Displaying publications 41 - 60 of 1783 in total

Abstract:
Sort:
  1. Pandey P, Gómez-Aguilar JF, Kaabar MKA, Siri Z, Mousa AAA
    Comput Biol Med, 2022 Jun;145:105518.
    PMID: 35447461 DOI: 10.1016/j.compbiomed.2022.105518
    The range of effectiveness of the novel corona virus, known as COVID-19, has been continuously spread worldwide with the severity of associated disease and effective variation in the rate of contact. This paper investigates the COVID-19 virus dynamics among the human population with the prediction of the size of epidemic and spreading time. Corona virus disease was first diagnosed on January 30, 2020 in India. From January 30, 2020 to April 21, 2020, the number of patients was continuously increased. In this scientific work, our main objective is to estimate the effectiveness of various preventive tools adopted for COVID-19. The COVID-19 dynamics is formulated in which the parameters of interactions between people, contact tracing, and average latent time are included. Experimental data are collected from April 15, 2020 to April 21, 2020 in India to investigate this virus dynamics. The Genocchi collocation technique is applied to investigate the proposed fractional mathematical model numerically via Caputo-Fabrizio fractional derivative. The effect of presence of various COVID parameters e.g. quarantine time is also presented in the work. The accuracy and efficiency of the outputs of the present work are demonstrated through the pictorial presentation by comparing it to known statistical data. The real data for COVID-19 in India is compared with the numerical results obtained from the concerned COVID-19 model. From our results, to control the expansion of this virus, various prevention measures must be adapted such as self-quarantine, social distancing, and lockdown procedures.
    Matched MeSH terms: India/epidemiology
  2. Shigli K, Nayak SS, Lagali-Jirge V, Kusurkar RA, Nerali JT, Oginni FO
    Gerontol Geriatr Educ, 2022 04 15;43(4):468-481.
    PMID: 35422199 DOI: 10.1080/02701960.2022.2058936
    The proportion of older adults is on the rise. Management of dental problems in this group is different from the general population, and hence requires special training. Gerodontology is yet to find its place in the Indian dental curriculum. A lack of training would result in inadequate care delivery. In this article, we share our views on the need for inclusion of the subject, potential challenges, and a guide for incorporation of gerodontology in undergraduate and postgraduate curriculum in the Indian dental institutes. We propose a framework based on the salient features of Kern's 6-step approach for curriculum development and Kotter's 8-step change management model. Some features are common to both the models. A combination of these models includes the following salient features: Problem identification and general needs assessment, beginning with a sense of urgency and targeted needs assessment, communication of the vision for change, working in guided coalitions and defining clear goals and objectives, adopting the relevant educational strategies, implementation strategies to enable change and generating short-term wins, evaluating the effectiveness of the curricular reform and sustaining and anchoring the change. The proposed framework may also be useful for countries where gerodontology is yet to be implemented.
    Matched MeSH terms: India
  3. Subsittipong N, Choi J, Kim TH, Han E
    PMID: 35409470 DOI: 10.3390/ijerph19073786
    Background: The introduction of new vaccines has been delayed in some countries in the Asia-Pacific region, which has led to delays in accessing vaccines for target patients. However, the approval lag of vaccines in the Asia-Pacific region has not been assessed. The objective of this study is to assess the availability and approval lag of vaccines in Asia-Pacific countries and compare them among Asia-Pacific countries, the United States (US), and Europe (EU). Methods: The information on vaccines prequalified by the World Health Organization (WHO) between 2010 and 2019 was obtained primarily from the WHO website. The date of approval of the WHO prequalified vaccine in Australia, India, South Korea, Thailand, Singapore, Malaysia, the US, and EU was retrieved from the official website of national regulatory agencies. The vaccines were divided into two groups based on their first approval pathway, that is, vaccines that were first approved by SRA (Stringent Regulatory Authority including the US, EU, and WHO) and those that were first approved by non-SRA. The absolute approval lag represented the availability of the vaccine. Relative approval lag represented the lag time between the approval date of the country of interest and the first global approval date and was measured as the median approval lag. A Mann−Whitney U test was used to examine statistical differences between relative approval lag between the SRA first and the non-SRA first groups. Results: A total of 92 vaccines were prequalified by the WHO between 2010 and 2019, but only 61 vaccines were included in the analysis. Over 50% of vaccines were first licensed by non-SRAs. Of all the WHO-prequalified vaccines, the median approval lag in the ASEAN countries in this study was longer than those in the US and EU, with a median of 30 months in Australia, 15 months in South Korea, 52 months in Thailand, and 23 months in Singapore, compared to 0 months in the US and EU. The differences in approval lags between SRA first vaccines and non-SRA first vaccines were statistically significant in South Korea and Thailand (p < 0.05). Conclusions: The approval lag of vaccines was observed in the Asia-Pacific region, indicating a gap between the Asia-pacific region and the US and EU in regard to access to new vaccines. Future studies need to analyze the background factors related to the gap in availability and vaccine approval lag in the Asia-Pacific region and assess the impact of vaccine approval lag in the region.
