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Estrogen receptor-negative breast ductal carcinoma: clinicopathological features and MIB-1 (Ki-67) proliferative index association

Mdpaiman N 1 , Md Ali SA 2 , Mdzin R 2 , Meor Kamal MZ 3 , Md Amin WA 3 , Nallusamy M 4 Show all authors , Puspanathan P 3 , Muhammad R 5 , Wan Puteh SE 6 , Das S 7

Affiliations 

  • 1 Department of Pathology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia ; Department of Pathology, Sultanah Bahiyah Hospital, Alor Setar, Malaysia
  • 2 Department of Pathology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 3 Department of Pathology, Sultanah Bahiyah Hospital, Alor Setar, Malaysia
  • 4 Department of Surgery, Sultanah Bahiyah Hospital, Alor Setar, Malaysia
  • 5 Department of Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 6 Department of Epidemiology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 7 Department of Anatomy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
PLoS One, 2014;9(2):e89172.
PMID: 24586570 DOI: 10.1371/journal.pone.0089172

Abstract

Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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