Browse publications by year: 2012

  1. Abukhadir SS, Mohamed N, Makpol S, Muhammad N
    PMID: 23049610 DOI: 10.1155/2012/656025
    The study determines the effects of palm vitamin E on the gene expression of bone-formation-related genes in nicotine-treated rats. Male rats were divided into three groups: normal saline olive oil (NSO), nicotine olive oil (NO), and nicotine palm vitamin E (NE). The treatment was carried out in 2 phases. During the first 2 months, the NSO group received normal saline while the NO and NE groups received nicotine 7 mg/kg, 6 days a week, intraperitoneally. The following 2 months, normal saline and nicotine administration was stopped and was replaced with oral supplementation of olive oil for the NSO and NO groups and oral supplementation of palm vitamin E (60 mg/kg) for the NE group. Both femurs were harvested to determine the gene expression of bone morphogenetic protein-2 (BMP-2), Osterix (OSX), and Runt-related transcription factor 2 (RUNX2). Nicotine significantly downregulated the gene expression. This effect was reversed by palm vitamin E treatment. In conclusion, palm vitamin E may play a role in osteoblast differentiation and can be considered as an anabolic agent to treat nicotine-induced osteoporosis.
    MeSH terms: Olive Oil; Animals; Femur; Male; Nicotine; Osteoblasts; Osteogenesis; Osteoporosis; Vitamin E; Dietary Supplements; Core Binding Factor Alpha 1 Subunit; Rats; Bone Morphogenetic Protein 2
  2. Shafiei Z, Shuhairi NN, Md Fazly Shah Yap N, Harry Sibungkil CA, Latip J
    PMID: 23049613 DOI: 10.1155/2012/825362
    Myristica fragrans Houtt is mostly cultivated for spices in Penang Island, Malaysia. The ethyl acetate and ethanol extracts of flesh, mace and seed of Myristica fragrans was evaluated the bactericidal potential against three Gram-positive cariogenic bacteria (Streptococcus mutans ATCC 25175, Streptococcus mitis ATCC 6249, and Streptococcus salivarius ATCC 13419) and three Gram-negative periodontopathic bacteria (Aggregatibacter actinomycetemcomitans ATCC 29522, Porphyromonas gingivalis ATCC 33277, and Fusobacterium nucleatum ATCC 25586). Antibacterial activities of the extracts was determined by twofold serial microdilution, with minimum inhibitory concentrations (MIC) ranging from 1.25 to 640 mg/mL and 0.075 to 40 mg/mL. The minimum bactericidal concentration (MBC) was obtained by subculturing method. Among all extracts tested, ethyl acetate extract of flesh has the highest significant inhibitory effects against Gram-positive and Gram-negative bacteria with mean MIC value ranging from 0.625 to 1.25 ± 0.00 (SD) mg/mL; P = 0.017) and highest bactericidal effects at mean MBC value ranging from 0.625 mg/mL to 20 ± 0.00 (SD) mg/mL. While for seed and mace of Myristica fragrans, their ethanol extracts exhibited good antibacterial activity against both groups of test pathogens compared to its ethyl acetate extracts. All of the extracts of Myristica fragrans did not show any antibacterial activities against Fusobacterium nucleatum ATCC 25586. Thus, our study showed the potential effect of ethyl acetate and ethanol extracts from flesh, seed and mace of Myristica fragrans to be new natural agent that can be incorporated in oral care products.
    MeSH terms: Acetates; Ethanol; Anti-Bacterial Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Malaysia; Streptococcus mutans; Porphyromonas gingivalis; Fusobacterium nucleatum; Aggregatibacter actinomycetemcomitans; Spices; Streptococcus mitis; Streptococcus salivarius
  3. Yap CK, Shahbazi A, Zakaria MP
    Bull Environ Contam Toxicol, 2012 Dec;89(6):1205-10.
