MyMedR

Fulltext Cut-it-out technique for ocular fish-hook injury

Ahmad SS, Seng CW, Ghani SA, Lee JF

J Emerg Trauma Shock, 2013 Oct;6(4):293-5.

PMID: 24339666 DOI: 10.4103/0974-2700.120384

An 11-year-old boy was involved in an injury with a fish-hook to his eye. The hook had impaled itself to the cornea and deeper structures. There was associated corneal edema and hyphema, making visualization difficult. In this case, we performed the unusual "cut-it-out" technique to remove the hook from the eye.

Matched MeSH terms: Corneal Injuries

Fulltext Cyphellophora sp. Isolated from a Corneal Ulcer in the Human Eye

Rajandran S, Razali KM, Mustapha M, Palaniappan PA, Amran F

Case Rep Ophthalmol Med, 2020;2020:5861258.

PMID: 32774963 DOI: 10.1155/2020/5861258

Cyphellophora is a black yeast-like fungus with most of the strains being isolated from soil and plants. It tends to cause sooty blotch and flyspeck disease in plants. In humans, it is known to cause superficial skin and nail infections. This report highlights the case of a patient who initially presented with a small corneal abrasion which rapidly progressed into a corneal ulcer after the patient did not respond to the initial conventional treatment. The laboratory results from the corneal scraping found it to be Cyphellophora sp.

Matched MeSH terms: Corneal Injuries

Fulltext The effects of acacia honey on in vitro corneal abrasion wound healing model

Ker-Woon C, Abd Ghafar N, Hui CK, Mohd Yusof YA, Wan Ngah WZ

BMC Cell Biol., 2015;16:2.

PMID: 25887200 DOI: 10.1186/s12860-015-0053-9

Acacia honey (AH) has been proven to improve skin wound healing, but its therapeutic effects on corneal epithelium has not been elucidated to date. This study aimed to investigate the effects of AH on cultured corneal epithelial cells (CEC) on in vitro corneal abrasion wound healing model. Six New Zealand white rabbits' CEC were isolated and cultured until passage 1. Circular wound area was created onto a confluent monolayer CEC using a corneal trephine which mimicked corneal abrasion and treated with 0.025% AH supplemented in basal medium (BM) and complete cornea medium (CCM). Wound healing was measured as the percentage of wound closure by the migration of CEC on day 0, day 3 and day 6, post wound creation. The morphological changes of CEC were assessed via phase contrast microscopy. Gene and protein expressions of cytokeratin (CK3), fibronectin and cluster of differentiation 44 (CD44) in AH treated groups and control groups were determined by real-time PCR and immunocytochemistry, respectively.

Matched MeSH terms: Corneal Injuries/pathology; Corneal Injuries/therapy

Fulltext Intralenticular matchstick in a toddler: a rare presentation of penetrating ocular injury from a toy gun

Royan, Jeyarine, Teo, Khairy Shamel Sonny, Vengadasalam, Selva Raja

Journal of Biomedical and Clinical Sciences, 2018;3(1):15-18.

MyJurnal

To report on a rare case of an intralenticular foreign body which
demonstrates that use of a spring-powered airsoft gun can result in a severe
ocular injury. A 2-year-old male presented following a trauma to the left eye.
The trauma was caused by a wooden matchstick from a spring-powered airsoft
gun being shot into his eye. On examination, there was a shallow anterior
chamber with a full thickness corneal laceration, with fragmented matchstick
pieces embedded in the cornea and in the lens. The corneal foreign bodies
were removed, corneal laceration wound sutured and lensectomy done. There
were no post-operative complications, and the cornea wound healed with a
scar. A few months later, he underwent a successful secondary intraocular lens
implantation surgery with an iris claw lens. Airsoft guns are easily available to
children who are unaware of its dangers. It can cause significant ocular
morbidity despite successful surgical treatment of the injury.

Matched MeSH terms: Corneal Injuries

Fulltext Gelam honey promotes ex vivo corneal fibroblasts wound healing

Md Yusof A, Abd Ghafar N, Kamarudin TA, Chua KH, Azmi MF, Ng SL, et al.