    Matched MeSH terms: India
  4. S C, M V P, S V, M N, K P, Panda B, et al.
    Environ Res, 2022 03;204(Pt A):111729.
    PMID: 34478727 DOI: 10.1016/j.envres.2021.111729
    This study was focused on identifying the region suitable for agriculture-based, using new irrigation groundwater quality plot and its spatio-temporal variation with fuzzy logic technique in a geographic information system (GIS) platform. Six hundred and eighty groundwater samples were collected during pre, southwest, northeast, and post monsoon periods. A new ternary plot was also attempted to determine the irrigation suitability of water by considering four essential parameters such as sodium adsorption ratio (SAR), permeability index (PI), Sodium percentage (Na %), and electrical conductivity (EC). The derived ternary plot was the most beneficial over other available plots, as it incorporated four parameters, and it differs from the US Salinity Laboratory (USSL) plot, such that the groundwater with higher EC could also be used for irrigation purposes, depending on the Na%. The ternary plot revealed that the groundwater predominantly manifested good to moderate category during post, northeast, and southwest monsoons. The assessment with the amount of fertilizer used during the study period showed that the NPK fertilizers were effectively used for irrigation during monsoon periods. Spatial maps on EC, Kelly's ratio, Mg hazard, Na%, PI, potential salinity (PS), SAR, residual sodium carbonate (RSC), and soluble sodium percentage (SSP) were prepared for each season using fuzzy membership values, integrated for each season. A final suitability map derived by an overlay of all the seasonal outputs has identified that the groundwater in the western and the eastern part of the study area are suitable for agriculture. The study recommends cultivation of groundwater-dependent short-term crops, along the western and northern regions of the study area during the pre-monsoon season.
    Matched MeSH terms: India
  5. Irfan M, Razzaq A, Suksatan W, Sharif A, Madurai Elavarasan R, Yang C, et al.
    J Therm Biol, 2022 Feb;104:103101.
    PMID: 35180949 DOI: 10.1016/j.jtherbio.2021.103101
    The emergence of new coronavirus (SARS-CoV-2) has become a significant public health issue worldwide. Some researchers have identified a positive link between temperature and COVID-19 cases. However, no detailed research has highlighted the impact of temperature on COVID-19 spread in India. This study aims to fill this research gap by investigating the impact of temperature on COVID-19 spread in the five most affected Indian states. Quantile-on-Quantile regression (QQR) approach is employed to examine in what manner the quantiles of temperature influence the quantiles of COVID-19 cases. Empirical results confirm an asymmetric and heterogenous impact of temperature on COVID-19 spread across lower and higher quantiles of both variables. The results indicate a significant positive impact of temperature on COVID-19 spread in the three Indian states (Maharashtra, Andhra Pradesh, and Karnataka), predominantly in both low and high quantiles. Whereas, the other two states (Tamil Nadu and Uttar Pradesh) exhibit a mixed trend, as the lower quantiles in both states have a negative effect. However, this negative effect becomes weak at middle and higher quantiles. These research findings offer valuable policy recommendations.
