MyMedR

Fulltext Conchological and molecular analysis of the "non-scaly" Bornean Georissa with descriptions of three new species (Gastropoda, Neritimorpha, Hydrocenidae)

Zacaery Khalik M, P Hendriks K, J Vermeulen J, Menno Schilthuizen

Zookeys, 2019;840:35-86.

PMID: 31065227 DOI: 10.3897/zookeys.840.33326

The Bornean representatives of the genus Georissa (Hydrocenidae) have small, dextral, conical, calcareous shells consisting of ca. three teleoconch whorls. Our recent study on the Georissa of Malaysian Borneo has revealed high intra- and inter-specific variation in the "scaly" group (a group of species with striking scale-like surface sculpture). The present study on the "non-scaly" Georissa is the continuation of the species revision for the genus. The "non-scaly" species are also diverse in shell sculptures. This informal group comprises Georissa with subtle spiral and/or radial sculpture. The combination of detailed conchological assessment and molecular analyses provides clear distinctions for each of the species. Conchological, molecular, and biogeographic details are presented for 16 species of "non-scaly" Georissa. Three of these are new to science, namely Georissacorrugatasp. n., Georissainsulaesp. n., and Georissatrusmadisp. n.

Matched MeSH terms: Skin

The Importance of Some Plant Extracts as Skin Anti-aging Resources: A Review

Yasin ZAM, Ibrahim F, Rashid NN, Razif MFM, Yusof R

Curr Pharm Biotechnol, 2017;18(11):864-876.

PMID: 29256348 DOI: 10.2174/1389201019666171219105920

BACKGROUND: Skin is the largest and most visible organ of the body. Many of its functions include temperature regulation, immunity from microorganisms, maintaining electrolyte balance, and protection from physical injuries, chemical agents and ultraviolet (UV) radiation. Aging occurs in every layer of the skin, primarily due to the degradation of its components. Induction of degradative enzymes and the abundant production of reactive oxygen species lead to skin aging. Understanding the complexity of skin structure and factors contributing to the skin aging will help us impede the aging process. Applications of anti-aging products are a common method to prevent or repair damages that lead to aging.

CONCLUSION: This review will provide information on the causes and indicators of skin aging as well as examine studies that have used plants to produce anti-aging products.

Matched MeSH terms: Skin Physiological Phenomena/drug effects; Skin Aging/drug effects*

Fulltext Ultrasonographic Evaluation of Skin Toxicity Following Radiotherapy of Breast Cancer: A Systematic Review

Hussein FA, Manan HA, Mustapha AWMM, Sidek K, Yahya N

Int J Environ Res Public Health, 2022 Oct 18;19(20).

PMID: 36294025 DOI: 10.3390/ijerph192013439

The present review aimed to systematically review skin toxicity changes following breast cancer radiotherapy (RT) using ultrasound (US). PubMed and Scopus databases were searched according to PRISMA guidelines. The characteristics of the selected studies, measured parameters, US skin findings, and their association with clinical assessments were extracted. Seventeen studies were included with a median sample size of 29 (range 11-166). There were significant US skin changes in the irradiated skin compared to the nonirradiated skin or baseline measurements. The most observed change is skin thickening secondary to radiation-induced oedema, except one study found skin thinning after pure postmastectomy RT. However, eight studies reported skin thickening predated RT attributed to axillary surgery. Four studies used US radiofrequency (RF) signals and found a decrease in the hypodermis's Pearson correlation coefficient (PCC). Three studies reported decreased dermal echogenicity and poor visibility of the dermis-subcutaneous fat boundary (statistically analysed by one report). The present review revealed significant ultrasonographic skin toxicity changes in the irradiated skin most commonly skin thickening. However, further studies with large cohorts, appropriate US protocol, and baseline evaluation are needed. Measuring other US skin parameters and statistically evaluating the degree of the association with clinical assessments are also encouraged.

