Browse publications by year: 2025

  1. Le Breton C, Laporta GZ, Sallum MAM, Hesse H, Salgado-Lynn M, Manin BO, et al.
    Trends Parasitol, 2025 Feb;41(2):150-161.
    PMID: 39809620 DOI: 10.1016/j.pt.2024.12.009
    Faced with the increased frequency of zoonotic spillover in recent decades, emerging vector-borne diseases from nonhuman primates pose a significant threat to global public health. Understanding transmission dynamics driven by arthropod vectors between wildlife populations is critical for surveillance, modeling, and mitigation. Elevated canopy-level sampling is a valuable approach for elucidating vector behavior and sylvatic transmission. However, this is underused in many regions because of the logistical and mechanical challenges of repurposing ground-based trapping for the forest canopy. We review methods of canopy-level entomological surveillance, present case studies, and identify opportunities to integrate new technologies. Paired with robust experimental design, canopy-level trapping can complement existing surveillance of emerging zoonotic diseases and provide critical insights into the role of vectors driving spillover risks.
    MeSH terms: Animals; Arthropod Vectors; Entomology/methods; Humans; Epidemiological Monitoring; Forests
  2. Wang Z, Zainal A, Siraj MM, Ghaleb FA, Hao X, Han S
    Sci Rep, 2025 Jan 14;15(1):1917.
    PMID: 39809850 DOI: 10.1038/s41598-024-85083-8
    The application of artificial neural networks (ANNs) can be found in numerous fields, including image and speech recognition, natural language processing, and autonomous vehicles. As well, intrusion detection, the subject of this paper, relies heavily on it. Different intrusion detection models have been constructed using ANNs. While ANNs are relatively mature to construct intrusion detection models, some challenges remain. Among the most notorious of these are the bloated models caused by the large number of parameters, and the non-interpretability of the models. Our paper presents Convolutional Kolmogorov-Arnold Networks (CKANs), which are designed to overcome these difficulties and provide an interpretable and accurate intrusion detection model. Kolmogorov-Arnold Networks (KANs) are developed from the Kolmogorov-Arnold representation theorem. Meanwhile, CKAN incorporates a convolutional computational mechanism based on KAN. The model proposed in this paper is constructed by incorporating attention mechanisms into CKAN's computational logic. The datasets CICIoT2023 and CICIoMT2024 were used for model training and validation. From the results of evaluating the performance indicators of the experiments, the intrusion detection model constructed based on CKANs has an attractive application prospect. As compared with other methods, the model can predict a much higher level of accuracy with significantly fewer parameters. However, it is not superior in terms of memory usage, execution speed and energy consumption.
  3. Azami MM, Pauzi NAS, Hamdan N, Sidik MR, Tulis AN, Hassan R, et al.
    Vet Res Commun, 2025 Jan 15;49(2):77.
    PMID: 39809923 DOI: 10.1007/s11259-025-10645-8
    African swine fever (ASF), a severe and highly contagious haemorrhagic viral disease of pigs, is becoming a major threat not only in Malaysia but around the world. The first confirmed case of ASF in Malaysia was reported in February 2021. Despite the emergence of ASF in Malaysia, genetic information on this causative pathogen for the local livestock is still limited. This study aimed to genetically characterize the African swine fever virus (ASFV) responsible for the 2021 outbreak in Malaysia. The genome of the ASFV isolated during the first outbreak in Malaysia was analysed as ASFV/Sabah/Malaysia/1160/21 which has 190,594 base pairs, with a nitrogenous bases (GC) content of 40.33% and 195 predicted Open Reading Frames (ORF). The complete genome sequence was compared with other annotated ASFV genomes retrieved from database of National Center for Biotechnology Information (NCBI) to obtain information based on target gene B646L, E183L, intergenic region (IGR) between I73R and I329L (IGRI73R-I329L), EP402R and B602L. The ASFV/Sabah/Malaysia/1160/21 genome had a high similarity percentage to the reference genome, Georgia 2007 and all Southeast Asian strains. Phylogenetic analysis revealed that the ASFV strain belonged to genotype II, serogroup 8, CVR1 and showed high characteristics of IGR variant II based on IGRI73R-I329L. This study expands our understanding of genetic diversity and provides significant insights into the genomic characteristics and variation of ASFV strains that are circulating in Malaysia.
    MeSH terms: Animals; Borneo/epidemiology; Malaysia/epidemiology; Phylogeny*; Swine; Genome, Viral*
  4. Sang CS, Samad NAFA, Saleh SB
    PMID: 39810009 DOI: 10.1007/s11356-025-35901-x
    Palm kernel shell (PKS) and empty fruit bunch (EFB) are potential biomass resources for producing solid biofuel for energy applications. However, raw EFB and PKS are not uniform in size and pose rotting behavior. Torrefaction and co-pelletization are both effective methods to improve their combustion and mechanical characteristics. This study aims to investigate the effect of torrefaction temperature and the blending ratio of PKS and EFB on the mechanical and combustion characteristics of co-pellets. Initially, PKS and EFB underwent torrefaction process for 30 min at three different temperatures (210 °C, 240 °C, and 270 °C). Then, both torrefied PKS and EFB were blended at five different ratios (0:100, 25:75, 50:50, 75:25, 100:0) with carboxymethyl cellulose as a binder (10% by weight). The results showed that pellet produced at higher torrefaction temperature at 270 °C resulted in an increment of the higher heating value (HHV) but weaker mechanical strength. Pellet with a blending ratio of PKS to EFB (75:25) torrefied at 240 °C showed the comparatively best pellet quality in terms of HHV (17.94 MJ/kg), high tensile strength (3.5 MPa), low ash content (3.97 wt%), and the lowest density changes (0.66%), which satisfy the standard requirements for commercial pellets, indicating that a high-quality biofuel pellet can be produced using torrefaction and co-pelletization.
  5. Zin RMWM, Mokhtar AH, Yahya A, Zain FM, Selamat R, Ishak Z, et al.
    BMC Public Health, 2025 Jan 14;24(Suppl 1):3627.
    PMID: 39810108 DOI: 10.1186/s12889-024-20724-1
    BACKGROUND: Recently, there has been an increase in the prevalence of childhood obesity in Malaysia, raising concerns about increased cardiometabolic morbidity. MyBFF@school is a multifaceted program comprising physical activity, nutritional education, and psychological empowerment introduced to combat childhood obesity in Malaysia. The efficacy of a six-month intervention on the body composition of overweight and obese primary schoolchildren was evaluated.