    PMID: 23052577 DOI: 10.1007/s00128-012-0838-x
    In this study, the ranges of pollutants found in the soft tissues of Perna viridis collected from Kg. Masai and Kg. Sg. Melayu, both located in the Straits of Johore, were 0.85-1.58 μg/g dry weight (dw) for Cd, 5.52-12.2 μg/g dw for Cu, 5.66-8.93 μg/g dw for Ni and 63.4-72.3 μg/g dw for Zn, and 36.4-244 ng/g dry weight for ∑PAHs. Significantly (p < 0.05) higher concentrations of Cd, Cu, Ni, Zn and ∑PAHs in the mussels were found in the water of a seaport site at Kg. Masai than a non-seaport site at Kg. Sg. Melayu population. The ratios of low molecular weight/high molecular weight hydrocarbons (2.94-3.42) and fluoranthene/pyrene (0.43-0.45) in mussels from both sites indicated the origin of the PAHs to be mainly petrogenic. This study has demonstrated the utility of using the soft tissues of P. viridis as a biomonitor of PAH contamination and bioavailability in the coastal waters of Peninsular Malaysia.
    MeSH terms: Animals; Environmental Monitoring*; Malaysia; Polycyclic Hydrocarbons, Aromatic/analysis; Polycyclic Hydrocarbons, Aromatic/metabolism*; Seawater/chemistry; Ships/statistics & numerical data; Water Pollutants, Chemical/analysis; Water Pollutants, Chemical/metabolism*; Water Pollution, Chemical/statistics & numerical data; Metals, Heavy/analysis; Metals, Heavy/metabolism*; Perna/metabolism*
  4. Mohd Redzwan S, Rosita J, Mohd Sokhini AM, Nurul Aqilah AR
    Bull Environ Contam Toxicol, 2012 Dec;89(6):1115-9.
    PMID: 23052590 DOI: 10.1007/s00128-012-0853-y
    This study aimed to find the association between urinary aflatoxin M(1) level and milk and dairy products consumption. Of 160 morning urine samples collected, aflatoxin M(1) was detected in 61.3 % samples (n = 98) [mean ± SD = 0.0234 ± 0.0177 ng/mL; range = 0-0.0747 ng/mL]. Of these positive samples, 67.3 % (n = 66) had levels above the limit of detection. Respondents with intake of milk and dairy products above median (67.79 g/day) had significantly high level of AFM(1) compared to those with low intake. A significant and positive association (φ = 0.286) was found between milk and dairy products consumption and urinary aflatoxin M(1) level.
    MeSH terms: Adult; Animals; Cattle; Dairy Products/statistics & numerical data*; Diet/statistics & numerical data; Female; Food Contamination/statistics & numerical data*; Goats; Humans; Malaysia; Male; Middle Aged; Poisoning/epidemiology*; Poisons/urine*; Sheep; Aflatoxin M1/urine*; Young Adult
  5. Karim AA, Azlan A
    Molecules, 2012 Oct 10;17(10):11931-46.
    PMID: 23052712 DOI: 10.3390/molecules171011931
    Fruit pods contain various beneficial compounds that have biological activities and can be used as a source of pharmaceutical and nutraceutical products. Although pods or pericarps are usually discarded when consuming the edible parts of fruits, they contain some compounds that exhibit biological activities after extraction. Most fruit pods included in this review contain polyphenolic components that can promote antioxidant effects on human health. Additionally, anti-inflammatory, antibacterial, antifungal and chemopreventive effects are associated with these fruit pod extracts. Besides polyphenolics, other compounds such as xanthones, carotenoids and saponins also exhibit health effects and can be potential sources of nutraceutical and pharmaceutical components. In this review, information on fruit pods or pericarp of Garcinia mangostana, Ceratonia siliqua, Moringa oleifera, Acacia nilotica, Sapindus rarak and Prosopis cineraria is presented and discussed with regard to their biological activity of the major compounds existing in them. The fruit pods of other ethno- botanical plants have also been reviewed. It can be concluded that although fruit pods are considered as being of no practical use and are often being thrown away, they nevertheless contain compounds that might be useful sources of nutraceutical and other pharmaceutical components.
    MeSH terms: Pharmaceutical Preparations/chemistry*; Fruit/chemistry*; Humans; Phytotherapy; Plant Extracts/chemistry*; Dietary Supplements*
  6. Phan CW, Sabaratnam V
    Appl Microbiol Biotechnol, 2012 Nov;96(4):863-73.
