 3.5 GHz. The linearity of the RFPA with a two-tone signal is measured and the value is less than -22 dBc all over the band.
Fulltext Impact of COVID-19 pandemic on radiology education, training, and practice: A narrative review

Majumder MAA, Gaur U, Singh K, Kandamaran L, Gupta S, Haque M, et al.

World J Radiol, 2021 Nov 28;13(11):354-370.
PMID: 34904050 DOI: 10.4329/wjr.v13.i11.354

Radiology education and training is of paramount clinical importance given the prominence of medical imaging utilization in effective clinical practice. The incorporation of basic radiology in the medical curriculum has continued to evolve, focusing on teaching image interpretation skills, the appropriate ordering of radiological investigations, judicious use of ionizing radiation, and providing exposure to interventional radiology. Advancements in radiology have been driven by the digital revolution, which has, in turn, had a positive impact on radiology education and training. Upon the advent of the corona virus disease 2019 (COVID-19) pandemic, many training institutions and hospitals adhered to directives which advised rescheduling of non-urgent outpatient appointments. This inevitably impacted the workflow of the radiology department, which resulted in the reduction of clinical in-person case reviews and consultations, as well as in-person teaching sessions. Several medical schools and research centers completely suspended face-to-face academic activity. This led to challenges for medical teachers to complete the radiology syllabus while ensuring that teaching activities continued safely and effectively. As a result, online teaching platforms have virtually replaced didactic face-to-face lectures. Radiology educators also sought other strategies to incorporate interactive teaching sessions while adopting the e-learning approach, as they were cognizant of the limitations that this may have on students' clinical expertise. Migration to online methods to review live cases, journal clubs, simulation-based training, clinical interaction, and radiology examination protocolling are a few examples of successfully addressing the limitations in reduced clinical exposure. In this review paper, we discuss (1) The impact of the COVID-19 pandemic on radiology education, training, and practice; (2) Challenges and strategies involved in delivering online radiology education for undergraduates and postgraduates during the COVID-19 pandemic; and (3) Difference between the implementation of radiology education during the COVID-19 pandemic and pre-COVID-19 era.
Fulltext Development of Protein Rich Pregelatinized Whole Grain Cereal Bar Enriched With Nontraditional Ingredient: Nutritional, Phytochemical, Textural, and Sensory Characterization

Allai FM, Dar BN, Gul K, Adnan M, Ashraf SA, Hassan MI, et al.

Front Nutr, 2022;9:870819.
PMID: 35464008 DOI: 10.3389/fnut.2022.870819

This study was aimed to use extrusion cooking as a pretreatment for non-conventional seeds (Indian horse chestnut flour) to blend them with whole grain flours (whole wheat flour, whole barley flour, and whole corn flour) for the development of a pregelatinized cereal bar (PCB). In this study, date paste (7.5-17.5%) and walnut grits (2.5-12.5%) were incorporated at varying levels to prepare PCB. The PCB was evaluated for its nutritional, color, textural (both three-point bending test and TPA), antioxidant activity, and sensory attributes. The flexural modulus, rupture stress, and fracture strain of PCB increased with the incorporation of a higher proportion of date paste. The protein and fiber content in PCB increased from 7.74 to 9.13% and 4.81 to 5.59% with the incorporation of walnut grits and date paste, respectively. The DPPH, total phenolic content, and water activity of PCB were determined, which progressively enhanced with increased levels of walnut grits and date paste. The correlation between sensory attributes and instrumental texture on PCB was also investigated. The correlation results showed a significant (p < 0.05) positive correlation between texture analysis and sensory hardness, springiness, adhesiveness, and negatively correlated to instrumental and sensory cohesiveness. For sensorial attributes, all PCB samples presented average scores of 7/10 and 4/5 for buying intention. Therefore, whole grain extrudates, date paste, and walnut grits can be efficiently used to develop PCB with improved nutritional, nutraceutical, and economic values.
Fulltext Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Abdulrahman MD, Zakariya AM, Hama HA, Hamad SW, Al-Rawi SS, Bradosty SW, et al.

