OBJECTIVES: The purpose of this study was to investigate the serial multiple mediating effect of perceived stress and self-control in the relationship between neuroticism and career anxiety among nursing interns in China.
DESIGN: A cross-sectional study.
METHODS: A total of 499 nursing interns from five tertiary hospitals in Xi'an, China, participated. Neuroticism, perceived stress, self-control, and career anxiety among nursing interns were assessed. Serial mediation analysis was conducted using the PROCESS Macro in SPSS. Statistical analyses included descriptive analysis, t-tests, ANOVA, Pearson correlation, and regression with bootstrapping.
RESULTS: (1)Career anxiety was significantly and positively correlated with neuroticism (r = 0.384, p
MATERIALS AND METHODS: Enamel specimens of 4 mm × 4 mm × 3 mm were cut and CQD solution was dialyzed in deionized water mixed with urea solution and placed in microwave system (800 W) to obtain *CQD0.1 %-, **CQD0.2 %-, ***CQD0.3 %-, and *****CQD0.5 % for enamel blocks to be immersed for 2 weeks. X-ray diffraction analysis and density-functional theory (DFT) calculations were performed to determine degree of phase purity. Transmission electron microscopy (TEM) was used for imaging of CQDs and treated enamel, with zeta potential measured with Zetasizer. Raman spectra was acquired with spectral range of 400-2000 cm-1. Atomic force microscopy was performed with a peak force set at 200 nN. Lactobacillus biofilm was prepared on treated enamel substrates and analysed using confocal, scanning electron microscopy and TEM.
RESULTS: DFT calculations summarised improved lattice parameters of HAp***CQD0.3 %- and HAp***CQD0.5 %-. Zeta potential is least for salineS and is maximum for *****CQD0.5 %- distributed system. The salineS, and *CQD0.1 %- groups had comparable v₁PO₄³⁻ value, indicating consistent phosphate intensities. TEM successfully verified carbon dots as spherical. Enamel crystals aligned their c-axis perpendicular to the electron beam within 1° with CQDs treated specimens exhibiting misoriented-crystals. *****CQD0.5 %- group had highest elastic modulus and nano hardness with maximum shear stress. Calculated bond length and angles using XRD show higher measures (p
METHODS: This case-control study analysed samples from adults aged 18 years and older who visited the otorhinolaryngology department in 32 government hospitals in Malaysia for pure tone audiometry(PTA) between January 25, 2020 and June 30, 2022. Cases comprised patients diagnosed with ISSNHL, while controls consisted of individuals with normal PTA assessments presenting for other otorhinolaryngology-related symptoms during the same period. Patients with known causes of hearing loss were excluded. Cases and controls were matched in a 1:5 ratio based on age (± 5 years) and index date (± 10 days). The study investigated the association between ISSNHL and both COVID-19 vaccination and COVID-19 infection using conditional logistic regression, with statistical significance set at P
METHODS: Data from the Global Burden of Disease 2021 study were used to assess larynx cancer mortality trends from 1990 to 2021 across global, regional, and national levels. Death rates, absolute mortality numbers, and Estimated Annual Percentage Change (EAPC) were calculated.
RESULTS: Globally, the number of deaths from larynx cancer increased by 36.67% between 1990 and 2021, while death rates slightly declined, with an EAPC of -0.41. Males consistently accounted for the majority of deaths, with 100,393 deaths in 2021, though female mortality showed a larger percentage increase of 60.13% compared to 33.39% in males. Significant regional disparities were evident, with the highest death rates reported in Eastern Europe and Central Latin America, where countries like Bulgaria and Cuba recorded rates exceeding 6 per 100,000 population. In contrast, Oceania reported the lowest rates, below 0.5 per 100,000. The elderly (75 + years) experienced the largest increase in mortality, rising by 85.4%, while deaths among the 15-49 age group remained relatively stable. Additionally, larynx cancer death rates were correlated with SDI.
CONCLUSION: Despite slight declines in global death rates, the absolute burden of larynx cancer has increased due to population growth and aging. Regional disparities emphasize the need for targeted interventions and improved healthcare access. This study offers valuable insights for policy and resource planning.
