Goniolandrene A and B from Goniothalamus macrophyllus

Abdullah N 1 , Sahibul-Anwar H 1 , Ideris S 1 , Hasuda T 2 , Hitotsuyanagi Y 2 , Takeya K 2 Show all authors , Diederich M 3 , Choo C 4

Affiliations 

  • 1 MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia
  • 2 Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hajiochi, Tokyo 192-03, Japan
  • 3 Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9 Rue Edward Steichen, 2540 Luxembourg, Luxembourg
  • 4 MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia. Electronic address: choo715@puncakalam.uitm.edu.my
Fitoterapia, 2013 Jul;88:1-6.
PMID: 23570840 DOI: 10.1016/j.fitote.2013.03.028

Abstract

Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G. macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from this extracts afforded six compounds with two new compounds, namely goniolandrene-A (1), -B (2). The absolute configuration of goniolandrene B (2) was established by circular dichrosim. The compounds were cytotoxic against the P388 cells with IC50 values ranging from 0.42 to 160 μM. Goniothalamin (3) exhibited the highest inhibition of 0.42 μM.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications