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Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Weiss SL 1 , Fitzgerald JC 2 , Maffei FA 3 , Kane JM 4 , Rodriguez-Nunez A 5 , Hsing DD 6 Show all authors , Franzon D 7 , Kee SY 8 , Bush JL 9 , Roy JA 10 , Thomas NJ 11 , Nadkarni VM 12 , SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Network

Affiliations 

  • 1 Division of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. weisss@email.chop.edu
  • 2 Division of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. fitzgeraldj@email.chop.edu
  • 3 Division of Pediatric Critical Care, Janet Weis Children's Hospital at Geisinger Health System, Danville, PA, USA. famaffei@geisinger.edu
  • 4 Department of Pediatrics, Section of Critical Care, University of Chicago Medicine, Comer Children's Hospital, Chicago, IL, USA. jmkanemd@gmail.com
  • 5 Division of Pediatric Emergency and Critical Care, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain. antonio.rodriguez.nunez@sergas.es
  • 6 Division of Pediatric Critical Care Medicine, New York Presbyterian Hospital, Weill Cornell Medical School, New York, NY, USA. ddh9002@med.cornell.edu
  • 7 Division of Critical Care Medicine, Department of Pediatrics, Lucile Packard Children's Hospital, Stanford University, Palo Alto, CA, USA. dfranzon@stanford.edu
  • 8 Department of Pediatric Pulmonology, University Malaya Medical Centre, University of Malaya, Kuala Lumpur, Malaysia. sy_kee2004@icloud.com
  • 9 Division of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bushj1@email.chop.edu
  • 10 Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. jaroy@mail.med.upenn.edu
  • 11 Division of Pediatric Critical Care Medicine, Penn State Hershey Children's Hospital, Penn State University College of Medicine, Hershey, PA, USA. nthomas@hmc.psu.edu
  • 12 Division of Critical Care Medicine, Department of Anesthesia and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. nadkarni@email.chop.edu
Crit Care, 2015;19:325.
PMID: 26373923 DOI: 10.1186/s13054-015-1055-x

Abstract

Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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