Displaying publications 81 - 100 of 8473 in total

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  1. CHARACTERISTICS OF PATIENTS AND ILLNESSES SEEN AT TAMPOI MENTAL HOSPITAL; (A PRELIMINARY REPORT)
    TAN ES
    Med J Malaysia, 1964 Sep;19:3-7.
    PMID: 14240061
  2. Fulltext Breastfeeding practice in Klang district
    Tan KL
    Malaysian Journal of Public Health Medicine, 2007;7(2):10-14.
    MyJurnal
    This was a cross-sectional study which attempt; tu determine the prevalence of breastfeeding practice among mothers in Klcmg district, Malaysia and the association between lyrcastfceding practice with place of delivery and knowledge 011 breastfeeding. Dam collection was conducted by face·t0·face interview using a premuded structured questionnaire amung mothers with fum month old infants only who attended che government clinics in Klang, A total of 508 mothers were recruited ima the study. The study showed 92.9% ever breastfed, 55.1% exclusively lareastfed fur one month and 20.5% exclusively bremtfcd for four months. Malays brcastfed the most, while
    Chinese the least. Breastfeeding was more common among mothers with lower education, delivered in government hospitals and with good knowledge on breastfeeding. A high proportion uf mothers in Klang wouki initiate breastfeeding and the [neualence of exclusive breastfeeding was comparable nationally. Breastfeeding was associated with mothers delivered in government hospitals and with good knowledge on breastfeeding. Continued promotional efforts targeted at private hospitals with information on breastfeeding should result in further increase in breastfeeding prevalence.
    Study site: Klinik Kesihatan, Kelang district, Selangor, Malaysia
  3. Inhibition of hepatitis B virus assembly with synthetic peptides derived from the viral surface and core antigens
    Tan WS
    J Gen Appl Microbiol, 2002 Apr;48(2):103-7.
    PMID: 12469306
    The long surface antigen (L-HBsAg) of hepatitis B virus (HBV) plays a central role in the production of infectious virions. During HBV morphogenesis, both the PreS and S domains of L-HBsAg form docking sites for the viral nucleocapsids. Thus, a compound that disrupts the interaction between the L-HBsAg and nucleocapsids could serve as a therapeutic agent against the virus based upon inhibition of morphogenesis. Synthetic peptides correspond to the binding sites in L-HBsAg inhibited the association of L-HBsAg with core antigen (HBcAg). A synthetic peptide carrying the epitope for a monoclonal antibody to the PreS1 domain competed weakly with L-HBsAg for HBcAg, but peptides corresponding to a linear sequence at the tip of the nucleocapsid spike did not, showing that the competing peptide does not resemble the tip of the spike.
  4. Is the Singapore-Malaysia Congress of Medicine relevant in an age of specialisation?
    Tan WC
    Ann Acad Med Singap, 1999 May;28(3):315.
    PMID: 10575512
  5. Mock grant application roleplay as an alternative to lab-based activities in molecular biology
    Tan HS
    Biochem Mol Biol Educ, 2021 07;49(4):518-520.
    PMID: 33826248 DOI: 10.1002/bmb.21515
    Many universities resort to online teaching due to COVID-19 pandemic. It is a challenging endeavor, especially in Molecular Biology courses that require lab access. Mock grant application roleplay is one alternative to lab-based activities. Students are engaged in three aspects: (i) targeted literature review, (ii) research proposal writing and (iii) 5-min project pitching. The design of this module is flexible and, other lab-based courses can adopt it. This module encourages undergraduate students to explore the lab techniques they learnt and concisely present their research proposal.
  6. Early (at 34-35 weeks) external cephalic version reduced the risk of non-cephalic (breech) presentation at birth but has no effect on risk of caesarean section
    Tan PC
    Evid Based Med, 2012 Apr;17(2):45-6.