    METHODS: This is a school-based, cluster randomized controlled trial involving selected primary schools in Kuala Lumpur, Selangor, and Negeri Sembilan. A total of 1,397 primary-school students aged 9-11 with a body mass index (BMI) z -score (corrected for age) greater than + 1 standard deviation based on the World Health Organization 2007 Growth Reference were assigned to intervention ( n = 647 ) and control ( n = 750 ) groups. BMI z-score, waist circumference (WC), percentage body fat (PBF), and skeletal muscle mass (SMM) were assessed at baseline and after three and six months of the study. Analyses of all outcomes except for the baseline characteristics were conducted according to the intention-to-treat principle.

    RESULTS: After three months, there was no significant difference in the BMI z-score or PBF between the control and intervention groups, but SMM and WC were significantly higher in the intervention group versus the control group with mean difference of 0.15 kg; 95% confidence interval [CI]: 0.07-0.22, p 

    MeSH terms: Anthropometry; Body Composition*; Child; Female; Health Promotion/methods; Humans; Malaysia; Male; School Health Services; Program Evaluation; Body Mass Index; Overweight/therapy
  6. Wp SE, Norhidayah M, Ar MNA
    BMC Infect Dis, 2025 Jan 14;25(1):60.
    PMID: 39810126 DOI: 10.1186/s12879-024-10338-8
    INTRODUCTION: Antimicrobial resistance is a global issue, with the World Health Organization identifying it as one of the greatest threats to public health, with an estimated 4.95 million deaths linked to bacterial AMR in 2019. Our study aimed to determine the prevalence of mortality among multidrug-resistant organism (MDRO)-infected patients in state hospitals and major specialist hospitals and to identify risk factors that could be associated with mortality outcomes.

