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Displaying publications 501 - 520 of 7255 in total

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Sustaining life on earth system through clean air, pure water, and fertile soil

Ashraf MA, Mohd Hanafiah M

Environ Sci Pollut Res Int, 2019 05;26(14):13679-13680.
PMID: 30350141 DOI: 10.1007/s11356-018-3528-3
Four new Megaselia species (Diptera: Phoridae) from aanimal carcasses in Bangi, Malaysia

Zuha RM, Disney RHL

Zootaxa, 2018 Nov 02;4508(4):551-561.
PMID: 30485963 DOI: 10.11646/zootaxa.4508.4.3

Megaselia bangiensis Disney sp. nov., M. cumpapillarum Disney sp. nov., M. hyplongiseta Disney sp. nov. and M. selangorensis Disney sp. nov. were collected from rabbit carcasses placed in concealed environments in Bangi, Malaysia.
Does Natural Honey-Containing Fructose have Benefits to Diabetic Patients?

Akbar MF, Fiqriyana MA

Malays J Med Sci, 2016 Mar;23(2):86.
PMID: 27547121
Synthesis of 2-Furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives as suitable antibacterial agents with mild cytotoxicity

Abbasi MA, Nazeer MM, Rehman A, Siddiqui SZ, Hussain G, Shah SA, et al.

Pak J Pharm Sci, 2018 Nov;31(6):2477-2485.
PMID: 30473521

The aim of the present research work was synthesis of some 2-furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives and to ascertain their antibacterial potential. The cytotoxicity of these molecules was also checked to find out their utility as possible therapeutic agents. The synthesis was initiated by reacting furyl(-1-piperazinyl)methanone (1) in N,N-dimethylformamide (DMF) and lithium hydride with different aralkyl halides (2a-j) to afford 2-furyl[(4-aralkyl)-1-piperazinyl]methanone derivatives (3a-j). The structural confirmation of all the synthesized compounds was done by IR, EI-MS, 1H-NMR and 13C-NMR spectral techniques and through elemental analysis. The results of in vitro antibacterial activity of all the synthesized compounds were screened against Gram-negative (S. typhi, E. coli, P. aeruginosa) and Gram-positive (B. subtilis, S. aureus) bacteria and were found to be decent inhibitors. Amongst the synthesized molecules, 3e showed lowest minimum inhibitory concentration MIC = 7.52±0.μg/mL against S. Typhi, credibly due to the presence of 2-bromobenzyl group, relative to the reference standard, ciprofloxacin, having MIC = 7.45±0.58μg/mL.
Fulltext Abdominal obesity and high-sensitivity c-reactive protein level among malay obese adults in Kuantan, Malaysia

Siti Zuhaidah Shahadan, Muhammad Lokman Md. Isa, Azlina Daud, Ali Aminuddin Mohd Rasani, Muhammad Ibrahim, Samsul Deraman

International Medical Journal Malaysia, 2018;17(1):79-86.
MyJurnal

Introduction: Abdominal obesity and inflammation are two independent risk factors for cardiovascular disease. However, the inter-relationship between these two factors among Malay population is fragmented. The purpose of this study is to determine the association between waist circumference as a measure of abdominal obesity and high-sensitivity C-reactive protein as an indicator of inflammation status among Malay obese adults in Kuantan, Pahang. Materials and Methods: Ninety-three apparently healthy obese adults (BMI between 27.5 and 39.9 kg/m2 ) aged between 20 to 62 years old were recruited in this study (68% men and 32% women). Circumference tape was used to measure the waist circumference and fasting venous blood was obtained to determine the high-sensitivity C-reactive protein level. Results: On average, the waist circumference of obese men and women was 103 cm (SD = 8.7) and 94 cm (SD = 7.0), respectively. The median (IQR) of the hs-CRP level of the study participant was 3.80 mg/L (1.5, 10.1). The Kendall’s Tau correlation reveals that there is a significant positive linear correlation between waist circumference and hs -CRP level in obese men (r (30) = 0.355, p = 0.006) and women (r (63) = 0.177, p = 0.043). Conclusion: There is a significant inter-relationship between waist circumference and hs-CRP level among apparently healthy obese adults in Kuantan, Pahang. This study suggests that assessment of hs-CRP level is beneficial to predict the risk for future cardiovascular disease event and facilitate the management of obesity in this population. A prospective clinical study is recommended to confirm the findings.
Effects of debinding and sintering atmosphere on properties and corrosion resistance of powder injection molded 316 L - stainless steel

Raza MR, Sherazi I, Muhammad Aslam, Ahmad F, Abu Bakar Sulong, Muhamad Norhamidi, et al.

