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  1. Special tinted contact lens on colour-defects
    Mutilab HA, Sharanjeet-Kaur, Keu LK, Choo PF
    Clin Ter, 2012;163(3):199-204.
    PMID: 22964691
    PURPOSE: The objective of this study was to determine the visual function of colour-deficient subjects when wearing special red tint contact lenses.
    MATERIALS AND METHODS: A total of 17 subjects with congenital colour vision deficiency (14 deutans and 3 protans), voluntarily participated in this study. The average age for the subjects was 23.00 ± 4.06 years old. Visual functions tested were visual acuity (LogMAR), contrast sensitivity (FACT Chart) and stereopsis (TNO and Howard Dolman tests). Two types of special red tint lenses were used in this study; Type I (light red) and Type II (dark red).
    RESULTS: The protans and deutans showed no significant changes in visual acuity and contrast sensitivity when wearing either type of contact lens. Stereopsis testing using the Horward-Dolman test gave no significant changes but significant differences were seen using the TNO test. Stereopsis using the TNO test was significantly poorer with the red tinted contact lenses compared to without for both protons and deutans. Testing binocularly with Ishihara plates showed that 88% (n=15) of patients passed the test with Type I and Type II contact lenses. When D15 test was done, 3 patients (17.6%) were 'normal' when using the Type I contact lenses and 2 patients (11.8%) were 'normal' when using the Type II contact lenses. However, with FM100Hue test, most patients showed deutan responses. Total error scores (TES) were found to be higher with Type I and Type II contact lenses compared to without.
    CONCLUSIONS: The Type I and II special tinted contact lens used in this study did not cause a reduction of visual acuity and contrast sensitivity for the colour defects. Stereopsis was also not reduced with the Type I and Type II contact lenses for the colour defects except when tested with the TNO test. Colour vision defects became difficult to detect using the Ishihara plates but FM100Hue test did not show any improvement with the Type I and Type II contact lenses.
    Matched MeSH terms: Color Vision Defects/rehabilitation*
  2. The incidence of colour-blindness among different dialect groups of Chinese, Malay and Indian schoolboys in Singapore
    Saha N, Tan PY, Tan BH
    Z Morphol Anthropol, 1980;71(1):107-9.
    PMID: 6969497
    1829 school-boys of Singapore comprised of 849 Chinese, 469 Malays and 511 Indians were investigated for the incidence of red-green colour-blindness with Ishihara's plates. The incidence of red-green colour-blindness was found to be 3.8%, 4.5% and 4.5%, respectively in Chinese, Malay and Indian boys. The incidence among the different dialect groups was variable with the highest incidence of red-green colour-blindness among Mandarin speaking group (14.3%), followed by Hainanese speaking (6.7%) and other dialect groups of Chinese (2.8% to 4.5%). The incidence of red-green colour-blindness was higher in the older boys compared with the younger boys when all the three ethnic groups are combined.
    Matched MeSH terms: Color Vision Defects/epidemiology*
  3. Fulltext Colour vision of workers in the plastics industry
    Kaur S, Mursyid A, Ariffin AE
    Journal of Occupational Safety and Health, 2004;1(1):25-30.