Cytotechnology, 2019 Dec;71(6):1121-1135.

PMID: 31606844 DOI: 10.1007/s10616-019-00349-8

This study evaluated the effects of Gelam honey (GH) on ex vivo corneal fibroblast ulcer model via wound healing assay, gene expression and immunocytochemistry. Corneal fibroblasts from New Zealand white rabbits were culture expanded. The corneal fibroblast wound healing capacity was observed by creating a circular wound onto confluent monolayer cells cultured in basal medium (BM), BM with GH, serum-enriched basal medium (BMS) and BMS with GH respectively. Wound healing assay and phenotypic characterization of the corneal fibroblast were performed at different stages of wound closure. Expression of aldehyde dehydrogenase (ALDH), vimentin, α-smooth muscle actin (α-SMA), lumican, collagen I and matrix metalloproteinase 12 (MMP 12) were measured at day 1, day 3 and complete wound closure day. Corneal fibroblast cultured in BMS with GH demonstrated the fastest wound closure, at day 5 post wounding. The gene expressions of ALDH and vimentin were higher than control groups while α-SMA expression was lower, in GH enriched media. The expressions of lumican, collagen I and MMP 12 were also higher in cells cultured in GH enriched media compared to the control groups. GH was shown to promote in vitro corneal fibroblast wound healing and may be a potential natural adjunct in the treatment of corneal wound.

Matched MeSH terms: Corneal Injuries

Injuries to the eye and associated structures

Lowther AH

Journal of the Malaya Branch of the British Medical Association, 1939;3:326-38.

Matched MeSH terms: Corneal Injuries

Fulltext The use of preserved bovine pericardium for emergency temporizing graft in corneal perforation

Koay AC, Yew YH, Ngo CT, Loo VP, Intan G, Chua CN

Med J Malaysia, 2008 Dec;63(5):421-2.

PMID: 19803308 MyJurnal

Corneal perforation is an ocular emergency that requires early intervention to avoid permanent visual loss from endophthalmitis or irreversible structural changes. Although tectonic keratoplasty is the best choice for patching a large perforation, a donor cornea is not always immediately available. Consequently, an alternative material is required while awaiting a donor cornea. We report the use of preserved bovine pericardium as a temporizing graft to maintain the ocular integrity in two patients with corneal perforation.

Matched MeSH terms: Corneal Injuries*

Bovine pericardium in treating large corneal perforation secondary to alkali injury: a case report

Khanna RK, Mokhtar E

Indian J Ophthalmol, 2008 8 20;56(5):429-30.

PMID: 18711278

To describe use of a locally processed bovine pericardium (BP) to cover a large central corneal perforation following alkali injury and discuss postoperative outcome. A 27-year-old Malay male patient presented two weeks after alkali splashed in his left eye while working. A clinical diagnosis of left central corneal ulcer with limbal ischemia following alkali injury with secondary infection was made. After failed medical therapy, we performed a Gunderson conjunctival flap under local anesthesia that retracted after one week and resulted in a large central corneal perforation with surrounding stromal thinning. The perforation was covered with a locally processed BP xenograft (Lyolemb) supplied by the National Tissue Bank, University Sains Malaysia. Nine months follow-up showed a well-taken graft without any exposure/dehiscence and minimal inflammation. Amniotic membrane transplantation when used as a patch graft needs an urgent tectonic graft to promote corneal stability in patients with severe corneal thinning. The use of processed BP can be a viable option in treating such cases.

Matched MeSH terms: Corneal Injuries*

Use of commercially available sodium hyaluronate 0.18% eye drops for corneal epithelial healing in diabetic patients

Ling K, Bastion MC

Int Ophthalmol, 2019 Oct;39(10):2195-2203.

PMID: 30536185 DOI: 10.1007/s10792-018-1057-1

PURPOSE: To evaluate the effect of topical sodium hyaluronate (SH) 0.18% treatment on corneal epithelial healing after epithelial debridement in pars plana vitrectomy in diabetic patients.