Sains Malaysiana, 2017;46:285-293.

316L stainless steel is a common biomedical material. Currently, biomedical parts are produced through powder injection molding (PIM). Carbon control is the most critical in PIM. Improper debinding can significantly change the properties of the final product. In this work, thermal debinding and sintering were performed in two different furnaces (i.e. laboratory and commercially available furnaces) to study the mechanical properties and corrosion resistance. Debounded samples were sintered in different atmospheres. The samples sintered in inert gas showed enhanced mechanical properties compared with wrought 316L stainless steel and higher corrosion rate than those sintered in the vacuum furnace. The densification and tensile strength of the hydrogen sintered samples increased up to 3% and 51%, respectively, compared with those of the vacuum-sintered samples. However, the samples sintered in inert gas also exhibited reduced ductility and corrosion resistance. This finding is attributed to the presence of residual carbon in debonded samples during debinding.
Profiling of anti-oxidative enzymes and lipid peroxidation in leaves of salt tolerant and salt sensitive maize hybrids under nac1 and cd stress

Ghulam Hasan Abbasi, Javaid Akhtar, Muhammad Anwar-ul-haq, Moazzam Jamil, Shafaqat Ali, Rafiq Ahmad, et al.

Sains Malaysiana, 2016;45:177-184.

Effects of NaCl salinity and cadmium on the anti-oxidative activity of enzymes like superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), ascorbate peroxidase (APX), glutathione reductase (GR) and lipid peroxidation contents; malondialdehyde (MDA) were studied in two maize hybrids of different salt tolerance characteristics. An increase in the amount of lipid peroxidation indicated the oxidative stress induced by NaCl and Cd. The results also depicted that NaCl stress caused an increase in the activities of POD, SOD, CAT, APX and GR while cadmium stress increased the activities of POD, SOD and APX but showed no significant effect on CAT and GR in both the studied hybrids. The combined effect of salinity and cadmium on these parameters was higher than that of sole effect of either NaCl or Cd. It was also found that maize hybrid 26204 had better tolerance against both stresses with strong antioxidant system as compared to that of maize hybrid 8441. A comparison of the antioxidants and lipid peroxidation in two maize hybrids having varying level of NaCl and Cd stress tolerance corroborated the importance of reactive oxygen species (ROS) in defense against abiotic stresses.
Synthesis and characterization of gd2o2s:pr3+ nanophosphors using gamma irradiation method

Muhammad Hassyakirin Hasim, Irman Abdul Rahman, Sapizah Rahim, Muhammad Taqiyuddin Mawardi Ayob, Liyana Mohd Ali Napia, Shahidan Radiman

Sains Malaysiana, 2018;47:1861-1866.

Praseodymium ion, Pr3+ doped Gd2
O2
S nanophosphors were successfully synthesized via gamma irradiation route
along with the heat treatment. The effect of the gamma irradiation (0-150 kGy) on the structural, morphology and
photoluminescence properties of Gd2
O2
S:Pr3+ were characterized via X-ray diffraction (XRD), field emission scanning
electron microscope (FESEM) and photoluminescence spectroscopy (PL). The thermal properties of precursor sample
were tested by the thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The chemical bonding of
the precursor samples were analyzed by Fourier transform infrared spectroscopy (FT-IR). The XRD result confirmed the
formation of hexagonal phase of Gd2
O2
S:Pr3+ without the presence of any impurities. The FESEM inspection showed the
non-symmetrical shape of particles transformed into grain-like shape. The optimum photoluminescence (PL) emission
intensities of Gd2-xO2
S:xPr3+ occur at 50 kGy dose of gamma irradiation and 2 mol% concentration dopant of Pr3+ ions.
The spectra under 325 nm UV excitation shows a strong green emission at 515 nm, which match the 3
P0 → 3
H4
transition
of Pr3+ ions. The Gd2
O2
S:Pr3+ nanophosphors possessed many useful approaches in various applications mainly as
radiation detection and biomedical diagnostic.
Comment on: "Projections of the Healthcare Costs and Disease Burden due to Hepatitis C Infection Under Different Treatment Policies in Malaysia, 2018-2040"

