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The high-affinity human IgG receptor Fc gamma receptor I (FcγRI) is not associated with vascular leakage of dengue

Mohamad Zamberi Z 1 , Zakaria Z 2 , Abdul Aziz AT 3 , Heng BS 4 , Zaid M 5 , Chong CL 6 Show all authors , Noor FM 7 , Abu Bakar S 8 , Boon Peng H 9

Affiliations 

  • 1 Institute of Molecular Medical Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. zaiharina@gmail.com
  • 2 Institute of Molecular Medical Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. zuraihan_zakaria@yahoo.com
  • 3 Institute of Molecular Medical Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. thalhahaziz@salam.uitm.edu.my
  • 4 Hospital Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia. limsim7@yahoo.com
  • 5 Hospital Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia. maxx_liza@yahoo.co.uk
  • 6 Hospital Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia. chrislee@moh.gov.my
  • 7 Microbiology Unit, Centre for Pathology Diagnostic and Research Laboratories (CPDRL), Level 1, Clinical Training Centre (CTC), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia. fadzi456@salam.uitm.edu.my
  • 8 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. sazaly@um.edu.my
  • 9 Institute of Molecular Medical Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. hoh.boonpeng@gmail.com
J Negat Results Biomed, 2015;14:1.
PMID: 25566870 DOI: 10.1186/s12952-014-0020-6

Abstract

Dengue is a major public health problem in many tropical and sub-tropical countries. Vascular leakage and shock are identified as the major causes of deaths in patients with severe dengue. Studies have suggested the potential role of Fc gamma receptors I (FcγRI) in the pathogenesis of dengue. We hypothesized that the circulating level of Fcγ receptor I could potentially be used as an indicator in assisting early diagnosis of severe dengue.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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