    PMID: 21949255 DOI: 10.1136/ebm.2011.100125
  7. Short taxonomic review of little-known Phaneropterinae (Orthoptera: Tettigoniidae) from Malay Peninsula
    Tan MK
    Zootaxa, 2014;3826(2):329-40.
    PMID: 24990050 DOI: 10.11646/zootaxa.3826.2.3
    The taxonomy of three genera of little-known Phaneropterinae from Malay Peninsula (Singapore and Peninsular Malaysia) is reviewed: Cesasundana Koçak & Kemal, 2009, Elbenia Stål, 1876 and Macedna Karsch, 1891. One new species each from the genera Cesasundana and Elbenia are described from Singapore and Peninsular Malaysia respectively: Cesasundana lorniensis sp. n. and Elbenia fraser sp. n. Keys to species of Cesasundana and Elbenia are also included. The taxonomic position of monotypic genus Macedna is validated, male is redescribed and the female is described for the first time.
  8. Fulltext Down syndrome: multimodality imaging of associated congenital anomalies and acquired diseases
    Tan AP
    Med J Malaysia, 2013 Dec;68(6):482-9.
    PMID: 24632922
    Down syndrome (Trisomy 21) is the most common chromosomal abnormality among liveborn infants. It is the most frequent form of intellectual disability caused by a microscopically demonstrable chromosomal aberration. Management requires a multidisciplinary approach to the ongoing evaluation and monitoring for associated congenital anomalies and acquired disorders.Trisomy 21 is characterized by a variety of dysmorphic features, congenital anomalies and associated medical conditions. Knowledge of these associated conditions are important for clinicians involved in the management of these patients. Appropriate radiologic imaging with prompt, accurate interpretation plays an important role in the diagnosis and management of these diseases. The primary goal of this pictorial review is to unravel the radiological findings of these associated conditions.
  9. Review: calcium supplementation during pregnancy reduces the risk of pre-eclampsia
    Tan PC
    Evid Based Med, 2008 Jun;13(3):83.
    PMID: 18515630 DOI: 10.1136/ebm.13.3.83
  10. Fulltext Factors Associated with Non-exclusive Breastfeeding among 4-Week Post-partum Mothers in Klang District, Peninsular Malaysia
    Tan KL
    Malays J Nutr, 2009 Mar;15(1):11-8.
    PMID: 22691800 MyJurnal
    This is a cross-sectional study which investigated the association between non-exclusive breastfeeding and maternal, paternal, obstetric and infant factors. Data on maternal, paternal, obstetric and infant factors were collected through face-to-face interview using a structured questionnaire from 498 mothers with four-week-old infants who attended government clinics in Klang district between 17 and 28 July 2006. The prevalence of non-exclusive breastfeeding at four weeks was 45.8%. Factors significantly associated with non-exclusive breastfeeding at four weeks included Indian ethnic mother (OR = 4.06), working mother (OR = 3.55), mother from high household income (OR = 1.90), mother who smokes (OR = 7.27), primiparous (OR = 1.97), infant not sharing a bed with mother (OR = 1.75) and infant born prematurely (OR = 7.69). Identification of risk factors should assist in targeting women who are at increased risk of non-exclusive breastfeeding.
  11. Optimization of peritoneal dialysis services through research activities
    Tan SY
    Perit Dial Int, 2008 Jun;28 Suppl 3:S49-52.
    PMID: 18552263
    Although peritoneal dialysis (PD) is an effective alternative to hemodialysis (HD) and indeed, in terms of survival, superior to HD in first year of dialysis, the utilization rate for PD remains low. Although the utilization rate of PD varies considerably, the worldwide penetration rate appears to be falling. Still, in rapidly developing countries such as China, the PD penetration rate is rising-an encouraging sign. Clearly, considerable room for improvement remains, particularly with the take-on rate of PD, and one of the potentially influential factors is the role of research activities in improving both the quantity and quality of life of patients on PD.
  12. Bed sharing among mother-infant pairs in Klang district, Peninsular Malaysia and its relationship to breast-feeding
    Tan KL
    J Dev Behav Pediatr, 2009 Oct;30(5):420-5.