METHOD: This is prospective and randomized clinical trial. Our study population included 30 eyes undergoing pars plana vitrectomy that required near total corneal debridement intra-operatively for surgical view. We compared the residual wound and wound healing rate in between 3 groups: 10 diabetic eyes (DMV) on topical SH 0.18%; 10 diabetic eyes (DMC) and 10 non-diabetic eyes (NDM) not treated with topical SH 0.18%. The corneal epithelial wound was measured at 12, 24, 36, 48, 60, 72 and 120 h after the vitrectomy surgery.

RESULTS: DMC group had corneal wounds that reepithelialization significantly more slowly than in NDM and DMV groups at 12, 24, 36 and 48 h (Mann-Whitney test p corneal epithelial wound, corneal melting or corneal neovascularization was noted.

CONCLUSION: Diabetic patients on SH 0.18% four times daily for epithelial defect had similar corneal wounds healing rate as non-diabetics. This treatment significantly improved corneal wound healing and accelerated complete corneal wound resurfacing in diabetic patients.

Matched MeSH terms: Epithelium, Corneal/injuries

Edible Bird's Nest: The Functional Values of the Prized Animal-Based Bioproduct From Southeast Asia-A Review

Lee TH, Wani WA, Lee CH, Cheng KK, Shreaz S, Wong S, et al.

Front Pharmacol, 2021;12:626233.

PMID: 33953670 DOI: 10.3389/fphar.2021.626233

Edible Bird's Nest (EBN) is the most prized health delicacy among the Chinese population in the world. Although some scientific characterization and its bioactivities have been studied and researched, no lights have been shed on its actual composition or mechanism. The aim of this review paper is to address the advances of EBN as a therapeutic animal bioproduct, challenges and future perspectives of research involving EBN. The methodology of this review primarily involved a thorough search from the literature undertaken on Web of Science (WoS) using the keyword "edible bird nest". Other information were obtained from the field/market in Malaysia, one of the largest EBN-producing countries. This article collects and describes the publications related to EBN and its therapeutic with diverse functional values. EBN extracts display anti-aging effects, inhibition of influenza virus infection, alternative traditional medicine in athletes and cancer patients, corneal wound healing effects, stimulation of proliferation of human adipose-derived stem cells, potentiate of mitogenic response, epidermal growth factor-like activities, enhancement of bone strength and dermal thickness, eye care, neuroprotective and antioxidant effects. In-depth literature study based on scientific findings were carried out on EBN and its properties. More importantly, the future direction of EBN in research and development as health-promoting ingredients in food and the potential treatment of certain diseases have been outlined.

Matched MeSH terms: Corneal Injuries

Fulltext Toxic keratouveitis secondary to Euphorbia lactea sap: a case report

Yihui Goh, Pooi Wah Lott, Sujaya Singh

Malaysian Journal of Medicine and Health Sciences, 2020;16(3):328-330.

MyJurnal

A 42-year-old gentleman presented with left eye pain after accidental contact with Euphorbia lactea sap while gar- dening. At presentation, left eye best-corrected visual acuity (BCVA) was 20/30. Ocular examination revealed left eye conjunctiva congestion and cornea abrasion. Eye symptoms and BCVA deteriorated over 12 hours. Cornea showed diffuse stromal oedema with presence of anterior uveitis. A diagnosis of toxic keratouveitis was made. He was treat- ed with intensive topical steroids, cycloplegics, lubricants, prophylactic antibiotics and oral non-steroidal anti-in- flammatory analgesic. Patient achieved complete resolution two weeks later. We aim to raise awareness among the ophthalmologists to detect and manage these injuries.

Matched MeSH terms: Corneal Injuries

Fulltext Large leaking descemetocele presenting as a traumatic corneal laceration

Logeswary, K., Jemaima Che-Hamzah, Aida Zairani, M.Z.

Journal of Surgical Academia, 2017;7(1):59-61.