    Matched MeSH terms: India/epidemiology
  6. Selvaraj S, Naing NN, Wan-Arfah N, Karobari MI, Marya A, Prasadh S
    Medicina (Kaunas), 2022 Jan 02;58(1).
    PMID: 35056376 DOI: 10.3390/medicina58010068
    Background and objectives: The Indian population faces numerous challenges to attain better oral hygiene due to a lack of oral health literacy. For the past 10 years, the prevalence of dental-related conditions in India has become a considerable problem in every state of India. A health-education-based oral health promotion strategy will be an ideal choice for the Indian population instead of endorsing conventional oral health promotion. The use of unsuitable tools to measure may lead to misleading and vague findings that might result in a flawed plan for cessation programs and deceitful effectiveness. Therefore, the research aimed to develop and validate an instrument that can assess the oral health knowledge, attitude and behavior (KAB) of adults in India. Materials and Methods: This study was carried among adults in India, who live in Chennai, Tamil Nadu. A questionnaire was fabricated and then validated using content, face, as well as construct. The knowledge domain was validated using item response theory analysis (IRT), whereas exploratory factor analysis (EFA) was used to validate the behavior domain and attitude. Results: Four principal sections, i.e., knowledge, attitude, demography and behavior, were used to fabricate a questionnaire following validation. Following analysis of item response theory on the knowledge domain, all analyzed items in the domain were within the ideal range of difficulty and discrimination. The Kaiser-Meyer-Olkin measure of sampling adequacy was 0.65 for the attitude and 0.66 for the behavior domain. A Bartlett's test of sphericity was conducted and demonstrated that outcomes for both domains were highly significant (p < 0.001). The factor analysis resulted in three factors with a total of eight items in the attitude domain and three factors with a total of seven items in the behavior domain depicting satisfactory factor loading (>0.3). Across the three factors, i.e., knowledge, attitude and behavior, internal consistency reliability was tested using Cronbach's alpha, and the values obtained were 0.67, 0.87, 0.67, and 0.88, respectively. Conclusions: The findings of this study that assessed validity and reliability showed that the developed questionnaire had an acceptable psychometric property for measuring oral health KAB among adults in India.
    Matched MeSH terms: India
  7. Chidambaram S, Panda B, Keesari T, Prasanna MV, Singh DK, Ramanathan AL
    Mar Pollut Bull, 2022 Jan;174:113273.
    PMID: 35090268 DOI: 10.1016/j.marpolbul.2021.113273
    The dynamics of the coastal aquifers are well-expressed by geochemical and isotopic signatures. Coastal regions often exhibit complex groundwater recharge pattern due to the influence of depression in the Bay of Bengal, tidal variations on surface waters, saline water intrusion and agricultural return flows. In this research, groundwater recharge processes occurring in coastal Tamil Nadu, South India were evaluated using major ion chemistry and environmental isotopes. A total of 170 groundwater samples were collected from shallow and deep aquifers during both post-monsoon (POM) and pre-monsoon (PRM) seasons. The isotopic results showed a wide variation in the shallow groundwater, suggesting contribution from multiple recharge sources. But, the deeper groundwater recharge is mainly from precipitation. The northern part of the study area showed more depleted isotopic values, which rapidly changed towards south from -6.8 to -4.4‰. Alternatively, central and southern parts exhibited relatively enriched isotopic content with variation from -0.58 to -2.7‰. Groundwater was discerned to be brackish to saline with chloride content, 600-2060 mgL-1 and δ18O ranging from -5.8 to -4.5‰, suggesting influence of the saline water sources. A minor influence of anthropogenic activities was also observed in the deeper groundwater during PRM, which was confirmed by tritium and Cl- trends. The old groundwater with depleted isotopic content infer recharged by distant sources while modern groundwater with enriched isotopes points to the influence of evaporated recharge.
    Matched MeSH terms: India
  8. Ramanathan K, Schliemann D, Binti Ibrahim Tamin NS, Mohan D, Donnelly M, Su TT
    PLoS One, 2022;17(12):e0279489.