    PMID: 23053096 DOI: 10.1007/s00253-012-4446-9
    Mushroom industries generate a virtually in-exhaustible supply of a co-product called spent mushroom substrate (SMS). This is the unutilised substrate and the mushroom mycelium left after harvesting of mushrooms. As the mushroom industry is steadily growing, the volume of SMS generated annually is increasing. In recent years, the mushroom industry has faced challenges in storing and disposing the SMS. The obvious solution is to explore new applications of SMS. There has been considerable discussion recently about the potentials of using SMS for production of value-added products. One of them is production of lignocellulosic enzymes such as laccase, xylanase, lignin peroxidase, cellulase and hemicellulase. This paper reviews scientific research and practical applications of SMS as a readily available and cheap source of enzymes for bioremediation, animal feed and energy feedstock.
    MeSH terms: Agaricales/enzymology*; Agaricales/metabolism; Cellulase/metabolism; Cellulose/metabolism; Fungal Proteins/metabolism*; Industrial Microbiology*; Lignin/metabolism*; Peroxidases/metabolism; Waste Products/analysis; Laccase/metabolism
  7. Mediani A, Abas F, Ping TC, Khatib A, Lajis NH
    Plant Foods Hum Nutr, 2012 Dec;67(4):344-50.
    PMID: 23054393 DOI: 10.1007/s11130-012-0317-x
    The impact of tropical seasons (dry and wet) and growth stages (8, 10 and 12 weeks) of Cosmos caudatus on the antioxidant activity (AA), total phenolic content (TPC) as well as the level of bioactive compounds were evaluated using high performance liquid chromatography (HPLC). The plant morphology (plant height) also showed variation between the two seasons. Samples planted from June to August (during the dry season) exhibited a remarkably higher bioactivity and height than those planted from October to December (during the wet season). The samples that were harvested at eight weeks of age during the dry season showed the highest bioactivity with values of 26.04 g GAE/100 g and 22.1 μg/ml for TPC and IC₅₀, respectively. Identification of phytochemical constituents in the C. caudatus extract was carried out by liquid chromatography coupled with diode array detection and electrospray tandem mass (LC-DAD-ESIMS/MS) technique and the confirmation of constituents was achieved by comparison with literature data and/or co-chromatography with authentic standards. Six compounds were indentified including quercetin 3-O-rhamnoside, quercetin 3-O-glucoside, rutin, quercetin 3-O-arabinofuranoside, quercetin 3-O-galactoside and chlorogenic acid. Their concentrations showed significant variance among the 8, 10 and 12-week-old herbs during both seasons.
    MeSH terms: Antioxidants/analysis; Antioxidants/isolation & purification; Antioxidants/metabolism*; Chlorogenic Acid/analysis; Chlorogenic Acid/isolation & purification; Chlorogenic Acid/metabolism; Chromatography, High Pressure Liquid; Phenols/analysis; Phenols/isolation & purification; Phenols/metabolism*; Quercetin/analysis; Quercetin/isolation & purification; Quercetin/metabolism*; Rutin/analysis; Rutin/isolation & purification; Rutin/metabolism*; Seasons; Weather; Free Radical Scavengers/analysis; Free Radical Scavengers/isolation & purification; Free Radical Scavengers/metabolism; Asteraceae/growth & development; Asteraceae/chemistry*; Spectrometry, Mass, Electrospray Ionization
  8. Muzaliha MN, Nurhamiza B, Hussein A, Norabibas AR, Mohd-Hisham-Basrun J, Sarimah A, et al.
    Clin Ophthalmol, 2012;6:1527-33.
    PMID: 23055674 DOI: 10.2147/OPTH.S33270
    There is limited data in the literature concerning the visual status and skills in children with learning disabilities, particularly within the Asian population. This study is aimed to determine visual acuity and visual skills in children with learning disabilities in primary schools within the suburban Kota Bharu district in Malaysia.
    MeSH terms: Child; Humans; Learning Disorders; Malaysia; Publications; Schools; Visual Acuity
  9. Syazwan A, Rafee BM, Juahir H, Azman A, Nizar A, Izwyn Z, et al.
    Drug Healthc Patient Saf, 2012;4:107-26.