    PMID: 19827222 DOI: 10.1097/DBP.0b013e3181ba083a
    OBJECTIVE: The aim of the study was to determine the prevalence of mother-infant bed sharing in Klang district, Peninsular Malaysia and to identify factors associated with bed sharing.

    METHOD: This was a cross-sectional study involving 682 mother-infant pairs with infants up to 6 months attending government clinics in Klang district, Peninsular Malaysia. Data were collected by face-to-face interview using a pretested structured questionnaire for a 4-month period in 2006. Data regarding maternal, paternal, obstetric, infant, occupancy, breast-feeding characteristics, and bed-sharing practice were collected. Data on bed sharing were based on practice in the past 1-month period. Bed sharing was defined as an infant sharing a bed with mother, and infant must be within arms reach from the mother, whereas a bed was defined as either a sleeping mattress placed on a bed frame or placed on the floor. The prevalence of bed sharing was estimated. Relationship and magnitude of association between independent factors and bed sharing were examined using odds ratio and 95% confidence interval. Logistic regression analysis was used to control for confounding factors.

    RESULTS: The prevalence of bed sharing among mothers with infants aged between 1 and 6 months was 73.5% (95% confidence interval: 70.0-76.7). In multivariate analysis, urban/rural differences, mothers' ethnicity, occupation, family income, husbands' support on bed sharing, number of children younger than 12 years staying in the house, and breast-feeding were associated with bed sharing.

    CONCLUSIONS: These factors need to be considered in analyzing the overall risks and benefits of bed sharing, paying attention to breastfeeding practices.
  13. Controversy of proton pump inhibitor and clopidogrel interaction: a review
    Tan HJ
    J Dig Dis, 2010 Dec;11(6):334-42.
    PMID: 21091895 DOI: 10.1111/j.1751-2980.2010.00466.x
    A proton pump inhibitor (PPI) is often co-prescribed with clopidogrel to reduce the gastrointestinal risk of bleeding ulcers in patients following acute coronary syndrome or a stent implant. However, the safety issue of such practice has been scrutinized after some studies reporting an increased incidence of cardiovascular events and mortality, although there have also been contrary research reports. This has lead to a warning statement from the US Food and Drug Administration cautioning the concomitant use of PPI and clopidogrel. This review examines the evidence of PPI as gastroprotective agent, histamine H(2) antagonists as an alternative therapy, the influence of PPI on the antiplatelet effect of clopidogrel, and the controversies of various studies.
  14. Isolation and characterization of the thrombin-like enzyme from Cryptelytrops purpureomaculatus venom
    Tan NH
    Comp Biochem Physiol C Toxicol Pharmacol, 2010 Jan;151(1):131-6.
    PMID: 19770070 DOI: 10.1016/j.cbpc.2009.09.002
    A thrombin-like enzyme, purpurase, was purified from the Cryptelytrops purpureomaculatus (mangrove pit viper) venom using high performance ion-exchange and gel filtration chromatography. The purified sample (termed purpurase) yielded a homogeneous band in SDS-polyacrylamide gel electrophoresis with a molecular weight of 35,000. The N-terminal sequence of purpurase was determined to be VVGGDECNINDHRSLVRIF and is homologous to many other venom thrombin-like enzymes. Purpurase exhibits both arginine ester hydrolase and amidase activities. Kinetic studies using tripeptide chromogenic anilide substrates showed that purpurase is not fastidious towards its substrate. The clotting times of fibrinogen by purpurase were concentration dependent, with optimum clotting activity at 3mg fibronogen/mL. The clotting activity by purpurase was in the following decreasing order: cat fibrinogen>human fibrinogen>dog fibrinogen>goat fibrinogen>rabbit fibrinogen. Reversed-phase HPLC analysis of the products of action of purpurase on bovine fibrinogen showed that only fibrinopeptide A was released. Indirect ELISA studies showed that anti-purpurase cross-reacted strongly with venoms of most crotalid venoms, indicating the snake venom thrombin-like enzymes generally possess similar epitopes. In the more specific double-sandwich ELISA, however, anti-purpurase cross-reacted only with venoms of certain species of the Trimeresurus complex, and the results support the recent proposed taxonomy changes concerning the Trimeresurus complex.