    PMID: 36580458 DOI: 10.1371/journal.pone.0279489
    BACKGROUND: Colorectal cancer (CRC) incidence in Malaysia is increasing, and most CRC patients are diagnosed at a late stage. This study investigated participant awareness of CRC and their perceptions and views about CRC screening, barriers, benefits, and facilitators towards CRC screening participation as well as health-seeking behaviour and the use of preventative health services.

    METHOD: Eleven focus group discussions (FGDs) were conducted with a purposive sample of 89 participants aged > 50 from the major ethnic groups in the Segamat District, Johor State. FGDs were audiotaped, transcribed verbatim, and translated into English. Data were analysed using thematic analysis.

    RESULTS: We identified trust in doctors as a key reason for whether or not to seek health care. Generally, the participants had low awareness of CRC sign/symptoms and screening. Emotional and logistic concerns about sending a stool sample to a clinic emerged as the main barriers to screening. Simplified illustrated instructions about stool collection in Malay, Chinese and Tamil, free screening at health clinics and reminders to complete the iFOBT test were perceived to facilitate engagement in screening, and posited as strategies that were likely to increase iFOBT uptake.

    CONCLUSION: Primary care physicians play a crucial role in terms of reducing patient's misperceptions, recommending screening to patients, enhancing attendance, and improving uptake of CRC screening. There is a need for further research to investigate ways in which to reduce identified barriers and implement and test potential facilitative strategies as well as examine adherence by doctors to clinical guidelines about CRC screening.

    Matched MeSH terms: India
  9. Selvavinayagam ST, Yong YK, Joseph N, Hemashree K, Tan HY, Zhang Y, et al.
    Front Public Health, 2022;10:1018399.
    PMID: 36211690 DOI: 10.3389/fpubh.2022.1018399
    The rapid spread of SARS-CoV-2 variants in the global population is indicative of the development of selective advantages in emerging virus strains. Here, we performed a case-control investigation of the clinical and demographic characteristics, clinical history, and virological markers to predict disease progression in hospitalized adults for COVID-19 between December 2021 and January 2022 in Chennai, India. COVID-19 diagnosis was made by a commercial TaqPath COVID-19 RT-PCR, and WGS was performed with the Ion Torrent Next Generation Sequencing System. High-quality (<5% of N) complete sequences of 73 Omicron B.1.1.529 variants were randomly selected for phylogenetic analysis. SARS-CoV-2 viral load, number of comorbidities, and severe disease presentation were independently associated with a shorter time-to-death. Strikingly, this was observed among individuals infected with Omicron BA.2 but not among those with the BA.1.1.529, BA.1.1, or the Delta B.1.617.2 variants. Phylogenetic analysis revealed severe cases predominantly clustering under the BA.2 lineage. Sequence analyses showed 30 mutation sites in BA.1.1.529 and 33 in BA.1.1. The mutations unique to BA.2 were T19I, L24S, P25del, P26del, A27S, V213G, T376A, D405N and R408S. Low SARS-CoV-2 viral load among vaccinated individuals infected with Delta B.1.617.2 and the Omicron BA.1.1.529 variant but not with Omicron BA.1.1 or BA.2 suggests that the newer strains are largely immune escape variants. The number of vaccine doses received was independently associated with increased odds of developing asymptomatic disease or recovery. We propose that the novel mutations reported herein could likely bear a significant impact on the clinical characteristics, disease progression, and epidemiological aspects of COVID-19. Surging rates of mutations and the emergence of eclectic variants of SARS-CoV-2 appear to impact disease dynamics.
    Matched MeSH terms: India/epidemiology
  10. Thangaraj S, Goh VT, Yap TTV
    F1000Res, 2022;11:246.
    PMID: 38152076 DOI: 10.12688/f1000research.73182.3
    BACKGROUND: Smart grid systems require high-quality Phasor Measurement Unit (PMU) data for proper operation, control, and decision-making. Missing PMU data may lead to improper actions or even blackouts. While the conventional cubic interpolation methods based on the solution of a set of linear equations to solve for the cubic spline coefficients have been applied by many researchers for interpolation of missing data, the computational complexity increases non-linearly with increasing data size.

