Displaying publications 1281 - 1300 of 25045 in total

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  1. Yusoff N, Anuar NN, Reza MF
    Malays J Med Sci, 2018 May;25(3):103-110.
    PMID: 30899191 MyJurnal DOI: 10.21315/mjms2018.25.3.10
    Background: Sex is a psychobiological factor that is important in the process of emotion. This study determines the effect of sex on the electropsychological process of various intensities of emotional arousal.

    Methods: In the Event-related Potential (ERP) session, electroencephalographic (EEG) data was recorded for 90 participants, 60% of whom were females. The participants responded to 30 universal emotional pictures, randomly chosen from the International Affective Picture System (IAPS), which were classified as invoking high, moderate, and low intensity of emotional arousal.

    Results: From the analysis of variance of two-way mixed design, the interaction between sex and emotional intensity was observed in the occipital regions (O2), indexed by the amplitude of P300 and N200 components. Males exhibited higher amplitude of P300 and N200 components (in the occipital region) as responded to high and low emotional arousal stimuli than females.

    Conclusion: Sex is a fundamental factor that modulates psychological states in reaction to emotional stimuli.

    Matched MeSH terms: Female
  2. George R, Donald PM, Nagraj SK, Idiculla JJ, Hj Ismail R
    Malays J Med Sci, 2013 Jan;20(1):76-80.
    PMID: 23785258 MyJurnal
    Sex determination is the most important step in personal identification in forensic investigations. DNA-based sex determination analysis is comparatively more reliable than the other conventional methods of sex determination analysis. Advanced technology like real-time polymerase chain reaction (PCR) offers accurate and reproducible results and is at the level of legal acceptance. But still there are situations like chimerism where an individual possess both male and female specific factors together in their body. Sex determination analysis in such cases can give erroneous results. This paper discusses the phenomenon of chimerism and its impact on sex determination analysis in forensic investigations.
    Matched MeSH terms: Female
  3. Nor Hayati O
    Malays J Med Sci, 2003 Jan;10(1):13-26.
    PMID: 23365496 MyJurnal
    Cancer of the cervix has the potential to be eradicated since the initiating cause is known. There was not much known about this cancer until the time of the Renaissance. In Malaysia, it is the second most common cancer among females after breast cancer. The strategies on prevention in this country are still not optimal. This article highlights the problems and also discusses the pathogenesis of this disease. The key to prevention is screening and the future is the era of molecular pap smear.
    Matched MeSH terms: Female
  4. Wan Mahmud WM, Awang A, Herman I, Mohamed MN
    Malays J Med Sci, 2004 Jul;11(2):19-25.
    PMID: 22973123
    Increased international collaboration in clinical trials has created a need for cross culturally valid instruments to assess the quality of life and behavioural disorders. Cross cultural studies of depressive symptomatology, in particular, must be preceded by an exhaustive study of the psychometric properties of the instruments to ensure the validity of the comparison. In this article, we examined the validity, reliability and factor structure of the Malay version of the Beck Depression Inventory II (BDI-II) among Malay postpartum women attending selected health centres in Kedah, North West of Peninsular Malaysia. Our findings indicated that the current version of the BDI-II is psychometrically strong and appropriate for use in assessing depressive symptomatology among this group of women.
    Matched MeSH terms: Female
  5. Kathirasan DRAL, Normizan SN'B, Salleh NABM, Poh-Yen K
    Bioorg Med Chem, 2024 Dec 15;116:118000.
    PMID: 39561584 DOI: 10.1016/j.bmc.2024.118000
    Toll-like receptor 4 (TLR4) plays a vital role in the innate immune response, but its overactivation has been associated with several diseases, such as aggressive progression of triple-negative breast cancer (TNBC). As a result, inhibiting TLR4 has emerged as a potential therapeutic strategy for this challenging breast cancer subtype. This review summarizes recent advancements in the development of small-molecule TLR4 antagonists to suppress TNBC growth, metastasis, and chemotherapy resistance. We also examine their potential in managing cancer-related complications and propose future directions for their application in TNBC therapy.
    Matched MeSH terms: Female
  6. Ramanathan A, Zaini ZM, Ghani WMN, Wong GR, Zainuddin NI, Yang YH, et al.
    Oral Dis, 2024 Nov;30(8):5483-5489.
    PMID: 38488212 DOI: 10.1111/odi.14927
    OBJECTIVE: This study evaluated the effectiveness of face-to-face (F2F) and online OralDETECT training programme in enhancing early detection skills for oral cancer.