  15. Expected quality factor of a simple tuned oscillator
    Tan KH
    IEEE Trans Ultrason Ferroelectr Freq Control, 2011 May;58(5):886-99.
    PMID: 21622044 DOI: 10.1109/TUFFC.2011.1889
    A positive feedback system oscillating under self-sustained mode is shown to have an extremely high gain. Modeled as one port, the expected Q is much higher than the loaded Q-factor of the resonator. With just thermal noise present, random phase/frequency deviation is linear. Centered about the oscillator frequency omega/(0), noise frequency on both sides is more amplified with decreasing separation distance. Ultimately, frequency pulling may result in synchronous locking with hysteresis, which occurs because a real oscillator displays a truncated limiting curve. Once locked onto a signal, smaller levels are ignored. A new approach to the design and characterization of a simple tuned oscillator is offered: According to the phenomenon of injection locking, there exists an expected quality factor relating the shape of the truncated limiting curve to an ideal curve. In this paper, synthesis and innovative analytical methods of academic interest are revealed: 1) application of the transducer loss method is revised to establish a new method for oscillator characterization; 2) a transparent method of normalizing a two-port network in the presence of white noise is developed; and 3) in quartz crystal controlled oscillators, characterization of the noise originating from an equivalent noise-resistance determined from parameter of the quartz crystal is proposed. It is shown that the two-port model can also be approximated on a one-port basis. In conclusion, a sample of closed-form estimation of expected Q-factor order of magnitude of piezoelectric resonator oscillators is calculated.
  16. Fulltext Factors associated with exclusive breastfeeding among infants under six months of age in peninsular malaysia
    Tan KL
    Int Breastfeed J, 2011 Feb 02;6(1):2.
    PMID: 21284889 DOI: 10.1186/1746-4358-6-2
    BACKGROUND: Breastfeeding is accepted as the natural form of infant feeding. For mothers to be able to breastfeed exclusively to the recommended six months, it is important to understand the factors that influence exclusive breastfeeding. The aim of the study was to identify factors associated with exclusive breastfeeding in Peninsular Malaysia.

    METHODS: This was a cross-sectional study involving 682 mother-infant pairs with infants up to six months attending maternal and child health section of the government health clinics in Klang, Malaysia. Data were collected by face-to-face interviews using a pre-tested structured questionnaire over 4 months in 2006. Data on breastfeeding were based on practice in the previous one month period. Logistic regression was used to assess the independent association between the independent variables and exclusive breastfeeding adjusting for infant age.

    RESULTS: The prevalence of exclusive breastfeeding among mothers with infants aged between one and six months was 43.1% (95% CI: 39.4, 46.8). In the multivariate model exclusive breastfeeding was positively associated with rural residence, Malay mothers, non-working and non-smoking mothers, multiparous mothers, term infants, mothers with husbands who support breastfeeding and mothers who practice bed-sharing.

    CONCLUSIONS: Interventions that seek to increase exclusive breastfeeding should focus on women who are at risk of early discontinuation of breastfeeding.

  17. Extracorporeal liver support and the role of liver transplantation
    Tan SS
    Med J Malaysia, 2005 Jul;60 Suppl B:133-5.
    PMID: 16108194
  18. The relationship of health beliefs and complication prevention behaviors of Chinese individuals with type 2 diabetes mellitus
    Tan MY
    Diabetes Res Clin Pract, 2004 Oct;66(1):71-7.