    MyJurnal
    A study was undertaken to determine the effect of polyethylene and polystyrene used in the manufacture of plastic items on colour perception. Colour vision was assessed using the Ishihara plates, panel 015 test and the Farnsworth Munsell 100-Hue test. Two factories were chosen at random. One factory (referred here as factory A) used virgin resin in pellet form (polyethylene) in the manufacturing of plastic containers to store consumer edible oil. The other factory (referred as factory B) used polystyrene to make plastic bags. A total of 39 healthy employees from factory A (mean age 26.4 :t 8.2 years) and 40 healthy employees from factory B (mean age 26.8 :t 9.6 years) were recruited in this study. A control group of 27 normal healthy subjects (mean age 27.4 :t 4.3 years) who were employees of UKM with no occupational involvement with petroleum derivatives were also recruited in this study and they performed the same colour vision tests. All subjects passed the Ishihara plates test showing that none of the subjects (employees of factory A and B, and control subjects) had a congenital red-green defect. All control subjects passed all of the colour vision tests whilst some employees of factories A and B failed the 015 and FM100 Hue tests. For employees from factory A results from the 015 test showed that 7 (17.9%) had a tritan (blue-yellow) type of defect and 1 (2.6%) had a complex type of defect. The FM 100 Hue results of factory A employees showed that 51.3% (n=20) had a complex type of defect. Total error scores (TES) calculated from the FM 100 Hue test revealed that employees from factory A had a statistically significant higher mean TES of 65.13:!: 48.31 compared to that of control subjects with a mean TES of 31.26:!: 14.93. For employees in factory B, 10 employees (25.0%) had a tritan (blue-yellow) type of defect and 2 (5.0%) had a complex type of defect. Results of the FM 100 Hue test showed that 4 employees (1.0%) had a tritan type of defect whereas 22 (55.0%) had a complex type of defect. Mean total error scores (TES) calculated from the FM 100 Hue test revealed that employees from factory B had a statistically significant higher mean TES of 71.54 :t 54.63 compared with that of control subjects with a mean TES of 31.26 :t. 14.93

    The above results show that employees of the plastic factories studies are associated with a higher risk of acquiring colour vision defects as compared to normal subjects who are not engaged in the plastic manufacturing industry. This may have an implication towards the future retinal health of employees in petrod1emical-based industries.
    Matched MeSH terms: Color Vision Defects; Color Vision
  4. Blue deficiency in patients with diabetes mellitus without retinopathy - its clinical implications
    Kaur S
    Sains Malaysiana, 1996;25(2):41-49.
    This study was conducted for 3 main purposes: 1) to determine if there was blue colour deficiency amongst diabetes mellitus (IDDM and NIDDM) patients without retinopathy, 2) to determine if the Dl5 test could be used to detect any colour vision defects amongst diabetics without retinopathy (all previous workers have used FM 100-Hue), and 3) to assess the performance of diabetics without retinopathy in detecting correct colour changes with the urine strip test. Thirty eight non-insulin dependent diabetes mellitus (NIDDM) and 30 insulin-dependent diabetes mellitus (IDDM) patients without retinopathy participated in this study. A control group of 23 normal subjects were also included in the study. Dl5 colour vision test was performed under daylight conditions. Colour dependent urine glucose test (Glukotest) was also performed on all subjects. The study showed that 47.1% of diabetics (47.4% NIDDM and 46.7% IDDM patients) without retinopathy had a blue colour deficiency. Amongst the diabetics with a blue colour deficiency, 25% of diabetics (22% of NIDDM and 28.6% of IDDM patients) failed to accurately match the strip colour with the comparison chart on the bottle.
    Kajian ini dilakukan untuk 3 tujuan: I) untuk menentukan samada terdapat gangguan penglihatan warna biru dalam pesakit diabetes mellitus (IDDM dan NIDDM) tanpa retinopati, 2) untuk menentukan samada ujian penglihatan warna Dl5 boleh digunakan untuk mengesan defek penglihatan warna dalam pesakit diabetes tanpa retinopati (kesemua kajian terdahulu menggunakan ujian FM 100-Hue). dan 3) untuk menilaikan prestasi pesakit diabetik tanpa retinopati dalam mengesan perubahan warna yang betul dengan menggunakan ujian strip urin. Tiga puluh lapan pesakit dengan non-insulin dependent diabetes (NIDDM) dan 30 pesakit dengan insulin dependent diabetes (IDDM) tanpa retinopati menyertai kajian ini. Kumpulan kawalan mengandungi 23 orang subjek yang normal juga terlibat di dalam kajian ini. Ujian penglihatan warna Dl5 dilakukan di bawah cahaya daylight. Ujian glukos urin berasaskan warna (Glukotest) dilakukan ke atas semua subjek. Kajian menunjukkan 47.1% pesakit diabetes (47.4% pesakit NIDDM dan 46.7% pesakit IDDM) tanpa retinopati mengalami defisiensi warna biru. Dalam kumpulan diabetik dengan defisiensi warna biru, 25% pesakit diabetes (22.2% adalah pesakit NIDDM dan 28.6% adalah pesakit IDDM) gagal untuk memadankan dengan tepat warna strip dengan carta perbandingan warna di atas botol.