    METHODS: In this work, a modified recurrent equation-based cubic spline interpolation procedure for recovering missing PMU data is proposed. The recurrent equation-based method makes the computations of spline constants simpler. Using PMU data from the State Load Despatch Center (SLDC) in Madhya Pradesh, India, a comparison of the root mean square error (RMSE) values and time of calculation (ToC) is calculated for both methods.

    RESULTS: The modified recurrent relation method could retrieve missing values 10 times faster when compared to the conventional cubic interpolation method based on the solution of a set of linear equations. The RMSE values have shown the proposed method is effective even for special cases of missing values (edges, continuous missing values).

    CONCLUSIONS: The proposed method can retrieve any number of missing values at any location using observed data with a minimal number of calculations.

    Matched MeSH terms: India
  11. Rajaiah P, Kumar A
    Indian J Med Res, 2022;156(4&5):588-597.
    PMID: 36926775 DOI: 10.4103/ijmr.IJMR_2606_19
    Japanese encephalitis (JE) is a leading cause of viral encephalitis in Southeast Asia. It is a serious public health issue in India, and cases have been emerging in newer areas of the country. Although vaccination efforts have already been initiated in the country since 2006 and later through the Universal Immunization Programme in 2011, still a significant reduction in the number of cases has to be achieved since an escalating trend of JE incidence has been reported in certain States such as Assam, Uttar Pradesh and West Bengal. Moreover, fresh cases of JE have been reported from certain pockets in Odisha as well. Despite the mass JE vaccination programme implemented in prioritized endemic zones in the country in 2011, a shift in the age group of JE virus (JEV) infection was noticed affecting the adult population in West Bengal. The recent detection of the circulation of genotype I (GI) in Gorakhpur, Uttar Pradesh and the co-circulation of GI and genotype III (GIII) in West Bengal are probably a warning signal for the public health personnel to strengthen the surveillance system in all endemic hotspots in the country. The abrupt emergence of JEV genotype V (GV) in China and Korea in 2009, after its first detection in Malaya in 1952, endemic countries have been cautioned to strengthen their surveillance, because GV has been suspected of getting dispersed efficiently in other parts of Asia. Moreover, the reduced protection efficiency of the JEV GIII-based vaccine against the JEV genotype V further warrants careful evaluation of the ongoing vaccination strategies in the endemic countries, anticipating the possible incursion of GV and its impact on future control strategies. In view of the above facts, the present communication reviews the current knowledge on the molecular epidemiology of JEV in India vis-a-vis the global scenario and discusses the future priorities in JEV research in India for effectively designing control strategies.
    Matched MeSH terms: India/epidemiology
  12. Chockalingam A, Kumar S, Ferrer MS, Gajagowni S, Isaac M, Karuparthi P, et al.
    Explore (NY), 2021 12 23;18(6):714-718.
    PMID: 34987003 DOI: 10.1016/j.explore.2021.12.003
    BACKGROUND: Morbid obesity (BMI > 35 kg/m2 with comorbid conditions) is present in 25 - 35% of acute decompensated heart failure (AHF) patients. Prevalence of HF increases with duration of morbid obesity from 30% at 15 years to over 90% at 30 years. There is a need to develop pragmatic therapies that address the unique physical and mental challenges faced by obese AHF patients. Siddha is 5,000 year old Tamil Medicine using yoga and mind-body methods towards higher consciousness. Hunger gratitude Experience (HUGE) is intuitive Siddha fasting method which may improve in-hospital AHF outcomes independent of weight reduction.

    CASE SUMMARY: We present 5 cases of morbidly obese patients with cardiorenal syndrome (CRS) that began intermittent fasting either during their AHF hospitalization or in the outpatient setting for refractory symptoms despite hospitalization. Initiation of fasting correlated with reduction of respiratory distress and edema as well as improvements in psychological wellbeing and functional capacity.

    DISCUSSION: Siddha fasting mediates hemodynamic and anti-inflammatory effects through natural ketosis and psychological benefits through empowerment in AHF. Potential role of fasting in reducing myocardial workload, coronary steal, angina, volume overload, and CRS needs further study in cardiac patients.