Hassan MRA, Chan HK

Appl Health Econ Health Policy, 2020 02;18(1):139-140.
PMID: 31853748 DOI: 10.1007/s40258-019-00543-x
An Overview on the Toxicological Properties of Ionic Liquids toward Microorganisms

Sivapragasam M, Moniruzzaman M, Goto M

Biotechnol J, 2020 Apr;15(4):e1900073.
PMID: 31864234 DOI: 10.1002/biot.201900073

Ionic liquids (ILs), a class of materials with unique physicochemical properties, have been used extensively in the fields of chemical engineering, biotechnology, material sciences, pharmaceutics, and many others. Because ILs are very polar by nature, they can migrate into the environment with the possibility of inclusion in the food chain and bioaccumulation in living organisms. However, the chemical natures of ILs are not quintessentially biocompatible. Therefore, the practical uses of ILs must be preceded by suitable toxicological assessments. Among different methods, the use of microorganisms to evaluate IL toxicity provides many advantages including short generation time, rapid growth, and environmental and industrial relevance. This article reviews the recent research progress on the toxicological properties of ILs toward microorganisms and highlights the computational prediction of various toxicity models.
A Case Report on Cholestatic Jaundice Secondary to Adverse Effect of Phaleria macrocarpa (Mahkota Dewa)

Rahim MFA, Payus AO

Acta Med Indones, 2019 Oct;51(4):344-347.
PMID: 32041919

Drug induced cholestatic liver injury can posed a great diagnostic difficulty as a result of its long non-exhaustive list of potential offending causes which can be either prescribed or over-the-counter medications, such as medicinal herbs and remedies. Phaleria macrocarpa, or more commonly known as the 'God's crown' by the local people of South East Asia, is not listed as one of the causes. This medicinal plant extract has been increasingly used for traditional treatment for various ailments. Here, we report a case of a young man who has no known medical illness presented with cholestatic pattern of liver injury which caused by chronic ingestion of Phaleria macrocarpa. The objective of this case report is to share the uncommon side effect of taking this traditional product which may have been under-reported due to the unknown effect.
Fulltext Common manifestations of systemic lupus erythematosus in tertiary rheumatology centre, Perak

Wahinuddin S., Rashrina A.R., Muhammad Faiz M.S., Muhammad A.A., Abdullah A.C., Ong, P.S., et al.

Asian Journal of Medicine and Health Sciences, 2019;2(1):94-100.
MyJurnal

Objective. A hospital-based cross-sectional descriptive study documenting the common clinical manifestations of systemic lupus erythematosus (SLE) in a tertiary rheumatology center in the state of Perak in Malaysia. Method. The 1997 American College of Rheumatology classification revised criteria and the 2012 Systemic Lupus International Collaborating Clinic criteria were used and all patients attending the rheumatology clinic at a tertiary referral centre were included. The demographics and other clinical information were retrieved from patients’ outpatient clinical records.

Results. One-hundred SLE patients were included in this cross-sectional study, the majority of whom were of the Malay ethnic group (47%) followed by Chinese (41%) and Indians (12%). Almost 91% of the patients in our study were females. Mean age was 34.94 years (SD = 12.7; 95% confidence interval, 32.42 – 37.46), almost 79% were in the 20-50 years age group. Anti-nuclear antibody (ANA) was positive in 70% of patients while only 28% were positive for anti-double-stranded deoxyribonucleic antibody (dsDNA). Major clinical manifestations were hematological disorders (53%) followed by a malar rash (41%), photosensitivity (30%) and oral ulcers (27%).

Conclusion. Clinical phenotypes, demographics of SLE patients in this study shows no significant difference across age, gender, and ethnic groups. The current data, though limited, shows a high frequency of hematological and mucocutaneous manifestation in these patients.
Could choline chloride-citric acid monohydrate molar ratio in deep eutectic solvent affect structural, functional and antioxidant properties of pectin?