    Matched MeSH terms: Color Vision Defects; Color Vision
  5. Fulltext Visual problems of new malaysian drivers
    Haliza A, Md Muziman Syah M, Norliza M
    Malays Fam Physician, 2010;5(2):95-8.
    PMID: 25606195 MyJurnal
    PURPOSE: The objective of this study was to determine the prevalence of poor visual acuity, colour blindness and visual field defect of new Malaysian drivers.

    METHODS: A total of 3717 new drivers (50.2% males and 49.8% females) age 19±6 years, voluntarily participated in this study. Standard optometric apparatus such as LogMAR Charts, Ishihara plates and HandHeld Bernell Perimeter were used and standard procedures were applied.

    RESULTS: The visual examination showed 6.7% (n=250) of subjects achieved less than 0.3 LogMAR with better eye whilst 2.2% (n=83) had failed the Ishihara Test (2.1% males and 0.1% females). Most of the affected drivers were deutranopia. Only 2094 subjects had their visual field using a mobile Handheld Bernell Perimeter. 1.72% (n=36) subjects have less than 120 degrees of peripheral field of vision.

    CONCLUSIONS: The visual status among new Malaysian drivers needs to be taken seriously to ensure safe driving. Other factors such as colour vision and visual field screening have to be considered seriously when evaluating the visual performance of a driver. Good visual performance is indispensible for safe driving.
    Matched MeSH terms: Color Vision Defects; Color Vision
  6. Fulltext Ethambutol ocular toxicity in a patient with pulmonary tuberculosis - a case report
    Tan AK, Mallika P, Md Aziz S, Asokumaran T, Intan G
    Malays Fam Physician, 2008;3(2):87-90.
    PMID: 25606123 MyJurnal
    Purpose. To highlight the importance of using the Farnsworth Panel D-15 Hue test in colour vision testing in patients on ethambutol treatment. Case Report. A 70 year-old lady received ethambutol as part of her anti-tuberculous regime. She developed blue-yellow colour defect detectable with the Farnsworth Panel D-15 Hue test, but not with the Isihara Pseudoisochromatic Plates. Ethambutol was immediately discontinued from her anti-tuberculous regime. Two months later, her colour vision returned to normal. Conclusion. This case report illustrates the importance of regular monitoring of patients receiving ethambutol for blue-yellow colour defect using the Farnsworth Panel D-15 Hue Test.
    Matched MeSH terms: Color Vision
  7. Fulltext Behavioural and emotional issues among primary school pupils with congenital colour vision deficiency in the Federal Territory of Kuala Lumpur, Malaysia: A case-control study
    Thomas BAWM, Kaur S, Hairol MI, Ahmad M, Wee LH
    F1000Res, 2018;7:1834.
    PMID: 30815251 DOI: 10.12688/f1000research.17006.1
    Background: Congenital colour vision deficiency (CCVD) is an untreatable disorder which has lifelong consequences. Increasing use of colours in schools has raised concern for pupils with CCVD. This case-control study was conducted to compare behavioural and emotional issues among age, gender and class-matched pupils with CCVD and normal colour vision (NCV). Methods: A total of 1732 pupils from 10 primary schools in the Federal Territory of Kuala Lumpur were screened, of which 46 pupils (45 males and 1 female) had CCVD. Mothers of male pupils with CCVD (n=44) and NCV (n=44) who gave consent were recruited to complete a self-administered parent report form, Child Behaviour Checklist for Ages 4-18 (CBCL/ 4-18) used to access behavioural and emotional problems. The CBCL/ 4-18 has three broad groupings: Internalising, Externalising and Total Behaviour Problems. Internalising Problems combines the Withdrawn, Somatic Complaints and Anxiety/ Depression sub constructs, while Externalising Problems combines the Delinquent and Aggressive Behaviour sub constructs. Results: Results from CBCL/ 4-18 showed that all pupils from both groups had scores within the normal range for all constructs. However, results from the statistical analysis for comparison, Mann-Whitney U test, showed that pupils with CCVD scored significantly higher for Externalising Problems (U=697.50, p=0.02) and Total Behaviour Problems (U=647.00, p= 0.01). Significantly higher scores were observed in Withdrawn (U=714.00, p=0.02), Thought Problems (U=438.50, p<0.001) and Aggressive Behaviour (U=738.00, p=0.04). Odds ratios, 95% CI, showed significant relative risk for high Total Behaviour Problem (OR:2.39 ,CI:1.0-5.7), Externalising Problems (OR:2.32, CI:1.0-5.5), Withdrawn (OR:2.67, CI:1.1-6.5), Thought Problems (OR:9.64, CI:3.6-26.1) and Aggressive Behaviour (OR:10.26, CI:3.4-31.0) scores among pupils with CCVD. Conclusion: Higher scores among CCVD pupils indicates that they present more behavioural and emotional problems compared to NCV pupils. Therefore, school vision screenings in Malaysia should also include colour vision to assist in the early clinical management of CCVD children.
