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  1. Fulltext Influence of an intervention program promoting voluntary fasting practices and its perceived barriers among overweight or obese Muslim women working in the public sector, Malaysia
    Suriani Ismail, Rosliza Abdul Manaf, Aidalina Mahmud, Khadijah Shamsuddin
    Malaysian Journal of Medicine and Health Sciences, 2018;14(2):1-2.
    MyJurnal
    Introduction: This article aims to describe the effect of an intervention to promote the practice of voluntary Islamic fasting and its barriers among a group of overweight and obese Muslim women working in the public sector in Malaysia. Materials and methods: In this quasi-experimental study, an intervention to encourage voluntary fasting was delivered in a half day seminar, supported by relevant booklets prepared. A self-administered questionnaire was used to capture data on voluntary fasting practices and its perceived barriers before and four months after the intervention. Data was analysed using Mc Nemar test to compare the proportion before and after the intervention. Significant level was set at p
    Matched MeSH terms: Malaysia
  2. Fulltext Plasmodium knowlesi malaria: current research perspectives
    Amir A, Cheong FW, de Silva JR, Liew JWK, Lau YL
    Infect Drug Resist, 2018;11:1145-1155.
    PMID: 30127631 DOI: 10.2147/IDR.S148664
    Originally known to cause simian malaria, Plasmodium knowlesi is now known as the fifth human malaria species. Since the publishing of a report that largely focused on human knowlesi cases in Sarawak in 2004, many more human cases have been reported in nearly all of the countries in Southeast Asia and in travelers returning from these countries. The zoonotic nature of this infection hinders malaria elimination efforts. In order to grasp the current perspective of knowlesi malaria, this literature review explores the different aspects of the disease including risk factors, diagnosis, treatment, and molecular and functional studies. Current studies do not provide sufficient data for an effective control program. Therefore, future direction for knowlesi research is highlighted here with a final aim of controlling, if not eliminating, the parasite.
    Matched MeSH terms: Malaysia
  3. Fulltext Anti-cyclic citrullinated peptide antibody and periodontal status in rheumatoid arthritis patients
    Mohamad WMW, Jia SK, Ghazali WSW, Taib H
    Pak J Med Sci, 2018 9 8;34(4):907-912.
    PMID: 30190751 DOI: 10.12669/pjms.344.15007
    Objectives: Studies have shown that periodontal disease and Rheumatoid Arthritis (RA) shared similar pathogenesis. Anti-Cyclic Citrullinated Peptide anibodies (anti-CCP) has recently been used for diagnosis of RA. Thus, this study aimed to assess the levels of anti-CCP antibodies and periodontal status in RA patients.
    Methods: Forty four RA patients were included in this study. The blood samples were analysed for anti-CCP levels. Plaque Score (PS), Gingivitis Score (GS), Probing Pocket Depth (PPD) and Clinical Attachment Loss (CAL) were recorded for assessment of periodontal status. Relevant clinical information was obtained from medical records.
    Results: Mean anti-CCP level was 180.8 ± 290.3 Unit/ml. The results showed that 27.3% patients had poor oral hygiene (PS >60%; mean anti-CCP 84.22 ± 167.51 Unit/ml), 52.3% had generalized gingivitis (mean anti-CCP 145.07 ± 269.17 Unit/ml), and 20.5% had mean CAL of >3mm (mean anti-CCP 56.81 ± 119.02 Unit/ml). None of patients presented with deep PPD > 4mm. The levels of anti-CCP showed no significant association with periodontal status (p=0.27).
    Conclusion: Most RA patients were positive for anti-CCP antibodies and presented with generalized gingivitis. Oral hygiene education should be reinforced in RA patients to prevent further progression of periodontal disease. Nevertheless, studies with larger sample size should be carried out to obtain more conclusive findings.