    METHODS: A total of 328 final-year dental students were trained across six cohorts. Three cohorts (175 students) received F2F training from the academic years 2016/2017 to 2018/2019, and the remaining three (153 students) underwent online training during the Covid-19 pandemic from 2019/2020 to 2021/2022. Participant scores were analysed using the Wilcoxon signed rank test, the Mann-Whitney test, Cohen's d effect size, and multiple linear regression.

    RESULTS: Both F2F and online training showed increases in mean scores from pre-test to post-test 3: from 67.66 ± 11.81 to 92.06 ± 5.27 and 75.89 ± 11.03 to 90.95 ± 5.22, respectively. Comparison between F2F and online methods revealed significant differences in mean scores with large effect sizes at the pre-test stage (p 

    Matched MeSH terms: Female
  7. Purushothaman VK, Ramalingam V, Subbarayalu AV, Raman V, Prabaharan S, Subramaniam A, et al.
    Work, 2024;79(3):1557-1565.
    PMID: 39121147 DOI: 10.3233/WOR-230745
    BACKGROUND: The global implementation of full-time telework became widespread during the new normal conditions following the pandemic, resulting in reduced physical activity (PA) among teleworkers and young adults. It is vital to comprehend how telehealth interventions favorably impact PA levels and overall well-being of young adults who face increasingly blurred boundaries between work and home life.

    OBJECTIVES: The aim of this study is to examine the effect of telerehabilitation (TR) on PA levels and quality of life (QoL) in young adult teleworkers.

    METHODS: A quasi-experimental study was conducted on 82 teleworkers (54 females and 28 males). Levels of PA and QoL were assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF) and the Health-Related Quality of Life (HRQOL-14) questionnaire. TR was provided to all participants for four weeks, three times a week, for 40 minutes per session. Levels of PA and QoL were evaluated at baseline and after four weeks of the intervention. Data were analyzed using descriptive and inferential statistics.

    RESULTS: After four weeks of TR, there has been a significant improvement in the scores of IPAQ and HRQOL-14 (p 