    METHODS: This is a cross-sectional study performed at 28 hospitals under the Ministry of Health, Malaysia, involved in the National Surveillance of Multidrug-Resistant Organism, which surveys 6 MDROs (Acinetobacter baumanii, extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae, carbapenem-resistant Entrobacterales (CRE), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE)).

    RESULTS: In terms of mortality, 9.6% (n = 951) of the patients died overall, whereas 90.4% (n = 8931) of the patients survived. Healthcare-acquired infection (HCAI) poses a high risk of mortality, with an adjusted odds ratio (aOR) of 2.91 (95% CI: 2.15-3.94). The presence of sterile specimens was significantly associated with increased mortality risk (aOR: 2.33, 95% CI: 2.02-2.68). Gram-negative bacteria had a greater mortality risk (aOR 1.63 95% CI: 1.37-1.93), whereas Acinetobacter baumanii had the highest prevalence of 30.7% (3033) among the 6 MDRO organisms isolated. Patients in medical-based departments had a greater mortality risk (aOR: 1.47, 95% CI: 1.22-1.75).

    CONCLUSION: HCAIs, Gram-negative bacteria, sterile specimens, medical-based departments and state hospitals have been shown to be associated with increased mortality risk in patients with MDRO infections. Improved surveillance and reporting mechanisms are necessary to better understand the burden of MDRO infections and guide research funding allocation.

    MeSH terms: Adolescent; Adult; Aged; Aged, 80 and over; Bacterial Infections/microbiology; Bacterial Infections/mortality; Bacterial Infections/epidemiology; Child; Child, Preschool; Cross Infection/microbiology; Cross Infection/mortality; Cross Infection/epidemiology; Cross-Sectional Studies; Female; Humans; Infant; Klebsiella pneumoniae/drug effects; Malaysia/epidemiology; Male; Middle Aged; Risk Factors; Prevalence; Drug Resistance, Multiple, Bacterial*; Acinetobacter baumannii/drug effects; Methicillin-Resistant Staphylococcus aureus/drug effects; Young Adult; Vancomycin-Resistant Enterococci
  7. Moharam LM, Salem HN, Abdou A, Afifi RH
    BMC Oral Health, 2025 Jan 15;25(1):66.
    PMID: 39810132 DOI: 10.1186/s12903-024-05390-4
    BACKGROUND: This study aimed to assess the influence of different pretreatment protocols and antioxidants application on the shear bond strength (SBS) of universal adhesive to sound (SoD) and caries-induced dentin (CID).

    METHODS: One hundred and twenty posterior teeth had their occlusal enamel removed, then the specimens were divided into two main groups according to dentin substrates; SoD and CID, three subgroups according to pretreatments protocols control (no pretreatment), NaOCl-treated, and Er, Cr:YSGG-treated and two divisions according to antioxidant application (with and without sodium ascorbate (SA) application). All-Bond Universal (ABU) universal adhesives was applied in self-etch (SE) mode then resin composite discs were built. The specimens were stored in distilled water for 24-hr at 37°C before SBS testing. Three-way ANOVA and Tukey HSD tests were used for data analysis (a = 0.05).

    RESULTS: 6% NaOCl resulted in a significant reduction in SBS in SoD without antioxidant application. 10% SA application showed significant increase in SBS for 6% NaOCl group only in SoD. Laser application recorded a significantly higher SBS compared to 6% NaOCl group without or with antioxidant application, while 10% SA application revealed a significant increase in SBS for control group only.

    CONCLUSIONS: Er, Cr:YSGG laser irradiation followed by antioxidant application has the potential to enhance the bonding quality of both tested dentin substrates. NaOCl application has significantly compromised the bonding to SoD and CID substrates.