Adv Pharmacol Pharm Sci, 2022;2022:4495688.
PMID: 35677711 DOI: 10.1155/2022/4495688

Medicinal plants are the primary raw materials used in the production of medicinal products all over the world. As a result, more study on plants with therapeutic potential is required. The tropical tree Ziziphus spina belongs to the Rhamnaceae family. Biological reports and traditional applications including management of diabetes and treatment of malaria, digestive issues, typhoid, liver complaints, weakness, skin infections, urinary disorders, obesity, diarrhoea, and sleeplessness have all been treated with different parts of Z. spina all over the globe. The plant is identified as a rich source of diverse chemical compounds. This study is a comprehensive yet detailed review of Z. spina based on major findings from around the world regarding ethnopharmacology, biological evaluation, and chemical composition. Scopus, Web of Science, BioMed Central, ScienceDirect, PubMed, Springer Link, and Google Scholar were searched to find published articles. From the 186 research articles reviewed, we revealed the leaf extract to be significant against free radicals, microbes, parasites, inflammation-related cases, obesity, and cancer. Chemically, polyphenols/flavonoids were the most reported compounds with a composition of 66 compounds out of the total 193 compounds reported from different parts of the plant. However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the leaf extract should be examined. The standard dose and safety of the leaf should be established.
Fulltext Anesthetic Effect of 2% Amitriptyline Versus 2% Lidocaine: A Comparative Evaluation

Patel N, B Urolagin S, Haq MA, Patel C, Bhatt R, Girdhar G, et al.

Cureus, 2023 Aug;15(8):e43405.
PMID: 37581201 DOI: 10.7759/cureus.43405

Introduction A common dental problem is the fear of pain during needle prick for giving local anesthesia (LA). The needle prick pain during dental procedures often varies with sex and age. Perception of pain depends on various factors, which can be psychological and biological. This perception of pain may change the behavior of patients toward dental treatments. Traditionally, lidocaine gel formulation was utilized before the parenteral dosage form. The lidocaine gel formulation is considered the drug of choice for LA in dental surgery. Currently, amitriptyline has been utilized in dental practice because of its beneficial pharmacology. Hence, the present study has been undertaken to compare the anesthetic ability of amitriptyline as an intraoral topical anesthetic agent with lidocaine gel. Methods This study was a comparative clinical study between two medications' anesthetic properties. This study included 120 patients indicated for bilateral orthodontics (the subdivision of dentistry that emphasizes identifying necessary interventions for the malocclusion of teeth) procedures. All the subjects were divided into amitriptyline and lidocaine groups. Both anesthetic gels were applied at separate sites before the injection of LA. The time of the onset of anesthesia was noted and analyzed. Patients were selected on the basis of inclusion and exclusion criteria. Individuals aged 18 to 30 years who were systemically healthy and orthodontically indicated for bilateral premolar extraction were included in this study. Again, patients with a history of neurological disorders and allergies to amitriptyline and lidocaine were excluded from the current study. Results Significant differences emerged between groups at five and 10 minutes, with amitriptyline-induced partial numbness (36.7% and 6.7%). At 40 and 45 minutes, both groups showed varied partial and complete numbness, with amitriptyline leading to partial recovery (23.3% and 73.3% complete numbness, 23.3% partial recovery) and lidocaine resulting in partial recovery (81.7%). When comparing the visual analog scale (VAS) scores, both groups exhibited a similar simultaneous effect at 15 minutes. Nonetheless, amitriptyline displayed significantly lower scores at 25 and 35 minutes (p < 0.001) in comparison to lidocaine. Similar observations were made when controlling for pain intensity. Conclusion It was concluded that amitriptyline holds both anesthetic and analgesic properties. Nevertheless, this study was unable to generalize the study findings because of the small sample size and being a single-center study. However, the VAS scores of anesthetic and analgesic pharmacodynamics properties of amitriptyline were statistically significantly lower than lidocaine, particularly at 25 and 35 minutes. Additionally, amitriptyline-induced anesthetic and analgesic pharmacology, especially pharmacokinetics properties, depends on the location and pattern of pain.

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