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Randomized Controlled Trial on the Effect of Channa striatus Extract on Measurement of the Uterus, Pulsatility Index, Resistive Index of Uterine Artery and Superficial Skin Wound Artery in Post Lower Segment Caesarean Section Women

Abu Bakar MR 1 , Abdul Kadir A 2 , Abdul Wahab SZ 2 , Abdul Karim AH 2 , Nik Hussain NH 2 , Mohd Noor N 2 Show all authors , Omar J 2 , Bin Bai Bae S 3 , Wan Mahmood WH 2 , Abdul Razak A 2 , Yunus R 4

Affiliations 

  • 1 Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kubang Kerian, Malaysia
  • 2 School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
  • 3 School of Pharmaceutical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
  • 4 International Medical University, Seremban, Malaysia
PLoS One, 2015;10(7):e0133514.
PMID: 26222158 DOI: 10.1371/journal.pone.0133514

Abstract

AIM: To compare the mean of anteroposterior (AP) measurements of the uterus in longitudinal and oblique transverse planes, and the pulsatility index (PI) and resistive index (RI) of the uterine artery and superficial skin wound artery between patients taking Channa striatus and placebo.

BACKGROUND: Channa striatus, also known as haruan, is a fresh water snakehead fish consumed in many parts of Southeast Asia. Channa striatus is also normally consumed by women postpartum to promote wound healing as well as to reduce post-operative pain.

METHODOLOGY: This study is a randomised, double blind, placebo-controlled study conducted in women after Lower Segment Caesarean Section (LSCS). Subjects were randomised to either a Channa striatus or a placebo group and were given a daily dosage of 500 mg of Channa striatus extract or 500 mg maltodextrin, respectively, for six weeks post LSCS. The anteroposterior measurements of the uterus in the longitudinal and oblique transverse planes, and the pulsatility index (PI) and resistive index (RI) of the uterine and superficial skin wound arteries were assessed using pelvic Gray-scale ultrasound and Doppler ultrasound at baseline (Day 3) and at two weeks, four weeks and six weeks post-operatively.

RESULTS: Sixty-six subjects were randomised into the study with 33 in the Channa striatus group and 33 in the placebo group. No significant differences were detected in terms of the pulsatility index (PI) and the resistive index (RI) of the uterine and superficial skin wound arteries between the Channa striatus and placebo groups. However, in the Channa striatus group, the AP measurements of the uterus on the longitudinal and oblique transverse planes were significantly lower compared to the placebo group (p<0.05 and p<0.001, respectively).

CONCLUSION: Daily intake of Channa striatus extract results in marked differences compared to placebo in terms of uterine involution and recovery in women post LSCS.

TRIAL REGISTRATION: www.isrctn.com 11960786.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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