    MeSH terms: Ascorbic Acid/pharmacology; Ascorbic Acid/therapeutic use; Composite Resins/chemistry; Dental Caries*; Humans; Materials Testing; Sodium Hypochlorite/pharmacology; Sodium Hypochlorite/therapeutic use; Dentin-Bonding Agents/chemistry; Resin Cements/chemistry; Shear Strength
  8. Mokhtar AH, Ishak Z, Zain FM, Selamat R, Yahya A, Jalaludin MY
    BMC Public Health, 2025 Jan 14;24(Suppl 1):3628.
    PMID: 39810143 DOI: 10.1186/s12889-025-21382-7
    Obesity trend among Malaysian children is on the rise. Noting that the tendency for them to grow into obese adults and the relationship of obesity to many non-communicable diseases, the My Body is Fit and Fabulous at School (MyBFF@school program) was designed to combat obesity among the schoolchildren. The program was piloted in 2014 in Putrajaya, Malaysia. There were several challenges during the pilot study which included strain in manpower, limited variation of physical activity, nutrition, and psychology modules, time-constraint after school hours, co-curriculum marks, contamination effect, and school selection. The main MyBFF@school in 2016 addressed the challenges and improvised the design which were elaborated in subsequent articles in this supplement. This cluster randomized controlled trial was conducted in three states; Federal Territory of Kuala Lumpur, Selangor and Negeri Sembilan in 23 primary and 15 secondary schools were selected through proportionate random sampling. The MyBFF@school intervention package consisted of physical activity, nutrition and psychology components were carried out for six months. Data were collected at baseline, mid (month-3) and end (month-6) of the study period. The effects of the program on body composition, clinical, physical fitness, nutrition, and psychology were assessed in primary schoolchildren aged 9 to 11 years old (children age group) and secondary schoolchildren (adolescent) aged 13 to 16 years old. The prevalence of overweight and obesity at screening (N=22,816) were 29.4% in primary and 26.8% in secondary schoolchildren. Outcomes of the trial is presented in this supplement. In summary, the MyBFF@school program is a school-based intervention for overweight and obese children and adolescent. It is a combination of physical activity, nutrition and psychology components. We present in this supplement, the rationale, methodology and the outcomes of this randomized control trial of the MyBFF@school program.
    MeSH terms: Adolescent; Child; Female; Health Promotion/methods; Humans; Malaysia/epidemiology; Male; Pilot Projects; Program Evaluation; Exercise*
  9. Zaid SM, Hutagalung FD, Abd Hamid HSB, Taresh SM
    BMC Psychol, 2025 Jan 14;13(1):38.
    PMID: 39810249 DOI: 10.1186/s40359-025-02354-3
    BACKGROUND: Emotions are a fundamental part of life and play a critical role in shaping individuals' experiences Effectively regulating emotions in socially appropriate ways is essential for navigating life successfully. This study investigated the impact of seven sadness regulation strategies on depression and anxiety and examined the mediating role of ER in the relationship between sadness regulation and depression and anxiety.

    METHOD: A cross-sectional design was employed with 350 participants (144 men, 206 women) aged 18 to 35.

    RESULTS: Regression analyses showed that sadness regulation strategies significantly predict both depression and anxiety. For depression, the model explained 18.6% of the variance (F (7,342) = 11.140, p 

    MeSH terms: Adaptation, Psychological; Adolescent; Adult; Cross-Sectional Studies; Female; Humans; Male; Young Adult
  10. He K, Zeng Y, Chen X, Bai W, Lin H, Chen J, et al.
    Integr Zool, 2025 Jan 14.
    PMID: 39810494 DOI: 10.1111/1749-4877.12950
    The genus Hylomys now comprises seven species instead of two; the Hylomys species in China should be classified as Hylomys peguensis.
  11. Al Hrout R, Ayasrah M, Noor Azman NZ
    Cancer Manag Res, 2025;17:11-22.
    PMID: 39810746 DOI: 10.2147/CMAR.S497104
    INTRODUCTION: Breast cancer is a significant worldwide health issue, particularly in Jordan, where early detection via mammography is essential for effective disease management. Despite the little radiation risk associated with mammography, it is crucial to monitor radiation exposure to guarantee patient safety. This study intends to assess skin entrance exposure and compute the Mean Glandular Dose (MGD) in mammography units to determine adherence to established criteria and pinpoint areas for enhancement.