    Study site: Rheumatology Clinic and Dental Clinic of Hospital Universiti Sains Malaysia (USM), Kubang Kerian, Kelantan, Malaysia
    Matched MeSH terms: Malaysia
  4. Fulltext Burden of disease attributable to overweight and obesity in Malaysia
    Foo, Lee Peng, Hanny Zurina Hamzah, Norashidah Mohamed Nor, Rusmawati Said
    Malaysian Journal of Public Health Medicine, 2018;18(1):0-0.
    MyJurnal
    The overweight and obese population may affect the population health which can lead to economic stability and development of the countries to be compromised. Thus, this study estimates the burden of disease attributable to overweight and obesity in Malaysia for adults aged 20-59 years old. Population attribution fraction (PAF) and disability-adjusted life year (DALY) have been used to quantify years of life lost from premature death and number of years lost due to disability resulting from obesity and overweight. The burden of disease attributable to overweight was 1582 and 1146 PYs per 1000 persons for male and female, respectively. Meanwhile, the burden of disease attributable to obesity was 2951 PYs per 1000 persons with women in the lead at 1657 PYs per 1000 persons. The burden of overweight and obesity among Malaysian adults is substantial. The outcome of this study is crucial as it gives a comprehensive information on the burden of overweight and obesity in Malaysia. The information from this study also enables the authorities to develop activities and programs to combat obesity and tomaintain healthy lifestyle among Malaysian.
    Matched MeSH terms: Malaysia
  5. Fulltext The Malaysia haze and its health economy impact: a literature review
    Norfazillah Ab Manan, Mohd Rizal Abdul Manaf, Rozita Hod
    Malaysian Journal of Public Health Medicine, 2018;18(1):0-0.
    MyJurnal
    Introduction: The transboundary smoke haze has become a major concern as it had a wide ranging impact in Southeast Asia from the aspect of public health to national economics. This review aims to synthesize available literature in epidemiology, economics and haze related studies to provide essential information for the valuation of health costs associated with haze in Malaysia. Methods: Evidence on health economic impact of haze was gathered by conducting a literature review and collecting information on the health effects of haze and the cost of it as well as the hospitalization cost from medical illnesses and hospital admissions due to haze. Articles were taken from those that were published from 1999 to 2016.Results: The 1997 Asian Haze episode has caused increasing trend of prematurity of mortality and respiratory problems and several series of haze later had caused increased number of hospitalization. The cost impact on hospital admission ranges from MYR1.8 million in 2005 to MYR118.9 million in 2013. During the 1997 haze, the incremental cost of illness (COI) was noted to be MYR 21million and it shot up to MYR 410 million during the 2013 haze. Conclusion: The haze gives a serious health effect to our country and our neighbours. These health effect has caused a significant health economy impact which include rise in hospital admission cost and medication, incremental cost of illness and extend to cost of medical-related leaves taken and lead to loss of income opportunities.
    Matched MeSH terms: Malaysia
  6. Climate change in Malaysia: Trends, contributors, impacts, mitigation and adaptations
    Tang KHD
    Sci Total Environ, 2019 Feb 10;650(Pt 2):1858-1871.
    PMID: 30290336 DOI: 10.1016/j.scitotenv.2018.09.316
    PURPOSE: This paper reviews the past and future trends of climate change in Malaysia, the major contributors of greenhouse gases and the impacts of climate change to Malaysia. It also reviews the mitigation and adaptations undertaken, and future strategies to manage the impacts of regional climate change.

    METHODOLOGY: The review encompasses historical climate data comprising mean daily temperature, precipitation, mean sea level and occurrences of extreme weather events. Future climate projections have also been reviewed in addition to scholarly papers and news articles related to impacts, contributors, mitigation and adaptations in relation to climate change.

    FINDINGS: The review shows that annual mean temperature, occurrences of extreme weather events and mean sea level are rising while rainfall shows variability. Future projections point to continuous rise of temperature and mean sea level till the end of the 21st century, highly variable rainfall and increased frequency of extreme weather events. Climate change impacts particularly on agriculture, forestry, biodiversity, water resources, coastal and marine resources, public health and energy. The energy and waste management sectors are the major contributors to climate change. Mitigation of and adaptations to climate change in Malaysia revolve around policy setting, enactment of laws, formulation and implementation of plans and programmes, as well as global and regional collaborations, particularly for energy, water resources, agriculture and biodiversity. There are apparent shortcomings in continuous improvement and monitoring of the programmes as well as enforcement of the relevant laws.

