Methodology approaches and challenges in population-based longitudinal study of a neuroprotective model for healthy longevity

Lau H 1 , Shahar S 1 , Hussin N 1 , Kamarudin MZ 1 , Hamid TA 2 , Mukari SZ 3 Show all authors , Rajab NF 1 , Din NC 1 , Omar A 4 , Singh DK 5 , Haron H 6 , Sharif R 6 , Yahya HM 1 , Fitri A 7 , Manaf ZA 6 , Mohammed Z 6 , Ishak WS 3

Affiliations 

  • 1 Faculty of Health Sciences, Center for Healthy Aging and Wellness, National University of Malaysia, Kuala Lumpur, Malaysia
  • 2 Institute of Gerontology, University Putra Malaysia, Serdang, Malaysia
  • 3 Institute of Ear, Hearing and Speech, National University of Malaysia, Kuala Lumpur, Malaysia
  • 4 Institute of Public Health, Ministry of Health, Kuala Lumpur, Malaysia
  • 5 Faculty of Health Sciences, Center for Rehabilitation and Special Needs, National University of Malaysia, Kuala Lumpur, Malaysia
  • 6 Faculty of Health Sciences, Center of Healthcare Sciences, National University of Malaysia, Kuala Lumpur, Malaysia
  • 7 Faculty of Health Sciences, Center of Diagnostic and Applied Science, National University of Malaysia, Kuala Lumpur, Malaysia
Geriatr Gerontol Int, 2019 Mar;19(3):233-239.
PMID: 30618211 DOI: 10.1111/ggi.13598

Abstract

AIM: The 36-month Long-Term Research Grant Scheme project: Towards Usual Aging - Neuroprotective Model for Healthy Longevity among Malaysian Elderly was designed to address multidimensional aspects including psychosocial, biophysical health, nutrition and dietary pattern, and auditory and visual function to highlight the magnitude of these associations in a single study.

METHODS: A total of 2322 respondents aged ≥60 years were recruited at baseline using the multistage sampling method, followed up at 18 months and 36 months.

RESULTS: Response rates at baseline, 18 months and 36 months were 87.8%, 77.3% and 67.1%, respectively. At baseline, the prevalence of successful aging, usual aging and mild cognitive impairment was 11%, 73% and 16%, respectively. The prevalence of single and multimorbidity at baseline were 25.9% and 50.3%, respectively. The incidence rates of mild cognitive impairment at 18 months and 36 months were 6.5 and 5.6 per 100 person-years. The incidence rates of multimorbidity at 18 months and 36 months were 23.7 and 21.5 per 100 person-years, respectively.

CONCLUSIONS: The Long-Term Research Grant Scheme project: Towards Usual Aging study provides an opportunity to investigate the interactions between wide ranges of aspects of the older population in a nationally representative sample of the older population. Geriatr Gerontol Int 2019; 19: 233-239.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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