Displaying publications 861 - 880 of 55650 in total

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  1. Low LE, Kong CK, Yap WH, Siva SP, Gan SH, Siew WS, et al.
    Chem Biol Interact, 2023 Dec 01;386:110750.
    PMID: 37839513 DOI: 10.1016/j.cbi.2023.110750
    Hydroxychloroquine (HCQ) is a unique class of medications that has been widely utilized for the treatment of cancer. HCQ plays a dichotomous role by inhibiting autophagy induced by the tumor microenvironment (TME). Preclinical studies support the use of HCQ for anti-cancer therapy, especially in combination with conventional anti-cancer treatments since they sensitize tumor cells to drugs, potentiating the therapeutic activity. However, clinical evidence has suggested poor outcomes for HCQ due to various obstacles, including non-specific distribution, low aqueous solubility and low bioavailability at target sites, transport across tissue barriers, and retinal toxicity. These issues are addressable via the integration of HCQ with nanotechnology to produce HCQ-conjugated nanomedicines. This review aims to discuss the pharmacodynamic, pharmacokinetic and antitumor properties of HCQ. Furthermore, the antitumor performance of the nanoformulated HCQ is also reviewed thoroughly, aiming to serve as a guide for the HCQ-based enhanced treatment of cancers. The nanoencapsulation or nanoconjugation of HCQ with nanoassemblies appears to be a promising method for reducing the toxicity and improving the antitumor efficacy of HCQ.
    Matched MeSH terms: Humans
  2. Balakrishnan P, Girija ASS, Kannan I, Vignesh R, Shankar EM, Sucharitha ST
    Indian J Med Microbiol, 2023;43:49-50.
    PMID: 36280566 DOI: 10.1016/j.ijmmb.2022.10.004
    Matched MeSH terms: Humans
  3. Maher S, Mikic Z, McDonald C, Flaherty GT, Hallahan B
    Ir J Psychol Med, 2023 Jun;40(2):127-133.
    PMID: 31969203 DOI: 10.1017/ipm.2019.52
    OBJECTIVES: To identify factors influencing successful international travel among patients with psychotic illness.

    METHODS: Eight individuals participated in a semi-structured interview of 15-20-minute duration with a clinician in relation to their recent experience of international travel. Clinical files were reviewed and a case series was compiled.

    RESULTS: Four individuals engaged in international travel without any adverse effects. Four other individuals experienced significant psychotic and/or affective symptoms while travelling. Treatment non-adherence, a lack of awareness of how to obtain support and limited or no pre-travel planning were noted in these individuals.

    CONCLUSIONS: Pre-travel counselling, treatment adherence, provision of information packages relating to their mental illness and having contact details of their treating mental health team increase the likelihood of successful international travel in patients with psychotic illness. Travelling with a companion may reduce fear of relapse.