    ORIGINALITY/VALUE: This paper presents a comprehensive review of the major themes of climate change in Malaysia and recommends pertinent ways forward to fill the gaps of mitigation and adaptations already implemented.

    Matched MeSH terms: Malaysia
  7. Fulltext Data on micrometeorological parameters and Energy Fluxes at an intertidal zone of a Tropical Coastal Ocean
    Yusup Y, Kayode JS, Alkarkhi AFM
    Data Brief, 2018 Dec;21:13-17.
    PMID: 30310834 DOI: 10.1016/j.dib.2018.09.108
    Data on the micrometeorological parameters and Energy Fluxes at an intertidal zone of a Tropical Coastal Ocean was carried out on an installed eddy covariance instruments at a Muka head station in the north-western end of the Pinang Island (5°28'06''N, 100°12'01''E), Peninsula Malaysia. The vast source of the supply of energy and heat to the hydrologic and earth׳s energy cycles principally come from the oceans. The exchange of energies via air-sea interactions is crucial to the understanding of climate variability, energy, and water budget. The turbulent energy fluxes are primary mechanisms through which the ocean releases the heat absorbed from the solar radiations to the environment. The eddy covariance (EC) system is the direct technique of measuring the micrometeorological parameters which allow the measurement of these turbulent fluxes in the time scale of half-hourly basis at 20 Hz over a long period. The data being presented is the comparison of the two-year seasonality patterns of monsoons variability on the measured microclimate variables in the southern South China Sea coastal area.
    Matched MeSH terms: Malaysia
  8. Fulltext Validity and reliability of Vicon™ motion capture camera over the traditional anthropometric method
    Muhammad Fikri, Z., Ruzy Haryati, H., Seri Rahayu, K.
    Malaysian Journal of Public Health Medicine, 2018;18(102):142-151.
    MyJurnal
    Anthropometric study is one of the oldest branches of study in ergonomics where it serves a purpose in study of
    proportion and size for human body. One of the common methods used in anthropometric measurement is traditional
    measurement or direct measurement. However, Malaysia is still left behind other countries in development of national
    anthropometric database. Researchers in Malaysia are still relying on the traditional anthropometric (TA)
    measurement. There are several important factors that contribute to problems in TA such as accuracy, time, posture,
    identification of landmarks, instrument positions and orientations, and pressure exerted due to measuring equipment. In
    view of the fact that the difficulties of obtaining human anthropometry, it becomes necessary to propose a method which
    has less contact executed to respondent. This study aims to propose a new anthropometric measurement method using
    motion capture camera (MCC) method, later to develop the database for youth male population. A pilot test was done
    in order to confirm the measuring procedure as well as the flow of the study. Next, the Minitab statistical software used
    to check the validity and reliability of data using the tests of a) Accuracy-Pearson/Spearman Correlation b) BiasPaired
    T-Test c) Test-Retest Reliability-Pearson/Spearman Correlation d) Precision-Mean Absolute Difference and
    Relative Error Measurement. Results showed that the validity and reliability of this motion camera has successfully
    obtained and the anthropometric data for youth male respondents has successfully constructed. These findings can be
    used and expended to the national anthropometric database to be utilised in ergonomics design.
    Matched MeSH terms: Malaysia
  9. Fulltext Predictors for inadequate knowledge and negative attitude towards childhood immunization among parents in Hulu Langat, Selangor, Malaysia
    Che Abdullah A, Nor Afiah MZ, Rosliza AM
    Malaysian Journal of Public Health Medicine, 2018;18(1):0-0.
