Affiliations 

  • 1 School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Malaysia
  • 2 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Mahal Road, Jaipur, India
  • 3 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County, Londonderry, BT52 1SA, Northern Ireland, United Kingdom
  • 4 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India
  • 5 Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, 2007, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), School of Biomedical Sciences and Pharmacy, The University of Newcastle (UoN), Callaghan, NSW, 2308, Australia; School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh, 173 229, India
  • 6 School of Medicine, University of Tasmania (UTAS), 7001, Hobart, Australia
  • 7 Faculty of Pharmacy, University of Tasmania (UTAS), 7001, Hobart, Australia
  • 8 Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Malaysia. Electronic address: dinesh_kumar@imu.edu.my
Chem Biol Interact, 2019 Nov 28;315:108911.
PMID: 31786185 DOI: 10.1016/j.cbi.2019.108911

Abstract

Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.