Shafie MH, Gan CY

Int J Biol Macromol, 2020 Apr 15;149:835-843.
PMID: 32027904 DOI: 10.1016/j.ijbiomac.2020.02.013

The deep eutectic solvents (DESs), which were made from different molar ratios (3:1, 2:1, 1:1, 1:2, 1:3) of choline chloride and citric acid monohydrate, were used as media for the pectic polysaccharide extraction from Averrhoa bilmbi (ABP). The physico-chemical, structural, functional and antioxidant properties of ABP were subsequently determined. The ABP was found to be xylogalacturonan. Moreover, results showed that different structures (i.e. linearity of pectin and branch size) of ABP were obtained, hence, affecting the solubility and functional properties due to the surface availability and steric effect. In addition, when increasing the molar ratio of citric acid monohydrate in DES, lower pH and higher TPC values were observed. These values were correlated with antioxidant activities (i.e. free radical scavenging activity and ferric reducing antioxidant power) of ABP. In conclusion, the molar ratio of the DES components plays an important role in extracting ABP with the aforementioned properties.
Intensity-duration-frequency approach for risk assessment of air pollution events

Masseran N, Mohd Safari MA

J Environ Manage, 2020 Jun 15;264:110429.
PMID: 32217317 DOI: 10.1016/j.jenvman.2020.110429

Intensity-duration-frequency (IDF) curves can serve as useful tools in risk assessment of extreme environmental events. Thus, this study proposes an IDF approach for evaluating the risk of expected occurrences of extreme air pollution as measured by an air pollution index (API). Hourly data of Klang city in Malaysia from 1997 to 2016 are analyzed. For each year, a block maxima size is determined based on four different monsoon seasons. Generalized extreme value (GEV) distribution is used as a model to represent the probabilistic behavior of maximum intensity of the API, which is derived from each block. Based on the GEV model, the IDF curves are developed to estimate the extreme pollution intensities that correspond to various duration hours and return periods. Considering the IDF curves, we found that for any duration hour, the magnitude of pollution intensity tends to be high in parallel with increasing return periods. In fact, a high-intensity pollution event that poses a high risk of affecting the environment is less frequent than low-intensity pollution. In conclusion, the IDF curves provide a good basis for decision makers to assess the expected risk of extreme pollution events in the future.
Fulltext The Importance of Derivatizing Reagent in Chromatography Applications for Biogenic Amine Detection in Food and Beverages

Munir MA, Badri KH

J Anal Methods Chem, 2020;2020:5814389.
PMID: 32377440 DOI: 10.1155/2020/5814389

Biogenic amines (BA) are chemical compounds formed in foods that contain protein, allowing the foods to undergo a bacterial degradation process. Biogenic amines are labeled as toxic food because its consumption exceeding the FDA regulation (50 mg/kg) can be harmful to humans. Some countries also have regulations that prohibit the consumption of biogenic amines in high concentrations, especially histamine. The chromatography methods generally applied by researchers are liquid chromatography (LC) and gas chromatography (GC), where the use of a derivatization reagent is necessary to increase their sensitivity. This review is based on past and present studies about biogenic amine detection related to food samples. The rationale of this study is also to provide data on the comparison of the analytical approaches between LC and GC methods. Furthermore, the various approaches of biogenic amine determination and the most applied analytical methods have been reviewed.
True Median Cleft Lip-15 Years of Review and Prevalence

Hamzan MI, Sulaiman WAW

Cleft Palate Craniofac J, 2020 08;57(8):1051-1054.
PMID: 32476501 DOI: 10.1177/1055665620926346

OBJECTIVES: The author presents 4 cases and attempts to analyze the prevalence of true median cleft lip (MCL) in one center. Embryology, associated anomalies, and surgical treatment are discussed.
DESIGN: A retrospective descriptive study.
SETTING: Hospital Universiti Sains Malaysia.
PARTICIPANTS: All patients with congenital facial cleft deformities from 2005 to 2019 were retrieved from the Plastic Surgery OR Registry. All characteristics in interest were individually tabulated and evaluated. Four cases were reviewed and discussed.
OUTCOME: Prevalence of true MCL.
RESULTS: Out of the 494 patients included in the study, only 4 (0.81%) were affected with a median cleft, and the prevalence of true median cleft was hence determined to be 3 (0.61%) among the cleft population.
CONCLUSION: The prevalence of the true MCL is rare which makes it hard to categorize these clefts, and the surgical protocol needs to be established for the definitive treatment.
Scaffolds for Cartilage Regeneration: To Use or Not to Use?