    METHODS: To assess MGD, the study utilized the American College of Radiologists (ACR) phantom alongside a RaySafe X2 MAM dosimeter. Measurements of entrance kerma and half-value layer (HVL) were taken across 25 mammography units in Jordan. The MGD was calculated according to the ACR's 2018 protocol, which provides a standardized approach to ensure accurate and comparable dose estimations. These measurements were then analyzed against the ACR's threshold of 3 mGy to assess compliance.

    RESULTS: The study found that the average MGD across all units was 2.3 mGy, with individual values ranging from 0.95 to 4.10 mGy. Although 67% of the units maintained MGD values within the ACR threshold, 33% exceeded the recommended limit of 3 mGy. Higher MGD values were particularly common in non-accredited facilities, where the average MGD reached 2.7 mGy, compared to 1.6 mGy in accredited units, suggesting gaps in quality control and adherence to best practices in non-accredited centers.

    CONCLUSION: This study emphasizes the critical role of accreditation and adherence to quality standards in maintaining safe and effective mammography practices. While most mammography units in Jordan meet the ACR's recommended MGD limits, the elevated dose levels in some non-accredited facilities highlight the need for more rigorous implementation of accreditation standards. Improving compliance with established guidelines will enhance breast cancer screening effectiveness, ultimately supporting better early detection and outcomes for breast cancer in Jordan.

  12. Kumoro AC, Wardhani DH, Kusworo TD, Djaeni M, Azis YMF, Alhanif M, et al.
    Food Chem X, 2025 Jan;25:102103.
    PMID: 39810951 DOI: 10.1016/j.fochx.2024.102103
    Protein concentrate (PC) is a potential solution to address the global protein shortage, with Indonesian shortfin eel being a suitable raw material. This research investigates the impact of ultrasound pretreatment and extraction parameters on the nutritional quality of eel protein concentrate (EPC). The study involved ultrasonic pretreatment at different times and power, and solvent extraction with different solvents, temperature, and solvent-solid-feed-ratio (SSFR). The results showed that the recommended conditions for EPC preparation were a mixture of ethanol-hexane, ultrasonic pretreatment at 250 W for 25 min, extraction temperature and SSFR of 40 °C and 6:1 v/w. The protein content of EPC increased gradually with the increase of SSFR until it reached a ratio of 6:1, further increase in SSFR promoted the development of a pseudo-homogeneous system, leading to a reduction in the solvent-eel flesh contact and the relative velocity between the extracting solvent and eel flesh, and consequently decreased the extraction yield. The prepared EPC is classified as type B EPC, with a protein content of 89.62 %w.b. and a lipid content of 2.21 %w.b. The EPC contains five types of peptides with a molecular weight of 5.00-76.00 kDa, with the main fraction having a MW ranging from 10.00 to 15.00 kDa, indicating potential for functional food products.
  13. Babu MA, Jyothi S R, Kaur I, Kumar S, Sharma N, Kumar MR, et al.
    Regen Ther, 2025 Mar;28:214-226.
    PMID: 39811069 DOI: 10.1016/j.reth.2024.11.017
    The Mesenchymal Stem Cell (MSC) is a multipotent progenitor cell with known differentiation potential towards various cell lineage, making it an appealing candidate for regenerative medicine. One major contributing factor to age-related MSC dysfunction is cellular senescence, which is the hallmark of relatively irreversible growth arrest and changes in functional properties. GATA4, a zinc-finger transcription factor, emerges as a critical regulator in MSC biology. Originally identified as a key regulator of heart development and specification, GATA4 has since been connected to several aspects of cellular processes, including stem cell proliferation and differentiation. Accumulating evidence suggests that the involvement of GATA4-nuclear signalizing in the process of MSC senescence-related traits may contribute to age-induced alterations in MSC behavior. GATA4 emerged as the central player in MSC senescence, interacting with several signaling pathways. Studies have shown that GATA4 expression is reduced with age in MSCs, which is associated with increased expression levels of senescence markers and impaired regenerative potential. At the mechanistic level, GATA4 regulates the expression of genes involved in cell cycle regulation, DNA repair, and oxidative stress response, thereby influencing the senescence phenotype in MSCs. The findings underscore the critical function of GATA4 in MSC homeostasis and suggest a promising new target to restore stem cell function during aging and disease. A better understanding of the molecular mechanisms that underlie GATA4 mediated modulation of MSC senescence would provide an opportunity to develop new therapies to revitalize old MSCs to increase their regenerative function for therapeutic purposes in regenerative medicine.
  14. Mohd Hanafiah Z, Hafsari AR, Elango M, Ilham Z, Doni F, Wan Mohtar WHM, et al.
    Heliyon, 2025 Jan 15;11(1):e41205.
    PMID: 39811270 DOI: 10.1016/j.heliyon.2024.e41205
    Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs. This study investigated the effectiveness of the bio-flocculation approach using the Ganoderma lucidum fungus strain BGF4A1 to remove these harmful blooms, specifically targeting cyanobacterial species like Microcystis PCC-7914. Key flocculation parameters, cyanobacterial concentrations, adsorption kinetics, and pellet morphology were explored in this research. Our results demonstrate that G. lucidum can effectively remove up to 93.70 % of cyanobacteria (measured as chlorophyll-a absorbance), 75.28 % of chemical oxygen demand (COD), and 92.09 % of total suspended solids (TSS) under optimal conditions: an initial pH of 4, 1 % fungal volume (w/v), 48 h of contact time, and 100 rpm agitation at room temperature. Microscopic examination of water samples before and after treatment confirmed a significant reduction in cyanobacterial colonies, indicating the death or decline of the targeted organisms. Morphological analysis using field emission scanning electron microscopy (FESEM) revealed that Microcystis cells were deposited on the hyphae of the G. lucidum pellets, in contrast to the smooth surface of control pellets. These novel culture technologies show great promise as bio-flocculating agents for removing blue-green algae and potentially be adapted for microalgae harvesting in biodiesel production.
  15. Ahmed AF, Mohamed Noor DA, Sabbah MA, Musa NF, Athirah Daud NA
    Heliyon, 2025 Jan 15;11(1):e41108.
    PMID: 39811327 DOI: 10.1016/j.heliyon.2024.e41108
    INTRODUCTION: Severe cutaneous adverse reactions (SCARs) are life-threatening and often linked to antiepileptic drugs (AEDs). Common types of SCARs include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS). Immune-mediated mechanisms involving human leukocyte antigen (HLA) alleles have been implicated in the pathogenesis of this reaction. This study examines the association between specific HLA alleles (HLA-A, -B, and -DRB1) and AED-induced SCARs in the Iraqi population.

    METHODOLOGY: A total of 50 patients diagnosed with SCARs and 90 tolerant controls were recruited from Dr. Saad Al-Wattari Hospital for Neurological Sciences and Baghdad Hospital - Medical City. HLA genotyping was performed using PCR-SSO method from peripheral blood samples. Statistical comparisons were made using the t-test or chi-square test, while univariate logistic regression with Bonferroni's correction (p 

