Displaying publications 1 - 20 of 121 in total

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  1. Khan NB, Ibrahim Z, Nguyen LTT, Javed MF, Jameel M
    PLoS One, 2017;12(10):e0185832.
    PMID: 28982172 DOI: 10.1371/journal.pone.0185832
    This study numerically investigates the vortex-induced vibration (VIV) of an elastically mounted rigid cylinder by using Reynolds-averaged Navier-Stokes (RANS) equations with computational fluid dynamic (CFD) tools. CFD analysis is performed for a fixed-cylinder case with Reynolds number (Re) = 104 and for a cylinder that is free to oscillate in the transverse direction and possesses a low mass-damping ratio and Re = 104. Previously, similar studies have been performed with 3-dimensional and comparatively expensive turbulent models. In the current study, the capability and accuracy of the RANS model are validated, and the results of this model are compared with those of detached eddy simulation, direct numerical simulation, and large eddy simulation models. All three response branches and the maximum amplitude are well captured. The 2-dimensional case with the RANS shear-stress transport k-w model, which involves minimal computational cost, is reliable and appropriate for analyzing the characteristics of VIV.
    Matched MeSH terms: Elasticity*
  2. Mustafa G, Baleanu D, Ejaz ST, Anjum K, Ahmadian A, Salahshour S, et al.
    Math Biosci Eng, 2020 09 28;17(6):6659-6677.
    PMID: 33378870 DOI: 10.3934/mbe.2020346
    In this paper, we first present a 6-point binary interpolating subdivision scheme (BISS) which produces a C2 continuous curve and 4th order of approximation. Then as an application of the scheme, we develop an iterative algorithm for the solution of 2nd order nonlinear singularly per-turbed boundary value problems (NSPBVP). The convergence of an iterative algorithm has also been presented. The 2nd order NSPBVP arising from combustion, chemical reactor theory, nuclear engi-neering, control theory, elasticity, and fluid mechanics can be solved by an iterative algorithm with 4th order of approximation.
    Matched MeSH terms: Elasticity
  3. Madun, A., Wijeyesekera, D.C., Ahmad Tajuddin, S.A., Zainalabidin, M.H., Yunus, R., Baharudin, M.F.
    MyJurnal
    Seismic surface waves are a non-destructive technique used to obtain the dynamic properties of soil by measuring the shear wave velocity and calculating the shear modulus of soil. The shear modulus is one of the parameters to measure the stiffness of materials. This study evaluates soil profiles and the position of the sensor while conducting measurements of two , soil profiles, i.e. lateral and vertical non-homogeneities, using a continuous surface wave analysis (CSW) and multi-channel analysis of surface waves (MASW). Results showed the dispersive curve demonstrated an increased shear wave velocity with increasing depth for the sensor pair measurements on the clay (between columns), and decreased shear wave velocity with increasing depth for the sensor pair measurements on the column. In both instances the surface wave velocity results influenced by the depth and size of the wavelength, indicating that depth and wavelength controlled the volume of measurement in an elliptical shape. Therefore, the shear wave velocities and thus stiffness measured from the surface wave velocity techniques are represented the volume of soil measured across the sensor length.
    Matched MeSH terms: Elasticity Imaging Techniques
  4. Ng YZ, Lai LL, Wong SW, Mohamad SY, Chuah KH, Chan WK
    PLoS One, 2021;16(5):e0250300.
    PMID: 33939744 DOI: 10.1371/journal.pone.0250300
    BACKGROUND & AIM: We studied FibroTouch (FT) and Fibroscan (FS) examination results and their repeatability when performed by healthcare personnel of different background.

    METHODS: FT and FS examinations were performed on patients with chronic liver disease by two operators, a doctor and a nurse, twice on each patient, at two different time points, independent of each other.

