Displaying publications 1 - 20 of 46 in total

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  1. Sakina G, Liew YT
    QJM, 2022 Jan 09;114(12):896-897.
    PMID: 34633460 DOI: 10.1093/qjmed/hcab264
  2. Ghauth S, Tan SH
    J Laryngol Otol, 2024 Jun;138(6):696-698.
    PMID: 37926907 DOI: 10.1017/S0022215123001858
    BACKGROUND: This paper reports the innovative use of a modified nasopharyngeal airway device as a temporary stent in patients with laryngotracheal stenosis. It also discusses the technique of endoscopic stent placement, and our experience in terms of the indications and suitability.

    METHOD: The nasopharyngeal airway device was modified to use as an airway stent by trimming it to the desired length. Next, the stent was inserted endoscopically and anchored using a novel approach.

    RESULTS: The surgery was performed successfully without complications. The patients had full use of their voice while the stent was in situ. No significant granulation tissue was observed.

    CONCLUSION: This paper demonstrates the feasibility of using a nasopharyngeal airway device as a temporary stent to prevent restenosis in cases where the patients have a strong demand for phonation. The modified nasopharyngeal airway device is potentially very promising, but cases must be selected carefully to avoid compromising efficacy and safety.

  3. Ghauth S, Tan SH
    PMID: 39613851 DOI: 10.1007/s00405-024-09104-y
    BACKGROUND: The T-tube poses significant challenges for positive pressure ventilation.

    METHOD: We describe the modification of a Foley catheter by trimming off the proximal urine drainage port, and using this opening to pass a metal stylet within the catheter, providing additional rigidity and allowing easier manipulation of the catheter tip. The catheter tip is then positioned in the superior limb of the T-tube, and the balloon inflated under direct visualization to occlude the opening and allow positive pressure ventilation through the external limb of the T-tube.

    CONCLUSION: This simple yet effective technique can be considered in patients with T-tubes.