Matched MeSH terms: Skin

Fulltext Tzanck cytology smear in diagnosis of cutaneous talaromycosis (penicilliosis)

Lai SK, Rauf NA, Preet KR, Tan LJ

Indian J Dermatol Venereol Leprol, 2023;89(2):233-236.

PMID: 33666044 DOI: 10.25259/IJDVL_268_20

Talaromyces marneffei infection is an AIDS-defining illness in South and Southeast Asia. Travel-related talaromycosis is being increasingly recognized in non-endemic areas too. It is a potentially fatal infection with rapid deterioration, if left untreated. Usage of Tzanck cytology smear for rapid diagnosis of T. marneffei is rarely described. In this case study, we report a man who presented with altered behaviour, headache, fever and cutaneous lesions. Tzanck smear test, skin biopsy and blood culture showed presence of T. marneffei. The cytomorphology findings of T. marneffei in Tzanck cytology smear were described. In conclusion, Tzanck smear is a simple and inexpensive test in establishing a rapid clinical diagnosis of talaromycosis before the culture is reported.

Matched MeSH terms: Skin

Comparison of UVA vs UVB Photoaging Rat Models in Short-term Exposure

Mayangsari E, Mustika A, Nurdiana N, Samad NA

Med Arch, 2024;78(2):88-91.

PMID: 38566862 DOI: 10.5455/medarh.2024.78.88-91

BACKGROUND: Prolonged exposure to sunlight is known to induce photoaging of the skin, leading to various skin changes and disorders, such as dryness, wrinkles, irregular pigmentation, and even cancer. Ultraviolet A (UVA) and ultraviolet B (UVB) radiation are particularly responsible for causing photoaging.

OBJECTIVE: This study aims to identify and compare photoaging rat models exposed to UVA and UVB.

METHODS: This research method compared macroscopic (scoring degree of wrinkling) and microscopic (histology) signs and symptoms on skin samples of rat exposed to UVA and UVB for 4 weeks at a radiation dose of 840mJ/cm2.

RESULTS: The results of this study indicated that the degree of wrinkling was highest in rat skin exposed to UVB rays by 51% (p<0.05). UVB histological results showed that the epidermis layer (40 µm, p<0.05) was thickened and the dermis layer (283 µm, p<0.05) was thinned in the skin of mice exposed to UVB light. The UVB group, showed the density of collagen in the dermis with a mean value of 55% (p<0.05).

CONCLUSION: Our results suggest that short-term exposure to UVB radiation (in the acute, subacute or subchronic phase) induces more rapid and pronounced damage to rat skin when compared to UVA radiation exposure.

Matched MeSH terms: Skin/pathology; Skin Aging*

Fulltext The impact of a pressure ulcer prevention educational program based on the health belief model for persons with spinal cord injury

Hashim NM, Engkasan JP, Hasnan N

J Spinal Cord Med, 2022 Nov;45(6):898-906.

PMID: 33465010 DOI: 10.1080/10790268.2020.1860868

STUDY DESIGN: Pre- and post- trial.

OBJECTIVES: To determine the changes of health belief levels after a pressure ulcer (PrU) prevention educational program based on the Health Belief Model (HBM).

SETTING: Department of Rehabilitation Medicine, University Medical Centre, Malaysia.

METHODS: This study was conducted between May 2016 and May 2018. We created a multidisciplinary structured PrU prevention education program based on the HBM, consisting of didactic lectures, open discussions and a practical session. The content of the program was based on several PrU prevention guidelines. The education program focused on a group of 6-10 participants, and was conducted by a multidisciplinary team; i.e. doctor, physiotherapist, occupational therapist and a nurse. The skin care belief scales (SCBS) questionnaire was administered pre, post and 8-week post intervention, which measured the 9 domains of HBM. The data from the study was analyzed using repeated measures ANOVA to assess the effectiveness of the program.