    Matched MeSH terms: Color Vision Defects/congenital*; Color Vision Defects/psychology*
  8. Fulltext Effectiveness of computerized visual screening tool used in driving schools in Malaysia
    Haliza AM
    Malays Fam Physician, 2011;6(1):15-8.
    PMID: 25606214 MyJurnal
    PURPOSE: A survey on new Malaysian drivers was conducted in Malaysia between year 2006-2009. The objective of this study was to look at the effectiveness of the present computerized visual screening tool and to compare it with the conventional testing method.
    METHODS: A total of 3717 drivers aged 19±6 years, who had passed in the computerized visual screening, participated in this study.
    RESULTS: 250 subjects achieved less than 0.3 LogMAR with their best eye and 83 subjects failed the Ishihara Test after retested using the conventional tool.
    CONCLUSION: These finding showed the computerized visual screening test failed to filter some subjects according to the standards set.
    KEYWORDS: Visual acuity; colour vision; driving; vision
    Matched MeSH terms: Color Vision Defects
  9. Fulltext Comparison on testability of visual acuity, stereo acuity and colour vision tests between children with learning disabilities and children without learning disabilities in government primary schools
    Abu Bakar NF, Chen AH
    Indian J Ophthalmol, 2014 Feb;62(2):141-4.
    PMID: 24008790 DOI: 10.4103/0301-4738.116481
    Children with learning disabilities might have difficulties to communicate effectively and give reliable responses as required in various visual function testing procedures.
    Matched MeSH terms: Color Vision/physiology*
  10. Spectral sensitivity in patients with dysthyroid eye disease
    Sharanjeet-Kaur, Dickinson CM, O'Donoghue E, Murray IJ
    Ophthalmic Physiol Opt, 1997 May;17(3):232-8.
    PMID: 9196665 DOI: 10.1111/j.1475-1313.1997.0_749.x
    The majority of patients with dysthyroid eye disease have an acquired colour vision defect. However, no psychophysical investigation of selective damage to colour or flicker pathways has been carried out. In order to clarify the nature of the visual pathology, we have used a psychophysical technique (spectral sensitivity) to selectively stimulate the chromatic and achromatic mechanisms. Spectral spots of size 1 degree presented at a rate of 1 Hz on a bright 1000 td white background are detected by the chromatic mechanism but a rate of 25 Hz reveals the achromatic mechanism. Fifteen patients (28 eyes) between the ages of 50-70 years were tested. The study showed that all patients had reduced spectral sensitivity, either 1 Hz, 25 Hz or both. The patients with reduced 1 Hz or 25 Hz spectral sensitivity only had a shorter systemic and ocular duration of the condition, had no proptosis, normal intraocular pressures in primary gaze, slightly higher intraocular pressures on upgaze, normal visual field plots and FM 100-Hue error scores higher than the normal age-matched values. The patients with reduced both 1 Hz and 25 Hz spectral sensitivities had a longer systemic and ocular duration of the condition, had proptosis, normal intraocular pressures in primary position, higher intraocular pressures on upgaze and higher FM 100-Hue error scores than the age-matched normals and those in Groups 1 and 2. A total of 50% of patients in Group 3 had defective visual field plots. These data suggest that there is a damage of the large achromatic fibres and small chromatic fibres in dysthyroid eye disease. The mechanism of the damage could be one of ischaemic or mechanical or both.
