Displaying publications 1 - 20 of 65 in total

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  1. Fulltext The Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Virus in the Vaginal Fluid of Females With Severe Coronavirus Disease 2019 (COVID-19) Infection: Scientific Facts
    Ahmad MF, Mahakkanukrauh P, Das S
    Clin Infect Dis, 2022 Jul 06;74(12):2262-2263.
    PMID: 33085746 DOI: 10.1093/cid/ciaa1608
    Matched MeSH terms: Body Fluids*
  2. Coeruloplasmin levels in body fluids in four ethnic groups
    VELLA F
    Med J Malaya, 1957 Dec;12(2):456-63.
    PMID: 13515878
    Matched MeSH terms: Body Fluids*
  3. A review of zeolitic imidazolate frameworks (ZIFs) as electrochemical sensors for important small biomolecules in human body fluids
    Feng Z, Lim HN, Ibrahim I, Gowthaman NSK
    J Mater Chem B, 2023 Oct 06;11(38):9099-9127.
    PMID: 37650588 DOI: 10.1039/d3tb01221b
    Small biomolecules play a critical role in the fundamental processes that sustain life and are essential for the proper functioning of the human body. The detection of small biomolecules has garnered significant interest in various fields, including disease diagnosis and medicine. Electrochemical techniques are commonly employed in the detection of critical biomolecules through the principle of redox reactions. It is also a very convenient, cheap, simple, fast, and accurate measurement method in analytical chemistry. Zeolitic imidazolate frameworks (ZIFs) are a unique type of metal-organic framework (MOF) composed of porous crystals with extended three-dimensional structures. These frameworks are made up of metal ions and imidazolate linkers, which form a highly porous and stable structure. In addition to their many advantages in other applications, ZIFs have emerged as promising candidates for electrochemical sensors. Their large surface area, pore diameter, and stability make them ideal for use in sensing applications, particularly in the detection of small molecules and ions. This review summarizes the critical role of small biomolecules in the human body, the standard features of electrochemical analysis, and the utilization of various types of ZIF materials (including carbon composites, metal-based composites, ZIF polymer materials, and ZIF-derived materials) for the detection of important small biomolecules in human body fluids. Lastly, we provide an overview of the current status, challenges, and future outlook for research on ZIF materials.
    Matched MeSH terms: Body Fluids*
  4. Fulltext Proteomic analysis of pitcher fluid from Nepenthes × ventrata
    Wan Zakaria WNA, Aizat WM, Goh HH, Noor NM
    Data Brief, 2018 Apr;17:517-519.
    PMID: 29876422 DOI: 10.1016/j.dib.2018.01.037
    The carnivorous plants of genus Nepenthes produce unique pitchers containing secretory glands, which secrete proteins into the digestive fluid. We investigated protein profile in the pitcher fluid during the first three days of opening to understand carnivory trait of Nepenthes × ventrata. The proteome analysis of pitcher fluid from N. × ventrata was performed by label-free quantitative liquid chromatography mass spectrometry (nLC-MS/MSALL). Raw MS data have been deposited to the ProteomeXchange with identifier PXD007251. This dataset allows the identification and quantification of proteins from pitcher fluids to elucidate proteins involved in carnivory physiology of Nepenthes species.
    Matched MeSH terms: Body Fluids
  5. Comparative analysis of relative permeability models with reference to extreme saturation limit and Its influence on reservoir performance prediction
    Muhammad Khurram Zahoor
    Sains Malaysiana, 2015;44:1407-1415.
    A number of relative permeability models were present in the literature, which were used to generate relative permeability data for the fluids, present in the porous medium. Some models were more significant to reservoir geology and displacement system (imbibitions and drainage system), while developing the correlations. Similarly, the same is kept in mind while performing reservoir studies. Therefore, in this study different models based on displacement system and formation geology have been compared, while including the effect of fluid saturation distribution/end point saturation in a reservoir. The generated relative permeability data by using these models have been further used to predict the reservoir performance for gas and water-displacement systems. The results based on this study showed that at lower saturations of displacing fluid (gas and/or water), the generated reservoir performance curves based on relative permeability data generated by using Corey and Wylie and Gardner models, gives higher degree of deviation on comparative basis. The behavior of these error or deviation curves for displacing phase is opposite in case of gas and water-oil displacement systems. While in case of displaced phase (oil), generally analogous behavior can be observed for both systems in terms of deviation/ error profiles trends. These reservoir performance curve(s) are of utmost significance in developing reservoir in an appropriate manner and a slight variation in relative permeability data can have a significant impact at macroscopic level.
