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An explorative analysis on the optimal cryo-passes and freezing time of the ultrathin cryoprobe in endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy

Kho SS 1 , Tan SH 2 , Soo CI 3 , Ramarmuty HYD 4 , Chai CS 5 , Huan NC 4 Show all authors , Ng KL 4 , Matsumoto Y 6 , Poletti V 7 , Tie ST 5

Affiliations 

  • 1 Division of Respiratory Medicine, Department of Medicine, Sarawak General Hospital, Jalan Hospital, Ministry of Health Malaysia, Kuching, Sarawak, Malaysia. khosze@moh.gov.my
  • 2 Clinical Research Centre, Sarawak General Hospital, Institute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Kuching, Sarawak, Malaysia
  • 3 Division of Respiratory Medicine, Department of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia
  • 4 Department of Respiratory Medicine, Queen Elizabeth Hospital, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia
  • 5 Division of Respiratory Medicine, Department of Medicine, Sarawak General Hospital, Jalan Hospital, Ministry of Health Malaysia, Kuching, Sarawak, Malaysia
  • 6 Respiratory Endoscopy Division, Department of Endoscopy, National Cancer Center Hospital, Tokyo, Japan
  • 7 Department of Medical Specialities-Pulmonology, GB Morgagni Hospital, Forlì, Italy
Sci Rep, 2024 Aug 12;14(1):18653.
PMID: 39134712 DOI: 10.1038/s41598-024-69702-y

Abstract

EBUS-guided transbronchial mediastinal cryobiopsy (TBMC) has emerged as a promising biopsy tool for diagnosing hilar and mediastinal pathologies. However, several fundamental technical aspects of TBMC remain unexplored. This study aims to determine the optimal number of cryo-passes and freezing time of the ultrathin cryoprobe in EBUS-TBMC concerning specimen size and procedural diagnostic yield. We conducted a retrospective chart review of patients with mediastinal and hilar lesions who underwent EBUS-TBMC between January 2021 and April 2023 across three hospitals in Malaysia. A total of 129 EBUS-TBMC procedures were successfully completed, achieving an overall diagnostic yield of 88.4%. Conclusive TBMC procedures were associated with larger specimen sizes (7.0 vs. 5.0 mm, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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