RESULTS: Thirty spinal cord injured participants who fulfilled the inclusion and exclusion criteria completed this study. The results of the education program show statistically significant effects on Susceptibility; F (2,58) = 12.53, P < 0.05, Barriers to Skin Check Belief; F(2,58) = 5.74, P > 0.05, Benefits to Wheelchair Pressure Relief Belief; F(1.65,47.8) = 3.97, P < 0.05, Barriers to Turning and Positioning Belief; F(2,58) = 3.92, P

Matched MeSH terms: Skin Care

Diversity in the clinical presentation of generalized pustular psoriasis (GPP): A series of case vignettes from around the world

Choon SE, Elewski BE, Fujita H, Geng S, van de Kerkhof P, Mburu S, et al.

Exp Dermatol, 2023 Aug;32(8):1284-1295.

PMID: 36999936 DOI: 10.1111/exd.14794

A key principle of clinical studies and case reports is that they should reflect the demographics and epidemiology of the patient population concerned. Here, we have compiled a diverse group of clinical cases of generalized pustular psoriasis (GPP) to showcase the differences in GPP presentation in patients worldwide. We attempt to capture the broad spectrum of clinical presentations of GPP and showcase the diversity of the patient population. The patients included in this series are diverse in age, genetic background, skin phototype and medical history. Moreover, they present with a variety of clinical courses of GPP and different degrees of systemic involvement, and experience flares triggered by different inciting factors. The key learnings from this case series may support physicians in identifying and managing patients with this rare and multifaceted disease that can affect patients both physically and psychologically.

Matched MeSH terms: Skin

Fulltext Identifying the Core Content of a Dermatology Module for Malaysian Medical Undergraduate Curriculum Using a Modified Delphi Method

Jamil A, Muthupalaniappen L, Md Nor N, Siraj HH, Salam A

Malays J Med Sci, 2016 May;23(3):78-85.

PMID: 27418873 MyJurnal

Dermatology is a minor module in internal medicine undergraduate curriculum. Limited time is allocated for its teaching. Most graduates are inadequately prepared to diagnose and manage skin diseases. We aimed to identify the core content of a more effective dermatology module.

Matched MeSH terms: Skin Diseases

Fulltext Preliminary study on the skin lightening practice and health symptoms among female students in Malaysia

Rusmadi SZ, Syed Ismail SN, Praveena SM

J Environ Public Health, 2015;2015:591790.

PMID: 26693230 DOI: 10.1155/2015/591790

Many cases of dermatologic complication were reported with the use of skin lightening products. This study assessed the skin lightening practice and health symptoms among female students. Self-administered questionnaire was distributed to 104 female students (56 undergraduates and 48 postgraduates) aged 24 ± 2 years in Universiti Putra Malaysia. A total of 60.6% (N = 63) of the female students used skin lightening products (61.9% of undergraduates and 38.1% of postgraduates). Reasonable price (N = 35, 55.6%) and ingredients (N = 29, 46%) were considered the most important factors in the product selection. Most respondents purchased the product from drugstores (N = 39, 61.9%). Twenty-two respondents (34.9%) in this study experienced skin problem from the products they used. Skin peeling (N = 13, 12.5%) and acne (N = 9, 8.7%) were the most frequent symptoms experienced. Most of the respondents have the perception that lighter skin provides high self-esteem (N = 56, 53.8%) and looks beautiful and healthier (N = 54, 51.9%). The use of skin lightening products is common among female students in this study and some of these products can cause skin problems such as skin peeling, acne, and itching.

Matched MeSH terms: Skin Care*

Fulltext An unusual localised reaction associated with vancomycin therapy

Tan CK, Huang YQ, Yap KB

Med J Malaysia, 2013 Oct;68(5):443-4.

PMID: 24632878

Vancomycin has been documented to cause various adverse cutaneous reactions. We present a case report of a man, who developed a large localized erythematous plaque in his forearm following parenteral vancomycin therapy. We believe this to be the first reported case of such cutaneous reaction associated with parenteral vancomycin therapy.

Matched MeSH terms: Skin; Skin Abnormalities

Fulltext Marjolin's ulcer--a near forgotten entity

Tan BC, Horton TC, Sara Ahmad T

Med J Malaysia, 2006 Feb;61 Suppl A:91-3.