    RESULTS: The data for 163 patients with 1304 examinations was analyzed. There was strong correlation between FT and FS for attenuation parameter (Spearman's rho 0.76, p<0.001) and liver stiffness measurement (LSM) (Spearman's rho 0.70, p<0.001). However, FT produced higher value at lower attenuation parameter and LSM, and lower value at higher attenuation parameter and LSM. There was substantial agreement when using 15kPa LSM cut-off, but only moderate agreement when using 10kPa and 20kPa LSM cut-offs and 248dB/m, 268dB/m and 280dB/m attenuation parameter cut-offs. The IQR for attenuation parameter and IQR/median for LSM were significantly lower for FT compared with FS (4dB/m vs 27dB/m, p<0.001, and 10 vs 12, p<0.001, respectively). The intra- and inter-observer reliability of attenuation parameter and LSM using FT and FS were good to excellent with intraclass correlation coefficients 0.89-0.99. FT had shorter examination time (33s vs 47s, p<0.001) and less invalid measurements (0 vs 2, p<0.001).

    CONCLUSION: Measurements obtained with FT and FS strongly correlated, but significant differences in their absolute values, consistency, examination time and number of invalid measurements were observed. Either device can be used by healthcare personnel of different backgrounds when sufficiently trained.

    Matched MeSH terms: Elasticity Imaging Techniques/instrumentation*; Elasticity Imaging Techniques/methods; Elasticity Imaging Techniques/standards
  5. Leong SS, Wong JHD, Md Shah MN, Vijayananthan A, Jalalonmuhali M, Mohd Sharif NH, et al.
    Ultrasound Med Biol, 2020 01;46(1):34-45.
    PMID: 31594681 DOI: 10.1016/j.ultrasmedbio.2019.08.011
    Tissue elasticity is related to the pathologic state of kidneys and can be measured using shear wave elastography (SWE). However, SWE quantification has not been rigorously validated. The aim of this study was to evaluate the accuracy of SWE-measured stiffness and the effect of tissue anisotropy on SWE measurements. Point SWE (pSWE), 2-D SWE and dynamic mechanical analysis (DMA) were used to measure stiffness and evaluate the effect of tissue anisotropy on the measurements. SWE and DMA were performed on phantoms of different gelatin concentrations. In the tissue anisotropy study, SWE and DMA were performed on the outer cortex of sheep kidneys. In the in vivo study, 15 patients with different levels of interstitial fibrosis were recruited for pSWE measurements. Another 10 healthy volunteers were recruited for tissue anisotropy studies. SWE imaging revealed a non-linear increase with gelatin concentration. There was a significant correlation between pSWE and 2-D SWE, leading to the establishment of a linear regression equation between the two SWE ultrasound measurements. In the anisotropy study, the median difference in stiffness between shear waves oriented at 0° and 90° towards the pyramid axis was significant. In the in vivo study, there was a strong positive linear correlation between pSWE and the percentage of interstitial fibrosis. There was a significant difference in the Young's modulus (YM) between severities of fibrosis. The mean YM values were lower in control patients than in patients with mild, moderate and severe fibrosis. YM values were also significantly higher when shear waves were oriented at 0° toward the pyramid axis. Tissue stiffness and anisotropy affects SWE measurements. These factors should be recognized before applying SWE for the interpretation of measured values.
    Matched MeSH terms: Elasticity Imaging Techniques*
  6. Hassan MA, Hamdi M, Noma A
    J Mech Behav Biomed Mater, 2012 Jan;5(1):99-109.
    PMID: 22100084 DOI: 10.1016/j.jmbbm.2011.08.011
    The mechanical behavior of the heart muscle tissues is the central problem in finite element simulation of the heart contraction, excitation propagation and development of an artificial heart. Nonlinear elastic and viscoelastic passive material properties of the left ventricular papillary muscle of a guinea pig heart were determined based on in-vitro precise uniaxial and relaxation tests. The nonlinear elastic behavior was modeled by a hypoelastic model and different hyperelastic strain energy functions such as Ogden and Mooney-Rivlin. Nonlinear least square fitting and constrained optimization were conducted under MATLAB and MSC.MARC in order to obtain the model material parameters. The experimental tensile data was used to get the nonlinear elastic mechanical behavior of the heart muscle. However, stress relaxation data was used to determine the relaxation behavior as well as viscosity of the tissues. Viscohyperelastic behavior was constructed by a multiplicative decomposition of a standard Ogden strain energy function, W, for instantaneous deformation and a relaxation function, R(t), in a Prony series form. The study reveals that hypoelastic and hyperelastic (Ogden) models fit the tissue mechanical behaviors well and can be safely used for heart mechanics simulation. Since the characteristic relaxation time (900 s) of heart muscle tissues is very large compared with the actual time of heart beating cycle (800 ms), the effect of viscosity can be reasonably ignored. The amount and type of experimental data has a strong effect on the Ogden parameters. The in vitro passive mechanical properties are good initial values to start running the biosimulation codes for heart mechanics. However, an optimization algorithm is developed, based on clinical intact heart measurements, to estimate and re-correct the material parameters in order to get the in vivo mechanical properties, needed for very accurate bio-simulation and for the development of new materials for the artificial heart.
    Matched MeSH terms: Elasticity*
  7. Khammas ASA, Mahmud R, Hassan HA, Ibrahim I, Mohammed SS
    J Ultrasound, 2023 Mar;26(1):13-38.
    PMID: 36040577 DOI: 10.1007/s40477-022-00712-0
    INTRODUCTION: Plantar fasciitis (PFS) is described by an intense pain over medial tubercle of calcaneus, increased with the first step after waking up, after rest and during weightbearing activity. It is the most common cause of plantar heel pain in adults with the prevalence estimated 10% of the general population. Ultrasound imaging is commonly being used to measure the PF thickness, evaluate the efficacy of different treatments and a guide therapeutic technique in patients with PFS. The objective of this study was to systematically review the studies that were previously published to evaluate the role of ultrasound in the assessment of PF in patients with PFS.