    PMID: 15364164 DOI: 10.1016/j.diabres.2004.02.021
    This study aimed to identify the relationship of health beliefs and complication prevention behaviors among Chinese individuals with Type 2 Diabetes Mellitus in Malaysia. A correlation study using the Health Belief Model (HBM) framework was undertaken with 128 Chinese subjects with Type 2 Diabetes of both gender, mean age 60.5 +/- 8.42 years from one urban hospital and four rural health centers. Research tool was a 60-item questionnaire with responses recorded on 5-point Likert scale. Data was analyzed with descriptive statistics, Spearmen correlation and Mann-Whitney U-test. The majority of the subjects had less than 6 years of education. Seventy-two percent of them were aware of diabetes complications and its risk factors. However, few subjects practiced complication preventive measures because of lack of perceived seriousness of diabetes and lack of perceived susceptibility to diabetes complications. There were significant correlations between complication prevention behaviors and perceived severity (P < 0.05), perceived susceptibility (P < 0.05 ) and perceived barrier (P < 0.05 ); subjects' education level and perceived severity (P < 0.05), perceived susceptibility (P < 0.05) and complication prevention behavior (P < 0.05). There was no significant correlation between health beliefs and settings; genders; disease duration and treatment mode. In conclusion, poor complication preventive behavior among the subjects was associated with lack of perceived seriousness of diabetes and lack of perceived susceptibility to diabetes complications.
  19. Fulltext Degenerated retained product of conception misdiagnosed as invasive trophoblastic disease
    Tan AP
    Med J Malaysia, 2015 Apr;70(2):100-1.
    PMID: 26162386
    Retained products of conception (POC) complicates nearly 1% of all pregnancies, occurring with greater frequency after termination of pregnancy than after vaginal or caesarean delivery. The presenting symptoms of retained products of conception are similar to those of gestational trophoblastic disease and hence accurate differentiation is difficult based on clinical history and physical examination alone. The distinction between these two entities is extremely important as the treatment differs dramatically. These patients often need to be further evaluated with either ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI) of the pelvis. Hence, radiologists play a vital role in clinching the diagnosis although at times it may be challenging to differentiate between these two entities. Herein, we discuss a case of degenerated retained products of conception which was initially misdiagnosed as invasive trophoblastic disease in a 41-year-old woman whom last known pregnancy was 10 years ago.
  20. Development and psychometric properties of a scale assessing the needs of caregivers of children with disabilities
    Tan SH
    Disabil Health J, 2015 Jul;8(3):414-23.
    PMID: 25595295 DOI: 10.1016/j.dhjo.2014.11.003
    BACKGROUND: Planning and evaluation of health care services for children with disabilities requires information on their caregivers' needs.
    OBJECTIVE: This paper aims to present the development and psychometric properties of the Caregiver Needs Scale (CNS), a scale assessing the needs of caregivers of children with disabilities aged 0-12 years in Malaysia.
    METHODS: Development of the scale went through a multistage process of literature review, modification of an existing instrument, input from experts and feedback from service users. Literature review identified content domains and response options. An exploratory factor analysis (EFA) was undertaken to identify subscales of caregiver needs. The internal consistency reliability, convergent validity and discriminant validity of the new scale were examined.
    RESULTS: 273 caregivers of children with disabilities completed the fielded questionnaire. EFA revealed 4 subscales of caregiver needs: need for 'Help getting information and services for the child,' 'Help coping with the child,' 'Help getting child care' and 'Help with finances.' Three items with factor loading <0.4 were dropped. Cronbach's alpha coefficients of the subscales ranged from 0.813 to 0.903. Total CNS score correlated with number of child's needs and unmet needs. The score was also higher in families with financial and employment problems.
    CONCLUSION: A new instrument was developed to assess the needs of caregivers of children with disabilities for use in the Malaysian population. The CNS showed satisfactory psychometric properties but further examination is warranted to confirm its validity.
    KEYWORDS: Caregivers; Children with disabilities; Instrument development; Needs assessment; Psychometric properties
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