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Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities

Ahmad R 1 , Sahidin I 2 , Taher M 3 , Low C 1 , Noor NM 1 , Sillapachaiyaporn C 4 Show all authors , Chuchawankul S 5 , Sarachana T 4 , Tencomnao T 4 , Iskandar F 6 , Rajab NF 6 , Baharum SN 7

Affiliations 

  • 1 Institute of Systems Biology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia
  • 2 Laboratory of Natural Products Chemistry, Faculty of Pharmacy, Universitas Halu Oleo, 93232, Kendari, Southeast Sulawesi, Indonesia
  • 3 Department of Pharmaceutical Technology, Kulliyah of Pharmacy, International Islamic University of Malaysia, Jalan Istana, 25200, Kuantan, Pahang, Malaysia
  • 4 Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand
  • 5 Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand
  • 6 Biocompatibility Laboratory, Centre for Research and Instrumentation Management (CRIM), Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia
  • 7 Institute of Systems Biology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia. nataqain@ukm.edu.my
Sci Rep, 2018 03 09;8(1):4202.
PMID: 29523802 DOI: 10.1038/s41598-018-22485-5

Abstract

Polygonumins A, a new compound, was isolated from the stem of Polygonum minus. Based on NMR results, the compound's structure is identical to that of vanicoside A, comprising four phenylpropanoid ester units and a sucrose unit. The structure differences were located at C-3″″'. The cytotoxic activity of polygonumins A was evaluated on several cancer cell lines by a cell viability assay using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The compound showed the highest antiproliferative (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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