    METHODS: A systematic search was carried out over the last 5 years from 2017 to 2022 on basis the following electronic databases: Science Direct, Scopus, Web of Science, Springer and PubMed. The keywords that used in the searching were: ultrasound, sonography, ultrasonography, plantar fasciitis, imaging of plantar fascia, physiotherapy of plantar fasciitis, interventional treatment of plantar fasciitis, randomized controlled trial of plantar fasciitis and interventional ultrasound. The review focused on the assessment of PF in patients with PFS underwent different interventions using B-mode, shear wave elastography (SWE) and color Doppler ultrasound.

    RESULTS: During the search process, 1661 were recorded using the proper keywords from 2017 to 2022 in which 666 original articles were found after removing the review and duplicated articles. Of these, thirty articles met the inclusion criteria and included in this review. The articles have assessed the PF in patients with PFS under different conditions using different ultrasound modes. Twenty-six articles evaluated the effectiveness of different treatment on PF in patients with PFS using different ultrasound modes. In 8 of 26 articles, the ultrasound was used as both an assessment tool of PF and guide therapeutic technique in patients with PFS. In 18 articles, the ultrasound was used as only assessment tool to identify the PF thickness and its observation changes in patients with PFS. Four articles compared the PF thickness and its intrafascial changes between patients with PFS and healthy subjects.

    CONCLUSION: The ultrasound can be a reliable tool in assessment the effect of different interventions on PF by evaluating its thickness, echogenicity and stiffness changes in patients with PFS. There were different methods and treatments were used among the studies.