    Matched MeSH terms: Humans
  4. Tatum M
    Lancet, 2023 Jun 10;401(10392):1915.
    PMID: 37302400 DOI: 10.1016/S0140-6736(23)01176-5
    Matched MeSH terms: Humans
  5. Hamza Hermis A, Tehrany PM, Hosseini SJ, Firooz M, Hosseini SR, Jamshidbeigi A, et al.
    Int Wound J, 2023 Nov;20(9):3855-3870.
    PMID: 37224877 DOI: 10.1111/iwj.14236
    Non-accidental burns (NABs) in children had some adverse effects, such as severe burns, requiring skin grafting, and mortality. Previous studies reported NABs in the form of neglect, suspected abuse, and child abuse. Also, different statistics were estimated for the prevalence of NABs in children. Therefore, the current study aimed to comprehensively review and summarise the literature on the prevalence of NABs in children. Also, factors related to NABs as a secondary aim were considered in this review. Keywords combined using Boolean operators and searches were performed in international electronic databases, such as Scopus, PubMed, and Web of Science. Only studies in English were considered from the earliest to 1 March 2023. The analysis was performed using STATA software version 14. Finally, 29 articles were retrieved for the quantitative analysis. Results found that the prevalence of child abuse, suspected abuse, neglect, 'child abuse or suspect abused', and 'abuse, suspect abused, or neglect' was 6% (ES: 0.06, 95% confidence interval [CI]: 0.05-0.07), 12% (ES: 0.12, 95% CI: 0.09-0.15), 21% (ES: 0.21, 95% CI: 0.07-0.35), 8% (ES: 0.08, 95% CI: 0.07-0.09), and 15% (ES: 0.15, 95% CI: 0.13-0.16) among burns victims, respectively. Also, factors related to NABs are categorised into age and gender, agent and area of burns, and family features. Considering the results of the current study, planning for rapid diagnosis and designing a process to manage NABs in children is necessary.
    Matched MeSH terms: Humans
  6. AlMatar M, Ramli ANM, Albarri O, Yi CX
    Comb Chem High Throughput Screen, 2023;26(11):1945-1959.
    PMID: 36366840 DOI: 10.2174/1386207326666221108095705
    SARS-CoV-2 is a disease that endangers both human life and the economy. There was an 11- month period of relative evolutionary standstill following the appearance of SARS-CoV-2 in late 2019. However, the emergence of clusters of mutations known as' variants of concern 'with variable viral properties such as transmissibility and antigenicity defined the evolution of SARS-CoV-2. Several efforts have been made in recent months to understand the atomic level properties of SARS-CoV-2. A review of the literature on SARS-CoV-2 mutations is offered in this paper. The critical activities performed by different domains of the SARS-CoV-2 genome throughout the virus's entry into the host and overall viral life cycle are discussed in detail. These structural traits may potentially pave the way for the development of a vaccine and medication to combat the SARS-CoV-2 sickness.
    Matched MeSH terms: Humans
  7. Teh CS, Mah MC, Rahmat K, Prepageran N
    Otol Neurotol, 2022 Jan 01;43(1):12-22.
    PMID: 34669685 DOI: 10.1097/MAO.0000000000003389
    OBJECTIVES: Persistent postural-perceptual dizziness (PPPD) is a chronic functional vestibular disorder that may have normal physical examination, clinical laboratory testing and vestibular evaluation. However, advances in neuroimaging have provided new insights in brain functional connectivity and structure in patients with PPPD. This systematic review was aimed at identifying significant structural or alterations in functional connectivity in patients with PPPD.

    DATABASES REVIEWED: Science Direct, Pubmed, Embase via Ovid databases, and Cochrane library.

    METHODS: This review following the guidelines of PRISMA, systematically and independently examined papers published up to March 2021 which fulfilled the predetermined criteria. PROSPERO Registration (CRD42020222334).

    RESULTS: A total of 15 studies were included (MRI = 4, SPECT = 1, resting state fMRI = 4, task-based fMRI = 5, task-based fMRI + MRI = 1). Significant changes in the gray matter volume, cortical folding, blood flow, and connectivity were seen at different brain regions involved in vestibular, visual, emotion, and motor processing.

    CONCLUSION: There is a multisensory dimension to the impairment resulting in chronic compensatory changes in PPPD that is evident by the significant alterations in multiple networks involved in maintaining balance. These changes observed offer some explanation for the symptoms that a PPPD patient may experience.Systematic Review Registration: This study is registered with PROSPERO (CRD42020222334).