    Matched MeSH terms: Female
  8. Mamun AA, Yudhastuti R, Mahmudiono T
    Afr J Reprod Health, 2024 Oct 31;28(10s):376-385.
    PMID: 39641303 DOI: 10.29063/ajrh2024/v28i10s.40
    Childhood stunting remains a global health issue with significant consequences for the growth, long-term health, and development of childre, Poor nutrition is a well-established contributor to childhood stunting. This study aims to investigate the potential of utilizing biscuits as a nutritional intervention to improve the child's stunting condition. This systematic review was consisted of a literature search in several databases: Scopus, Web of Science, mScience Direct, PubMed, and Springer, following the PRISMA methodology. Our search yielded a total of 836 records, while 11 studies were finally included after the screening. The studies revealed critical findings regarding the utilization of biscuits as a carrier in providing essential nutrients. Nevertheless, more well-designed and standardized studies are required to establish clear guidelines for the formulation and implementation of biscuitbased interventions. Policymakers and health practitioners should consider incorporating fortified biscuits into strategies aimed at reducing stunting, especially in regions with a high prevalence of stunting.
    Matched MeSH terms: Female
  9. Tilley A, Burgos A, Duarte A, Dos Reis Lopes J, Eriksson H, Mills D
    Ambio, 2021 Jan;50(1):113-124.
    PMID: 32385810 DOI: 10.1007/s13280-020-01335-7
    A greater understanding of gendered roles in fisheries is necessary to value the often-hidden roles that women play in fisheries and households. We examine women's contributions to household food and income using focus group discussions, market surveys, and landings data in six communities in Timor-Leste. Women were actively fishing more days per month than men. Gleaning was the most frequent activity and 100% of trips returned with catch for food and/or income. Mollusc and crab catches were common and exploitation appeared targeted on a dynamic reappraisal of changing food values and changing estimates of group needs. With as many as 80% of households in coastal areas involved in fishing, and at least 50% of women fishing, this highlights the current lack of women's engagement as a critical gap in fisheries management approaches. The current androcentric dialogue limits social-ecological understanding of these systems and the potential for their effective stewardship.
    Matched MeSH terms: Female
  10. Utap MS, Ng CJ, Lee YK, Kiyu A
    Asia Pac J Public Health, 2024 Mar;36(2-3):219-224.
    PMID: 38258742 DOI: 10.1177/10105395241227507
    In Malaysia, despite achieving leprosy-elimination status in 1994, leprosy remains a public health issue among the indigenous Penan community in Sarawak. This study aimed to determine the prevalence trend and clinical profile of leprosy among the Penans in rural Baram, Sarawak, Malaysia. A retrospective records review was conducted on 10-year (2008-2018) time trend of annual prevalence rate and 5-year (2013-2018) Penan leprosy patient clinical profile. Out of the 257 new cases of leprosy reported in Sarawak, 42.8% were Penans, and 72.7% were from Baram. The annual Penan ethnic-specific prevalence rate ranged from 2.08 to 35.5/10 000. Forty-six cases were analyzed for clinical profile: There were more males, active case detection, and multibacillary leprosy. The prevalence trend of leprosy among the Penans in rural Baram exceeded recommended elimination targets. Majority of the cases were detected through active case detection, but cases were detected late. Interventions are needed to improve early diagnosis and detection to achieve elimination of leprosy.
    Matched MeSH terms: Female
  11. Low HJ, Cheah OK, Ng BH, Siti Nidzwani MM, Wan Rahiza WM, Liu CY
    Med J Malaysia, 2024 Nov;79(6):764-769.
    PMID: 39614796
    INTRODUCTION: Anaesthesiology is a high-demand speciality with 24-hour on-call shifts, which can lead to significant stress and impaired sleep quality among anaesthetists. Nonpharmacological interventions like acupuncture have been widely explored for stress relief. This study aims to evaluate the impact of transcutaneous electrical acupoint stimulation (TEAS) on physiological parameters, specifically heart rate variability (HRV) and sleep quality, in anaesthesiology trainees following 24-hour on-call duty.

    MATERIALS AND METHODS: A total of 38 anaesthesiology trainees, following 24-hour ICU on-call shifts, were recruited for this single-centre cross-sectional clinical trial. The participants were required to complete two 24-hour on-call duties. Demographic data and baseline sleep quality assessments were collected following the first on-call duty. Upon completion of the second on-call shift, participants underwent 20 minutes of TEAS at bilateral PC6 (Neiguan), LI4 (Hegu), LR3 (Taichong), and ST41 (Jiexi) points. Heart rate variability (HRV) parameters, blood pressure, and heart rate were recorded before and after TEAS. Post-TEAS sleep quality was assessed following an overnight rest.

    RESULTS: The results demonstrated a significant reduction in systolic blood pressure compared to baseline (109.5±8.9 vs 111.9±10.1 mmHg, p = 0.006), as well as a significant decrease in diastolic blood pressure (69.3±8.0 vs 70.9±9.0 mmHg, p = 0.037) and heart rate (65.8±9.2 vs 67.4±9.8 bpm, p = 0.034). There was significant improvement in all aspects of sleep quality (p < 0.001). However, no statistically significant changes were observed in heart rate variability (HRV) parameters, including high-frequency (HF) power, lowfrequency (LF) power, and the LF/HF ratio.

    CONCLUSION: TEAS may offer potential benefits in managing cardiovascular stress and improving sleep quality in highstress environments, such as post-call recovery. Nevertheless, its impact on autonomic nervous system regulation, as reflected by HRV, appears limited.

    Matched MeSH terms: Female
  12. Saraluck A, Aimjirakul K, Jiet NJ, Chinthakanan O, Mangmeesri P, Manonai J
    Arch Gynecol Obstet, 2024 May;309(5):2237-2245.
    PMID: 38441602 DOI: 10.1007/s00404-024-07426-0
    OBJECTIVE: To investigate the prevalence of DD and AI with POP symptoms in females attending a urogynecology clinic, and to identify factors associated with DD and AI in POP symptoms patients.