    PMID: 23055779 DOI: 10.2147/DHPS.S33400
    To analyze and characterize a multidisciplinary, integrated indoor air quality checklist for evaluating the health risk of building occupants in a nonindustrial workplace setting.
    MeSH terms: Housing; Air Pollution, Indoor; Workplace; Checklist; Interdisciplinary Studies
  10. Kashiani P, Saleh G, Panandam JM, Abdullah NA, Selamat A
    Genet Mol Biol, 2012 Jul;35(3):614-21.
    PMID: 23055801 DOI: 10.1590/S1415-47572012000400012
    A study of genetic variation among 10 pairs of chromosomes extracted from 13 tropical sweet corn inbred lines, using 99 microsatellite markers, revealed a wide range of genetic diversity. Allelic richness and the number of effective alleles per chromosome ranged from 2.78 to 4.33 and 1.96 to 3.47, respectively, with respective mean values of 3.62 and 2.73. According to the Shannon's information index (I) and Nei's gene diversity coefficient (Nei), Chromosome 10 was the most informative chromosome (I = 1.311 and Nei = 0.703), while Chromosome 2 possessed the least (I = 0.762 and Nei = 0.456). Based on linkage disequilibrium (LD) measurements for loci less than 50 cM apart on the same chromosome, all loci on Chromosomes 1, 6 and 7 were in equilibrium. Even so, there was a high proportion of genetic variation in Chromosomes 4, 5, 8, 9 and 10, thereby revealing their appropriateness for use in the genetic diversity investigations among tropical sweet corn lines. Chromosome 4, with the highest number of loci in linkage disequilibrium, was considered the best for marker-phenotype association and QTL mapping, followed by Chromosomes 5, 8, 9 and 10.
    MeSH terms: Alleles; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 4; Chromosomes, Human, Pair 5; Zea mays; Humans; Phenotype; Genetic Variation; Linkage Disequilibrium; Microsatellite Repeats
  11. Rahman MA, Yusoff FM, Arshad A, Shamsudin MN, Amin SM
    ScientificWorldJournal, 2012;2012:938482.
    PMID: 23055824 DOI: 10.1100/2012/938482
    Salmacis sphaeroides (Linnaeus, 1758) is one of the regular echinoids, occuring in the warm Indo-West Pacific, including Johor Straits, between Malaysia and Singapore. In order to investigate the developmental basis of morphological changes in embryos and larvae, we documented the ontogeny of S. sphaeroides in laboratory condition. Gametes were obtained from adult individuals by 0.5 M KCl injection into the coelomic cavity. Fertilization rate at limited sperm concentration (10(-5) dilution) was 96.6 ± 1.4% and the resulting embryos were reared at 24°C. First cleavage (2-cell), 4-cell, 8-cell, 16-cell, 32-cell, and multicell (Morulla) stages were achieved 01.12, 02.03, 02.28, 02.51, 03.12, and 03.32 h postfertilization. Ciliated blastulae with a mean length of 174.72 ± 4.43 μm hatched 08.45 h after sperm entry. The gastrulae formed 16.15 h postfertilization and the archenteron elongated constantly while ectodermal red-pigmented cells migrated synchronously to the apical plate. Pluteus larva started to feed unicellular algae in 2 d, grew continuously, and finally attained metamorphic competence in 35 d after fertilization. Metamorphosis took approximately 1 h 30 min from attachment to the complete resorption of larval tissues and the development of complete juvenile structure with adult spines, extended tubefeet and well-developed pedicellaria, the whole event of which usually took place within 1 d postsettlement. This study represents the first successful investigation on embryonic, larval, and early juvenile development of S. sphaeroides. The findings would greatly be helpful towards the understanding of ontogeny and life-history strategies, which will facilitate us to develop the breeding, seed production, and culture techniques of sea urchins in captive condition.
    MeSH terms: Animals; Larva/growth & development*; Sea Urchins/embryology*; Sea Urchins/growth & development*; Tropical Climate
  12. Khan TM, Sulaiman SA, Hassali MA
    Arch Med Sci, 2012 Sep 8;8(4):697-703.