    Matched MeSH terms: Humans
  8. Mikton C, Beaulieu M, Burnes D, Choo WY, Herbst JH, Pillemer K, et al.
    Nat Aging, 2022 Nov;2(11):973-975.
    PMID: 37118090 DOI: 10.1038/s43587-022-00301-0
    Currently, there are no evidence-based interventions to prevent and respond to abuse of older people. We propose to create, within the Decade of Healthy Ageing 2021–2030, an intervention accelerator to speed up the development of effective interventions for abuse of older people in community and institutional settings within low-, middle- and high-income countries.
    Matched MeSH terms: Humans
  9. Morgan-Jones R, Sandy-Hodgetts K, Bruwer F, Chabal L, Clegg H, Couch K, et al.
    J Wound Care, 2023 Jul 01;32(Sup7b):1-16.
    PMID: 37494958 DOI: 10.12968/jowc.2023.32.Sup7b.1
    Matched MeSH terms: Humans
  10. Thomas AR, Reddy TVK, Tan JY, Qing SEJ, Qing CS, Xuan LY, et al.
    J Contemp Dent Pract, 2023 Apr 01;24(4):221-227.
    PMID: 37469260 DOI: 10.5005/jp-journals-10024-3471
    AIM: The purpose of this study was to evaluate and compare the canal transportation tendencies and centering ability of the TruNatomy shaper (TN) and XP-endo shaper (XPS) rotary systems in oval-shaped canals with moderate root curvature (15°-25°), using cone-beam computed tomography (CBCT) imaging.

    MATERIALS AND METHODS: Sixty single-rooted permanent human teeth were chosen after considering the inclusion and exclusion criteria. The teeth were divided into two groups (n = 30). The test group was instrumented with TN files and the other with XPS according to manufacturer's instructions. CBCT images were taken before and after instrumentation to record the root canal distances from mesial, distal, buccal, and lingual borders of the root at 3, 5, and 7 mm distances from the root apex using a specific formula. Statistical analysis was done using the Statistical Package for the Social Sciences software program, version 20.0. The data were analyzed using the unpaired t test.

    RESULTS: Both TN and XPS were safe for use in oval-shaped canals with moderate root curvature. However, the XPS showed higher buccolingual transportation as compared with TN at 3 mm from the apex and higher mesiodistal transportation at 3 and 5 mm levels from the apex as compared with TN.

    CONCLUSION: Canal transportation has been detected in both systems; however, the values obtained were within the safe range (<0.3 mm). Overall, no significant difference was observed between TN and XPS (p > 0.05) in their canal transportation tendencies and centering ability.

    CLINICAL SIGNIFICANCE: The study assesses the canal centering and transportation tendencies of the recently launched TN rotary system in extracted teeth with a combination of morphologies. The findings of the study are significant clinically as minimum transportation of the canal, minimal dentin removal, efficient disinfection, and three-dimensional obturation of the root canal are considered important factors in deciding the prognosis of endodontic therapy.