    METHODS: Computer-based medical records of women with POP symptoms attending a urogynecology clinic in a referral tertiary center between January 2016 and December 2020 were reviewed. Demographic data were collected. Selected defecatory dysfunction (DD) and anal incontinence (AI) were recorded. The associations between patient characteristics, site and severity of prolapse, and DD and AI symptoms in POP patients were investigated for identified associated factors.

    RESULTS: The mean age of the 754 participants was 65.77 ± 9.44 years. Seven hundred and fifteen (94.83%) were menopause. The prevalence of DD and AI in patients with POP symptoms was 44.03% (332/754) and 42.04% (317/754) according to the PFBQ and medical history records, respectively. Advanced posterior wall prolapse (OR 1.59, 95% CI 1.10-2.30) and wider GH (OR1.23, 95% CI 1.05-1.43) were identified as risk factors for DD by multivariate analysis. Additionally, single-compartment prolapse (OR 0.4, 95% CI 0.21-0.76) and a stronger pelvic floor muscle assessed with brink score (OR 0.94, 95% CI 0.88-0.98) are protective factors for AI.

    CONCLUSION: DD and AI are prevalent among women with POP symptoms who visit a urogynecology clinic. DD should be evaluated in women with POP symptoms especially in women with increased genital hiatus and point Ap beyond the hymen. To prevent AI, women with POP should be encouraged to perform pelvic floor muscle training in order to increase pelvic floor muscle strength.

    Matched MeSH terms: Female
  13. Tan TW, Tan HL, Chung YC
    Worldviews Evid Based Nurs, 2024 Dec;21(6):687-694.
    PMID: 39572015 DOI: 10.1111/wvn.12756
    BACKGROUND: Breast cancer patients undergoing chemotherapy experience body composition changes impacting treatment outcomes. The role of resistance training in mitigating chemotherapy-induced sarcopenia in breast cancer patients is not well defined.

    AIMS: This study aims to assess the efficacy of resistance training in preventing sarcopenia among breast cancer patients undergoing chemotherapy.

    METHODS: A systematic search was conducted across PubMed, EMBASE, Medline, the Cochrane Library, and CINAHL until May 5, 2023. Selected literature focused on the effects of resistance training on body fat, muscle mass, muscle strength, and physical performance in breast cancer patients undergoing chemotherapy. Cochrane Risk of Bias tool version 2.0 was employed for quality assessment, and data were analyzed using Comprehensive Meta-Analysis version 2.0.

    RESULTS: Eleven randomized controlled trials (RCTs) showed that resistance training had a significant positive impact on reducing body fat (SMD = -0.250, 95% CI [-0.450, -0.050]), increasing lean body mass (SMD = 0.374, 95% CI [0.178, 0.571]), and enhancing handgrip strength at both the affected site (SMD = 0.326, 95% CI [0.108, 0.543]) and the nonaffected site (SMD = 0.276, 95% CI [0.059, 0.492]). Additionally, significant improvements were observed in leg press strength (SMD = 0.598, 95% CI [0.401, 0.796]) and overall physical performance (SMD = 0.671, 95% CI [0.419, 0.923]).

    LINKING EVIDENCE TO ACTION: Resistance training is a recommended intervention for reducing body fat, increasing muscle mass, muscle strength, and enhancing physical performance in breast cancer patients undergoing chemotherapy. Ideal low-intensity resistance training programs span 8-24 weeks, with 20-to-90-min sessions 2-4 times weekly. Regimens generally entail 8-12 repetitions at 40%-90% of one-repetition maximum test, with free-weight resistance training targeting major muscle groups yielding substantial benefits. Further research should explore outcomes across different chemotherapy phases and investigate long-term resistance training effects for a comprehensive view.