    PMID: 23056083 DOI: 10.5114/aoms.2012.28601
    This study aims to highlight the factors associated with suicidal behavior among patients with depressive disorders.
  13. Vadivelu RK, Yeap SK, Ali AM, Hamid M, Alitheen NB
    PMID: 23056140 DOI: 10.1155/2012/251362
    Betulinic acid is a widely available plant-derived triterpene which is reported to possess selective cytotoxic activity against cancer cells of neuroectodermal origin and leukemia. However, the potential of betulinic acid as an antiproliferative and cytotoxic agent on vascular smooth muscle (VSMC) is still unclear. This study was carried out to demonstrate the antiproliferative and cytotoxic effect of betulinic acid on VSMCs using 3-[4,5-dimethylthizol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry cell cycle assay, BrdU proliferation assay, acridine orange/propidium iodide staining, and comet assay. Result from MTT and BrdU assays indicated that betulinic acid was able to inhibit the growth and proliferation of VSMCs in a dose-dependent manner with IC(50) of 3.8 μg/mL significantly (P < 0.05). Nevertheless, betulinic acid exhibited G(1) cell cycle arrest in flow cytometry cell cycle profiling and low level of DNA damage against VSMC in acridine orange/propidium iodide and comet assay after 24 h of treatment. In conclusion, betulinic acid induced G(1) cell cycle arrest and dose-dependent DNA damage on VSMC.
    MeSH terms: Acridine Orange; Bromides; Bromodeoxyuridine; Cell Cycle; Cell Division; DNA Damage; Flow Cytometry; Leukemia; Muscle, Smooth, Vascular; Propidium; Staining and Labeling; Triterpenes; Comet Assay; Cell Cycle Checkpoints
  14. Ash A, Scholz T, de Chambrier A, Brabec J, Oros M, Kar PK, et al.
    PLoS One, 2012;7(10):e46421.
    PMID: 23056306 DOI: 10.1371/journal.pone.0046421
    Tapeworms of Gangesia Woodland, 1924 (Cestoda: Proteocephalidea) parasitic in freshwater fishes in the Indomalayan Region were critically reviewed. Evaluation of type specimens and newly collected materials from Bangladesh, Cambodia and India, as well as critical examination of extensive literature have shown that only the following four species, instead of 48 nominal species of Gangesia and Silurotaenia Nybelin, 1942 reported from this region (36 new synonymies proposed), are valid: Gangesia bengalensis (Southwell, 1913), type-species of the genus and most common parasite of Wallago attu (Siluridae), G. macrones Woodland, 1924 typical of Sperata seenghala (Bagridae), both species characterized by the possession of two circles of hooks on the rostellum-like organ and several rows of hooklets on the anterior margins of suckers; G. agraensis Verma, 1928 from W. attu (typical host), which has the scolex with only one circle of hooks and 1-3 incomplete rows of tiny hooklets on the suckers; and G. vachai (Gupta and Parmar, 1988) n. comb. from several catfishes, which possesses 4-6 circles of hooks and 5-11 rows of hooklets on the anterior half of suckers. Scolex morphology, including surface ultrastructure (microtriches), of all but one species (G. vachai) is described for the first time using scanning electron microscopy. A phylogenetic analysis based on the partial sequences encoding the large nuclear ribosomal subunit RNA gene has shown that three Indomalayan species, namely G. bengalensis, G. macrones and G. vachai, form a monophyletic group within Gangesia, whereas G. agraensis tends to form a clade with the Palaearctic species of the genus. A table with differential characters of all species from the Indomalayan Region is also provided together with a key to identification of genera of the subfamily Gangesiinae. The present study demonstrates that species of Silurotaenia do not occur in the Indomalayan region.
    MeSH terms: Animals; Indonesia; Malaysia; Surface Properties
  15. Mirhosseini NZ, Shahar S, Ghayour-Mobarhan M, Parizadeh MR, Yusoff NA, Shakeri MT
    Iran J Pediatr, 2012 Jun;22(2):197-204.
    PMID: 23056886
    OBJECTIVE: The relationships between body fat distribution, lipid profile and blood pressure, have not been studied extensively in young population. This study was designed to evaluate the association between measures of adiposity and established cardiovascular risk factors in adolescent girls.