    Matched MeSH terms: Color Vision Defects/diagnosis*
  11. The influence of age, refractive error, visual demand and lighting conditions on accommodative ability in Malay children and adults
    Chen AH, Ahmad A, Kearney S, Strang N
    Graefes Arch Clin Exp Ophthalmol, 2019 Sep;257(9):1997-2004.
    PMID: 31273509 DOI: 10.1007/s00417-019-04405-z
    PURPOSE: Near work, accommodative inaccuracy and ambient lighting conditions have all been implicated in the development of myopia. However, differences in accommodative responses with age and refractive error under different visual conditions remain unclear. This study explores differences in accommodative ability and refractive error with exposure to differing ambient illumination and visual demands in Malay schoolchildren and adults.

    METHODS: Sixty young adults (21-25 years) and 60 schoolchildren (8-12 years) were recruited. Accommodative lag and accommodative fluctuations at far (6 m) and near (25 cm) were measured using the Grand Seiko WAM-5500 open-field autorefractor. The effects of mesopic room illumination on accommodation were also investigated.

    RESULTS: Repeated-measures ANOVA indicated that accommodative lag at far and near differed significantly between schoolchildren and young adults [F(1.219, 35.354) = 11.857, p  0.05). Accommodative lag and fluctuations were greater under mesopic room conditions for all ages [all p 

    Matched MeSH terms: Color Vision/physiology*
  12. Fulltext Euarchontan Opsin Variation Brings New Focus to Primate Origins
    Melin AD, Wells K, Moritz GL, Kistler L, Orkin JD, Timm RM, et al.
    Mol Biol Evol, 2016 Apr;33(4):1029-41.
    PMID: 26739880 DOI: 10.1093/molbev/msv346
    Debate on the adaptive origins of primates has long focused on the functional ecology of the primate visual system. For example, it is hypothesized that variable expression of short- (SWS1) and middle-to-long-wavelength sensitive (M/LWS) opsins, which confer color vision, can be used to infer ancestral activity patterns and therefore selective ecological pressures. A problem with this approach is that opsin gene variation is incompletely known in the grandorder Euarchonta, that is, the orders Scandentia (treeshrews), Dermoptera (colugos), and Primates. The ancestral state of primate color vision is therefore uncertain. Here, we report on the genes (OPN1SW and OPN1LW) that encode SWS1 and M/LWS opsins in seven species of treeshrew, including the sole nocturnal scandentian Ptilocercus lowii. In addition, we examined the opsin genes of the Central American woolly opossum (Caluromys derbianus), an enduring ecological analogue in the debate on primate origins. Our results indicate: 1) retention of ultraviolet (UV) visual sensitivity in C. derbianus and a shift from UV to blue spectral sensitivities at the base of Euarchonta; 2) ancient pseudogenization of OPN1SW in the ancestors of P. lowii, but a signature of purifying selection in those of C. derbianus; and, 3) the absence of OPN1LW polymorphism among diurnal treeshrews. These findings suggest functional variation in the color vision of nocturnal mammals and a distinctive visual ecology of early primates, perhaps one that demanded greater spatial resolution under light levels that could support cone-mediated color discrimination.
    Matched MeSH terms: Color Vision/genetics*
  13. Fulltext Study of Visual Function in Adult Epileptic Patients on Sodium Valproate or Carbamazepine Monotherapy
    Matthew TJH, Tharakan J, Tai E, Hussein A
    Cureus, 2019 Apr 27;11(4):e4553.
    PMID: 31275777 DOI: 10.7759/cureus.4553
    Objective Epilepsy is a debilitating disease. Visual function changes have been reported and may be attributed to the epileptic changes or as a result of medication side effect. Sodium valproate and carbamazepine are both first line anti-epileptic medications used in Malaysian health care. Sodium valproate inhibits glutamate and γ-aminobutyric acid (GABA) transaminase while carbamazepine acts on the sodium channel - both are an important part of the retina. This study aimed to compare the visual functions of epilepsy patients on carbamazepine or sodium valproate monotherapy. Design A cross-sectional study was conducted at a tertiary hospital between June 2016 and November 2018. Methods Patients with idiopathic epilepsy that fulfill the inclusion and exclusion criteria were recruited from the neurology clinic. They were divided into two groups and underwent complete eye examinations. Visual functions such as color vision testing, contrast sensitivity, visual field and retinal nerve fiber layer measurement were subsequently performed. Statistical analysis was done using Statistical Package for the Social Science, version 24 (SPSS Inc, Chicago, IL, USA). Results A total of 100 patients (sodium valproate: 50 patients; carbamazepine: 50 patients) were recruited for the study. There were no statistically significant changes in anatomical or visual function between the sodium valproate and carbamazepine group. However, patients from both groups displayed color vision defect in the blue and green axes. Changes in color vision could indicate early retina toxicity secondary to the medication. Although there were no visual field changes, patients recorded a slight reduction of mean deviation. Changes of mean deviation could be attributed to the side effect of medication or the disease process. Conclusions Epileptic patients taking sodium valproate or carbamazepine did not demonstrate statistically significant change in visual function.