METHODS: TOY8 was designed and developed to screen for developmental problems in children aged 3-5 years in Malay and English by an interdisciplinary research team drawing upon both national and international guidelines, and then reviewed by an expert panel (n = 5). Two samples of parents and their children were recruited: 1767 dyads to complete the English TOY8 and another 1724 dyads to complete the Malay TOY8.
RESULTS: The confirmatory factor analysis results indicated that the model structure of the English TOY8 matched that of the Malay TOY8. The split-half reliability coefficient indicated adequate to high reliability, which is also consistent with the Malay TOY8. Our results showed that all configural and metric invariance models across groups had a good fit to the data, demonstrating that multiple-group confirmatory factor analysis was appropriate. Finally, scalar invariance was only achieved in certain domains across gender and not in language versions or income groups.
CONCLUSION: The English TOY8 demonstrates construct validity and reliable screening tool for identifying developmental milestones in children aged 3-5 years in Malaysia. In addition, configural and metric invariances across groups in all domains were established, indicating the cross-cultural equivalence of the items, and scalar invariance was established across genders in most 3- to 5-year-old domains. These findings provide preliminary evidence supporting reliability and validity that aligns with previous literature on child development, which indicates a general similarity in the gender and cross-cultural development domains in the first years of life, but not for older children, in terms of language and socioemotional skills.
BACKGROUND: The International Parkinson and Movement Disorder Society (MDS) Evidence Based Medicine in Movement Disorders Committee recommendations for the treatments of PD were first published in 2002 and regularly updated. The current review uses a new methodology, including the Cochrane Risk of Bias tool and a modified version of GRADE (Grading of Recommendations, Assessment, Development, and Evaluations).
METHODS: On January 1, 2023, a literature search was conducted without date limit in the MEDLINE, Embase, and Cochrane databases using the following search terms: Parkinson disease, levodopa and, for the Embase database, randomized controlled trial (RCT). The inclusion criteria for studies were: patients with PD, on oral levodopa therapy, experiencing motor fluctuations, investigating an intervention that was (commercially) available in at least one country, study design RCT, and with a follow-up duration of at least 3 months.
RESULTS: A total of 102 studies were included. Levodopa extended release, pramipexole immediate release and extended release, ropinirole immediate release, rotigotine, opicapone, safinamide, and bilateral subthalamic nucleus deep brain stimulation (DBS) were assessed as efficacious, and continuous intestinal levodopa infusion, continuous subcutaneous levodopa, continuous subcutaneous apomorphine, ropinirole prolonged release, ropinirole patch, entacapone, rasagiline, istradefylline, amantadine extended release, zonisamide, bilateral globus pallidus DBS, and pallidotomy were assessed as likely efficacious for the treatment of motor fluctuations in people with PD who are already being treated with levodopa.
CONCLUSIONS: There are several treatment options that can improve motor fluctuations in PD. These recommendations will assist physicians and patients in determining which intervention to use. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
METHODS: Patients from FLAURA who received first-line osimertinib and from the AURA program (AURA, AURA2, AURA3) who received ≥ second-line osimertinib were included. Patients received osimertinib 80 mg once daily. Safety data were analyzed in patients who remained on treatment for ≥ 36 months. The post-study global safety database captured investigator-reported serious adverse events (SAEs) in patients who continued osimertinib beyond final data cut-off (DCO) of the studies. Best response data were analyzed in patients on treatment for ≥ 54 months (FLAURA) or ≥ 36 months (AURA program).