    Matched MeSH terms: India
  13. Wang L, Li Y, Liang S, Xu M, Qu S
    Sci Total Environ, 2021 Dec 20;801:149781.
    PMID: 34467898 DOI: 10.1016/j.scitotenv.2021.149781
    Increasing trade cooperation under the Belt and Road (B&R) Initiative has promoted economic development and intensified the water scarcity risk transmission between China and countries along the route (B&R countries). Local water scarcity risk (LWSR, the potential direct production losses induced by local water scarcity) can transcend geographical boundaries through global supply chains and influence production activities in downstream economies. To understand the vulnerability of the Initiative to water scarcity, we investigated the impacts of LWSR in China and B&R countries on each other's economies during 2001-2013, using a global environmentally extended multi-regional input-output model. Results reveal that more than 80% of China's trade-related water scarcity risk imports (TWSR imports, the vulnerability to foreign water scarcity risk through imports) originates from B&R countries. The share of TWSR from China in total imports of B&R countries has steadily increased. In particular, India, Thailand, Iran, Pakistan and Kazakhstan have the largest TWSR exports (LWSR in each nation transmitted to other nations through its exports) to China, while South Korea, Thailand, Malaysia, Singapore and Indonesia have the largest imports from China. Water scarcity to their Agriculture sectors is responsible for TWSR transmission between them. Our study can contribute to the policy-making of governments and firms involved in mitigating the supply chain wide water scarcity risk. It also reveals the need for nations to collectively manage water resources to achieve sustainable development.
    Matched MeSH terms: India
  14. Dhunputh P, Acharya R, Umakanth S, Shetty SM, Mohammed AP, Saraswat PP
    Kathmandu Univ Med J (KUMJ), 2021 11 26;19(74):248-252.
    PMID: 34819445
    Background Thrombocytopenia is a common haematological abnormality noted in clinical practice, however, it can be missed in cases where specific investigations are not asked for. Acute Febrile Illness with thrombocytopenia is a diagnostic and therapeutic challenge, as thrombocytopenia has an inverse relation to mortality and morbidity in various febrile illnesses. Vector-borne and zoonotic diseases (like malaria, dengue, scrub typhus, and leptospirosis), infections and sepsis are some of the common causes of fever with thrombocytopenia. Objective To identify the causes of fever with thrombocytopenia, assess the clinical complications associated with febrile thrombocytopenia, and overall study the clinical profile of thrombocytopenia in a tertiary care hospital Method Medical records of all adult patients, admitted to a tertiary level hospital, with fever and thrombocytopenia (platelet count < 1,00,000 /mm3 ) were assessed (from October 2009 to March 2011). Detailed case history, general physical examination findings, routine and specific examinations were recorded according to a pre-decided format. Data were analysed using SPSS 16.0 Result Acute febrile illness with thrombocytopenia was most commonly seen in Dengue patients. Headache and arthralgia were more commonly encountered in scrub typhus. Platelet transfusions were necessitated in a large number of patients, especially in scrub typhus. Malaria patients had the highest mortality rate. Conclusion Acute Febrile Illnesses (AFI) are of varied origins, and proper diagnosis is imperative. The degree of thrombocytopenia in infections has a prognostic value. It can also help in differential diagnosis and clear identification of aetiology of acute febrile illnesses. Timely identification and management of thrombocytopenia in acute febrile illness can positively impact the overall patient outcome.
    Matched MeSH terms: India
  15. Kamble CB, Raju R, Vishnu R, Rajkanth R, Pariatamby A
    Waste Manag Res, 2021 Nov;39(11):1427-1436.
    PMID: 34494917 DOI: 10.1177/0734242X211029159
    Management of waste is one of the major challenges faced by many developing countries. This study therefore attempts to develop a circular economy (CE) model to manage wastes and closing the loop and reducing the generation of residual wastes in Indian municipalities. Through extant literature review, the researchers found 30 success factors of CE implementation. Using the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) SIMOS approach, the rating and weight of decision makers (DMs) for each factor were collected. A structured questionnaire has been developed incorporating all these 30 factors, to extract the most important factors. The data was collected from top 10 officials (DMs) from the Chennai municipality, who handle three regions (metropolitan, suburbia and industrial). Based on the TOPSIS SIMOS analysis, nine CE implementing factors (critical success factors (CSFs)) among the 30 variables that were significant based on the cut-off value was identified. A CE model has been proposed based on these nine CSFs for waste management in India.