    MyJurnal
    Vaccine hesitancy among parents has led to re-emergence of vaccine preventable diseases. In Malaysia, measles cases had increased by three times in 2015 compared to previous year. Immunization coverage has always been above 95% since 2009. However, in 2014, Mumps-Measles-Rubella (MMR) coverage has a significant drop to 93.4%. The aim of the study was to identify predictors for inadequate knowledge and negative attitude towards childhood immunization among parents in Hulu Langat, Selangor. A cross sectional study design was conducted from January to July 2016 with 760 respondents. Respondents were selected by cluster random sampling and a validated self-administered questionnaire was used. The majority of respondents were female (70%), Malay (87%), employed (92%) and parents with tertiary education (99.7%). In this study, 12.8% parents have an inadequate knowledge on childhood immunization and 47.6% parents have a negative attitude towards childhood immunization. The predictors for inadequate knowledge on childhood immunizations were last child’s age of 2 years old or more (AOR=1.413 95% CI 0.28-0.69); parents without tertiary education (AOR=2.02 95% CI 1.15-3.54); parents without educational exposure on childhood immunization (AOR=2.87 95% CI 1.59-5.18) and parents who obtained information on childhood immunization from non-healthcare provider (AOR=2.66 95% CI 1.50-4.70). Predictors for negative attitude on childhood immunizations were being male (AOR=1.44 95% CI 1.04-2.01); parents without tertiary education (AOR=1.67 95% CI 1.04-2.68); household income of less than RM5000 (AOR=1.85 95% CI 1.28-2.67) and unsatisfactory religious belief (AOR=2.76 95% CI 2.03-3.75). Therefore, these predictors should be considered in any health intervention on childhood immunizations for parents in Malaysia.
    Matched MeSH terms: Malaysia
  10. The first Philippine species of Loeblites Franz (Coleoptera: Staphylinidae: Scydmaeninae)
    JaŁoszyŃski P
    Zootaxa, 2018 Sep 04;4471(1):185-188.
    PMID: 30313426 DOI: 10.11646/zootaxa.4471.1.11
    Loeblites Franz, 1986 is a genus of Glandulariini with adults sharing a very similar body form and most taxonomically important structures with Syndicus Motschulsky, 1851. One of the most conspicuous differences between these genera is the antennal structure. In Syndicus, the antennomere XI is strongly reduced, much shorter than X and lacks the basal stalk, so that the two terminal antennomeres are compactly assembled. They either form one oval structure that appears as a single antennomere because the base of subconical antennomere XI is as broad as apex of X (Syndicus s. str.) or the antennomere XI forms a distinct small 'papilla' on top of X (subgen. Semisyndicus Jałoszyński, 2004) because the base of antennomere XI is much narrower than apex of X. Adults of Loeblites have unmodified antennae, with the antennomere XI strongly elongate and with a narrow basal stalk; additionally the antennae are strikingly slender, nearly filiform. Morphological structures of both genera were described and illustrated by Jałoszyński (2004, 2005). While Syndicus is species-rich, often abundant in leaf litter and under bark in subtropical forests (Jałoszyński 2004, 2006, 2008, 2009, 2011, 2014; Jałoszyński Nomura 2006; Yin Li 2015; Yin et al. 2014; Yin Zhou 2016; Zhou Yin 2017), and broadly distributed from southeastern Australia, through Southeast Asia, Yunnan (China) and Ryukyus (Japan), up to Sri Lanka, India and the Himalayas, Loeblites comprises merely four species known to occur in Malaysia, Thailand and China (Jałoszyński 2005; Zhou Li 2015). Loeblites mastigicornis Franz, 1986 is known to occur in Chiang Mai (northern Thailand), L. sabahensis Franz, 1992 and L. minor Jałoszyński, 2005 in Sabah (northern Borneo), and L. chinensis Zhou Li, 2015 in Yunnan (southwest China). Two females representing an undescribed species were also recorded from Yunnan by Zhou Li (2015). Specimens of this interesting genus are found rarely, in small numbers and they are typically sifted from leaf litter in subtropical forests.
    Matched MeSH terms: Malaysia
  11. Revision of the Agrilus gratiosus species-group (Coleoptera, Buprestidae, Agrilinae)
    Jendek E
    Zootaxa, 2018 Jun 13;4433(3):478-490.
