Calcium carbonate (CaCO3
) plays a crucial role in influencing the growth of osteoblast. This study was conducted
to compare the performance of alginate/cockle shell powder nanobiocomposite (nCP) bone scaffold developed from
naturally occurring CaCO3 with alginate/calcium carbonate (CC) bone scaffold developed using synthetic CaCO3. The
study compares the performance of the scaffold in supporting the growth of osteoblast through in vitro evaluations as
well as initial biocompatibility observations through in vivo methods. Both scaffolds were developed using the mixture
of 40% alginate solution with either 60% of nano cockle shell powder or synthetic CaCO3 to obtain a three dimensional
scaffold structure. In vitro evaluation on calcium release and ALP enzyme activity was conducted on both scaffolds seeded
with osteoblast on day’s three, five and seven using commercial kits. In vivo observations using histological methods
were further conducted by implanting osteoblast seeded scaffold subcutaneously at the dorsum of 8 albino mice for 21
days. Findings from in vitro studies showed a significant increase (p < 0.05) in the release of calcium and ALP enzyme
activity in nCP scaffolds on day seven compared to days three and five of CC scaffold. Histological observations using
H&E and von Kossa staining showed infiltration and proliferation of osteoblast on both scaffolds as well as early stage
bone tissue formation. Formation of new blood vessels within the scaffolds was also observed in nCP scaffold. Both the
developed scaffolds were noted to support osteoblast growth and new tissue formation with better potentials displayed by
nCP scaffolds comparatively. This study shows that naturally occurring CaCO3 obtained from cockle shells in the form
of nano powder has good potentials to be used as a biomaterial for bone tissue engineering applications.
The study aims to investigate the effect of injection moulding parameters on plastic flows behaviour of the multiple-cavity polyethylene terephthalate (PET) cylindrical containers via injection moulding process. The motivation of this study is to present an alternative manufacturing solution to make cylindrical type containers that are commonly used in packaging beverages, such as the 330 ml standard size for packaging carbonated soft drink. The PET cylindrical container was modelled using CATIA drawing software and the injection moulding simulation process was done via Moldflow software. The investigation was done by varying two significant moulding parameters; the material melt temperature and the mould temperature. The effects of these two parameters on the PET plastic flow behaviour were studied. In particular, the simulations of the model were analysed and focused on the mould filling time as well as the moulded PET cylindrical container’s shrinkage occurrence. Three types of mould cavities structure were understudied; single-cavity, four-cavity and eight-cavity. Results show that the eight-cavity mould yielded higher production rate. The simulation results indicated that the production rate of 4-cavity and 8-cavity mould increased by 258.5% and 578.8% respectively. It was observed by increasing the melting temperature, the mould filling time is shorter and as a result, the production rate has increased by 7.75% per °C. But with this Mouldflow setting, the volumetric shrinkage and the maximum deflection have been significantly affected; increased by 23.15% and 29.26% respectively. The mould filling time and maximum deflection did not show a steady trend line however, the volumetric shrinkage increased by 7.28% per °C.
Haemolytic Disease of Foetus and Newborn (HDFN) and Haemolytic Transfusion Reaction (HTR) may occur due to antibodies against Kidd antigen. In Malaysia, the prevalence of RBC alloimmunization due to Kidd antibody for cases of HDFN and HTR have been reported [1-2] however there is insufficient data in Hospital Umum Sarawak (HUS).The aim of this study is to determine whether Kidd alloimmunization causes HDFN and HTR. Indirectly categorize Kidd phenotype blood in regular blood donors.
The molecular biology knowledge in β-thalassaemia is limited due to the involvement of various erythropoeitic processes where the genetic information is lack due to nucleus ejection throughout the maturation of red blood cell activities concurrence with the accumulation of haemoglobin. Nucleated red blood cells (NRBCs) are typically found in peripheral blood (PB) of β-thalassaemia transfusion dependent patients and abundant in post splenectomy (Fig. 1A) [1]. The presence of NRBCs will provide further understanding on the molecular aspect of ineffective erythropoiesis in β-thalassaemia patients. Therefore, the objectives of this study were to isolate the NRBCs using CD71 magnetic beads from PB of β-thalassaemia patients and to compare the quantity of NRBCs enriched between non-splenectomised transfusion dependent and post-splenectomised transfusion dependent β-thalassaemia patients.