  4. Rahman Z, Sahibin A, Lihan T, Idris W, Sakina M
    Sains Malaysiana, 2013;42:881-891.
    Surfactants are often used as a cleaning agent for restoration of oil-contaminated soil. However the effect of surfactant on the geotechnical properties of soil is not clearly understood. In this study, the effects of surfactant on silty soil were investigated for consistency index, compaction, permeability and shear strength. Sodium dodecyl sulfate (SDS) was used in this study to prepare the surfactant-treated soil. Our results showed that the soil with added surfactant exhibited a decrease in liquid and plastic limit values. Maximum dry densities increased and optimum moisture contents decreased as contents of added surfactant were increased. The presence of surfactant assists the soil to achieve maximum density at lower water content. The addition of surfactant decreased the permeability of soil from 6.29×10-4 to 1.15×10-4 ms-1. The shear strength of soil with added surfactant was examined using the undrained unconsolidated triaxial tests. The results showed that the undrained shear strength, Cu was significantly affected, decreased from 319 kPa to 50 kPa for soil with 20% of added surfactant. The results of this study showed that the presence of surfactant in soil can modify the mechanical behaviour of the soil.
  5. Ghauth S, Yew Toong L
    Indian J Otolaryngol Head Neck Surg, 2024 Dec;76(6):5847-5851.
    PMID: 39559073 DOI: 10.1007/s12070-024-04847-w
    Mastoid fistula is a rare condition, its causes include chronic suppurative otitis media and repeated ear surgeries. Management is challenging, simple closure typically leads to recurrence due to surrounding necrotic skin edges. Several surgical techniques have been described. In this paper, we present a case of a 60 year old lady who presented with chronic right ear discharge post radical mastoidectomy due to acquired cholesteatoma. At presentation, there was a mastoid opening found over her auricular sulcus, endoscopic examination showed a well epithelized mastoid cavity with mucopurulent discharge, CT of temporal bone correlated with physical findings. The fistula was surgically closed with a three-layer pedicled flap and the fistula was fully healed at the 1-month follow up.
  6. Gendeh BS, Sakina MS, Selladurai BM, Jegan T, Misiran K
    Med J Malaysia, 2006 Aug;61(3):349-54.
    PMID: 17240588
    A retrospective review was performed on 11 patients who had undergone the transcolumellar transsphenoidal hypophysectomy in our center. There were eight females and three males with age ranging from 17 to 72 years (mean 50 years). Ten patients had pituitary macroadenomas and one had suprasellar cyst. The mean follow up duration for these 11 patients post surgery was 7.2 months. Complications included two cerebrospinal leaks, one postoperative sphenopalatine bleed, one septal perforation and one patient developed numbness of the tip of the nose. We found that this approach is a preferred alternative technique especially in smaller Oriental noses with lower complication rate and better aesthetic result.
  7. Sakina MS, Goh BS, Abdullah A, Zulfiqar MA, Saim L
    Int J Pediatr Otorhinolaryngol, 2006 Dec;70(12):2093-7.
    PMID: 16996619
    Sensorineural hearing loss (SNHL) due to internal auditory canal (IAC) stenosis with hypoplasia of the cochleovestibular nerve is a rare disorder. The diagnosis of the IAC stenosis requires both high resolution computed tomography scan (HRCT) and magnetic resonance imaging (MRI).
  8. Saadawi S, Jalil J, Jasamai M, Jantan I
    Molecules, 2012;17(5):4824-35.
    PMID: 22538486 DOI: 10.3390/molecules17054824
    Acetylmelodorinol, chrysin and polycarpol, together with benzoic acid, benzoquinone and stigmasterol were isolated from the leaves of Mitrella kentii (Bl.) Miq. The compounds were evaluated for their ability to inhibit prostaglandin E₂ (PGE₂) and thromboxane B₂ (TXB₂) production in human whole blood using a radioimmunoassay technique. Their inhibitory effect on platelet activating factor (PAF) receptor binding to rabbit platelet was determined using ³H-PAF as a ligand. Among the compounds tested, chrysin showed a strong dose-dependent inhibitory activity on PGE(2) production (IC₅₀ value of 25.5 µM), which might be due to direct inhibition of cyclooxygenase-2 (COX-2) enzymatic activity. Polycarpol, acetylmelodorinol and stigmasterol exhibited significant and concentration-dependent inhibitory effects on TXB₂ production with IC₅₀ values of 15.6, 19.1 and 19.4 µM, respectively, suggesting that they strongly inhibited COX-1 activity. Polycarpol and acetylmelodorinol showed strong dose-dependent inhibitory effects on PAF receptor binding with IC₅₀ values of 24.3 and 24.5 µM, respectively.
  9. Ghauth S, Toong LY, Sakina G, Liew YT
    QJM, 2022 Jan 09;114(12):889-890.
    PMID: 34597409 DOI: 10.1093/qjmed/hcab256
  10. Yew Toong L, Ghauth S, Yin Xuan N
    OTO Open, 2024;8(3):e70001.
    PMID: 39206427 DOI: 10.1002/oto2.70001
    OBJECTIVE: The primary objective of this study is to review the clinical parameters associated with skull base osteomyelitis (SBO), with a secondary aim of studying their association with patient outcomes 1 and 6 months after treatment initiation.

    STUDY DESIGN: This is a single-center restrospective observational study.

    SETTING: The study was conducted from January 2018 to December 2022 at the University Malaya Medical Center in Kuala Lumpur.

    METHODS: Patients aged over 15 years with a diagnosis of SBO were included in the study. Clinical parameters, investigations, and follow-up records were recorded. The disease outcomes were analyzed at 1 and 6 months after treatment initiation using multivariable analyses.

    RESULTS: The study identified 31 patients with SBO, the majority of whom were elderly males with comorbidities such as diabetes and hypertension. Otalgia and otorrhea were the most common symptoms, and computed tomography scans were used for diagnosis. Pseudomonas aeruginosa was the most commonly identified pathogen, and intravenous broad-spectrum antimicrobials were used to treat all patients. Surgical intervention was required for 25% of patients, and underlying ischemic heart disease, anemia, and single nerve palsy were significantly associated with an unfavorable prognosis. Patients with higher body mass index and elevated C-reactive protein showed poorer outcomes after 1 and 6 months of treatment, respectively.

    CONCLUSION: Early recognition, prompt treatment, better control of comorbidities, nutrition, and monitoring can improve SBO outcomes and reduce complications. Therefore, as the prevalence of SBO increases, diagnostic criteria or management guidelines should be established to guide the best clinical practice.