    Matched MeSH terms: India
  16. Gupta G, S R, Singh Y, Thangavelu L, Singh SK, Dureja H, et al.
    Drug Dev Res, 2021 11;82(7):880-882.
    PMID: 34323298 DOI: 10.1002/ddr.21862
    COVID-19's second wave had a significant impact on India, on May 7, 2021, the largest daily recorded case count was a little more than 4 million, and it has since fallen. Although the number of new cases reported has dropped, during the third week of May 2021, India accounted for about 45% of new cases identified globally and around 34% of deaths. As India maintains its present level of stability, a new urgent threat has emerged in the form of coronavirus-associated mucormycosis. Mucormycosis, an acute and deadly fungal infection caused by Mucorales-related fungal species, is a fungal emergency with a particularly aggressive propensity for contiguous spread, associated with a poor prognosis if not properly and immediately identified, and treated. Mucormycosis, sometimes referred to as the "black fungus," has increased more rapidly in India during the second wave of COVID-19 than during the first wave, with at least 14,872 cases as of May 28, 2021. Uncontrolled diabetic mellitus (DM) and other immunosuppressive diseases such as neutropenia and corticosteroid treatment have traditionally been identified as risk factors for mucormycosis. Therefore, the use of glucocorticoids or high doses of glucocorticoids in mild COVID-19 cases (without hypoxemia) should be avoided. In addition, drugs that target the immune pathway, such as tocilizumab, are not recommended without clear benefits.
    Matched MeSH terms: India
  17. Alsubih M, El Morabet R, Khan RA, Khan NA, Ul Haq Khan M, Ahmed S, et al.
    Environ Sci Pollut Res Int, 2021 Nov;28(44):63017-63031.
    PMID: 34218378 DOI: 10.1007/s11356-021-15062-3
    Groundwater is a primary natural water source in the absence of surface water bodies. Groundwater in urban environments experiences unprecedented stress from urban growth, population increase, and industrial activities. This study assessed groundwater quality in terms of arsenic and heavy metal contamination in three industrial areas (Shahdara, Jhilmil, and Patparganj), Delhi, India. The water quality was assessed over a 3-year time interval (i.e., 2015 and 2018). The groundwater constituents investigated were As, Fe, Cr, Cd, Ni, Zn, Mn, Cu, and Pb. Metal index and heavy metal pollution indexes were estimated to assess groundwater pollution. The health risk was evaluated in terms of non-carcinogenic and carcinogenic risk assessment. Patparganj industrial area saw increment in concentration for Cu 0.23 mg/L (2015)-0.85 mg/L (2018), Zn 0.51 mg/L (2015)-7.2 mg/L (2018), Fe 0.32 mg/L (2015)-0.9 mg/L (2018), Cr 0.21 mg/L (2015)-0.26 mg/L (2018), Mn 0.14 mg/L (2015)-0.25 mg/L (2018), Ni 0.04 mg/L (2015)-0.34 mg/L (2018), and As 0.01 mg/L (2015)-0.18 mg/L (2018). Cd and Pb concentrations were observed to decrease by 40-90 % and 85-99% for all the three industrial areas. Metal index and heavy metal index values were found to be >1 for all locations. The risk quotient value > 1 was observed for all locations in the year 2015 but was found to increase further to a range of RQ 10-62 in the year 2018, inferring increased non-carcinogenic risk to consumers. The carcinogenic risk was significant with respect to Fe (0.2-0.7), Zn (0.001-0.007), and As (0.002-0.003) for all locations in the year 2015. This study concludes that groundwater in the three industrial areas is highly polluted and is not fit for human consumption. Further studies are required to explore possible control measures and develop methods to mitigate groundwater pollution, sustainable management, and optimized use to conserve it for future generations.
    Matched MeSH terms: India
  18. Aranjani JM, Manuel A, Abdul Razack HI, Mathew ST
    PLoS Negl Trop Dis, 2021 Nov;15(11):e0009921.