    Matched MeSH terms: Body Fluids
  6. Effects of inter-electrode gap and discharge voltage on EUV emission from stainless steel vacuum spark plasma
    Saboohi S, Yap S, Chan L, Wong C
    Sains Malaysiana, 2012;41:879-884.
    The emission of Extreme Ultra Violet (EUV) from plasma produced by vacuum spark discharge using stainless steel as anode material was investigated. The operating pressure for all the experiments carried out was maintained at below 10-4 mbar. The discharge voltage tested was from 8 kV to 20 kV. The inter-electrode distance suitable for high intensity and reproducible EUV emissions was found to be in the range of 2.6 mm to 4.6 mm. The output EUV energy scaled as ~ V02, where V0 is the discharge voltage.
    Matched MeSH terms: Body Fluids
  7. Effect of plasma treatment (he/ch4) on the glass surface for the reduction of powder flux adhesion in the spray drying process
    Nadiah Ramlan, Nazirah Wahidah Mohd Zamri, Mohamad Yusof Maskat, Mohd Suzeren Md Jamil, Saiful Irwan Zubairi, Chin OH, et al.
    Sains Malaysiana, 2018;47:1147-1155.
    A 50Hz glow discharge He/CH4
    plasma was generated and applied for the glass surface modification to reduce the powder
    adhesion on wall of spray dryer. The hydrophobicity of the samples determined by the water droplet contact angle and
    adhesion weight on glass, dependent on the CH4 flow rate and plasma exposure time. The presence of CH3
    groups and
    higher surface roughness of the plasma treated glass were the factors for its hydrophobicity development. Response
    surface methodology (RSM) results using central composite rotatable design (CCRD) showed that optimal responses
    were obtained by the combination of parameters, CH4
    gas flow rate = 3 sccm and exposure time = 10 min. In optimum
    conditions, the contact angle increased by 47% and the weight of the adhesion reduced by 38% (w/w). The plasma
    treatment could enhance the value of the contact angle and thus reduced the adhesion on the spray dryer glass surface.
    Matched MeSH terms: Body Fluids
  8. Fulltext Effect of Maghemite (γ-Fe2O3) Nano-powder mixed dielectric medium on Tool Wear Rate (TWR) During Micro-EDM of Co- Cr-Mo
    Elsiti, N.M., Noordin, M.Y., Idris, A.
    Pertanika Journal of Science & Technology, 2017;25(3):847-858.
    MyJurnal
    Micro Electro Discharge Machining (micro-EDM) is widely used for producing different types of micro features and micro components. Tool wear rate (TWR) is an important factor that affects the accuracy of machining as well as the productivity of micro-EDM process. This study examines the effects of process parameters and the use of Maghemite (γ-Fe2O3) nano-powder mixed dielectric medium on tool wear rate when micro-EDM Co-Cr-Mo. A Copper electrode with 300 μm diameter and positive polarity was used to evaluate the machining process by focusing on TWR. Two different concentrations of nano-powder (i.e., 2 g/l and 4 g/l) were added to the dielectric. Results showed that increasing the discharge current and voltage leads to a corresponding increase in TWR, while the presence of γ-Fe2O3 nano-powder in the dielectric liquid decreases TWR. Mixed micro-EDM with 2 g/l of nano-powder achieved a lower TWR.
    Matched MeSH terms: Body Fluids
  9. A simple, safe, and effective surgical technique for the treatment of post-traumatic parotid sialocoele
    Asha'ari ZA, Razali MS, Leman WI, Ahmad A
    Malays J Med Sci, 2014 Jan;21(1):72-4.
    PMID: 24639617
    Post-traumatic parotid sialocoele is a subcutaneous extravasation of saliva from the parotid gland secondary to traumatic disruption of its duct or parenchyma. Currently, there is no consensus regarding the best therapy for parotid sialocoele, as it is resistant to conservative management. The present paper puts forward a relatively simple, safe and effective technique for the treatment of parotid sialocoele, specifically a peroral drainage technique. The results justify our recommendation to use this approach for the treatment of sialocoele.