    Matched MeSH terms: Humans
  11. Loch A, Siew KSW, Tan KL, Azman Bin Raja Aman RRAB
    Singapore Med J, 2023 Jun;64(6):366-372.
    PMID: 35509213 DOI: 10.11622/smedj.2022042
    Matched MeSH terms: Humans
  12. Norfuad FA, Mokhtar MH, Nur Azurah AG
    Nutrients, 2023 Jun 13;15(12).
    PMID: 37375637 DOI: 10.3390/nu15122733
    Probiotics are live microorganisms that confer beneficial effects on human health when an adequate dose is administered. Recently, the use of probiotics has gained tremendous interest from the public due to its promising effects in the management of various reproductive diseases. However, the review of probiotics' benefits on benign gynaecological disorders, including vaginal infections, polycystic ovary syndrome (PCOS) and endometriosis, remains scarce. Therefore, this review is built on current knowledge on the beneficial effects of probiotics against selected benign gynaecological disorders. Recent findings point out that probiotics' supplementation in different clinical and in vivo models showed promising health effects and results in the amelioration of disease symptoms. Thus, in this review, we showed the findings of both studies performed in clinical settings and animal studies. However, current information, solely based on clinical trials or animal studies, is inadequate in communicating the excellent findings on the beneficial effects of probiotics on human health. Therefore, future clinical intervention studies are required to further elucidate the evidence of the benefits of probiotics benefits regarding these gynaecological disorders.
    Matched MeSH terms: Humans
  13. Ramly F, Mahamooth MIJ, Abidin HAZ, Hassan J
    Int J Gynaecol Obstet, 2023 May;161(2):667-669.
    PMID: 36637245 DOI: 10.1002/ijgo.14669
    Matched MeSH terms: Humans
  14. Hassan Raza S, Yousaf M, Zaman U, Waheed Khan S, Core R, Malik A
    Vaccine, 2023 Mar 03;41(10):1703-1715.
    PMID: 36754765 DOI: 10.1016/j.vaccine.2023.01.047
    Guarding against an anti-science camouflage within infodemics is paramount for sustaining the global vaccination drive. Vaccine hesitancy remains a growing concern and a significant threat to public health, especially in developing countries. Infodemics, conspiracy beliefs and religious fatalism primarily fuel vaccine hesitancy. In addition, anti-vaccine disinformation, lack of understanding, and erroneous religious beliefs also trigger vaccine hesitancy. Global behavioral strategies such as wearing face masks and long-term preventive measures (i.e., COVID-19 vaccination) have effectively limited the virus's spread. Despite the alarming rate of global deaths (i.e., over 99% being unvaccinated), a large proportion of the global population remains reluctant to vaccinate. New evidence validates the usefulness of technology-driven communication strategies (i.e., digital interventions) to address the complex socio-psychological influence of the pandemic. Hence, the present research explored the digital information processing model to assess the interface between informational support (through digital interventions) and antecedents of vaccine hesitancy. This research involved two separate studies: a focus group to operationalize the construct of infodemics, which remained ambiguous in previous literature (Study 1), followed by a cross-sectional survey (Study 2) to examine the conceptual model. Data were collected from 1906 respondents through a standard questionnaire administered online. The focus group's findings revealed a multi-dimensional nature of infodemics that was also validated in Study 2. The cross-sectional survey results substantiated infodemics, religious fatalism and conspiracy beliefs as significant predictors of vaccine hesitancy. Similarly, conspiracy beliefs negatively influence an individual's psychological well-being. Furthermore, information support (through digital intervention) affected infodemics and religious fatalism, whereas it inversely influenced the strength of their relationships with vaccine hesitancy. Information support (through digital intervention) also moderated the relationship between conspiracy beliefs and psychological well-being.
    Matched MeSH terms: Humans
  15. Siew ZY, Loh A, Segeran S, Leong PP, Voon K
    DNA Cell Biol, 2023 Jun;42(6):289-304.
    PMID: 37015068 DOI: 10.1089/dna.2022.0561
    Orthoreovirus is a nonenveloped double-stranded RNA virus under the Reoviridae family. This group of viruses, especially mammalian orthoreovirus (MRV), are reported with great therapeutic values due to their oncolytic effects. In this review, the life cycle and oncolytic effect of MRV and a few emerging reoviruses were summarized. This article also highlights the challenges and strategies of utilizing MRV and the emerging reoviruses, avian orthoreovirus (ARV) and pteropine orthoreovirus (PRV), as oncolytic viruses (OVs). Besides, the emergence of potential ARV and PRV as OVs were discussed in comparison to MRV. Finally, the risk of reovirus as zoonosis or reverse zoonosis (zooanthroponosis) were debated, and concerns were raised in this article, which warrant continue surveillance of reovirus (MRV, ARV, and PRV) in animals, humans, and the environment.
    Matched MeSH terms: Humans
  16. Orth Z, Meyer Z, Singh S, Riha J
    BMJ, 2023 Jun 02;381:1268.
    PMID: 37268315 DOI: 10.1136/bmj.p1268
    Matched MeSH terms: Humans
  17. Beishenaliev A, Loke YL, Goh SJ, Geo HN, Mugila M, Misran M, et al.
    J Control Release, 2023 Jul;359:268-286.
    PMID: 37244297 DOI: 10.1016/j.jconrel.2023.05.032
    Monospecific antibodies have been utilised increasingly for anti-cancer drug targeting owing to their ability to minimise off-target toxicity by binding specifically to a tumour epitope, hence selectively delivering drugs to the tumour cells. Nevertheless, the monospecific antibodies only engage a single cell surface epitope to deliver their drug payload. Hence, their performance is often unsatisfactory in cancers where multiple epitopes need to be engaged for optimal cellular internalisation. In this context, bispecific antibodies (bsAbs) that simultaneously target two distinct antigens or two distinct epitopes of the same antigen offer a promising alternative in antibody-based drug delivery. This review describes the recent advances in developing bsAb-based drug delivery strategies, encompassing the direct conjugation of drug to bsAbs to form bispecific antibody-drug conjugates (bsADCs) and the surface functionalisation of nanoconstructs with bsAbs to form bsAb-coupled nanoconstructs. The article first details the roles of bsAbs in enhancing the internalisation and intracellular trafficking of bsADCs with subsequent release of chemotherapeutic drugs for an augmented therapeutic efficacy, particularly among heterogeneous tumour cell populations. Then, the article discusses the roles of bsAbs in facilitating the delivery of drug-encapsulating nanoconstructs, including organic/inorganic nanoparticles and large bacteria-derived minicells, that provide a larger drug loading capacity and better stability in blood circulation than bsADCs. The limitations of each type of bsAb-based drug delivery strategy and the future prospects of more versatile strategies (e.g., trispecific antibodies, autonomous drug delivery systems, theranostics) are also elaborated.
    Matched MeSH terms: Humans
  18. Adeel A, Kee DMH, Qasim Daghriri Y
    Front Public Health, 2022;10:965278.
    PMID: 36339231 DOI: 10.3389/fpubh.2022.965278
    PURPOSE: We seek to understand whether relationship conflicts of co-workers affect the validation of creative ideas or not. Furthermore, what boundary conditions may help prevent potential drawbacks of relationship conflicts with co-workers to validate their creative ideas?