Iron deficiency anemia is the most common form of anemia in pregnancy. The present study was carried out to determine the prevalence of antenatal anemia and iron deficiency in the Malaysian population and its correlation with sociodemographic and obstetric profile. It was a cross-sectional study conducted at an urban health clinic over a period of six months. A single blood sample was drawn from apparently healthy pregnant mothers at antenatal booking and sent for laboratory assessment of full blood count and serum ferritin as screening tools for anemia and iron status. SPSS version 19.0 was used for statistical analyses. The results showed that out of 250 subjects, 43.6% had anemia and 31.6% had iron deficiency. Whilst 47.7% of subjects with anemia were iron deficient, 19.1% of subjects without anemia were also iron deficient. Serum ferritin correlated negatively with period of gestation at booking (p<0.001), with 77.6% of these women not having prior iron supplements. Serum ferritin was also significantly lower among grandmultiparae (p=0.01). Iron deficiency was significantly (p=0.024) more common among Indians (42.5%) compared to Malays (33.5%) and Chinese (13.0%). In conclusion, continuation of the current practice of routine antenatal iron supplementation is still warranted and justifiable in Malaysia as there is high prevalence of iron deficiency in pregnancy not only in the presence of anemia but also in the presence of normal hemoglobin values. Keywords: anaemia, ferritn, pregnancy
Objective: ADHD is a complex neurobiological disorder, which required tactful
intervention. Besides pharmacotherapy, there is still limited information in
addressing the efficacy of cognitive behavior therapy (CBT) for treating this
developmental disorder.
Methods: We report a case of late diagnosed of ADHD
whose facing difficulty to cope with her undergraduate degree. She has to repeat
her semester examination due to lack of attention. Denial was seen in both
patient and family in accepting the diagnoses, and posed roadblock for
successful intervention.
Results: Six sessions of CBT were conducted, coupled
with psycho education for both the family and patient. Consultation from the
university’s management helped her to accept and cope with her ADHD
symptoms, i.e. attention and impulsivity. The patient showed improvement
following this intensive bio-psycho-social intervention.
Conclusion: The short
duration of CBT was found suitable to be adapted and implemented in young
adult ADHD.
The aim of this study is to examine the effect of surface treatments involving shot blasting and paste boronizing on the microstructure, microhardness and density of 316L stainless steel. Shot blasting using glass beads was carried out prior to paste boronizing at fix boronizing temperature and soaking time of 850°C and 8 hours respectively. The results show paste boronizing produces boride layers that consist of FeB and Fe2B on the surface of 316L stainless steel with high hardness. Shot blasting on the other hand creates grain refinement on the metal’s surface which increases boron diffusion into the surface and improves the case depth of boride layers formed and also its hardness. Higher shot diameter used in shot blasting also influence in improving the case depth of boride layers produced and hardness of 316L stainless steel. The effect of shot blasting using a higher shot diameter and paste boronizing reduces the density of 316L stainless steel very slightly.
In the electrodeposition system, adding saccharin alters the properties of the metal deposits by changing the electrode kinetics of the deposited surface. In this study, nanocrystalline cobalt-iron (CoFe) coating was synthesised using the electrodeposition technique with different saccharin concentrations. The results obtained showed that the coating thickness increased while the grain size decreased from 51 nm to 40 nm when the saccharin concentration increased from 0 to 2 g/L. The nanocrystalline CoFe coating produced with 2 g/L of saccharin concentration resulted in the smallest particle size of 71.22 nm and the highest microhardness of 251.86 HV. From the salt spray test (24 and 48 hours) it was found that the use of saccharin at higher concentration of 2 g/L improves the corrosion resistance of the nanocrystalline CoFe coating significantly due to the change of surface morphology as well as the decrease in grain size.
Aluminium foam tube is a metal that consists of porous medium with special characteristics such as good energy absorption, good heat transfer and high thermal conductivity. These make it suitable to be used in a wide range of applications such as in heat exchangers. The aim of this project is to identify and analyse mechanical behaviour and microstructure aluminium foam tube produced and fabricated with infiltration method with vacuum-gas. The density of aluminium foam tube was also determined and an average aluminium foam tube with porosity 50% - 80% with the average NaCl particle size 2mm, 3mm and 4mm was produced. Foams with porosity 60%-75% NaCl has higher energy absorption. These was based on foam structure, density and maximum compressive load test result.