    Matched MeSH terms: Color Vision Defects; Color Vision
  14. Fulltext The prevalence of visual defect among commercial vehicle drivers in Selangor, Malaysia
    Hoe VCW
    JUMMEC, 2006;9(1):35-38.
    MyJurnal
    A cross-sectional survey of commercial vehicle drivers who were renewing their own licences was conducted at the Selangor Road Transport Department office in Padang Jawa between 1 February 2002 and 28 February 2002, using questionnaire and medical examination. The objective was to determine the prevalence of myopia, colour vision deficiency and visual field defect among the commercial vehicle drivers. The respondents that reported visual defect at the time of interview was compared with those detected by the author through medical examination. Out of the 223 respondents, 21 (9.4%) reported to have myopia by the questionnaire survey. Through the visual examination there were 63 (28.3%) with myopia (visual acuity worse than 6/12),six (2.6%) had a visual field defect and 14 (6.3%) had red-green colour deficiency. The visual defect detected during the study among the commercial vehicle drivers, which were missed at the time of the routine medical examination were significant. The process of the statutory medical examination should be reviewed.
    Matched MeSH terms: Color Vision Defects
  15. Fulltext Colour vision deficiency among failed candidates for driving license in Sabah. [Abstract]
    Azmi N, Yahya AN, Gilong HCS, Anne SJ, Ting RHY, Amil Bangsa NH, et al.
    Borneo Journal of Medical Sciences, 2020;3(101):11-12.
    MyJurnal
    Introduction: Good visual acuity (VA) coupled with the ability to discriminate colours and having a sufficiently wide field of view are factors needed for safe driving. This study aimed to determine the types of colour vision deficiency (CVD) among failed candidates for driving license and to identify the accuracy of the Road transport Department (RTD) screening tests in detecting those who have poor VA and CVD in Sabah.
    Methods: A cross-sectional study on the patient’s records of all failed candidates for the driving license that were referred for further assessment by an optometrist. This study was conducted at eight hospitals in Sabah from March to June 2019. Basic demographic data, distance VA, Ishihara test and Farnsworth-Munsell D15 test were collected. Descriptive statistics were used to summarise the results. All subjects referred with best-corrected visual acuity (BCVA) 0.3 LogMAR were included.
    Results: A total of 73 subjects (79% males and 21% females), age range from 16 to 61 years (mean 29±13 years) were recruited. Bajau, Dusun, Bugis and Kadazan were the major ethnic among the subjects. Mean VA on attendance was 0.1 ± 0.19 LogMAR, while BCVA was 0.0 ± 0.07 LogMAR. Thirty-six subjects (49%) were found to have CVD. The prevalence of CVD was more in males than females (45% vs 4%). Most of the CVD were deutans (25%) followed by protans (22%), no findings of tritan CVD In this study, 37 subjects (51%) passed the Ishihara test. These were the false-positive error of the RTD screening tests.
    Conclusions: Hereditary red-green perceptive disorder was the commonest CVD in Sabah. The severity of CVD was not been evaluated in this study because it is best evaluated using Hardy Rand and Rittler (HRR) test. The false-positive results might be because of technical error or unfamiliar of using computerized colour vision test, especially among elderly candidates. Visual field screening might be considered in the future to ensure safe driving.