    Matched MeSH terms: Body Fluids
  10. Exposure measurement of aflatoxins and aflatoxin metabolites in human body fluids. A short review
    Leong YH, Latiff AA, Ahmad NI, Rosma A
    Mycotoxin Res, 2012 May;28(2):79-87.
    PMID: 23606045 DOI: 10.1007/s12550-012-0129-8
    Aflatoxins are highly toxic secondary fungal metabolites mainly produced by Aspergillus flavus and A. parasiticus. Human exposure to aflatoxins may result directly from ingestion of contaminated foods, or indirectly from consumption of foods from animals previously exposed to aflatoxins in feeds. This paper focuses on exposure measurement of aflatoxins and aflatoxin metabolites in various human body fluids. Research on different metabolites present in blood, urine, breast milk, and other human fluids or tissues including their detection techniques is reviewed. The association between dietary intake of aflatoxins and biomarker measurement is also highlighted. Finally, aspects related to the differences between aflatoxin determination in food versus the biomarker approach are discussed.
    Matched MeSH terms: Body Fluids/chemistry*
  11. Assessment of body fluid status in hemodialysis patients using the body composition monitor measurement technique
    Mamat R, Kong NC, Ba'in A, Shah SA, Cader R, Wong V, et al.
    J Clin Nurs, 2012 Oct;21(19-20):2879-85.
    PMID: 22646855 DOI: 10.1111/j.1365-2702.2012.04091.x
    The main objective of the study was to correlate the target dry weight in haemodialysis (HD) patients as assessed clinically by nephrologists to those measured by the Body Composition Monitor (BCM - Fresenius) machine. The second objective was to compare pre and postdialysis changes of extracellular fluid and clinical parameters.
    Matched MeSH terms: Body Fluids*
  12. Changes in body fluid distribution in experimental protein malnutrition
    Chandrasekharan N, Ho CL
    Med J Malaysia, 1976 Jun;30(4):266-72.
    PMID: 824533
    Matched MeSH terms: Body Fluids/metabolism*
  13. Metabolomic-guided discovery of Alzheimer's disease biomarkers from body fluid
    Enche Ady CNA, Lim SM, Teh LK, Salleh MZ, Chin AV, Tan MP, et al.
    J Neurosci Res, 2017 Oct;95(10):2005-2024.
    PMID: 28301062 DOI: 10.1002/jnr.24048
    The rapid increase in the older population has made age-related diseases like Alzheimer's disease (AD) a global concern. Given that there is still no cure for this neurodegenerative disease, the drastic growth in the number of susceptible individuals represents a major emerging threat to public health. The poor understanding of the mechanisms underlying AD is deemed the greatest stumbling block against progress in definitive diagnosis and management of this disease. There is a dire need for biomarkers that can facilitate early diagnosis, classification, prognosis, and treatment response. Efforts have been directed toward discovery of reliable and distinctive AD biomarkers but with very little success. With the recent emergence of high-throughput technology that is able to collect and catalogue vast datasets of small metabolites, metabolomics offers hope for a better understanding of AD and subsequent identification of biomarkers. This review article highlights the potential of using multiple metabolomics platforms as useful means in uncovering AD biomarkers from body fluids. © 2017 Wiley Periodicals, Inc.
    Matched MeSH terms: Body Fluids/chemistry*
  14. Hollow fiber liquid phase microextraction with in situ derivatization for the determination of trace amounts of metformin hydrochloride (anti-diabetic drug) in biological fluids
    Ben-Hander GM, Makahleh A, Saad B, Saleh MI
    J Chromatogr B Analyt Technol Biomed Life Sci, 2013 Dec 15;941:123-30.