PMID: 17042239

We report a case of a 55-year-old man who presented with a 6-month history of a fungating ulcer on the right hand at the site of a previously healed ulcer that had been present for 40 years. Histopathological examination of four-quadrant biopsy specimens showed a moderately differentiated squamous cell carcinoma (SCC). A transradiocarpal amputation with stump closure using radial flap was performed as it was not possible to achieve a functionally and cosmetically acceptable hand after a wide excision with 2 cm tumour-free margin. It is our intention to highlight this rare condition as reminder to consider this entity as a differential diagnosis of chronic non-healing skin ulcer.

Matched MeSH terms: Skin Neoplasms/diagnosis*; Skin Neoplasms/etiology; Skin Neoplasms/surgery; Skin Ulcer/diagnosis*; Skin Ulcer/etiology; Skin Ulcer/surgery

Fulltext Low-grade liquid silicone injections as a penile enhancement procedure: Is bigger better?

Sasidaran R, Zain MA, Basiron NH

Urol Ann, 2012 Sep;4(3):181-6.

PMID: 23248528 DOI: 10.4103/0974-7796.102672

To report our experience with 5 cases of complications of penile enhancement procedures secondary to liquid silicone injections and our method of management of its debilitating effects. All five patients were treated with excision of penile shaft skin down to buck's fascia followed by resurfacing with split thickness skin grafting. We conclude that penile enhancement procedures with liquid silicone by non-medical personnel could result in devastating consequences. We also demonstrate that a simple method of excision of the entire penile shaft skin and resurfacing with split skin grafting showed improvement in cosmetic as well as functional outcome.

Matched MeSH terms: Skin; Skin Transplantation

Does Order of Application of Emollient and Topical Corticosteroids Make a Difference in the Severity of Atopic Eczema in Children?

Ng SY, Begum S, Chong SY

Pediatr Dermatol, 2016 Mar;33(2):160-4.

PMID: 26856694 DOI: 10.1111/pde.12758

Atopic eczema (AE) is a common chronic inflammatory skin disorder in children, with emollients and topical corticosteroids (TCSs) commonly prescribed as treatment. There is no published guidance on the correct order of application of emollient and TCS in children with AE.

Matched MeSH terms: Skin; Skin Diseases

Obtaining a reliable travel history from III returned travellers

Gately R, Economos H, Fleming C, Flaherty G

Travel Med Infect Dis, 2015 Jul-Aug;13(4):342-3.

PMID: 26005161 DOI: 10.1016/j.tmaid.2015.05.003

Matched MeSH terms: Skin Diseases, Infectious/diagnosis*

Dermatology in Penang, Malaysia

Nagreh DS

Australas J Dermatol, 1976 Dec;17(3):121-5.

PMID: 1023874

Matched MeSH terms: Skin Diseases/epidemiology*

Fulltext Reconstruction options following wide excision of basal cell carcinoma of the face

Khoo, Hau Chun, Enda Gerard, Kelly, Mohd Ali Mat Zain, Farrah-Hani Imran

Journal of Surgical Academia, 2015;5(2):70-74.

MyJurnal

Basal cell carcinoma is the commonest skin malignancy diagnosed in Malaysia. Surgery is the recommended treatment of choice with the lowest failure rate provided a clear margin is obtained. However, the defect may be too large to be repaired primarily. Formal reconstruction using grafts and flaps should be done to achieve the optimal aim of maintaining the integrity, function and cosmetic patient outcome. Three reconstructive methods are described in this series to restore the facial defect following the wide local excision. The procedures described were peri-alar crescentic advancement flap, nasolabial rotational flap and full thickness skin graft using supraclavicular skin. This series highlights the usage of the procedures based on solid foundation and principles, without compromising the desired outcomes for the patient.

Matched MeSH terms: Skin Neoplasms; Skin Transplantation

Fulltext Multiple Scattered and Small Lesions of Lower Limbs: Idiopathic Calcinosis Cutis: A Case Report

Ferdaus-Kamudin NA, Mohamed-Haflah NH

Malays Orthop J, 2018 Mar;12(1):66-68.

