METHODS: A multicenter cross-sectional survey was conducted. Participants were recruited by a multi-stage stratified cluster-sampling procedure from a mountainous region in Lishui City, Zhejiang Province, China. A validated questionnaire of Healthy Aging Instruments (HAI), Basic Psychological Needs Satisfaction (BPNS), Patient Health Questionnaire (PHQ-9), Ascertain Dementia 8 questionnaire (AD8), Family Adaption Scale (FAS), Community-Based Health Promotion Activity Questionnaires (HPAQ), Social Function Questionnaire for Chinese Older Adults (SFQCOA), Adult Health Self-Management Skills (ability) Rating Scale (AHSMSRS) was incorporated. The questionnaire also captured sociodemographic characteristics, lifestyle behaviors, and Self-Perceived Healthy Ageing (SPHA). Multivariate stepwise linear regression analysis was performed.
RESULTS: The mean score of the Healthy Aging index was 136.5 (18.22). The majority of the participants have a high level of healthy aging (65.5%). Regression analysis showed 12 predictors of healthy aging: self-perceived economic independence, lifestyle-related behaviors, subjective physical health, psychological health, better competence of BPNS, frequency of community-based HPA participation, lower HPA-perceived barriers, social support, social engagement, and Health Self-Management (HSM) ability with two dimensions HSM-Consciousness and HSM-Behavior, as well as SPHA (P
METHODS: Monthly Pharmaceutical Benefits Scheme (PBS) and Repatriation PBS (RPBS) Item Reports of ADHD prescriptions and Australian ADHD-related Google Trends (GT) data (2004-2023) were sourced. We modelled the lagged effect of GT on ADHD medication prescriptions, using an autoregressive moving average model with autoregressive conditional heteroskedasticity, adjusting for COVID-19 lockdown effects. Results were compared to a model of GT for pain-related searches and PBS/RPBS opioid prescriptions, and counterfactual alternatives: (1) ADHD-related GT and opioid prescriptions and (2) pain-related GT and ADHD prescriptions. We descriptively analysed additional ADHD-related online news data.
RESULTS: Annual prescriptions doubled from 1,424,904 in 2020 to 3,112,072 in 2023. ADHD medication prescriptions and ADHD-related GT considerably increased since the COVID-19 pandemic. GT had a statistically significant positive lagged association with ADHD prescriptions. Comparator models did not show statistically significant associations between GT and prescriptions. Online news data supported recently increased public interest in ADHD.
CONCLUSIONS: ADHD-related online interest predicts increased ADHD prescriptions, which was accentuated during the pandemic. Studies are needed to evaluate causal pathways, health information quality and sociodemographic determinants.
AIM: This study aimed to identify the range of clinical pharmacy activities in ambulatory care, assess the suitability of the existing ward-based tool for capturing these activities, and recommend modifications.
METHOD: Non-participant direct observations were conducted to record pharmacists' clinical activities in ambulatory clinics and multidisciplinary meetings. These observations were compared to the existing ward-based tool to identify discrepancies. Semi-structured interviews with eight ambulatory pharmacists were transcribed verbatim and thematically analysed inductively to explore the tool's representativeness of their routine clinical activities.
RESULTS: Twenty-nine clinical pharmacy activities were observed in ambulatory services. Only fifteen were captured by the existing tool, with therapy monitoring and recommending therapeutic changes not accurately captured. Pharmacists agreed that the tool was not fully representative and included irrelevant activities. Four common uncaptured activities were multidisciplinary meeting-specific activities, arranging laboratory tests, monitoring patient outcomes, and liaising with community healthcare professionals. This study identified 33 candidate ambulatory clinical pharmacy activities.
CONCLUSION: The existing ward-based tool does not fully capture the full range of ambulatory care clinical pharmacy activities, highlighting the need for an improved tool. Pharmacists recommended including the uncaptured activities. The candidate activities provide a foundation for standardised measurement of relevant ambulatory care activities to enable effective workforce deployment and improve patient outcomes.