  16. Arockiasamy FS, Manoharan B, Santhi VM, Prakalathan K, Periasamy D, Dhandapani A, et al.
    Heliyon, 2025 Jan 15;11(1):e41188.
    PMID: 39811333 DOI: 10.1016/j.heliyon.2024.e41188
    Cellulose nanocrystals (CNCs) are a class of materials that have received significant attention in recent years due to their unique properties and potential applications. CNCs are extracted from plant fibers and possess high strength, stiffness, and biocompatibility, making them attractive materials for use in various fields such as biomedical engineering, renewable energy, and nanotechnology. This provides an in-depth discussion of the extraction, characterization, and promising applications of CNCs. Furthermore, it discusses the sources of CNCs and the methods used for their extraction as well as the common techniques used to characterize their properties. This work also highlights various applications of CNCs and their advantages over other materials. The challenges associated with the use of CNCs and the current research efforts to address these challenges were analyzed. In addition, the potential future directions and applications for CNCs were discussed. This review article aims to provide a comprehensive understanding of CNCs and their potential as versatile and sustainable materials.
  17. Herlina T, Rizaldi Akili AW, Nishinarizki V, Hardianto A, Latip JB
    Heliyon, 2025 Jan 15;11(1):e41395.
    PMID: 39811340 DOI: 10.1016/j.heliyon.2024.e41395
    The Fabaceae family, particularly genus Erythrina, is renowned for significant medicinal properties. These plants have been used as natural remedies to address various health issues and are rich in flavonoids. Therefore, this review aimed to provide a comprehensive overview of antibacterial activity, structure-activity relationship, especially against drug-resistance Staphylococcus aureus, and mode of action for flavonoids isolated from Erythrina. Data were collected from reputable electronic scholarly resources focusing on publications from 2000 to 2022. The results showed that the evaluated flavonoids include 31 % pterocarpans, 22 % flavanones, 20 % isoflavanones, 18 % isoflavones, 4 % isoflavans, 3 % isoflav-3-enes, 1 % 3-arylcoumarins, and 1 % coumestans. Most of these compounds in Erythrina plants were extracted from the roots and stem bark. Among these group of flavonoids, pterocarpan stands out as the most active class against S. aureus. Structure-activity relationship study emphasized pivotal contribution of the prenyl functional group to enhance antibacterial activity of flavonoids. Increasing the number of prenyl groups enhanced antibacterial effectiveness while modifying the group reduced this activity. The proposed antibacterial mechanisms of these flavonoids include the suppression of nucleic acid synthesis, disruption of cytoplasmic membrane function, and modulation of energy metabolism. Among the potent antibacterial flavonoids from genus Erythrina, compound 3,9-dihyroxy-10-γ,γ-dimethylallyl-6a,11a-dehydropterocarpan was found as the most potent against Methicillin-Resistant Staphylococcus aureus (MRSA) through the inhibition of nucleic acid synthesis. Other common flavonoids such as genistein, daidzein, apigenin, and luteolin exert antibacterial activity through the inhibition of ATP synthase.
  18. Abdul Rahim KS, Samsuri A, Jamal SH, Mohd Nor SA, Rusly SNA, Ariff H, et al.
    Heliyon, 2025 Jan 15;11(1):e41282.
    PMID: 39811357 DOI: 10.1016/j.heliyon.2024.e41282
    Nitrocellulose (NC)-based propellants have played a pivotal role in the development of energetic materials for both military and civilian applications. This review offers a comprehensive exploration of NC-based propellants, tracing their evolution from their historical origins as smokeless gunpowder to modern advancements. It discusses the chemical composition and classifications of NC propellants, along with continuous efforts to refine smokeless powder formulations through studies on smoke formation, residues, and additives. Modern techniques such as PCR-based detection and dynamic light scattering have enabled precise analysis of NC properties, including variations in the degree of substitution and molar mass, which allow for tailoring the chemical structure to meet specific performance needs. Special attention is given to the combustion dynamics of NC-based propellants, with an emphasis on reaction zones, performance characteristics, and optimization strategies that enhance their overall efficacy. The review also highlights the significant impact of nitrogen content, additives, and processing methods on the performance, stability, and safety of NC-infused propellants. While higher nitrogen content improves energetic output, it also increases surface cracking and gas production, necessitating the use of stabilizers and additives like Bu-NENA, copper compounds, and MgH2 to enhance flexibility, thermal stability, and reduce sensitivity to mechanical and thermal stimuli. Aging and environmental factors further influence burn rate variation, underscoring the need for tailored formulations. In terms of environmental sustainability, this review addresses safety considerations in handling and disposing of NC-based materials, focusing on innovations such as alkaline hydrolysis and NC recovery to mitigate environmental risks. Stabilizers and eco-friendly additives effectively prevent chemical degradation, reduce shock sensitivity, and enhance thermal stability. The review concludes with future research directions aimed at further improving the stability and safety of NC-based propellants, ensuring their continued relevance in modern applications.
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