This paper presents adaptive particle swarm optimization for solving non-convex economic dispatch problems. In this study, a new technique was developed known as adaptive particle swarm optimization (APSO), to alleviate the problems experienced in the traditional particle swarm optimisation (PSO). The traditional PSO was reported that this technique always stuck at local minima. In APSO, economic dispatch problem are considered with valve point effects. The search efficiency was improved when a new parameter was inserted into the velocity term. This has achieved local minima. In order to show the effectiveness of the proposed technique, this study examined two case studies, with and without contingency.
Rapid urbanisation and industrialisation have had an adverse and deep impact on the environment contributing to global warming and climate change. These thermal environmental problems can be even more challenging to people living in regions with warm and humid climatic conditions throughout the year, such as Malaysia. This paper analyses wind characteristics and outdoor thermal comfort index at the hottest temperatures based on data recorded hourly between 2012 and 2014 for two cities in East Malaysia, namely Kuching (Sarawak) and Kota Kinabalu (Sabah). Wind characteristics were analysed using only wind velocity and direction, while the level of outdoor thermal comfort was measured using Universal Thermal Climate Index (UTCI). The results showed that hourly average wind velocities for Kuching and Kota Kinabalu were 1.84 m/s and 2.15 m/s respectively while the highest average wind velocities was 10.1 m/s and 12.4 m/s respectively. No wind movement (i.e. 0 m/s) was recorded for both locations. The prevailing annual wind flow is generally from South-Southeast (150°) in Sarawak and from East-Southeast (110°) in Sabah. It was also found that both Kuching and Kota Kinabalu experienced strong and extreme heat stress conditions with UTCI levels of 44.8°C and 49.8°C respectively. Thus, it can be concluded that, East Malaysia faces strong and extreme heat stress conditions. This study is an original contribution on the subject of outdoor thermal environment in Malaysia, Further research to better understand outdoor thermal environmental problems is recommended.
This paper presents the development of a Graphical User Interface (GUI)
for calculating the sum of nail-fold (NF) and distal interphalangeal joint
(DIP) ratios for all ten fingers. The sum of NF:DIP ratios for all ten fingers
leads to the Digital Index (DI) that was used as the measure for identifying
and determining the presence of finger clubbing symptom. This GUI system
was developed to serve as a simple and user-friendly interface for clinicians
to calculate DI value of patients in a busy clinic practice. It is also equipped
with the capability to keep the patient’s past diagnosis medical check-up
data for future monitoring purposes. The result shows that the developed
system helps the clinicians to perform calculation of DI value and identify
the presence of finger clubbing in a very short time. The average time taken
to measure both NF and DIP circumferences using Finger Clubbing Meter,
and to compute DI values using Digital Index Evaluation System (DIES)
interface is 6:36 ± 1:24 minutes (Mean ± SD) .This system is expected to
contribute in detecting the finger clubbing problem at early stage of so the
treatment can be performed immediately.
The objective of this study was to compare the extraction of peanut skin using supercritical carbon dioxide extraction and soxhlet extraction in terms of oil yield and catechin. For supercritical fluid extraction, the temperatures used were 40 and 70°C, while pressure used was 10 and 30 MPa, the flow rate was CO2 3 mL/min, and the concentration of co-solvents was 0 and 5%. Meanwhile, for soxhlet extraction, the extraction time was 6 hr with ethanol, hexane and water as the solvents. The results showed that soxhlet extraction gave the highest yield of extract (36.282%) using ethanol as solvent as compared with supercritical CO2 extraction (15.47%) at pressure 30 MPa, temperature 70°C and 5% concentration of co-solvent. This study reveals that the extracts from SC-CO2 extraction yielded the highest amount of catechin (208.73 µg/g sample) compared with that yielded in the soxhlet extraction (42.24 73 µg/g sample) with distilled water as a solvent analysed with High Performance Liquid Chromatography (HPLC).