    Keywords:visual acuity (VA), colour vision deficiency (CVD), driving license
    NMRR Research ID: NMRR-19-1785-48811
    Matched MeSH terms: Color Vision Defects
  16. Fulltext Evaluation of retinal nerve fiber layer thickness and optic nerve functions in fellow eye of neuromyelitis optica with unilateral optic neuritis
    Ong Chin Feng W, Wan Hitam WH
    Taiwan J Ophthalmol, 2020 06 20;10(3):189-196.
    PMID: 33110750 DOI: 10.4103/tjo.tjo_22_20
    Purpose: Peripapillary retinal nerve fibre layer (RNFL) thickness might be useful in monitoring ongoing subclinical structural damage especially in eyes with no history of optic neuritis (ON) in neuromyelitis optica (NMO).

    Objective: To evaluate the peripapillary RNFL thickness and optic nerve functions in fellow eye of NMO with unilateral optic neuritis.

    Materials and Methods: A comparative cross-sectional study was conducted in 2 tertiary hospitals from August 2017 to May 2019. RNFL thickness and optic nerve functions were evaluated. Statistical analysis was performed using Statistical Package for Social Science version 24.

    Results: A total of 26 NMO patients and 26 controls were involved in this study. The median age (IQR) of NMO patients was 32.5 (12) years old. The RNFL thickness was significantly reduced in NMO patients with non-ON eyes as compared to control group. Best corrected visual acuity between the 2 groups were comparable (0.20 vs 0.00, p=0.071). Contrast sensitivity was also reduced in NMO patients (non-ON eyes) at all 5 spatial frequencies. In NMO group, 34.6% have normal colour vision. The mean deviation (MD) of Humphrey visual field (HVF) was higher in NMO group (p<0.001). There was a moderate correlation between RNFL thickness and contrast sensitivity. Weak correlation was found between the RNFL thickness with visual acuity and mean deviation of visual field test.

    Conclusion: Our study showed that the fellow eye of NMO patients with unilateral ON revealed a significant reduction in RNFL thickness and all the optic nerve functions have subtle early changes that signify a subclinical retinal damage.

    Matched MeSH terms: Color Vision
  17. Visual Presentation and Factors Affecting Visual Outcome in Children with Craniopharyngioma in East Coast States of Peninsular Malaysia: A Five-year Review
    Mohd-Ilham IM, Ahmad-Kamal GR, Wan Hitam WH, Shatriah I
    Cureus, 2019 Apr 08;11(4):e4407.
    PMID: 31205829 DOI: 10.7759/cureus.4407
    Purpose To describe the visual presentation and factors affecting visual outcome in pediatric patients treated for craniopharyngioma at a referral center in the East Coast states of Peninsular Malaysia. Methodology A retrospective review of medical records of children aged 17 years and below who had been treated for craniopharyngioma in Hospital Universiti Sains Malaysia from January 2014 to December 2018. The data collected included age, gender, presenting symptoms and duration, visual acuity, visual fields, color vision, light brightness, relative afferent pupillary defects, fundus examination and cranial nerves examination. The best corrected visual acuity during presentation, and after a one-year post-operative period, was documented. Records on investigations, surgical procedures, therapeutic modalities and recurrences were also reviewed. Results A total of 11 pediatric patients (22 eyes) were recruited. Fifty percent presented with optic atrophy. The mean duration of the onset of symptoms before consultation was 22.3 (24.5) months. A final best corrected visual acuity of 6/12 (20/40) or better was observed in 50% of the patients. There was a statistically significant association between presenting visual acuity, optic nerve function and visual field defects, and the final visual outcome. Conclusions Visual presentations in our study were fairly similar to previous reported studies. One-third presented late with permanent visual loss. Almost half had significant visual impairment after one-year post-operative period. Significant associations were observed between presenting visual acuity, duration of symptoms, impairment of optic nerve function tests, and visual field defects during presentation, and final visual acuity at one year after treatment.
    Matched MeSH terms: Color Vision
  18. Fulltext Diffuse unilateral subacute neuroretinitis in a young boy: a case report
    Guan-Fook N, Hayati AA, Raja-Azmi MN, Liza-Sharmini AT, Wan-Hazabbah WH, Zunaina E
    Clin Ophthalmol, 2012;6:487-90.