  11. Alya Nadhira Nasron, Ninna Sakina Azman, Nor Syaidatul Syafiqah Mohd Rashid, Nur Rahimah Said
    MyJurnal
    Degradation of azo dyes by using advanced oxidation processes (AOPs) was conducted. In this approach, different AOPs, which are Fenton process and titanium dioxide (TiO2) catalyst, were examined and compared for the degradation of an azo dye (i.e., Congo red dye). The sample was tested under UV light and the experiment was conducted for 90 min with 15 min interval. The degradation rate of dye was determined using UV-Vis spectrophotometry. The effect of several parameters on the degradation process such as the concentration of metal ions (Fe2+, Cu2+, and Mn2+) as the catalyst in Fenton process, the concentration of hydrogen peroxide (H2O2), the mass of TiO2, and pH value of the dye solution were investigated. The initial Congo red concentration used for both techniques was 5 ppm. The results showed that the percentage degradation followed the sequence of H2O2/Fe2+/UV, H2O2/Cu2+/UV, H2O2/Mn2+/UV, and TiO2/UV. The best operating conditions for H2O2/Fe2+/UV were pH 3, 0.2 M concentration of H2O2, and 0.02 M concentration of metal ion in 15 min, which achieved 99.92% degradation of dye. The Fourier transform infrared (FTIR) spectrum showed the absence of azo bond (N=N) peak after degradation process, which indicates the successful cleavage of azo bond in the chemical structure of Congo red.
  12. Tan SH, Ghauth S, Liew YT, Abu Bakar Z
    Eur Arch Otorhinolaryngol, 2024 Feb;281(2):1053-1055.
    PMID: 38078971 DOI: 10.1007/s00405-023-08364-4
    BACKGROUND: We report the first case of cimetidine as an alternative adjuvant therapy in a pregnant woman with recurrent respiratory papillomatosis (RRP). A 40 year old woman at 19 week gestation presented with progressive hoarseness and shortness of breath for 1 month. Flexible nasopharyngolaryngoscopy revealed multiple papillomatous lesions over both vocal cords and subglottic area obstructing 60% of her airway. She had previously been diagnosed with juvenile onset RRP at the age of 5 and underwent endoscopic clearance regularly every 6 months.

    METHOD: The patient was started on a trial of oral cimetidine at a dose of 30 mg/kg and responded well, eventually requiring endoscopic excision only after 2 years. Subsequently, she underwent in vitro fertilisation treatment and stopped taking her cimetidine. After undergoing endoscopic clearance of her papillomata under general anaesthesia, she restarted on cimetidine during her 2nd and 3rd trimester.

    RESULTS: Ensuing follow-up demonstrated stable minimal papillomata lesions on her right inferior surface of her vocal cord with no recurrence on her left vocal cord and subglottic area.

    CONCLUSION: Cimetidine is generally safe and not known to be associated with any major teratogenic risks during pregnancy. RRP is postulated to worsen in pregnant women due to the increase in oestrogen levels during pregnancy. Hence, adjuvant therapy was imperative for our patient to reduce recurrent papillomata formation during her pregnancy. Larger scale studies are warranted to assess the use of long-term high-dose cimetidine in terms of efficacy and safety in pregnancy.