    PMID: 34793455 DOI: 10.1371/journal.pntd.0009921
    Coronavirus Disease 2019 (COVID-19), during the second wave in early 2021, has caused devastating chaos in India. As daily infection rates rise alarmingly, the number of severe cases has increased dramatically. The country has encountered health infrastructure inadequacy and excessive demand for hospital beds, drugs, vaccines, and oxygen. Adding more burden to such a challenging situation, mucormycosis, an invasive fungal infection, has seen a sudden surge in patients with COVID-19. The rhino-orbital-cerebral form is the most common type observed. In particular, approximately three-fourths of them had diabetes as predisposing comorbidity and received corticosteroids to treat COVID-19. Possible mechanisms may involve immune and inflammatory processes. Diabetes, when coupled with COVID-19-induced systemic immune change, tends to cause decreased immunity and an increased risk of secondary infections. Since comprehensive data on this fatal opportunistic infection are evolving against the backdrop of a major pandemic, prevention strategies primarily involve managing comorbid conditions in high-risk groups. The recommended treatment strategies primarily included surgical debridement and antifungal therapy using Amphotericin B and selected azoles. Several India-centric clinical guidelines have emerged to rightly diagnose the infection, characterise the clinical presentation, understand the pathogenesis involved, and track the disease course. Code Mucor is the most comprehensive one, which proposes a simple but reliable staging system for the rhino-orbital-cerebral form. A staging system has recently been proposed, and a dedicated registry has been started. In this critical review, we extensively analyse recent evidence and guidance on COVID-19-associated mucormycosis in India.
    Matched MeSH terms: India/epidemiology
  19. Joshi D, Sharma I, Gupta S, Singh TG, Dhiman S, Prashar A, et al.
    Environ Sci Pollut Res Int, 2021 Nov;28(42):59608-59629.
    PMID: 34515931 DOI: 10.1007/s11356-021-16345-5
    Medical devices, being life-saving tools, are considered to be a boon for healthcare system. However, in addition to their therapeutic effects, there are several ill consequences that are caused by these devices. An effective cohort vigilant system was needed to manage such adverse effects. This had led to the introduction of materiovigilance. Materiovigilance is the study and follow-up of occurrences that arise as a result from the usage of the medical equipment. It not only manages adverse events (AE) but also creates harmonization among countries. Keeping these objectives in focus, the principles, perspectives, and practices with regard to materiovigilance that are followed in the USA, Europe, China, Japan, Australia, Canada, and India are being compared. Such a comparison is essential, which will help us to understand the gaps in the current regulatory systems in the above-mentioned countries and furthermore will provide a comprehensive picture to the regulatory authorities to amend any existing laws if required. These amendments may ensure optimal patient safety by providing them a benign experience from the use of medical devices.
    Matched MeSH terms: India
  20. Dash B, Rout SS, Lovaraju A, Charan Kumar B, Bharati A, Ganesh T, et al.
    Mar Pollut Bull, 2021 Oct;171:112775.
    PMID: 34375747 DOI: 10.1016/j.marpolbul.2021.112775
    The present study examines historical perspectives of the macrobenthic community in response to different phases of anthropogenic perturbations in Kakinada Bay, a tropical embayment on the east coast of India. Multivariate analysis of the snapshot data (1958-2017) revealed considerable changes in the Bay environment following a breakwater construction across the Bay mouth in 1997. Subsequently, port expansion activities, industrialization, urbanization, and geomorphic alterations in the Godavari delta brought deterrent changes in the Bay. The fluctuations over the years in hydrographical and sediment characteristics increased environmental heterogeneity and caused significant spatio-temporal shifts in the macrobenthic community between 1995-1996 and 2016-2017. The observed variabilities were suggestive of anthropogenic perturbations of the system with future repercussions on Bay ecosystem functioning. Overall, this study provides evidence on the long-term impact of anthropogenic activities on coastal marine communities and stresses the importance of macrobenthos as bioindicators of such changes in tropical systems.
    Matched MeSH terms: India
Filters
Contact Us

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links