    PMID: 24200841 DOI: 10.1016/j.jchromb.2013.10.007
    A three phase hollow fiber liquid-phase microextraction with in situ derivatization (in situ HF-LPME) followed by high-performance liquid chromatography-ultraviolet detection (HPLC-UV) method was developed for the trace determination of metformin hydrochloride (MH) in biological fluids. A new derivatization agent pentafluorobenzoyl chloride (PFBC) was used. Several parameters that affect the derivatization and extraction efficiency were studied and optimized (i.e., type of organic solvent, volume of NaOH (4M) and derivatization agent in the donor phase, acceptor phase (HCl) concentration, stirring speed, temperature, time and salt addition). Under the optimum conditions (organic solvent, dihexyl ether; volume of NaOH (4M) and derivatization agent (10mg PFBC in 1mL acetonitrile) in the donor phase, 600 and100μL, respectively; acceptor phase, 100mM HCl (10μL); stirring speed, 300rpm; extraction time, 30min; derivatization temperature, 70°C; without addition of salt) an enrichment factor of 210-fold was achieved. Good linearity was observed over the range of 1-1000ngmL(-1) (r(2)=0.9998). The limits of detection and quantitation were 0.56 and 1.68ngmL(-1), respectively. The proposed method has been applied for the determination of MH in biological fluids (plasma and urine) and water samples. Prior to the microextraction treatment of plasma samples, deproteinization step using acetonitrile was conducted. The proposed method is simple, rapid, sensitive and suitable for the determination of MH in a variety of samples.
    Matched MeSH terms: Body Fluids/chemistry*
  15. Fulltext Parametric evaluation of electrical discharge coatings on nickel-titanium shape memory alloy in deionized water
    Mansor AF, Azmi AI, Zain MZM, Jamaluddin R
    Heliyon, 2020 Aug;6(8):e04812.
    PMID: 32913911 DOI: 10.1016/j.heliyon.2020.e04812
    Nickel-titanium shape memory alloy (NiTi) has a unique capacity to restore its initial shape after deformation, which is highly applicable to orthopaedic implantations, especially for the minimization of invasive surgeries. The high nickel content of this alloy can lead to unfavourable effects on the human body upon dissolution; thus, a reliable barrier of coatings on the NiTi surface is required to alleviate the nickel migration and increase its biocompatibility. In this paper, analyses of a titanium oxide layer development on NiTi surface using electrical discharge coating (EDC) process is presented. The recast layer thickness, crater sizes, and surface roughness were characterized based on five parameters; polarity, discharge duration, pulse interval, peak current, and gap voltage. The results show that the discharge duration is the most significant parameter to influence all responses, followed by peak current. The surface characteristics of the EDC substrate is depending on the crater formations and is highly correlated with the discharge energy intensity. As a result, appropriate parametric conditions of the electrical discharge coating process can enhance the NiTi surface for future medical applications, without compromising the shape memory effect.
    Matched MeSH terms: Body Fluids
  16. Kesan psikostres terhadap kerosakan dna dan ketaknormalan titisan sitoplasma sperma manusia
    Norhamizan Hashim, Khairul Osman, Siti Fatimah Ibrahim, Rosliah Harun, Rafeah Pakri Mohamed
    Sains Malaysiana, 2016;45:1931-1938.
    Ketidaksuburan idiopati dalam kalangan lelaki telah dikaitkan dengan kesan psikostres. Walaupun begitu, hubungan langsung antara psikostres dan ketaknormalan kualiti semen masih samar. Maka, kajian ini dijalankan untuk menentukan kesan psikostres terhadap kualiti semen terutama kesan berdasarkan residu sitoplasma dan kerosakan DNA sperma. Dalam kajian ini, responden lelaki berumur antara 25-45 tahun dipilih secara rawak dalam kalangan pesakit yang mendapatkan rawatan di Pusat Kesuburan Lembaga Penduduk dan Pembangunan Keluarga Negara (LPPKN). Seramai 331 responden akhirnya telah dipilih daripada 628 responden selepas mengambil kira faktor penolakan. Setiap responden perlu menjawab borang keizinan dan soal selidik GHQ-12 bagi penentuan tahap stres sebelum pengambilan sampel semen mengikut piawaian WHO (2010). Tahap stres diukur berdasarkan keadaan semasa responden dalam tempoh 3-4 minggu sebelum kajian. Analisis semen, pewarnaan papanicolau dan asai komet neutral digunakan untuk penentuan kualiti semen dan kerosakan DNA sperma. Keputusan menunjukkan tidak terdapat hubungan yang signifikan antara psikostres dan ketaknormalan residu sitoplasma (U=895.50, p=0.08). Namun begitu, psikostres memberi kesan kepada peratus morfologi normal (U=6317.50, p<0.05) dan kerosakan DNA sperma (U=1047.00, p<0.01). Kesimpulannya, psikostres kronik boleh menjejaskan kualiti semen dan kerosakan DNA sperma serta mempengaruhi kesuburan.