  13. Razuan NA, Mun OK, Ghauth S, Toong LY
    Ear Nose Throat J, 2023 Aug 08.
    PMID: 37551681 DOI: 10.1177/01455613231189047
    A physically independent and mentally competent 61-year-old gentleman was diagnosed with left upper alveolar spindle cell carcinoma. He underwent left infrastructure maxillectomy with reconstruction and had bismuth iodoform paraffin paste packed in the post-operative cavities. The patient subsequently exhibited labile emotions and acute delirium. Further investigation showed that his urine iodine level was highly elevated. He eventually made a full recovery and returned home.
  14. Rose SE, Toong LY, Ghauth S, Ong DB
    Ear Nose Throat J, 2023 Nov 24.
    PMID: 37997797 DOI: 10.1177/01455613231212597
    Cavernous hemangioma is a noncancerous vascular growth that arises from different parts of the head and neck region. However, parapharyngeal space contributes a very small percentage for its occurrence. We present a case of right parapharyngeal cavernous hemangioma, a very rare clinical presentation. This is a 57-year-old female presented with throat discomfort for 3 months. Examination finding showed a soft, diffuse, and non-pulsating mass over the right upper jugulodigastric region. A contrasted computed topographic scan revealed multiple calcifications in right parapharyngeal space. T2-weighted magnetic resonance imaging showed right parapharyngeal space mass with high signal and multiple phleboliths and dynamic angiogram unremarkable. Surgical resection done via transcervical approach and histopathological report revealed cavernous hemangioma with calcified thrombi. In conclusion, surgical intervention is the mainstay treatment and transcervical approach which is adopted in this case is the commonest approach used in surgical resection of cavernous hemangioma.
  15. Lim CC, Liew YT, Ghauth S, Narayanan P
    Turk Arch Otorhinolaryngol, 2024 Jul 03;62(1):33-37.
    PMID: 39257051 DOI: 10.4274/tao.2024.2023-12-15
    Endoscopic transoral excision of parapharyngeal space (PPS) tumors is often condemned for its many limitations. We revisit this approach and aim to introduce some updated perspectives following the advancement of endoscopic instrumentation, robotic transoral surgery, and radical tonsillectomy. We illustrate the techniques that were deployed for six patients with huge benign PPS tumors originating from the pre-styloid compartment at our center. Only patients who had a tumor size of five cm or larger were included in this study. We summarized our patients' outcomes, the important considerations, and the advantages and disadvantages of this approach. With accurate selection and surgical strategy, all our patients had good clinical outcomes. We demonstrated that even larger tumors can be safely removed endoscopically. Surely, this approach will gain traction, and better-designed studies should be conducted in the future to assess its credibility.
  16. Noor Hayati Azami, Nora Sakina Mohd Noor, Wei, Pin Ngan, Tze, Jovian Yu Then, Yeong, Chee Teoh
    Ann Dent, 2018;25(2):53-57.
    MyJurnal
    Aesthetic or cosmetic dentistry is one of the main areas of dental practice. Increasing demands of patients for
    aesthetics has resulted in the development of several techniques for restoring the anterior teeth. Composite
    resin restorations have become an integral part of contemporary restorative dentistry and can be called “star
    of minimal invasion” due to its conservative concepts. The direct composite veneering allows restoring the
    tooth in a natural way and preservation of sound tooth structure when compared to indirect restorations.
    Before placement of direct composite veneers, a proper diagnosis, available treatment options, cost of
    treatment, patient’s expectations and duration of treatment should be taken into consideration. This article
    presents three case reports of aesthetic rehabilitation of anterior teeth using direct composite with
    satisfactory outcome that mimic the natural dentition.
  17. Mahdi SS, Jafri HA, Allana R, Battineni G, Khawaja M, Sakina S, et al.
    BMC Emerg Med, 2023 Jun 06;23(1):62.
    PMID: 37280514 DOI: 10.1186/s12873-023-00836-4
  18. Mahdi SS, Jafri HA, Allana R, Battineni G, Khawaja M, Sakina S, et al.
    BMC Emerg Med, 2023 May 24;23(1):52.
    PMID: 37226121 DOI: 10.1186/s12873-023-00824-8
    INTRODUCTION: The simulation exercise (SimEx) simulates an emergency in which an elaboration or description of the response is applied. The purpose of these exercises is to validate and improve plans, procedures, and systems for responding to all hazards. The purpose of this study was to review disaster preparation exercises conducted by various national, non-government, and academic institutions.

    METHODOLOGY: Several databases, including PubMed (Medline), Cumulative Index to Nursing and Allied Health Literature (CINAHL), BioMed Central, and Google Scholar, were used to review the literature. Information was retrieved using Medical Subject Headings (MeSH) and documents were selected according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). To assess the quality of the selected articles, the Newcastle-Ottawa Scale (NOS) technique was utilized.

    RESULTS: A total of 29 papers were selected for final review based on PRISMA guidelines and the NOS quality assessment. Studies have shown that many forms of SimEx commonly used in disaster management including tabletop exercises, functional exercises, and full-scale exercises have their benefits and limitations. There is no doubt that SimEx is an excellent tool for improving disaster planning and response. It is still necessary to give SimEx programs a more rigorous evaluation and to standardize the processes more thoroughly.

    CONCLUSIONS: Drills and training can be improved for disaster management, which will enable medical professionals to face the challenges of disaster management in the 21st century.

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