Histopathological changes of reproductive organs of goats immunized with Corynebacterium pseudotuberculosis killed vaccine

Umer M 1 , Jesse FFA 2 , Mohammed Saleh WM 3 , Chung ELT 4 , Haron AW 5 , Saharee AA 5 Show all authors , Mohd Lila MA 6 , Ariff AB 7 , Mohammad K 8 , Sharif A 9

Affiliations 

  • 1 Department of Animal Reproduction, Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Pakistan
  • 2 Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia. Electronic address: jesse@upm.edu.my
  • 3 Department of Internal and Preventive Medicine, Faculty of Veterinary Medicine, University of Basra, Basra State, Iraq
  • 4 Department of Animal Science, Faculty of Agriculture, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia
  • 5 Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia
  • 6 Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, UPM, Serdang, Selangor, Malaysia
  • 7 Department of Bioprocess Technology, Faculty of Biotechnology and Bio-molecular Sciences, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia
  • 8 Department of Veterinary Parasitology and Entomology, University of Maiduguri, Borni State, Nigeria
  • 9 Government Poultry Farm, Bahawalpur, Livestock and Dairy Development Department, Punjab, District Bahawalpur, Pakistan
Microb Pathog, 2020 Dec;149:104539.
PMID: 33007431 DOI: 10.1016/j.micpath.2020.104539

Abstract

Caseous lymphadenitis (CLA) caused by Corynebacterium pseudotuberculosis is characterized by the development of abscesses, mainly in superficial and internal lymph nodes, visceral and reproductive organs in small ruminants. This study aims to examine the histopathological changes in reproductive organs of goats immunized with killed vaccine of C. pseudotuberculosis. In this study, twenty four (24) clinically healthy bucks and does were divided into four groups A, B, C and D. Animals in groups A and B were immunized with 0.5 and 1% formalin killed vaccine, respectively; followed by a booster dose. After the booster dose of immunization, groups A, B and C were challenged with C. pseudotuberculosis at 106 cfu/ml. Goats in group D were immunize and unchallenged and left as control group. All C. pseudotuberculosis infected animals were euthanized humanely 12 weeks post-challenged. Tissue samples such as testes, epididymis, spermatic cord, penis, pituitary gland, mammary gland, vulva, vagina, cervix, uterus, fallopian tube and ovaries were collected for histopathology study. Microscopic examination of all tissues (testes, seminiferous tubules, spermatic cord, penile tissues and the pituitary gland) in the male reproductive organs of the bucks that were inoculated with 2 ml of 0.5% and 1.0% of C. pseudotuberculosis killed vaccine showed normal (animals inoculated with 1.0%) to mild (animals inoculated with 0.5%) histopathological changes when compared with those from group C which showed varying degrees of histopathological changes (p 

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