    Matched MeSH terms: Elasticity Imaging Techniques*
  8. Ch'ng SY, Andriyana A, Tee YL, Verron E
    Materials (Basel), 2015 Mar 02;8(3):884-898.
    PMID: 28787977 DOI: 10.3390/ma8030884
    The effect of carbon black on the mechanical properties of elastomers is of great interest, because the filler is one of principal ingredients for the manufacturing of rubber products. While fillers can be used to enhance the properties of elastomers, including stress-free swelling resistance in solvent, it is widely known that the introduction of fillers yields significant inelastic responses of elastomers under cyclic mechanical loading, such as stress-softening, hysteresis and permanent set. When a filled elastomer is under mechanical deformation, the filler acts as a strain amplifier in the rubber matrix. Since the matrix local strain has a profound effect on the material's ability to absorb solvent, the study of the effect of carbon black content on the swelling characteristics of elastomeric components exposed to solvent in the presence of mechanical deformation is a prerequisite for durability analysis. The aim of this study is to investigate the effect of carbon black content on the swelling of elastomers in solvent in the presence of static mechanical strains: simple extension and simple torsion. Three different types of elastomers are considered: unfilled, filled with 33 phr (parts per hundred) and 66 phr of carbon black. The peculiar role of carbon black on the swelling characteristics of elastomers in solvent in the presence of mechanical strain is explored.
    Matched MeSH terms: Elasticity
  9. Abu Hassan Shaari Mohd Nor, Fauziah Maarof
    The main purpose of this article is to introduce the technique of panel data analysis in econometrics modeling. The elasticity of labour, capital and economic of scale for twenty two food manufacturing firms covering from 1989 to 1993 is estimated using the Cobb-Douglas model. The three main techniques of panel data analysis discussed are least square dummy variables (LSDV), analysis of covariance (ANCOVA) and generalized least square (GLS). Ordinary Least Square (OLS) method is included as the basis of comparison.
    Matched MeSH terms: Elasticity
  10. Paracha KN, Butt AD, Alghamdi AS, Babale SA, Soh PJ
    Sensors (Basel), 2019 Dec 28;20(1).
    PMID: 31905646 DOI: 10.3390/s20010177
    This work reviews design aspects of liquid metal antennas and their corresponding applications. In the age of modern wireless communication technologies, adaptability and versatility have become highly attractive features of any communication device. Compared to traditional conductors like copper, the flow property and lack of elasticity limit of conductive fluids, makes them an ideal alternative for applications demanding mechanically flexible antennas. These fluidic properties also allow innovative antenna fabrication techniques like 3D printing, injecting, or spraying the conductive fluid on rigid/flexible substrates. Such fluids can also be easily manipulated to implement reconfigurability in liquid antennas using methods like micro pumping or electrochemically controlled capillary action as compared to traditional approaches like high-frequency switching. In this work, we discuss attributes of widely used conductive fluids, their novel patterning/fabrication techniques, and their corresponding state-of-the-art applications.
    Matched MeSH terms: Elasticity
  11. Leong SS, Wong JHD, Md Shah MN, Vijayananthan A, Jalalonmuhali M, Chow TK, et al.
    Nephrology (Carlton), 2021 Jan;26(1):38-45.
    PMID: 33058334 DOI: 10.1111/nep.13805
    AIM: Renal biopsy is the gold standard for the histological characterization of chronic kidney disease (CKD), of which renal fibrosis is a dominant component, affecting its stiffness. The aim of this study was to investigate the correlation between kidney stiffness obtained by shear wave elastography (SWE) and renal histological fibrosis.

    METHODS: Shear wave elastography assessments were performed in 75 CKD patients who underwent renal biopsy. The SWE-derived estimates of the tissue Young's modulus (YM), given as kilopascals (kPa), were measured. YM was correlated to patients' renal histological scores, broadly categorized into glomerular, tubulointerstitial and vascular scores.