    Matched MeSH terms: Body Fluids
  17. Telemetric EEG and the rat: a guide for neuroscientists
    Abdullah JM, Rafiqul Islam M
    Malays J Med Sci, 2012 Oct;19(4):1-5.
    PMID: 23613643
    Telemetric EEG in the rat's brain has been used for experiments which tests the effects of an antiepileptic compound on it's antiseizures activity. A simple classification correlating epileptiform discharge and Racine's behavioral activity is discussed.
    Matched MeSH terms: Body Fluids
  18. Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers
    Tan PPS, Hall D, Chilian WM, Chia YC, Mohd Zain S, Lim HM, et al.
    Am J Physiol Heart Circ Physiol, 2021 04 01;320(4):H1486-H1497.
    PMID: 33577433 DOI: 10.1152/ajpheart.00888.2020
    MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potential as noninvasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension, and the potentials of exosomal miRNAs as biomarkers in comparison with other free circulating miRNAs. Finally, challenges and future research surrounding exosomal miRNAs will also be discussed. This review will aid in the understanding of noninvasive biomarkers for the early diagnosis of hypertension and for probing therapeutic efficacy.
    Matched MeSH terms: Body Fluids
  19. An insight into the role of Artificial Intelligence in the early diagnosis of Alzheimer's disease
    Verma RK, Pandey M, Chawla P, Choudhury H, Mayuren J, Bhattamisra SK, et al.
    CNS Neurol Disord Drug Targets, 2021 May 11.
    PMID: 33982657 DOI: 10.2174/1871527320666210512014505
    BACKGROUND: The complication of Alzheimer's disease (AD) has made the development of its therapeutic a challenging task. Even after decades of research, we have achieved no more than a few years of symptomatic relief. The inability to diagnose the disease early is the foremost hurdle behind its treatment. Several studies have aimed to identify potential biomarkers that can be detected in body fluids (CSF, blood, urine, etc) or assessed by neuroimaging (i.e., PET and MRI). However, the clinical implementation of these biomarkers is incomplete as they cannot be validated.

    METHOD: To overcome the limitation, the use of artificial intelligence along with technical tools has been extensively investigated for AD diagnosis. For developing a promising artificial intelligence strategy that can diagnose AD early, it is critical to supervise neuropsychological outcomes and imaging-based readouts with a proper clinical review.

    CONCLUSION: Profound knowledge, a large data pool, and detailed investigations are required for the successful implementation of this tool. This review will enlighten various aspects of early diagnosis of AD using artificial intelligence.

    Matched MeSH terms: Body Fluids
  20. Synergistic green extraction of nickel ions from electroplating waste via mixtures of chelating and organophosphorus carrier
    Sulaiman RNR, Othman N
    J Hazard Mater, 2017 Oct 15;340:77-84.
    PMID: 28711835 DOI: 10.1016/j.jhazmat.2017.06.060
    The discharge of electroplating waste containing nickel ions has led to environmental issues owing to the toxicity problem mainly to the aquatic organisms and humans. Liquid-liquid extraction offers a great potential treatment for nickel removal with several advantages of simple, high efficiency and high separation factor. In this study, a green synergistic liquid-liquid extraction of nickel ions from electroplating waste solution using chelating oxime (LIX63) and organophosphorus (D2EHPA) carriers individually as well as their synergistic mixture has been studied. The result demonstrated that about 83% of nickel ions have been successfully extracted via the mixture system of 0.08M LIX63 +0.02M D2EHPA with the maximum synergistic enhancement factor, Rmax of 29.56. Meanwhile, the back extraction study also revealed that HNO3 was the most suitable stripping agent while the diluent screening also showed that palm oil has high potential to be incorporated as a diluent in the green synergistic liquid-liquid extraction of nickel.
    Matched MeSH terms: Body Fluids
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