    METHODS: A total of 477 adolescent girls aged 15 to 18 years were recruited from Mashhad high schools. Socio-demographic characteristics were assessed using a self-administered questionnaire. Anthropometric assessments, blood pressure measurement and biochemical assessment were performed. Total and regional fat mass were determined by bio-impedance analysis. Cardiovascular disease risk factors were assessed in relation to body fat measures with adjustment for confounder factors including age and family socioeconomic status.

    FINDINGS: The prevalence of overweight and obesity was 14.6% and 3.4% respectively; 16% of study population had greater fat mass compared to its ideal distribution. The majority of cardiovascular risk factors, especially systolic and diastolic blood pressure, triglyceride concentration, CRP and fasting blood sugar were significantly higher in group with a high body fat when compared to those with normal and low values. All anthropometric indices showed significant correlation with fat mass, fat free mass, total and regional body fat percent (P<0.001). After adjustment for age and family socioeconomic status, a high fat mass especially, truncal fat, was positively associated with triglyceride and blood pressure.

    CONCLUSION: Adiposity, especially truncal adiposity, which can be assessed by simple measures such as Body Mass Index (BMI) and Waist Circumference (WC) may predispose adolescent girls for demonstration of metabolic abnormalities and consequently cardiovascular diseases.

  16. Shetty YN, Majid IA, Patel RU, Shammam M
    Case Rep Dent, 2012;2012:954789.
    PMID: 23056963 DOI: 10.1155/2012/954789
    Maxillary dentigerous cysts although uncommon need to be considered in the differential diagnosis in children with painless facial swelling. We present a case of dentigerous cyst associated with maxillary deciduous canine and maxillary premolars manifesting as a unilateral swelling in canine region of the face. A ten-year-old boy came to oral and maxillofacial surgery unit with a painless left facial swelling. The local dentist had prescribed antibiotics for treatment for the facial swelling, but the swelling did not subside, and the parents brought the child to our unit in Zliten Dental College. After clinical examination and imaging, the diagnosis of dentigerous cyst was made. Caldwell-Luc approach was done, the cyst was enucleated, and primary closure was done. The patient was followed up for a period of two years and there was no evidence of any recurrence.
  17. Gay H
    Ambix, 2012 Jul;59(2):88-108.
    PMID: 23057183
    The use of chemical pesticides increased considerably after World War II, and ecological damage was noticeable by the late 1940s. This paper outlines some ecological problems experienced during the post-war period in the UK, and in parts of what is now Malaysia. Also discussed is the government's response. Although Rachel Carson's book, Silent Spring (1962), was important in bringing the problems to a wider public, she was not alone in sounding the alarm. Pressure from the public and from British scientists led, among other things, to the founding of the Natural Environment Research Council in 1965. By the 1970s, environmentalism was an important movement, and funding for ecological and environmental research was forthcoming even during the economic recession. Some of the recipients were ecologists working at Imperial College London. Moved by the political climate, and by the evidence of ecological damage, they carried out research on the biological control of insect pests.
    MeSH terms: Agriculture/history; Agriculture/instrumentation; Agriculture/methods; Environment*; Great Britain; Insecticides/history*; Insecticides/toxicity; Malaysia; Pest Control/history*; Pest Control/methods; Pest Control/standards; Pest Control, Biological/history*; Pest Control, Biological/methods; Pest Control, Biological/standards; History, 20th Century
  18. Wong LP
    BMC Public Health, 2012;12:865.
    PMID: 23057505 DOI: 10.1186/1471-2458-12-865
    BACKGROUND: The increasing trend of premarital sexual experience and unintended pregnancies in Malaysia warrants sustained and serious attention. The sensitivities of sex-related issues in a Muslim-majority country create various types of barriers to sexual and reproductive health information, support and practices. This study aims to gain understanding of knowledge, attitudes and behaviours of young women in Malaysia concerning reproductive, contraception and premarital sexual practices.
    METHODS: A cross-sectional study was performed, using an anonymous self-administered questionnaire carried out among 1695 female university students in a public university in Malaysia.