    RESULTS: Young's modulus correlates significantly with tubulointerstitial score (ρ = 0.442, P 

    Matched MeSH terms: Elasticity/physiology; Elasticity Imaging Techniques/methods*
  12. Sze-Yin, S., Lai-Hoong, C.
    MyJurnal
    The objective of this work was to study the effects of trehalose and maltodextrin on Chinese
    steamed bread (CSB) prepared from frozen dough. Trehalose (0.1 and 0.2% w/w) and
    maltodextrin (1 and 2% w/w) were added and CSB prepared from the fresh dough and the
    frozen dough was characterized in terms of spread ratio, specific volume, staling index and
    stress relaxation properties. Upon frozen storage, spread ratio and specific volume of CSB,
    and elasticity of the bread crumb were reduced. The extend of deterioration was significantly
    reduced with the addition of 0.1% trehalose and 2% maltodextrin. Excessive addition of
    trehalose and maltodextrin was found to cause detrimental effects to CSB quality.
    Matched MeSH terms: Elasticity
  13. Wang D, Fu Y, Ashraf MA
    Open Med (Wars), 2015;10(1):425-433.
    PMID: 28352731 DOI: 10.1515/med-2015-0074
    Tagged Magnetic Resonance Imaging (MRI) is a noninvasive technique for examining myocardial function and deformation. Tagged MRI can also be used in quasi-static MR elastography to acquire strain maps of other biological soft tissues. Harmonic phase (HARP) provides automatic and rapid analysis of tagged MR images for the quantification and visualization of myocardial strain. We propose a new artifact reduction method in strain maps. Image intensity of the DC component is estimated and subtracted from spatial modulation of magnetization (SPAMM) tagged MR images. DC peak interference in harmonic phase extraction is greatly reduced after DC component subtraction. The proposed method is validated using both simulated and MR acquired tagged images. Strain maps are obtained with better accuracy and smoothness after DC component subtraction.
    Matched MeSH terms: Elasticity Imaging Techniques
  14. Liu J, Tan CS, Yu Z, Lan Y, Abell C, Scherman OA
    Adv Mater, 2017 Mar;29(10).
    PMID: 28092128 DOI: 10.1002/adma.201604951
    Biomimetic supramolecular dual networks: By mimicking the structure/function model of titin, integration of dynamic cucurbit[8]uril mediated host-guest interactions with a trace amount of covalent cross-linking leads to hierarchical dual networks with intriguing toughness, strength, elasticity, and energy dissipation properties. Dynamic host-guest interactions can be dissociated as sacrificial bonds and their facile reformation results in self-recovery of the dual network structure as well as its mechanical properties.
    Matched MeSH terms: Elasticity
  15. Solarin SA, Bello MO
    Environ Sci Pollut Res Int, 2021 Dec;28(46):65313-65332.
    PMID: 34235686 DOI: 10.1007/s11356-021-15113-9
    The energy profile of India is dominated by fossil fuels, which create concerns over resource and environmental sustainability as fossil fuels are non-renewable and high carbon emitting. This scenario has necessitated the call for more renewables to replace fossil fuels to address resource and environmental sustainability concerns. This study, therefore, investigates the possibility of switching the fossil fuels of oil, coal, and natural gas for renewable energy in India. Using annual Indian data spanning more than four decades, a transcendental logarithmic production function based on a second-order Taylor Series approximation is estimated with the ridge regression technique. To achieve robustness, two equations with gross domestic product and adjusted net savings as regressands are estimated to proxy economic growth and sustainable development, respectively. The empirical results show substantial substitution possibilities between the fuels for both gross domestic product and adjusted net savings equations. The empirical findings show that India has the capacity to satisfy its energy needs through renewables to pursue not only economic growth but sustainable development. To actualize this potential, the Indian government should promote investment in renewables as this also promotes economic growth and development.