MATERIALS AND METHODS: A 21-point electronic survey (Federation of Asian Radiation Oncology Research Network [FERN]-S-005) was designed by the FERN and was circulated through the FARO research secretariat to the FARO council member countries and the responses were collected between August and November 2023.
RESULTS: Twelve of 14 member countries (85.7%) responded to the survey. Twenty-seven responses were received and 78% of the respondents belonged to government/teaching academic institute. 4/27 (14.8%) reported never using HYPO-RT for any of the clinical subsite of HNCs, while the majority (85.2%) used it for glottic cancers and 22% also used it for postoperative setting. Majority (77.7%) used a fractionation schedule with dose per fraction ranging between 2.2 and 2.5 Gy. 6/27 (22.2%) used AFRT for definitive setting and five of these also used concurrent chemoradiotherapy. 4/27 (14.8%) centers reported using HFRT. The most common reason (62.9%) for the limited usage of AFRT/HFRT was reported to be logistical, such as unavailability of machine slots, patient load, and so on.
CONCLUSION: The result of the survey suggests that among the ALFT strategies for HNCs, HYPO-RT schedules have common interest and feasibility among the FARO member countries and also highlights the challenges in the delivery of AFRT/HFRT in the Asian region.
METHODS: A direct drug loading approach in the HMN matrix was introduced in this work following a pH modification step. The effect of pH modification on the physicochemical properties of HMN was studied. Then, bovine serum albumin (BSA), a model protein, was loaded into the pH-modified HMN, and the morphological changes in HMN and protein stability were also assessed. Finally, the efficacy of BSA-loaded HMN in the transdermal delivery was evaluated ex vivo.
RESULTS: A significant increase in swelling was recorded following the pH modification of HMN (p < 0.001). The structure of pH-modified hydrogel was highly porous, and ATR-FTIR spectra indicated a shift in the carboxylic peak. The secondary structure of BSA loaded in the pH-modified HMN was also preserved. The BSA-loaded HMN mediated a sustained ex-vivo drug release with a cumulative release of 64.70% (3.88 mg) in 24 h.
CONCLUSION: Hence, the model drug-incorporated PMVE/MA HMN system shows potential for sustainable transdermal delivery of proteins.
METHODS: The antiproliferative activity of TQ-PLGA-PF68 nanoparticles was measured using the MTS assay. The cytotoxic effects were further evaluated through colony formation assay and scratch-wound healing assay. Terminal deoxynucleotidyl transferase dUTP Nick End Labeling (TUNEL) assay was performed to determine the characteristics of the apoptosis as well as cell cycle arrest induced by TQ-PLGA-PF68 nanoparticles. The localization of these nanoparticles in the cells was examined using Transmission Electron Microscopy (TEM).
RESULTS: With a TQ concentration of 58.5 μM encapsulated within the nanoparticles, cytotoxicity analysis revealed a significant inhibition of cell proliferation (p<0.05). This finding was corroborated by the results of the colony formation assay. Treatment with TQ-PLGA-PF68 nanoparticles significantly decreased the number of surviving TamR MCF-7 cells by 35% (p<0.001) compared to untreated TamR MCF-7 cells. Concurrently, the scratch-wound healing assay indicated a closure rate of 50% versus >80% (p<0.05) in untreated TamR MCF-7 cells at 12 hours post-wounding. The TUNEL assay successfully confirmed the apoptosis characteristics associated with cell cycle arrest. TEM observation confirmed the cellular internalization of these nanoparticles, suggesting the in vitro therapeutic potential of the formulation.
CONCLUSION: In this study, a significant functional change in TamR MCF-7 cells induced by the TQ nanoparticles was observed. The unique incorporation of TQ into the PLGA-PEG and Pluronics F68 formulation preserved its bioactivity, thereby reducing the migratory and proliferative traits of drug-resistant cells. This discovery may pave the way for exploring the application of biocompatible polymeric TQ nanoparticles as a novel therapeutic approach in future studies pertaining to resistant breast cancer.
