Apocynum venetum leaf extract, an antihypertensive herb, inhibits rat aortic contraction induced by angiotensin II: a nitric oxide and superoxide connection

Lau YS; Kwan CY; Ku TC; Hsieh WT; Wang HD; Nishibe S; Dharmani M; Mustafa MR

doi:10.1016/j.jep.2012.07.012

Apocynum venetum leaf extract, an antihypertensive herb, inhibits rat aortic contraction induced by angiotensin II: a nitric oxide and superoxide connection

Lau YS ¹ , Kwan CY , Ku TC , Hsieh WT , Wang HD , Nishibe S Show all authors , Dharmani M , Mustafa MR

Affiliations

¹ Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

J Ethnopharmacol, 2012 Sep 28;143(2):565-71.

PMID: 22835814 DOI: 10.1016/j.jep.2012.07.012

Abstract

The leaves extract of Apocynum venetum (AVLE), also known as "luobuma", have long been used in traditional Chinese medicine to treat hypertension and depression in parts of China and it has been shown to possess anti-oxidant and anti-lipid peroxidation effects. AVLE (10 μg/ml) has been reported to have a long-lasting endothelium-dependent relaxant effect and this effect has been proposed to be due to its nitric oxide(NO)-releasing and superoxide anion(SOA)-scavenging properties.

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