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Prevalence, clinical correlates, and outcomes of anaemia in multi-ethnic Asian patients with heart failure with reduced ejection fraction

Goh VJ 1 , Tromp J 2 , Teng TK 3 , Tay WT 3 , Van Der Meer P 2 , Ling LH 4 Show all authors , Siswanto BB 5 , Hung CL 6 , Shimizu W 7 , Zhang S 8 , Narasimhan C 9 , Yu CM 10 , Park SW 11 , Ngarmukos T 12 , Liew HB 13 , Reyes E 14 , Yap J 3 , MacDonald M 15 , Richards MA 4 , Anand I 16 , Lam CSP 2 , ASIAN-HF investigators

Affiliations 

  • 1 Singapore General Hospital, Singapore
  • 2 Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
  • 3 National Heart Centre Singapore, Singapore
  • 4 National University Heart Centre, Singapore
  • 5 National Cardiovascular Center Universitas Indonesia, Jakarta, Indonesia
  • 6 Mackay Memorial Hospital, Taipei, Taiwan
  • 7 Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan
  • 8 Fuwai Cardiovascular Hospital, Beijing, China
  • 9 Care Hospital, Hyderabad, India
  • 10 The Chinese University of Hong Kong, Hong Kong
  • 11 Sejong General Hospital, Seoul, South Korea
  • 12 Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • 13 Queen Elizabeth II Hospital, Clinical Research Center, Sabah, Malaysia
  • 14 Manila Doctors Hospital, Manila, Philippines
  • 15 Changi General Hospital, Singapore
  • 16 Veterans Affairs Medical Center, Minneapolis, MN, USA
ESC Heart Fail, 2018 08;5(4):570-578.
PMID: 29604185 DOI: 10.1002/ehf2.12279

Abstract

AIMS: Recent international heart failure (HF) guidelines recognize anaemia as an important comorbidity contributing to poor outcomes in HF, based on data mainly from Western populations. We sought to determine the prevalence, clinical correlates, and prognostic impact of anaemia in patients with HF with reduced ejection fraction across Asia.

METHODS AND RESULTS: We prospectively studied 3886 Asian patients (60 ± 13 years, 21% women) with HF (ejection fraction ≤40%) from 11 regions in the Asian Sudden Cardiac Death in Heart Failure study. Anaemia was defined as haemoglobin <13 g/dL (men) and <12 g/dL (women). Ethnic groups included Chinese (33.0%), Indian (26.2%), Malay (15.1%), Japanese/Korean (20.2%), and others (5.6%). Overall, anaemia was present in 41%, with a wide range across ethnicities (33-54%). Indian ethnicity, older age, diabetes, and chronic kidney disease were independently associated with higher odds of anaemia (all P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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