RESULTS: In FLAURA, 76 (28 %) and 36 (13 %) of 267 patients received first-line osimertinib for ≥ 36 and ≥ 54 months, respectively; median exposure: 52.5 and 64.5 months, respectively. Across the AURA program,124 (16 %) of 799 patients received ≥ second-line osimertinib for ≥ 36 months; median exposure: 44.7 months. Investigators reported on-study SAEs in 17 % (FLAURA) and 35 % (AURA program) of patients who continued treatment for ≥ 36 months. Post-study incidences of SAEs were 11 % (FLAURA) and 21 % (AURA program). On-study, adverse events (AEs) of cardiac effects (indicative of cardiac failure; grouped term) occurred in 7 % (FLAURA) and 5 % (AURA program) of patients; AEs of interstitial lung disease (ILD; grouped term) occurred in 0 (FLAURA) and 1 (AURA program) patient. No post-study SAEs were reported for the grouped terms cardiac effects and ILD. Most patients treated for ≥ 54 months (FLAURA) and ≥ 36 months (AURA program) had a best on-study response of partial response.
CONCLUSION: This analysis demonstrated that long-term treatment with osimertinib of ≥ 36 months was well tolerated in patients with EGFRm advanced NSCLC.
METHODS: The study was conducted from April 2023 to August 2024 in 8 hospitals across India, Malaysia, Papua New Guinea, Colombia, Egypt, and Turkey. Data were collected prospectively using the INICC Surveillance Online System. Cases and controls were recruited simultaneously. Data were analyzed using t tests, χ² tests, and Fisher exact tests when indicated. Relative risks (RR) and their corresponding 95% confidence intervals (CI) were calculated.
RESULTS: A total of 6,672 patients were included. Patients with impregnated CLs had 4,721 CL-days, while those with plain CLs had 18,822 CL-days. The CLABSI rate in patients with impregnated CLs was 1.48 per 1,000 CL-days, compared to 4.78 per 1,000 CL-days in those with plain CLs (RR=0.31, 95%CI=0.14-0.67, P=.003). A subgroup analysis excluding patients with hemodialysis but using central venous catheters (CVCs) showed 1.72 CLABSIs per 1,000 CL-days in patients with impregnated CVCs compared to 5.84 per 1,000 CL-days in those with plain CVCs (RR=0.29, 95%CI=0.12-0.68, P=.004).
CONCLUSIONS: This study highlights the significant benefits of impregnated CLs over plain CLs in reducing CLABSI rates, achieving a 69% decrease in incidence.
METHODS: A cross-sectional study was conducted among menopausal women (n = 390) in Kuala Lumpur in the form of self-administered questionnaire. Data was collected using convenience sampling. The questionnaire was adopted from previous studies and some literature reviews with modifications. It was composed of 4 sections. Statistical analyses were performed using the IBM SPSS Statistics Version 26. Data obtained was analysed using descriptive and inferential analysis such as independent t test, one way ANOVA and chi square test.
RESULTS: The prevalence of T&CM used among menopausal women was found to be 27.2%. Evening primrose oil (53.2%), vitamins and minerals (53.2%) and black cohosh (48%) were most frequently used. Black cohosh and phytoestrogens were perceived as effective in relieving menopausal symptoms by 36.6% and 43.4% of respondents, respectively. Over half of the respondents had poor knowledge (51.3%), negative attitude (56.9%) and poor practice (55.7%) regarding the utilization of T&CM in menopause. There was a significant association between knowledge and attitude (p value RM10,1000) showed higher knowledge and positive attitude.
CONCLUSIONS: Menopausal women in Kuala Lumpur were found to have a low prevalence rate of T&CM utilization. Respondents' low understanding and unfavourable views might significantly impact the inadequate usage of T&CM.
METHODS: Forty skilled youth male tennis players were assigned to the functional training group (n = 20) or the control training group (n = 20). The control group received a traditional resistance training program by their coach, whereas the functional training group was given Santana's Racket Sports Program. Each group received 60-minute training sessions three times per week for 12 weeks. At baseline (T0), after six weeks (T6), and after 12 weeks (T12), the participants' skill performance was measured according to the International Tennis Federation's protocol, and movement quality was measured according to the functional movement screening assessment recommended by Gray Cook. The data were analyzed via a generalized estimation equation model.
RESULTS: The results revealed that there were no significant differences in skill performance or movement quality between the groups at baseline (p > 0.05), but there were significant differences in those variables between the groups after 6 weeks of the intervention and 12 weeks of the intervention (p