MyJurnal

A 47-year-old healthy Indonesian gentleman, presented with blurring of vision on the left eye associated with pain
and redness after history of foreign body entering the eye. A general practitioner prescribed him some eye drops;
however, his symptoms worsened. A corneal laceration wound measuring 0.5 x 3.5mm with a large stromal abscess
measuring 9.0 x 5.0mm with flat anterior chamber was seen on the left eye. Emergency corneal T&S revealed a large
descemetocele and cyanoacrylate corneal glue was applied on the area. C&S showed Pseudomonas aeruginosa.
Patient was subsequently undergone penetrating keratoplasty as a definitive measure. This case highlights the rapid
progression of pseudomonas keratitis, presented with a large descemetocele, which can be mistaken as an infected
corneal laceration wound. Corneal cyanoacrylate glueing together with corneal suturing is a viable temporary method
for large descemetoceles awaiting definitive surgery.

Matched MeSH terms: Corneal Injuries

Fulltext Rare Kodamaea ohmeri keratitis following a trivial vegetative trauma

Saud Al-Abbas AH, Ling JL, Muhammed J, Hussein A

BMJ Case Rep, 2019 Jun 22;12(6).

PMID: 31229985 DOI: 10.1136/bcr-2019-229660

Kodamaea ohmeri keratitis is an opportunistic pathogen seen in patients who have undergone invasive procedures and immunocompromised state. It has been identified in septicemia patients, resulting in mortality. To the best of our knowledge, we identified the first case of K. ohmeri keratitis following an injury with vegetative material. A 57-year-old woman with underlying, poorly controlled diabetes mellitus was gardening when a tree leaf accidentally poked her in the eye. Two weeks later, the patient presented with right eye pain, redness and progressive blurring of vision due to a traumatised right cornea. Slit-lamp examination showed a small inferior paracentral corneal stromal infiltrate with overlying epithelial defect. A corneal scraping sample yielded K. ohmeri from Analytical Profile Index (API) 20C yeast identification system. She was treated with intensive topical amphotericin B and fluconazole. After 6 weeks of treatment, the keratitis resolved with faint scar tissue, and her visual acuity improved.

Matched MeSH terms: Corneal Injuries/complications

Cladosporium cladosporioides keratomycosis: a case report

Chew FLM, Subrayan V, Chong PP, Goh MC, Ng KP

Jpn. J. Ophthalmol., 2009 Nov;53(6):657-659.

PMID: 20020251 DOI: 10.1007/s10384-009-0722-3

Matched MeSH terms: Corneal Injuries*

Fulltext Effects of edible bird's nest (EBN) on cultured rabbit corneal keratocytes

Zainal Abidin F, Hui CK, Luan NS, Mohd Ramli ES, Hun LT, Abd Ghafar N

BMC Complement Altern Med, 2011;11:94.

PMID: 21992551 DOI: 10.1186/1472-6882-11-94

There has been no effective treatment or agent that is available for corneal injury in promoting corneal wound healing. Previous studies on edible bird's nest extract (EBN) had reported the presence of hormone-like substance; avian epidermal growth factor that could stimulate cell division and enhance regeneration. This study aimed to investigate the effects of EBN on corneal keratocytes proliferative capacity and phenotypical changes.

Matched MeSH terms: Corneal Injuries

Fulltext Anti-inflammatory and antioxidant effects of Tualang honey in alkali injury on the eyes of rabbits: experimental animal study

Bashkaran K, Zunaina E, Bakiah S, Sulaiman SA, Sirajudeen K, Naik V

BMC Complement Altern Med, 2011;11:90.

PMID: 21982267 DOI: 10.1186/1472-6882-11-90

Alkali injury is one of the most devastating injuries to the eye. It results in permanent unilateral or bilateral visual impairment. Chemical eye injury is accompanied by an increase in the oxidative stress. Anti-inflammatory and antioxidant agents play a major role in the treatment of chemical eye injuries. The purpose of this study is to evaluate the anti-inflammatory (clinical and histopathological) and antioxidant effects of Tualang honey versus conventional treatment in alkali injury on the eyes of rabbits.

Matched MeSH terms: Corneal Injuries

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