    RESULTS: Respondents had low scores for knowledge of reproduction and pregnancy (median=4, of maximum score 10), contraceptive uses (median=6, of maximum score 16) and contraceptive availability (median=3, of maximum score 13). The majority of women surveyed do not have liberal values in relation to premarital sexual behaviour (median=37, of maximum 40); higher scores on this scale corresponded to opposing premarital sex. The multivariate analyses showed that ethnic group was the strongest correlate of knowledge and attitude scores; being of Malay Muslim ethnicity was associated significantly with lower knowledge scores and premarital sex permissiveness. Other significant correlates were year of study, maternal occupational groups, level of religious faith, dating status and urban-rural localities. Level of premarital sex permissiveness was inversely correlated with reproduction and pregnancy knowledge score, and contraceptive knowledge scores.
    CONCLUSION: Reproductive health knowledge and attitudes were intricately linked to religious values and cultural norms differences surrounding sexual issues.
    MeSH terms: Adolescent; Adult; Contraception Behavior/ethnology; Cross-Sectional Studies; Ethnic Groups/psychology*; Female; Humans; Islam/psychology*; Health Knowledge, Attitudes, Practice/ethnology*; Malaysia; Malaysia/ethnology; Pregnancy; Surveys and Questionnaires; Sexual Behavior/ethnology*; Students; Universities; Multivariate Analysis; Marital Status/ethnology*; Reproductive Behavior/ethnology*; Young Adult
  19. Haerian BS, Baum L, Tan HJ, Kwan P, Raymond AA, Saruwatari J, et al.
    Pharmacogenomics, 2012 Oct;13(13):1477-85.
    PMID: 23057548 DOI: 10.2217/pgs.12.127
    Approximately 30% of epilepsy patients do not response to antiepileptic drugs (AEDs). The functional SCN1A IVS5N+5 polymorphism may play a role in response to some AEDs. The purpose of this study was to examine this hypothesis in a cohort study of Malaysian and Hong Kong Chinese epilepsy patients on sodium valproate (VPA) monotherapy and in a meta-analysis.
    MeSH terms: Adolescent; Adult; Anticonvulsants/pharmacology*; Child; Epilepsy/drug therapy*; Epilepsy/genetics*; Epilepsy, Generalized/drug therapy; Epilepsy, Generalized/genetics; Female; Gene Frequency; Hong Kong; Humans; Malaysia; Male; Middle Aged; Models, Genetic; Polymorphism, Genetic; Valproic Acid/pharmacology*; Cohort Studies; Alternative Splicing; Asian Continental Ancestry Group/genetics; Young Adult; Genetic Association Studies; NAV1.1 Voltage-Gated Sodium Channel/genetics*
  20. Farooqui M, Hassali MA, Abdul Shatar AK, Shafie AA, Farooqui MA, Saleem F, et al.
    Complement Ther Clin Pract, 2012 Nov;18(4):252-6.
    PMID: 23059441 DOI: 10.1016/j.ctcp.2012.06.005
    This study sought to evaluate Malaysian oncology patients CAM disclosure to the health care providers. Patients were interviewed across three major Malaysian ethnic groups, Malay, Chinese and Indian. Thematic content analysis identified three themes: reasons of CAM disclosure, reasons of CAM non-disclosure and preference of CAM discussion to health care providers. Patients agreed that CAM disclosure is important to avoid any interaction with the conventional medicines. Perceived lack of physicians' knowledge & interest in CAM, fear of termination of therapy by the physicians upon CAM disclosure, and perceived simplicity of some of the CAM therapies were among the reasons of non-disclosure. Given the option of oncologists, pharmacists or nurses, patients described oncologists as the most suitable person to discuss or disclose CAM use due to confidence in their clinical skills. Understanding the underlying beliefs of patients' reluctance to disclose CAM to health care providers is important especially when they are on an ongoing treatment for cancer.
    MeSH terms: Adult; Aged; Complementary Therapies/utilization*; Data Collection; Female; Humans; Malaysia; Male; Middle Aged; Neoplasms/therapy*; Physician-Patient Relations; Truth Disclosure*; Young Adult; Patient Preference
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