    PMID: 30313214 DOI: 10.11646/zootaxa.4433.3.5
    The newly defined Agrilus gratiosus species-group comprising ten species from the Oriental region is revised. A key to species is provided and complemented with illustrations of habitus, genitalia and type specimens. The following seven new species are described: Agrilus cultus sp. nov. (Laos); A. oudomxai sp. nov. (Laos); A. pergratus sp. nov. (Malaysia); A. pluridens sp. nov. (Laos, Thailand); A. pubinotus sp. nov. (Indonesia: Sumba Island); A. siberuticola sp. nov. (Indonesia: Siberut Island) and A. signipes sp. nov. (Vietnam). Agrilus makiharai Tôyama, 1987 is considered conspecific with A. bacchus Kerremans, 1913 and therefore the name makiharai syn. nov. is a junior subjective synonym of the name bacchus.
    Matched MeSH terms: Malaysia
  12. Elevational size variation and two new species of torrent frogs from Peninsular Malaysia (Anura: Ranidae: Amolops Cope)
    Onn CK, Abraham RK, Grismer JL, Grismer LL
    Zootaxa, 2018 Jun 15;4434(2):250-264.
    PMID: 30313185 DOI: 10.11646/zootaxa.4434.2.2
    Previously, only one species of torrent frog (Amolops larutensis) was thought to occur throughout Peninsular Malaysia. However, genomic work has demonstrated that populations from eastern Peninsular Malaysia form two separate lineages that are genetically distinct from A. larutensis that is now restricted to the western half of Peninsular Malaysia. This study demonstrates that all three lineages can be morphologically distinguished from each other, thereby providing additional support for the recognition of the eastern lineages as two distinct species. These lineages are described herein as Amolops gerutu sp. nov. from the eastern states of Kelantan, Terengganu, and Pahang, and A. australis sp. nov. from the southern-most state of Johor. In general, these two new species form a clade that is sister to A. larutensis and can be readily distinguished from it by having: (1) considerably denser and more pronounced dorsal tubercles, and (2) the posterodorsal surface of thighs having dense, dark stippling as opposed to broad vermiculations. Although differences in other morphometric characters were detected, their utility as diagnostic characters should be applied with caution due to the large intraspecific variation that overlaps among different species in many of the characters we measured. As such, we advocate for the use of tuberculation and pattern of the posterodorsal portion of the thighs as primary diagnostic characters. These characters can readily distinguish A. larutensis from the two new species. To differentiate A. australis sp. nov. from A. gerutu sp. nov. and A. larutensis, body size can be a good diagnostic character as A. australis sp. nov. is significantly smaller in both males (mean = 31.04 ± 1.59 mm) and females (mean = 46.48 ± 3.2 mm). Additionally, we show a strong positive correlation between body size and elevation, with populations from montane forests (>900 m asl) being considerably larger than populations at lower elevations.
    Matched MeSH terms: Malaysia
  13. New records of species of the Polyonyx sinensis group (Crustacea: Decapoda: Anomura: Porcellanidae) from Japan, the Philippines, Singapore, and Malaysia, with descriptions of two new species
    Osawa M, Naruse T, Ng PKL
    Zootaxa, 2018 Jun 06;4429(2):303-323.
    PMID: 30313270 DOI: 10.11646/zootaxa.4429.2.6
    Five species of the genus Polyonyx Stimpson, 1858 are reported from southern Japan, the Philippines, Singapore, and Peninsular Malaysia. All of them belong to the P. sinensis group, which is morphologically defined by having the dactyli of the ambulatory legs each with the dorsal claw being much smaller than the ventral claw. Two species are described as new to science, one each from Peninsular Malaysia and the Ryukyu Islands in Japan, and their affinities are discussed. Polyonyx boucheti Osawa, 2007, P. heok Osawa Ng, 2016, and P. thai Werding, 2001, are also newly reported from southern Japan, the Philippines, and Singapore. A key to the Indo-West Pacific species of the P. sinensis group is provided.
    Matched MeSH terms: Malaysia
  14. Fulltext The effectiveness of food handler training programmes in Malaysia and Ireland to prevent food-borne disease
    Tirmizi, L.I.T., Brand, H., Son, R., New, C.Y.
    Food Research, 2018;2(3):247-257.
    MyJurnal
    According to the World Health Organisation (WHO), globally 600 million people suffer
    from food-borne diseases (FBD), and 420,000 people die as a result. The European Food
    Safety Authority (EFSA) has stated that FBD are linked to the food industry, with the
    most common means of transmission being due to poor food handling and hygiene by
    food handlers working in the food industry. The aim of this research was to investigate the
    effectiveness of mandatory food handler training programmes (FHTP) to prevent FBD in
    Malaysia and Ireland. To do this, the FHTP existing in Malaysia and Ireland were
    analysed, in addition to the legislation they fall under in each respective country.
    Effectiveness was determined by investigating the level of food safety knowledge (FSK)
    and food safety practices (FSP) of food handlers in Malaysia and Ireland. A systematic
    literature review (SLR) and a narrative literature review (NLR) were conducted for this
    research. The SLR was based on the PRISMA diagram, using the Confidence in the
    Evidence from Reviews of Qualitative research (CERQual) approach to evaluate the
    studies used for this research. A total of 8 Malaysian studies and 1 Irish study were used to
    determine the level of FSK and FSP of food handlers in each respective country, to
    examine the effectiveness of FHTP. The results of the studies used for this research have
    depicted overall good FSP and FSK of food handlers in Malaysia and Ireland; yet trends
    continue to show that food handlers are one of the biggest contributors to FBD,
    demonstrating that FHTP are not effective in preventing FBD. The findings from this
    research highlights that although these trainings can be an effective tool to prevent FBD, if
    they are not executed correctly, food handlers will continue to contribute to FBD.
    Matched MeSH terms: Malaysia
  15. Fulltext A rare cause of proximal thigh discomfort and weakness with type 2 diabetes mellitus
    Low QJ, Ng BHS, Cheo SW
    Borneo Journal of Medical Sciences, 2018;12(1):57-63.
    MyJurnal
    Diabetic amyotrophy also known as Bruns-Garland syndrome is diabetic neuropathy subtype affecting the lumbosacral nerve roots and peripheral nerves. There is an ongoing debate on the pathophysiology behind this condition whether is it ischaemic, metabolic (hyperglycaemia) or inflammatory. A 36-year-old man with uncontrolled diabetes mellitus complained of unprovoked weight lost and right proximal thigh discomfort with weakness for one week duration. In neurological examination, his right hip flexion was at medical research council (MRC) grade 3, right hip extension MRC grade 4, his knee and ankle flexion and extension are normal (MRC grade 5). The muscle tones and reflexes were normal. Sensation and proprioception were intact bilaterally. Nerve conduction study (NCS) showed markedly reduced amplitude of the compound muscle action potentials and sensory nerve action potentials, while conduction velocities show only mild slowing. He was started on a course of oral prednisolone 10 mg daily and improved gradually. At three months follow-up, his right lower limb power has recovered fully and he can walk without any assistance. Diabetic amyotrophy was confirmed by suggestive clinical features supported by electrophysiological findings of the affected nerves. This condition is due to metabolic derangement and vasculopathy or immune mediated nerve injury. So, the healthcare providers should be aware about this rare complication of diabetes.
    Matched MeSH terms: Malaysia
  16. Fulltext Factors affecting the prescribing pattern of non-steroidal anti-inflammatory drugs at outpatient departments in government and private polyclinics in Kota Kinabalu, Sabah
    Rahman, Md. Shamsur, Matanjun, David, Parash, M. Tanveer Hossain, Shimmi, Sadia Choudhury, Tan, Tek Song, D’Souza, Urban John Arnold, et al.
    Borneo Journal of Medical Sciences, 2018;12(1):43-47.
    MyJurnal
    The main objective of this study was to obtain information regarding the effects of educational and socio-economic status of the patients on the prescribing pattern of non-steroidal antiinflammatory drugs (NSAIDs) by the qualified medical personnel in the outpatient departments (OPDs) of two selected polyclinics in Kota Kinabalu, Sabah, Malaysia. A total of 200 selected patients (100 from each polyclinic) attending the OPDs were interviewed using a questionnaire. Again data were collected, photocopied and later analyzed. Educated and higher income group of patients mostly attended in a Private Polyclinic (PPC) whereas less educated and lower income group of patients generally attended UMS Polyclinic (UPC). This was reported as a probable reason for the wide variations in the prescribing pattern with respect to pharmacological subclasses of NSAIDs in the OPDs of two polyclinics. The present results strongly support that probable reason. The number of patients taking NSAIDs before coming to hospital was more in PPC compared to UPC. They were influenced by pharmacists, friends and doctor’s advice given previously. In conclusion, it may be mentioned that overall prescribing pattern of NSAIDs among two polyclinics is rational.
    Matched MeSH terms: Malaysia
  17. Fulltext Role of febuxostat in retarding progression of diabetic kidney disease with asymptomatic hyperuricemia: A 6-months open-label, randomized controlled trial
    Mukri MNA, Kong WY, Mustafar R, Shaharir SS, Shah SA, Abdul Gafor AH, et al.
    EXCLI J, 2018;17:563-575.
    PMID: 30108461 DOI: 10.17179/excli2018-1256
    Introduction: Hyperuricemia is associated with chronic kidney disease (CKD) progression and poor cardiovascular outcomes. We studied the effect of febuxostat on estimated glomerular filtration rate (eGFR), proteinuria and monitored the safety profile of the medication.
    Material and Methods: This is a prospective open-label, randomized study in CKD stage 3 and 4 patients with diabetic nephropathy and asymptomatic hyperuricemia. Patients were randomized into febuxostat 40 mg daily and no treatment group using block randomization method and were followed up for 6 months. Their usual care for diabetes mellitus, hypertension and dyslipidemia were continued in the study. Blood and urine investigations were monitored at baseline, 3 months and 6 months.
    Results: The eGFR in febuxostat group was stabilized at 6 months with no significant reduction [26.2 (IQR 14.30) at baseline to 26.3 (IQR 15.2) ml/min/1.73 m2]. Whereas, there was a significant reduction of the eGFR in no treatment group from 28.2 (IQR 17.9) to 27.6 (IQR 19.3) ml/min/1.73 m2 (p value < 0.01). We found the HbA1c (glycosylated hemoglobin) was significantly increased in febuxostat group from 7.2 ± 0.5 % at baseline to 7.6 ± 1.4 at 6 months (p value 0.04) but no significant change of HbA1c in the no treatment group. Proteinuria level was unchanged in both groups. The commonest adverse event was joint pain.
    Conclusions: Febuxostat was able to preserve eGFR in CKD patients with diabetic nephropathy and this effect was beyond glycemic control. Increment of HbA1c level in febuxostat group needs further larger trials.
    Study site: Chronic kidney disease clinic, Hospital Canselor Tuanku Muhriz, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia
    Matched MeSH terms: Malaysia
  18. Fulltext Identifying self-care behaviour and its predictors among type 2 diabetes mellitus patients at a district of northern peninsular Malaysia
    Kang CY, Md Said S, Abdul Manaf R
    Malaysian Journal of Medicine and Health Sciences, 2018;14(2):17-29.
    MyJurnal
    Introduction: The prevalence of diabetes mellitus among Malaysian aged ≥ 18 years increased from 11.6% (2006) to 17.5% (2015). Positive self–care behaviour leads to good glycaemic control. The objective of this study is to determine the self-care behaviour, its associated factors and predictors among type 2 diabetes mellitus (T2DM) patients in government health clinics at a district of Northern Peninsular Malaysia.
    Methodology: A cross-sectional study was conducted on 546 T2DM patients aged ≥ 18 years, recruited by simple random sampling method. A validated self-administered questionnaire including socio-demographic characteristics, diabetes profile, knowledge, Health Belief Model (HBM) and Summary of Diabetes Self-care Activity Scale (SDSCA) was used. Data were analysed using SPSS version 22.0. Self-care behaviour is the dependent variable.
    Results: The respondents practised 3.4 (SD = 1.11) days self-care behaviour past 1 week. The predictors of self-care behaviour were self-efficacy (standardized β = 0.257, p < 0.001), knowledge (standardized β = 0.112, p = 0.007), female (standardized β = 0.107, p = 0.010), combination oral hypoglycaemic agents (OHA) and insulin (standardized β = -0.182, p = 0.002), and monthly income < RM1,000 (standardized β = -0.129, p = 0.002). The entire group of variables significantly predicted self-care behaviour [F (6, 539) = 15.79, p < 0.001, adjusted R2 = 0.140] with total variance of 14.9%. Self-efficacy was the strongest predictor in self-care behaviour.
    Conclusion: The findings enable us to identify the specific groups with predicted lower self-care behaviour which are useful in future planning and implementation of intervention.
    Study site: Klinik Kesihatan, Malaysia
    Matched MeSH terms: Malaysia
  19. Fulltext Factors associated with awareness, knowledge and attitude towards prostate cancer among Malay men in traditional Malay Villages, Negeri Sembilan, Malaysia
    Suriani Ismail, Huda Zainuddin, Titi Rahmawati Hamedon, Muhammad Hanafiah Juni, Nor Afiah Mohd. Zulkefli, Suhainizam bin Muhamad Saliluddin
    Malaysian Journal of Medicine and Health Sciences, 2018;14(2):31-38.
    MyJurnal
    Background: Lack of awareness, poor knowledge and attitude regarding cancer have been identified as possible reasons accounting for the late presentation which lead to the poor survival of cancer patients in Malaysia. Method: A cross sectional study was conducted in three traditional Malay villages in Negeri Sembilan among adult males. Those who were already diagnosed with prostate cancer or Non malaysians were excluded from the study. Data was collected using self-administered questionnaires which consist of several sections namely socio-demographic, awareness about prostate cancer, sources of information, family history of prostate cancer, lifestyle associated with risk of cancer, knowledge and attitude towards prostate cancer. Data was analysed using SPSS version 22.0. Chisquare test was used to determine associations. Level of significance was set at p
    Matched MeSH terms: Malaysia
  20. Fulltext Breastfeeding practice, support, and self- efficacy among working mothers in a rural health clinic in Selangor
    Aneesa Abdul Rashid, Nurainul Hana Shamsuddin, Raja Dalila Athirah Raja Malek Ridhuan, Nurin Amalina Sallahuddin, Devaraj, Navin Kumar
    Malaysian Journal of Medicine and Health Sciences, 2018;14(2):39-49.
    MyJurnal
    Introduction: In first six months of life, breastfeeding is the recommended form of feeding by the World Health Organisation for the growing child. To enable the working mother to continue this noble practice, adequate workplace breastfeeding support and self- efficacy is needed. This study aims to determine the prevalence of breastfeeding among working mothers of children aged three months to two years and factors associated with breastfeeding practice including workplace support and mother’s self-efficacy. Method: This is a cross sectional questionnaire study carried out in a rural Health Clinic in Selangor using socio-demographic data, Workplace Breastfeeding Support Scale (WBSS), and the Breastfeeding Self-Efficacy Scale Short Form (BSES-SF). This study was conducted for a period of three months from April to June 2015. The respondents were employed Malaysian mothers of healthy infants aged three months to two years. A total of 84 participants were involved in the study. Data analysis was done with SPSS 22.Results: The prevalence of breastfeeding among working mothers were high at 97.6%. We found significant association of breastfeeding practice with workplace breastfeeding support (p=0.005) and self-efficacy (p= 0.017). We also noted a significant correlation between breastfeeding workplace support and breast feeding self-efficacy (r= 0.40, p
    Matched MeSH terms: Malaysia
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