    Matched MeSH terms: Female
  14. Syasyila K, Gin LL, Jamaludin ANSJ
    J Cogn Psychother, 2024 Nov 11;38(4):353-359.
    PMID: 39528297 DOI: 10.1891/JCP-2023-0031
    This clinical case assessed the efficacy of cognitive behavioral therapy (CBT) in treating major depressive disorder in a 26-year-old female, Sara, attributing her depression to pregnancy, financial constraints, parental duties, and emotional stress. Sara had eight sessions of CBT, during which her symptoms were measured using the Hamilton Depression Rating Scale (HAM-D) and the Beck Depression Inventory-Second Edition (BDI-II). Sara's depressive symptoms dramatically decreased after the intervention, moving her HAM-D and BDI-II scores from moderate to mild depression and from clinically depressed to mild, respectively. The assessment showed improved interest, concentration, energy levels, and a more positive self-perception. Integrating Malaysian cultural elements into CBT, emphasizing family support, community engagement, and spirituality positively impacted Sara. This study emphasizes the value of culturally appropriate CBT for depression as it can help with symptom management, challenging negative thoughts, and bolstering self-esteem. This method identifies and addresses cultural impacts on mental health, recommending the incorporation of cultural aspects in therapy, enhancing relapse prevention and quality of life for Malaysians experiencing depression.
    Matched MeSH terms: Female
  15. Henry Basil J, Premakumar CM, Mhd Ali A, Mohd Tahir NA, Seman Z, Voo JYH, et al.
    J Adv Nurs, 2025 Feb;81(2):820-833.
    PMID: 38803148 DOI: 10.1111/jan.16247
    AIM(S): To determine the prevalence of medication administration errors and identify factors associated with medication administration errors among neonates in the neonatal intensive care units.

    DESIGN: Prospective direct observational study.

    METHODS: The study was conducted in the neonatal intensive care units of five public hospitals in Malaysia from April 2022 to March 2023. The preparation and administration of medications were observed using a standardized data collection form followed by chart review. After data collection, error identification was independently performed by two clinical pharmacists. Multivariable logistic regression was used to identify factors associated with medication administration errors.

    RESULTS: A total of 743 out of 1093 observed doses had at least one error, affecting 92.4% (157/170) neonates. The rate of medication administration errors was 68.0%. The top three most frequently occurring types of medication administration errors were wrong rate of administration (21.2%), wrong drug preparation (17.9%) and wrong dose (17.0%). Factors significantly associated with medication administration errors were medications administered intravenously, unavailability of a protocol, the number of prescribed medications, nursing experience, non-ventilated neonates and gestational age in weeks.

    CONCLUSION: Medication administration errors among neonates in the neonatal intensive care units are still common. The intravenous route of administration, absence of a protocol, younger gestational age, non-ventilated neonates, higher number of medications prescribed and increased years of nursing experience were significantly associated with medication administration errors.

    IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: The findings of this study will enable the implementation of effective and sustainable interventions to target the factors identified in reducing medication administration errors among neonates in the neonatal intensive care unit.

    REPORTING METHOD: We adhered to the STROBE checklist.

    PATIENT OR PUBLIC CONTRIBUTION: An expert panel consisting of healthcare professionals was involved in the identification of independent variables.