    DESIGN/METHODOLOGY/APPROACH: The proposed model was tested by using multisource data collected across two points in time from final year nursing students and medical dispensers of five nursing colleges of south-Punjab, Pakistan. The model was analyzed with Mplus for random coefficient models for direct effects, mediated moderation, and UCINET for central tendency of creative idea validation.

    FINDINGS: It was found that relationship conflicts with co-workers were negatively related to their validation of creative ideas. However, supervisory support and team affective tone independently attenuate the negative effects of relationship conflicts with co-workers and the validation of creative ideas. Positive affective tone emerged as a positive predictor of creative idea validation. Additionally, positive affective tone as affected by supervisory support attenuated the negative relationship between relationship conflicts with co-workers and their validation of creative ideas. Finally, the relationship between relationship conflicts with co-workers and their validation of creative ideas is more positive when both supervisory support and positive affective tone are high, however, low otherwise.

    PRACTICAL IMPLICATIONS: This study will help policymakers understand what might be hindering the transfer of creative ideas to influential others (Leaders, Managers, etc.) and what they need to do to enhance the creative pool of their organizations. Although developing an environment that fosters creativity is important for the organizations, developing strategies to manage relationship conflicts related to supervisory support and positive affective tone will help transfer creative ideas to higher offices even when there are dysfunctional conflicts.

    ORIGINALITY/VALUE: This research shifts the conventional focus of understanding creativity from the generating side by explaining challenges that creative individuals face in promoting creative ideas with more criticism and offense by coworkers than support. Also, the interplay between the relationship conflicts with co-workers and team affective tone affected by supervisory support for validation of creative ideas enhanced our understanding of the boundary conditions of relationship conflict and creative idea validation.

    Matched MeSH terms: Humans
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