Recent Update on the Anti-infective Potential of β-carboline Analogs

Faheem 1 , Kumar BK 1 , Sekhar KVGC 2 , Kunjiappan S 3 , Jamalis J 4 , Balaña-Fouce R 5 Show all authors , Sankaranarayanan M 1

Affiliations 

  • 1 Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Vidya Vihar, Pilani-333031, Rajasthan, India
  • 2 Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, R.R. Dist. Hyderabad, 500078, Telangana, India
  • 3 Department of Biotechnology, Kalasalingam Academy of Research and Education, Krishnankoil 626126, India
  • 4 Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310, Malaysia
  • 5 Department of Biomedical Sciences; University of Leon, 24071 Leon, Spain
Mini Rev Med Chem, 2021;21(4):398-425.
PMID: 33001013 DOI: 10.2174/1389557520666201001130114

Abstract

β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and antithrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishmanial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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