PMID: 29725520 MyJurnal DOI: 10.5704/MOJ.1803.008

Calcinosis cutis is a rare presentation and not many cases have been reported especially of idiopathic type. We are reporting a case of idiopathic calcinosis cutis of lower limbs in a 33-year old female who presented to our clinic for multiple painless swellings over her lower limbs for the past six months, without any history of trauma or infection. We have decided to observe her condition on regular follow-up and conservative management.

Matched MeSH terms: Skin; Skin Diseases

Incarcerated strangulated anal fibroepithelial polyp: a rare case of anorectal emergency

Nor AM, Mohamad AM, Elagili F, Hamdan A

ANZ J Surg, 2021 12;91(12):2855-2856.

PMID: 34913562 DOI: 10.1111/ans.17303

Matched MeSH terms: Skin Neoplasms*

Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing

Khan MUA, Aslam MA, Yasin T, Abdullah MFB, Stojanović GM, Siddiqui HM, et al.

Biomed Mater, 2024 Jul 16;19(5).

PMID: 38976990 DOI: 10.1088/1748-605X/ad6070

Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular and molecular levels. Quick wound healing and the problems associated with traditional wound repair techniques are being overcome with multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, are now considered a promising class of well-suited porous materials for wound healing in addition to their other biological applications. This detailed literature review provides an overview of the latest developments in MOFs for wound healing applications. We have discussed the synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, and their wound-healing applications. The possible major challenges and limitations of MOFs have been discussed, along with conclusions and future perspectives. This overview of the literature review addresses MOFs-based wound healing from several angles and covers the most current developments in the subject. The readers may discover how the MOFs advanced this discipline by producing more inventive, useful, and successful dressings. It influences the development of future generations of biomaterials for the healing and regeneration of skin wounds.

Matched MeSH terms: Skin*

Quality management overview for the production of a tissue-engineered human skin substitute in Malaysia

Seet WT, Mat Afandi MA, Ishak MF, Hassan MNF, Ahmat N, Ng MH, et al.

Stem Cell Res Ther, 2023 Oct 20;14(1):298.

PMID: 37858277 DOI: 10.1186/s13287-023-03536-9

Treatments for skin injuries have recently advanced tremendously. Such treatments include allogeneic and xenogeneic transplants and skin substitutes such as tissue-engineered skin, cultured cells, and stem cells. The aim of this paper is to discuss the general overview of the quality assurance and quality control implemented in the manufacturing of cell and tissue product, with emphasis on our experience in the manufacturing of MyDerm®, an autologous bilayered human skin substitute. Manufacturing MyDerm® requires multiple high-risk open manipulation steps, such as tissue processing, cell culture expansion, and skin construct formation. To ensure the safety and efficacy of this product, the good manufacturing practice (GMP) facility should establish a well-designed quality assurance and quality control (QA/QC) programme. Standard operating procedures (SOP) should be implemented to ensure that the manufacturing process is consistent and performed in a controlled manner. All starting materials, including tissue samples, culture media, reagents, and consumables must be verified and tested to confirm their safety, potency, and sterility. The final products should also undergo a QC testing series to guarantee product safety, efficacy, and overall quality. The aseptic techniques of cleanroom operators and the environmental conditions of the facility are also important, as they directly influence the manufacturing of good-quality products. Hence, personnel training and environmental monitoring are necessary to maintain GMP compliance. Furthermore, risk management implementation is another important aspect of QA/QC, as it is used to identify and determine the risk level and to perform risk assessments when necessary. Moreover, procedures for non-conformance reporting should be established to identify, investigate, and correct deviations that occur during manufacturing. This paper provides insight and an overview of the QA/QC aspect during MyDerm® manufacturing in a GMP-compliant facility in the Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia.

Matched MeSH terms: Skin, Artificial*

Displaying publications 41 - 60 of 963 in total