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Peginterferon alfa-2b in the treatment of Chinese patients with HBeAg-positive chronic hepatitis B: a randomized trial

Cheng J 1 , Wang Y 2 , Hou J 3 , Luo D 4 , Xie Q 5 , Ning Q 6 Show all authors , Ren H 7 , Ding H 8 , Sheng J 9 , Wei L 10 , Chen S 11 , Fan X 12 , Huang W 13 , Pan C 14 , Gao Z 15 , Zhang J 16 , Zhou B 17 , Chen G 18 , Wan M 19 , Tang H 20 , Wang G 21 , Yang Y 22 , Mohamed R 23 , Guan R 24 , Lee TH 25 , Chang WH 26 , Zhenfei H 27 , Ye Z 27 , Xu D 28

Affiliations 

  • 1 Beijing Ditan Hospital, Capital Medical University, No. 8, East Jingshun Street, Beijing 100015, China. Electronic address: jun.cheng.ditan@gmail.com
  • 2 Southwest Hospital Affiliated Third Military Medical University, No. 29, Gao Tan Yan Zhengjie, Shapingba, Chongqing 400038, China
  • 3 Guangzhou Nanfang Hospital, No. 1838, N. Guangzhou Avenue, Guangzhou 510515, China
  • 4 Xiehe Hospital Affiliated Tongji Medical College of Huazhong University of Science & Technology, No. 1277, Jiefang Avenue, Wuhan 430022, China
  • 5 Shanghai Ruijin Hospital Affiliated Shanghai Jiao Tong University, No. 197, Ruijiner Rd., Shanghai 200025, China
  • 6 Tongji Hospital Affiliated Tongji Medical College of Huazhong University of Science & Technology, No. 1095, Jiefang Avenue, Wuhan 430030, China
  • 7 The Second Affiliated Hospital, Chongqing Medical University, No. 76, Linjiang Rd., Chongqing 400010, China
  • 8 Beijing You'an Hospital, Capital Medical University, No. 8, You An Men Wai Street, Fengtai District, Beijing 100069, China
  • 9 The First Affiliated Hospital of Zhejiang University Medical College, No. 79, Qingchun Rd., Hangzhou 310003, China
  • 10 Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China
  • 11 Jinan Infectious Disease Hospital, No. 173, Jingshi Rd., Jinan 250021, China
  • 12 Beijing Ditan Hospital, Capital Medical University, No. 8, East Jingshun Street, Beijing 100015, China
  • 13 No. 1 Hospital of Chongqing Medical University, No. 1, Youyi Rd., Chongqing 400016, China
  • 14 Fuzhou Infectious Disease Hospital, No. 312, Xihong Rd., Gulou District, Fuzhou 350025, China
  • 15 The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Rd., Guangzhou 510630, China
  • 16 Huashan Hospital, Fudan University, No. 12, Middle Wurumuqi Rd., Shanghai 200040, China
  • 17 Shenzhen Donghu Hospital, No. 2019, Buxin Rd., Shenzhen 518020, China
  • 18 Beijing 302 Hospital, No. 100, Xi Si Huan Zhong Lu, Beijing 100039, China
  • 19 Shanghai Changhai Hospital, No. 174, Changhai Rd., Shanghai 200433, China
  • 20 Huaxi Hospital of Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, China
  • 21 Peking University First Hospital, No. 8, Xicheng Xishiku Street, Beijing 100034, China
  • 22 Henan Provincial People's Hospital, No. 7, Weiwu Rd., Zhengzhou 450003, China
  • 23 University Malaya Medical Centre, Malaysia, Clinical Investigation Centre, 13th Floor, Main Tower, University Malaya Medical Centre, Lembah Pantai 59100, Malaysia
  • 24 Medical Clinic One, Mount Elizabeth Medical Centre, Singapore, #17-02, 3 Mt. Elizabeth, 228510 Singapore, Singapore
  • 25 Far Eastern Memorial Hospital, Taiwan, No. 21, Sec. 2, Nanya S. Rd., Banciao District, New Taipei City 22060, Taiwan
  • 26 Mackay Memorial Hospital, Taiwan, 92, Section 2, Chung Shan North Rd., Taipei City 10449, Taiwan
  • 27 Merck, Sharp & Dohme, Shanghai, China, 20/F Park Place, 1601 Nanjing Rd. (w), Shanghai 200040, China
  • 28 Beijing Ditan Hospital, Capital Medical University, No. 8, East Jingshun Street, Beijing 100015, China. Electronic address: xudaozhen@126.com
J Clin Virol, 2014 Dec;61(4):509-16.
PMID: 25200354 DOI: 10.1016/j.jcv.2014.08.008

Abstract

In mainland China, peginterferon (PEG-IFN) alfa-2b 1.0μg/kg/wk for 24 weeks is the approved treatment for HBeAg-positive chronic hepatitis B.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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