Electrocardiography (ECG) sensors play a vital role in the Internet of Medical Things, and these sensors help in monitoring the electrical activity of the heart. ECG signal analysis can improve human life in many ways, from diagnosing diseases among cardiac patients to managing the lifestyles of diabetic patients. Abnormalities in heart activities lead to different cardiac diseases and arrhythmia. However, some cardiac diseases, such as myocardial infarction (MI) and atrial fibrillation (Af), require special attention due to their direct impact on human life. The classification of flattened T wave cases of MI in ECG signals and how much of these cases are similar to ST-T changes in MI remain an open issue for researchers. This article presents a novel contribution to classify MI and Af. To this end, we propose a new approach called deep deterministic learning (DDL), which works by combining predefined heart activities with fused datasets. In this research, we used two datasets. The first dataset, Massachusetts Institute of Technology-Beth Israel Hospital, is publicly available, and we exclusively obtained the second dataset from the University of Malaya Medical Center, Kuala Lumpur Malaysia. We first initiated predefined activities on each individual dataset to recognize patterns between the ST-T change and flattened T wave cases and then used the data fusion approach to merge both datasets in a manner that delivers the most accurate pattern recognition results. The proposed DDL approach is a systematic stage-wise methodology that relies on accurate detection of R peaks in ECG signals, time domain features of ECG signals, and fine tune-up of artificial neural networks. The empirical evaluation shows high accuracy (i.e., ≤99.97%) in pattern matching ST-T changes and flattened T waves using the proposed DDL approach. The proposed pattern recognition approach is a significant contribution to the diagnosis of special cases of MI.
The human foot serves as an important part to support
the body weight and accounts for the majority of our
movements. A mangled limb involves injury to at least
three out of four systems, namely the soft tissues, nerves,
blood supply and bone. While amputation is indicated in
some cases of mangled limb, with proper planning, limb
salvaging surgical management is also a viable option.
Special consideration to the skeletal stabilization, control
of infection, vascular status and soft tissue coverage is
paramount to the success of limb salvaging surgery. We
present a case of mangled limb which was successfully
treated with limb salvaging surgical management. Initial
debridement, Kirschner wires insertion and cross ankle
external fixation were used for skeletal stabilization. An
antibiotic spacer was inserted for local antibiotic and to
maintain the length left due to the loss of medial and
intermediate cuneiform bones. The anterior tibialis
artery and its venae comitantes were utilized for free
vascularized fibular graft to provide bony reconstruction
as well as soft tissue coverage for the mangled foot.
Forensic odontology plays an important role in human identification and dental age estimation is an integral part of this process. The aim of the study was to investigate the association between chronological age and pulp/tooth volume ratio in a Malaysian population (Malays and Chinese) from cone-beam computed tomography (CBCT) scans, enhanced with Mimics software. Three hundred CBCT scans of 153 males and 147 females, aged between 16 and 65 years were divided into 5 age groups. Volumetric analysis of the pulp/tooth ratio was performed in maxillary left canines, maxillary right canines and maxillary right central incisors. Simple linear regression and Pearson correlation analysis indicated the strongest coefficient of correlation (R) values for maxillary right central incisors (0.83) followed by maxillary right canines (0.74) and maxillary left canines (0.73). Fisher's Z test indicated that dental age estimation is gender independent. The derived regression equations were further validated on an independent group of 126 teeth. The results indicated mean absolute error (MAE) values of 6.48 and 8.58 years for maxillary right central incisors and maxillary canines respectively. It was also noticed that MAE values were higher among the age groups ranging from 46 to 65 years. This study showed that a volumetric change in the pulp cavity with age is a valuable assessment method for dental age estimation among Malaysian population.
This social psychology study sought to understand how the inability of former drug addicts controlling
interpersonal conflict that occurs in the community resulted in relapse or back to their addiction. A
qualitative phenomenological approach was taken to conduct interviews with former drug addicts that
are participating in a rehab program in Cure and Care Service Centre, Kuala Pilah, Negeri Sembilan,
Malaysia. Eight informants were consented and interviewed. Purposive sampling was used and
responses were analyzed thematically. These themes included the issue of labeling drug addicts as
convicts, isolation from the community and restricted from participating in community-based
programs. Researcher suggests related agencies to work with rehabilitation officers in restructuring the
rehabilitation learning module and improve the interpersonal conflict management module. Therefore,
it is hoped that in the future, former drug addicts would be capable to manage interpersonal conflict
and simultaneously avoid from recidivism in addiction.
