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Novel application of chemical shift gradient echo in- and opposed-phase sequences in 3 T MRI for the detection of H-MRS visible lipids and grading of glioma

Ramli N 1 , Khairy AM 2 , Seow P 3 , Tan LK 3 , Wong JH 3 , Ganesan D 4 Show all authors , Rahmat K 3

Affiliations 

  • 1 Department of Biomedical Imaging, University Malaya Research Imaging Centre, University of Malaya, 59100, Kuala Lumpur, Malaysia. norlisahramli@gmail.com
  • 2 Department of Radiology, Sultan Ismail Hospital, Jalan Persiaran Mutiara Emas Utama, Taman Mount Austin, 81100, Johor Bahru, Malaysia
  • 3 Department of Biomedical Imaging, University Malaya Research Imaging Centre, University of Malaya, 59100, Kuala Lumpur, Malaysia
  • 4 Division of Neurosurgery, Department of Surgery, University of Malaya, 59100, Kuala Lumpur, Malaysia
Eur Radiol, 2016 Jul;26(7):2019-29.
PMID: 26560718 DOI: 10.1007/s00330-015-4045-0

Abstract

OBJECTIVES: We evaluated the feasibility of using chemical shift gradient-echo (GE) in- and opposed-phase (IOP) imaging to grade glioma.

METHODS: A phantom study was performed to investigate the correlation of (1)H MRS-visible lipids with the signal loss ratio (SLR) obtained using IOP imaging. A cross-sectional study approved by the institutional review board was carried out in 22 patients with different glioma grades. The patients underwent scanning using IOP imaging and single-voxel spectroscopy (SVS) using 3T MRI. The brain spectra acquisitions from solid and cystic components were obtained and correlated with the SLR for different grades.

RESULTS: The phantom study showed a positive linear correlation between lipid quantification at 0.9 parts per million (ppm) and 1.3 ppm with SLR (r = 0.79-0.99, p 

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