    Matched MeSH terms: Elasticity
  16. Hu Q, Ma F, Wei H, Yang W, Deng S, Yu X, et al.
    J Texture Stud, 2023 Aug;54(4):582-594.
    PMID: 37400374 DOI: 10.1111/jtxs.12785
    The aim of this study was to compare the investigations of various contents of egg white protein (2.0%-8.0%, EWP), microbial transglutaminase (0.1%-0.4%, MTGase), and konjac glucomannan (0.5%-2.0%, KGM) on the gelling properties and rheological behavior of Trachypenaeus Curvirostris shrimp surimi gel (SSG), and assessed the modification mechanisms through the analysis of structure characteristics. The findings suggested that all modified SSG samples (expect SSG-KGM2.0% ) had the higher gelling properties and the denser network structure than those of unmodified SSG. Meanwhile, EWP could give SSG a better appearance than MTGase and KGM. Rheological results showed that SSG-EWP6% and SSG-KGM1.0% had the highest G' and G″, demonstrating that the formation of higher levels of elasticity and hardness. All modifications could increase gelation rates of SSG along with the reduction of G″ during the degeneration of protein. According to the FTIR results, three modification methods changed SSG protein conformation with the increasing α-helix and β-sheet contents and the decreasing of random coil content. LF-NMR results indicated that more free water could be transformed into immobilized water in the modified SSG gels, which contributed to improve the gelling properties. Furthermore, molecular forces showed that EWP and KGM could further increase the hydrogen bonds and hydrophobic interaction in SSG gels, while MTGase could induce the formation of more disulfide bonds. Thus, compared with another two modifications, EWP modified SSG gels showed the highest gelling properties.
    Matched MeSH terms: Elasticity
  17. Acharya UR, Ng WL, Rahmat K, Sudarshan VK, Koh JEW, Tan JH, et al.
    Comput Biol Med, 2017 12 01;91:13-20.
    PMID: 29031099 DOI: 10.1016/j.compbiomed.2017.10.001
    Shear wave elastography (SWE) examination using ultrasound elastography (USE) is a popular imaging procedure for obtaining elasticity information of breast lesions. Elasticity parameters obtained through SWE can be used as biomarkers that can distinguish malignant breast lesions from benign ones. Furthermore, the elasticity parameters extracted from SWE can speed up the diagnosis and possibly reduce human errors. In this paper, Shearlet transform and local binary pattern histograms (LBPH) are proposed as an original algorithm to differentiate malignant and benign breast lesions. First, Shearlet transform is applied on the SWE images to acquire low frequency, horizontal and vertical cone coefficients. Next, LBPH features are extracted from the Shearlet transform coefficients and subjected to dimensionality reduction using locality sensitivity discriminating analysis (LSDA). The reduced LSDA components are ranked and then fed to several classifiers for the automated classification of breast lesions. A probabilistic neural network classifier trained only with seven top ranked features performed best, and achieved 98.08% accuracy, 98.63% sensitivity, and 97.59% specificity in distinguishing malignant from benign breast lesions. The high sensitivity and specificity of our system indicates that it can be employed as a primary screening tool for faster diagnosis of breast malignancies, thereby possibly reducing the mortality rate due to breast cancer.
    Matched MeSH terms: Elasticity Imaging Techniques/methods*
  18. Harry S, Lai LL, Nik Mustapha NR, Abdul Aziz YF, Vijayananthan A, Rahmat K, et al.
    Clin Gastroenterol Hepatol, 2020 04;18(4):945-953.e2.
    PMID: 31442603 DOI: 10.1016/j.cgh.2019.08.023
    BACKGROUND & AIMS: HepaFat-Scan is a magnetic resonance imaging-based method for quantification of hepatic steatosis by volumetric liver fat fraction (VLFF) measurement. We aimed to validate VLFF and to compare it with controlled attenuation parameter (CAP) for determination of hepatic steatosis grade in patients with NAFLD, using histopathology and stereologic analyses of biopsies as the reference standard.

    METHODS: We performed a prospective study of consecutive adults with NAFLD who were scheduled for a liver biopsy at a tertiary hospital in Malaysia. Patients underwent VLFF and CAP measurements on the same day as their liver biopsy. Histopathology analyses of liver biopsy specimens were reported according to the Nonalcoholic Steatohepatitis Clinical Research Network scoring system. Stereologic analysis was performed using grid-point counting method combined with the Delesse principle.

    RESULTS: We analyzed data from 97 patients (mean age 57.0 ± 10.1 years; 44.33% male; 91.8% obese; 95.9% centrally obese). Based on histopathology analysis, the area under receiver operating characteristic curve (AUROC) for VLFF in detection of steatosis grade ≥S2 was 0.92 and for CAP the AUROC was 0.65 (P < .001). Based on stereological analysis, the AUROC for VLFF for detection of steatosis grade ≥S2 was 0.92 and for CAP the AUROC was 0.63, (P = .002); for identification of steatosis grade S3, the AUROC for VLFF was 0.92 and for CAP the AUROC was 0.68 (P < .001).

    CONCLUSIONS: In a prospective study of patients with NAFLD undergoing liver biopsy analysis, we found VLFF to more accurately determine grade of hepatic steatosis than CAP.

    Matched MeSH terms: Elasticity Imaging Techniques*
  19. Wong SW, Chan WK, Mohamed R
    J Viral Hepat, 2020 12;27(12):1297-1305.
    PMID: 32668489 DOI: 10.1111/jvh.13361
    Hepatic steatosis is increasingly common and has been implicated in progression of liver fibrosis in chronic hepatitis B (CHB) patients. We aimed to investigate the impact of hepatic steatosis on liver fibrosis and clinical outcomes in CHB patients. Consecutive CHB patients who underwent transient elastography between 2013 and 2017 at a tertiary hospital were included in this longitudinal cohort study. Presence of hepatic steatosis was defined as controlled attenuation parameter, CAP ≥ 248 dB/m, while advanced liver fibrosis was defined as liver stiffness measurement, LSM ≥ 9.4 kPa. Cardiovascular events, liver-related complications, malignancy and mortality and a composite of these outcomes were evaluated with Kaplan-Meier analysis and Cox proportional hazards regression. Our study cohort included 614 patients with median follow-up of 45 (32-63) months. Hepatic steatosis was present in 294 patients (47.9%), and advanced liver fibrosis was present in 127 patients (21.0%). Presence of hepatic steatosis (OR: 1.956, 95% CI: 1.250-3.060) and diabetes mellitus (OR: 3.507, 95% CI: 2.069-5.944) was independently associated with advanced fibrosis. Advanced fibrosis was independently associated with composite outcome (HR: 2.496, 95% CI: 1.352-4.606), liver-related complications (HR: 3.765, 95% CI: 1.380-10.271) and mortality (HR: 3.632, 95% CI: 1.342-9.826), but not cardiovascular events and malignancy. Hepatic steatosis was not associated with any adverse outcomes. We conclude that hepatic steatosis is common and associated with advanced fibrosis in CHB patients. Unlike advanced fibrosis, hepatic steatosis does not predict adverse outcomes in CHB patients.
    Matched MeSH terms: Elasticity Imaging Techniques*
  20. Adams LA, Chan WK
    Semin Liver Dis, 2020 11;40(4):331-338.
    PMID: 32526784 DOI: 10.1055/s-0040-1713006
    Noninvasive serum and imaging methods offer accessible, accurate, and safe assessment of fibrosis severity in nonalcoholic fatty liver disease. In contrast, current serum and imaging methods for the prediction of nonalcoholic steatohepatitis are not sufficiently accurate for routine clinical use. Serum fibrosis markers that incorporate direct measures of fibrogenesis (for example, hyaluronic acid) or fibrinolysis are generally more accurate than biomarkers not incorporating direct measures of fibrogenesis. Elastography methods are more accurate than serum markers for fibrosis assessment and particularly for the determination of cirrhosis, but have a significant failure and/or unreliability rate in obese individuals. To overcome this, combining serum and elastography methods in a sequential manner minimizes indeterminate results and maintains accuracy. The accuracy of current noninvasive methods for monitoring fibrosis response to treatment are limited; however, new tools derived from "omic" methodologies offer promise for the future.
    Matched MeSH terms: Elasticity Imaging Techniques*
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