Tawaf ritual performed during Hajj and Umrah is one of the most unique, large-scale multi-cultural events in this modern day and age. Pilgrims from all over the world circumambulate around a stone cube structure called Ka’aba. Disasters at these types of events are inevitable due to erratic behaviours of pilgrims. This has prompted researchers to present several solutions to avoid such incidents. Agentbased simulations of a large number of pilgrims performing different the ritual can provide the solution to obviate such disasters that are either caused by mismanagement or because of irregular event plans. However, the problem arises due to limited parallelisation capabilities in existing models for concurrent execution of the agent-based simulation. This limitation decreases the efficiency by producing insufficient frames for simulating a large number of autonomous agents during Tawaf ritual. Therefore, it has become very necessary to provide a parallel simulation model that will improve the performance of pilgrims performing the crucial ritual of Tawaf in large numbers. To fill in this gap between large-scale agentbased simulation and navigational behaviours for pilgrim movement, an optimised parallel simulation software of agent-based crowd movement during the ritual of Tawaf is proposed here. The software comprises parallel behaviours for autonomous agents that utilise the inherent parallelism of Graphics Processing Units (GPU). In order to implement the simulation software, an optimized parallel model is proposed. This model is based on the agent-based architecture which comprises agents having a reactive design that responds to a fixed set of stimuli. An advantage of using agents is to provide artificial anomaly to generate heterogeneous movement of the crowd as opposed to a singular movement which is unrealistic. The purpose is to decrease the execution time of complex behaviour computation for each agent while simulating a large crowd of pilgrims at increased frames per second (fps). The implementation utilises CUDA (Compute Unified Device Architecture) platform for general purpose computing over GPU. It exploits the underlying data parallel capability of an existing library for steering behaviours, called OpenSteer. It has simpler behaviours that when combined together, produces more complex realistic behaviours. The data-independent nature of these agent-based behaviours makes it a very suitable candidate to be parallelised. After an in-depth review of previous studies on the simulation of Tawaf ritual, two key behaviours associated with pilgrim movement are considered for the new model. The parallel simulation is executed on three different high-performance configurations to determine the variation in different performance metrics. The parallel implementation achieved a considerable speedup in comparison to its sequential counterpart running on a single-threaded CPU. With the use of parallel behaviours, 100,000 pilgrims at 10 fps were simulated.
The control of cost and time in construction projects is one of the most important issues in construction since the emergence of the construction industry. A successful project should meet not only quality output standards, but also time and budget objectives. The management and control of cost and time in construction is fundamental in every project. An effective cost and time management and control technique for construction projects is important in managing risk of cost overrun and delay in completion of projects. Construction projects are becoming more complex as they now involve many stakeholders from different disciplines. The emergence of Building Information Model (BIM), an alternative technology is believed to solve issues related to project cost and time control as it efficiently increases collaboration between stakeholders. The aim of this paper is to review and summarise the causes of delay and cost overrun in construction industries, which are the main causes of disputes and abandonment of projects in the industry. It was found that delays and cost overrun eat deep into the industry and leave the construction industry with a bad image for decades even with rapid advancement in technology. The review of the applications of BIM showed that most of the applications are geared towards minimising construction cost and time spent on projects. This means that the use of BIM in the management of construction projects has great impact on project cost and time.
Objective: The present study is designed to investigate the occurrence of Acanthamoeba in air ventilation and air-conditioning systems in selected buildings in Kuantan.
Methods: Acanthamoeba was isolated from dust samples taken from filters of air ventilation systems in selected buildings in Kuantan. The dusts were collected by using sterile cotton swabs, cultured in a xenic culture medium on non-nutrient agar (NNA) plates and incubated at 37º C. The plates were examined daily for any presence of Acanthamoeba cysts up to 7 days of incubation.
Results: Based on the results obtained, there were no cysts or trophozoites of Acanthamoeba successfully isolated from all 75 dust samples. After three days of incubation, all culture plates examined show negative findings.
Conclusions: The negative findings of this study were probably due to the limitations of the sampling method. It is recommended that future studies use the method proposed by National Institute of Occupational Safety and Health (NIOSH) for indoor air quality monitoring.