Affiliations 

  • 1 Clinical Epidemiology Unit, National Clinical Research Centre, Level 3, Dermatology Block, Kuala Lumpur Hospital
  • 2 Julius Centre University of Malaya, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Centre for Public Health, Queen's University Belfast, Royal Victoria Hospital Site, Belfast, UK
  • 4 Department of Surgery
  • 5 Department of Pathology
  • 6 Department of Clinical Oncology, Faculty of Medicine, University of Malaya, Kuala Lumpur
  • 7 Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia
Medicine (Baltimore), 2020 Feb;99(6):e19093.
PMID: 32028433 DOI: 10.1097/MD.0000000000019093

Abstract

Percutaneous biopsy in breast cancer has been associated with an increased risk of malignant cell seeding. However, the importance of these observations remains obscure due to lack of corroborating evidence from clinical studies. We determined whether method of biopsy is associated with breast cancer survival. This hospital registry-based cohort study included 3416 non-metastatic breast cancer patients diagnosed from 1993 to 2011 in a tertiary setting. Factors associated with biopsy methods were assessed. Multivariable Cox regression analysis was used to determine the independent prognostic impact of method of biopsy. Overall, 990 patients were diagnosed by core needle biopsy (CNB), 1364 by fine needle aspiration cytology (FNAC), and 1062 by excision biopsy. Excision biopsy was significantly associated with more favorable tumor characteristics. Radiotherapy modified the prognostic impact of biopsy method (Pinteraction 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.