Fulltext

Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies

Suthandiram S 1 , Gan GG , Zain SM , Bee PC , Lian LH , Chang KM Show all authors , Ong TC , Mohamed Z

Affiliations 

  • 1 The Pharmacogenomics Laboratory, Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia
Pharmacogenomics, 2014 Aug;15(11):1479-94.
PMID: 25303299 DOI: 10.2217/pgs.14.97

Abstract

Pharmacogenetics of methotrexate (MTX) contributes to interindividual differences in toxicity. We aimed to evaluate the impact of SNPs within the MTX pathway genes on MTX-induced toxicity and MTX plasma levels at 48 h following treatment in Asian adults with acute lymphoblastic leukemia or non-Hodgkin lymphoma.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications