Evaluation of retinal nerve fiber layer thickness in eyes with hypertensive uveitis

Din NM 1 , Taylor SR 2 , Isa H 1 , Tomkins-Netzer O 3 , Bar A 3 , Talat L 3 Show all authors , Lightman S 3

Affiliations 

  • 1 Institute of Ophthalmology, University College London, Moorfields Eye Hospital, London, England2Department of Ophthalmology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 2 Institute of Ophthalmology, University College London, Moorfields Eye Hospital, London, England3Division of Immunology and Inflammation, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, England4Department of Ophthalmology, Royal
  • 3 Institute of Ophthalmology, University College London, Moorfields Eye Hospital, London, England
JAMA Ophthalmol, 2014 Jul;132(7):859-65.
PMID: 24789528 DOI: 10.1001/jamaophthalmol.2014.404

Abstract

IMPORTANCE: Uveitic glaucoma is among the most common causes of irreversible visual loss in uveitis. However, glaucoma detection can be obscured by inflammatory changes.

OBJECTIVE: To determine whether retinal nerve fiber layer (RNFL) measurement can be used to detect glaucoma in uveitic eyes with elevated intraocular pressure (IOP).

DESIGN, SETTING, AND PARTICIPANTS: Comparative case series of RNFL measurement using optical coherence tomography performed from May 1, 2010, through October 31, 2012, at a tertiary referral center. We assigned 536 eyes with uveitis (309 patients) in the following groups: normal contralateral eyes with unilateral uveitis (n = 72), normotensive uveitis (Uv-N) (n = 143), raised IOP and normal optic disc and/or visual field (Uv-H) (n = 233), and raised IOP and glaucomatous disc and/or visual field (Uv-G) (n = 88).

EXPOSURES: Eyes with uveitis and elevated IOP (>21 mm Hg) on at least 2 occasions.

MAIN OUTCOMES AND MEASURES: Comparison of RNFL values between groups of eyes and correlation with clinical data; risk factors for raised IOP, glaucoma, and RNFL thinning.

RESULTS: Mean (SD) global RNFL was thicker in Uv-N (106.4 [21.4] µm) compared with control (96.0 [9.0] µm; P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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