Sha'ban M, Ahmad Radzi MA

Adv Exp Med Biol, 2020;1249:97-114.
PMID: 32602093 DOI: 10.1007/978-981-15-3258-0_7

Joint cartilage has been a significant focus on the field of tissue engineering and regenerative medicine (TERM) since its inception in the 1980s. Represented by only one cell type, cartilage has been a simple tissue that is thought to be straightforward to deal with. After three decades, engineering cartilage has proven to be anything but easy. With the demographic shift in the distribution of world population towards ageing, it is expected that there is a growing need for more effective options for joint restoration and repair. Despite the increasing understanding of the factors governing cartilage development, there is still a lot to do to bridge the gap from bench to bedside. Dedicated methods to regenerate reliable articular cartilage that would be equivalent to the original tissue are still lacking. The use of cells, scaffolds and signalling factors has always been central to the TERM. However, without denying the importance of cells and signalling factors, the question posed in this chapter is whether the answer would come from the methods to use or not to use scaffold for cartilage TERM. This paper presents some efforts in TERM area and proposes a solution that will transpire from the ongoing attempts to understand certain aspects of cartilage development, degeneration and regeneration. While an ideal formulation for cartilage regeneration has yet to be resolved, it is felt that scaffold is still needed for cartilage TERM for years to come.
Modeling the transition behaviors of PM10 pollution index

Masseran N, Safari MAM

Environ Monit Assess, 2020 Jun 17;192(7):441.
PMID: 32557137 DOI: 10.1007/s10661-020-08376-1

Modeling and evaluating the behavior of particulate matter (PM10) is an important step in obtaining valuable information that can serve as a basis for environmental risk management, planning, and controlling the adverse effects of air pollution. This study proposes the use of a Markov chain model as an alternative approach for deriving relevant insights and understanding of PM10 data. Using first- and higher-order Markov chains, we analyzed daily PM10 index data for the city of Klang, Malaysia and found the Markov chain model to fit the PM10 data well. Based on the fitted model, we comprehensively describe the stochastic behaviors in the PM10 index based on the properties of the Markov chain, including its states classification, ergodic properties, long-term behaviors, and mean return times. Overall, this study concludes that the Markov chain model provides a good alternative technique for obtaining valuable information from different perspectives for the analysis of PM10 data.
Fulltext COVID-19 pandemic: stringent measures of Malaysia and implications for other countries

Umair S, Waqas U, Faheem M

Postgrad Med J, 2021 Feb;97(1144):130-132.
PMID: 32561598 DOI: 10.1136/postgradmedj-2020-138079
Fulltext A Systematic Review on Clinimetric Properties of Play Instruments for Occupational Therapy Practice

Romli MH, Wan Yunus F

Occup Ther Int, 2020;2020:2490519.
PMID: 32821250 DOI: 10.1155/2020/2490519

Play is considered the main occupation for children. Pediatric occupational therapists utilize play either for evaluation or intervention purpose. However, play is not properly measured by occupational therapists, and the use of play instrument is limited. This systematic review was aimed at identifying play instruments relevant to occupational therapy practice and its clinimetric properties. A systematic search was conducted on six databases (Academic Search Complete, CINAHL, MEDLINE, Psychology and Behavioral Science Collection, Scopus, and ASEAN Citation Index) in January 2020. The quality of the included studies was evaluated using Law and MacDermid's Appraisal for Clinical Measurement Research Reports, and psychometric properties of play instruments were evaluated using Terwee's checklist while the clinical utility is extracted from each instrument. Initial search identifies 1,098 articles, and only 30 articles were included in the final analysis, extracting 8 play instruments. These instruments were predominantly practiced in the Western culture, which consists of several psychometric evidences. The Revised Knox Preschool Play Scale is considered the most extensive and comprehensive play instrument for extrinsic aspect, whereas the Test of Playfulness + Test of Environmental Supportiveness Unifying Measure is a promising play instrument for intrinsic aspect on play, where both instruments utilize observation. My Child's Play is a potential questionnaire-based play instrument. However, the current development of play instruments in the occupational therapy field is immature and constantly evolving, and occupational therapists should exercise good clinical reasoning when selecting a play instrument to use in practice.

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