    Matched MeSH terms: Female
  16. Wang X, Soh KG, Samsudin S, Li L, Liu C, Sun M, et al.
    Sci Rep, 2025 Jan 13;15(1):1763.
    PMID: 39800767 DOI: 10.1038/s41598-024-83161-5
    This review aims to conduct a meta-analysis of the impact of high-intensity training (HIT) on athlete jumping performance. As of May 2024, we conducted a comprehensive search on PubMed, Web of Science, SCOPUS, and EBSCOhost databases in accordance with the PRISMA guidelines. Use the PEDro scale to evaluate the methodological quality of the included study. Meta-analysis of random effects model calculations. Conduct subgroup analysis (participant age, gender, training experience, intervention length and frequency). 18 high-quality studies met the inclusion criteria, including 490 athletes aged between 6 and 27 years old. The results showed that high-intensity interval training (HIIT) has a moderate effect on athlete jumping performance (ES = 0.918), while high-intensity functional training (HIFT) has a small effect on athlete jumping performance (ES = 0.581). The sub analysis of moderating variables includes 19 datasets. Compared with the control group, HIT has a positive impact on the jumping performance of athletes. The training experience, age, gender, intervention frequency, and intervention length of participants did not have a significant impact on the jumping performance of athletes, indicating the applicability of HIT as a training method. However, more extensive exercise experiments are needed to obtain stronger evidence.
    Matched MeSH terms: Female
  17. Kodama T, Arimura H, Tokuda T, Tanaka K, Yabuuchi H, Gowdh NFM, et al.
    Comput Biol Med, 2025 Feb;185:109519.
    PMID: 39667057 DOI: 10.1016/j.compbiomed.2024.109519
    We hypothesized that persistent lifetime (PLT) images could represent tumor imaging traits, locations, and persistent contrasts of topological components (connected and hole components) corresponding to gene mutations such as epidermal growth factor receptor (EGFR) mutant signs. We aimed to develop a topological radiogenomic approach using PLT images to identify EGFR mutation-positive patients with non-small cell lung cancer (NSCLC). The PLT image was newly proposed to visualize the locations and persistent contrasts of the topological components for a sequence of binary images with consecutive thresholding of an original computed tomography (CT) image. This study employed 226 NSCLC patients (94 mutant and 132 wildtype patients) with pretreatment contrast-enhanced CT images obtained from four datasets from different countries for training and testing prediction models. Two-dimensional (2D) and three-dimensional (3D) PLT images were assumed to characterize specific imaging traits (e.g., air bronchogram sign, cavitation, and ground glass nodule) of EGFR-mutant tumors. Seven types of machine learning classification models were constructed to predict EGFR mutations with significant features selected from 2D-PLT, 3D-PLT, and conventional radiogenomic features. Among the means and standard deviations of the test areas under the receiver operating characteristic curves (AUCs) of all radiogenomic approaches in a four-fold cross-validation test, the 2D-PLT features showed the highest AUC with the lowest standard deviation of 0.927 ± 0.08. The best radiogenomic approaches with the highest AUC were the random forest model trained with the Betti number (BN) map features (AUC = 0.984) in the internal test and the adapting boosting model trained with the BN map features (AUC = 0.717) in the external test. PLT features can be used as radiogenomic imaging biomarkers for the identification of EGFR mutation status in patients with NSCLC.
    Matched MeSH terms: Female
  18. Zaid SM, Hutagalung FD, Abd Hamid HSB, Taresh SM
    BMC Psychol, 2025 Jan 14;13(1):38.
    PMID: 39810249 DOI: 10.1186/s40359-025-02354-3
    BACKGROUND: Emotions are a fundamental part of life and play a critical role in shaping individuals' experiences Effectively regulating emotions in socially appropriate ways is essential for navigating life successfully. This study investigated the impact of seven sadness regulation strategies on depression and anxiety and examined the mediating role of ER in the relationship between sadness regulation and depression and anxiety.

    METHOD: A cross-sectional design was employed with 350 participants (144 men, 206 women) aged 18 to 35.

    RESULTS: Regression analyses showed that sadness regulation strategies significantly predict both depression and anxiety. For depression, the model explained 18.6% of the variance (F (7,342) = 11.140, p 

    Matched MeSH terms: Female
  19. Lei M, Alam GM, Bashir K
    Front Public Health, 2024;12:1460724.
    PMID: 39830187 DOI: 10.3389/fpubh.2024.1460724
    OBJECTIVES: This present study investigates whether performance can influence job burnout, and it further examines whether there is a meaningful difference in the association between job burnout and job performance in universities. Provided here are applicable strategies aimed at preventing and maximizing job burnout crises before the job is taken and during its execution.

    METHODOLOGY: To answer the research questions quantitatively, group regression analysis utilizing panel data from 2020 to 2023 was employed. The instruments include the KPI and mental health records to evaluate the level of job performance and job burnout. Likewise, a total of nine universities were purposively and randomly selected, and 1,113 academics were sampled for the study. The KPI scores and frequency of burnout counseling was collected from the human resource department and the medical health centers.

    FINDINGS: The results showed that academics' job burnout is influenced by their job performance (β = -0.014, p 

    Matched MeSH terms: Female
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