METHOD: The current study used 9,013 children under five years old. An ordinal logistic regression (e.g., proportional odds model) was applied to determine the associated risk factors of being underweight. The current study used SAS software version 9.4 at the 5% significance level.
RESULTS: The prevalence of underweight was 25.3%. Variables such as children's sex, place of residence, whether the child is twin at birth, breastfeeding status, size of children at birth, childbirth order, employment status of mothers, parents' educational level, children's age groups, the incidence of diarrhea in the past two weeks, and baby fortified food were statistically associated with underweight among under-five age in years.
CONCLUSIONS: Underweight among under-five children is predicted by place of residence. In addition, there is a regional disparity of underweight among children. Therefore, further effort is needed to improve health education in children's welfare and health facilities to enhance patients' understanding of proper information and feeding.
METHODS: We systematically searched PubMed, Embase, and Web of Science for studies evaluating the GNRI in patients with ACS. Inclusion criteria were observational studies reporting all-cause mortality or major adverse cardiovascular events (MACEs) among ACS patients categorized by low versus normal GNRI. Data extraction and quality assessment were independently performed by two authors, utilizing a random-effects model to account for potential heterogeneity.
RESULTS: Eleven cohort studies, encompassing 18 616 patients with ACS, were included. A low GNRI was associated with significantly increased risks of all-cause mortality (RR, 1.95; 95% CI, 1.63-2.34; P 0.05). Sensitivity analyses conducted by sequentially excluding individual studies confirmed the stability of these results.
CONCLUSION: A low GNRI at the time of admission is a significant predictor of increased all-cause mortality and MACEs in patients with ACS.
METHODS: The translation, validation, and reliability assessment process followed guidelines from the World Health Organization, with adaptations from Sousa and Rojjanasrirat's recommendations. The process encompassed five steps: forward translation, harmonisation of the forward translation, backward translation, pretesting and cognitive interviews, and psychometric testing to assess the validity and reliability.
RESULTS: The Malay version of the MOQ (MOQ-M) demonstrated excellent item-level face validity index (I-FVI) and average scale-level face validity index (S-FVI/Ave), both scoring a perfect 1.00. Additionally, it exhibited excellent item-level content validity index (I-CVI) and average scale-level content validity (S-CVI/Ave), with scores ranging from 0.90 to 1.00 and 0.99 to 1.00, respectively. Internal consistency, measured using Cronbach's alpha, surpassed the minimum threshold for good reliability, with all three average scales in MOQ-M scoring between 0.84 and 0.99. Weighted average Cohen's Kappa coefficient revealed substantial agreement in the test-retest reliability across the three scales.
CONCLUSION: The MOQ-M is a valid and reliable instrument for assessing meaningful time use among Malay-speaking older persons in Malaysia.
CONSUMER AND COMMUNITY INVOLVEMENT: There was no consumer and community involvement in this study.
PLAIN LANGUAGE SUMMARY: This study aimed to translate the Modified Occupational Questionnaire (MOQ) into Bahasa Melayu (MOQ-M). The MOQ is a tool used by occupational therapists to understand how unemployed people spend their time and the reasons they are doing it. The translation was necessary because the original version of the MOQ was developed in an English-speaking country and might not be suitable for the Malay-speaking population in Malaysia due to cultural differences. A careful process was followed to make sure the translation was accurate and reliable. The translated version, MOQ-M, was then tested with older persons, most of whom were unemployed, to learn about their daily activities and the reasons for doing them. Understanding their daily routines is important for predicting their health and well-being. The results showed that the MOQ-M worked well, providing useful and consistent information. This means that the tool is reliable and can be trusted to measure how older persons spend their time and what activities are important to them. With this information, programmes can be created to better support older persons, helping them live healthier and happier lives as they age. However, it is important to note that most of the study participants were Malay, so this may not fully represent the different cultural groups in Malaysia.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13205-025-04213-9.