    PMID: 22536041 DOI: 10.2147/OPTH.S29806
    We report a case of diffuse unilateral subacute neuroretinitis in a young boy with no clinical visualization of nematode. The diagnosis was made based on clinical findings and detection of Toxocara immunoglobulin G by Western blot test. An 11-year-old Malay boy presented with progressive blurring of vision in the left eye for a duration of 1 year. It was associated with intermittent floaters. Visual acuity in the left eye was 6/45 and improved to 6/24 with pinhole. There was positive relative afferent pupillary defect, impaired color vision, and presence of red desaturation in the left eye. There were occasional cells in the anterior chamber with no conjunctiva injection. Posterior segment examination revealed mild-to-moderate vitritis and generalized pigmentary changes of the retina with attenuated vessels. The optic disk was slightly hyperemic with mild edema. There was presence of multiple, focal, gray-white subretinal lesions at the inferior part of the retina. Full blood picture results showed eosinophilia with detection of Toxocara immunoglobulin G by Western blot test. Investigations for other infective causes and connective tissue diseases were negative. The diagnosis of diffuse unilateral subacute neuroretinitis secondary to Toxocara was made based on clinical findings and laboratory results. He was treated with oral albendazole 400 mg daily for 5 days and oral prednisolone 1 mg/kg with tapering doses over 6 weeks. At 1 month follow-up, the inflammation had reduced, and multiple, focal, gray-white subretinal lesions were resolved; however there was no improvement of vision.
    Matched MeSH terms: Color Vision
  19. Fulltext Prevalence of colour vision deficiency among medical students and health personnel.
    Balasundaram R, Reddy SC
    Malays Fam Physician, 2006;1(2):52-53.
    PMID: 27570586 MyJurnal
    A survey of colour vision deficiency among 1427 medical students and healthcare personnel in Seremban revealed a prevalence of 3.2% with a marked male predominance (males 6.7%, females 0.4%). In view of the potential difficulties faced by such personnel in clinical works, early detection of this deficiency allowed appropriate counselling.
    Matched MeSH terms: Color Vision Defects
  20. Neural activation patterns and connectivity in visual attention during number and non-number processing: An ERP study using Ishihara pseudoisochromatic plates
    Al-Marri F, Reza F, Begum T, Hitam WHW, Jin GK, Xiang J
    J Integr Neurosci, 2018 Aug 15;17(3):257-269.
    PMID: 30338955 DOI: 10.31083/JIN-170058
    Visual cognitive function is important in the construction of executive function in daily life. Perception of visual number form (e.g. Arabic digits) and numerosity (numeric magnitude) is of interest to cognitive neuroscientists. Neural correlates and the functional measurement of number representations are complex events when their semantic categories are assimilated together with concepts of shape and color. Color perception can be processed further to modulate visual cognition. The Ishihara pseudoisochromatic plates are one of the best and most common screening tools for basic red-green color vision testing. However, there has been little study of visual cognitive function assessment using such pseudoisochromatic plates. 25 healthy normal trichromat volunteers were recruited and studied using a 128-sensor net to record event-related electroencephalogram. Subjects were asked to respond by pressing numbered buttons when they saw the number and non-number plates of the Ishihara color vision test. Amplitudes and latencies of N100 and P300 event related potential components were analyzed from 19 electrode sites in the international 10-20 system. A brain topographic map, cortical activation patterns, and Granger causation (effective connectivity) were analyzed from 128 electrode sites. No significant differences between N100 event related potential components for either stimulus indicates early selective attention processing was similar for number and non-number plate stimuli, but non-number plate stimuli evoked significantly higher amplitudes, longer latencies of the P300 event related potential component with a slower reaction time compared to number plate stimuli imply the allocation of attentional load was more in non-number plate processing. A different pattern of the asymmetric scalp voltage map was noticed for P300 components with a higher intensity in the left hemisphere for number plate tasks and higher intensity in the right hemisphere for non-number plate tasks. Asymmetric cortical activation and connectivity patterns revealed that number recognition occurred in the occipital and left frontal areas where as the consequence was limited to the occipital area during the non-number plate processing. Finally, results demonstrated that the visual recognition of numbers dissociates from the recognition of non-numbers at the level of defined neural networks. Number recognition was not only a process of visual perception and attention, but was also related to a higher level of cognitive function, that of language.
    Matched MeSH terms: Color Vision
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