Novel Ag/cellulose-doped CeO2 quantum dots for efficient dye degradation and bactericidal activity with molecular docking study

Ikram M 1 , Hayat S 2 , Imran M 3 , Haider A 4 , Naz S 5 , Ul-Hamid A 6 Show all authors , Shahzadi I 7 , Haider J 5 , Shahzadi A 7 , Nabgan W 8 , Ali S 2

Affiliations 

  • 1 Solar Cell Application Research Lab, Department of Physics, Government College University Lahore, Lahore 54000, Punjab, Pakistan. Electronic address: dr.muhammadikram@gcu.edu.pk
  • 2 Department of Physics, Riphah Institute of Computing and Applied Sciences (RICAS), Riphah International University, 14 Ali Road, Lahore, Pakistan
  • 3 State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing Engineering Centre for Hierarchical Catalysts, Beijing University of Chemical Technology, Beijing 100029, China
  • 4 Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore 54000, Punjab, Pakistan
  • 5 Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China
  • 6 Core Research Facilities, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia. Electronic address: anwar@kfupm.edu.sa
  • 7 College of Pharmacy, University of the Punjab, 54000 Lahore, Pakistan
  • 8 School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia. Electronic address: wnabgan@gmail.com
Carbohydr Polym, 2021 Oct 01;269:118346.
PMID: 34294353 DOI: 10.1016/j.carbpol.2021.118346

Abstract

In the present study, the novel Ag/cellulose nanocrystal (CNC)-doped CeO2 quantum dots (QDs) with highly efficient catalytic performance were synthesized using one pot co-precipitation technique, which were then applied in the degradation of methylene blue and ciprofloxacin (MBCF) in wastewater. Catalytic activity against MBCF dye was significantly reduced (99.3%) for (4%) Ag dopant concentration in acidic medium. For Ag/CNC-doped CeO2 vast inhibition domain of G-ve was significantly confirmed as (5.25-11.70 mm) and (7.15-13.60 mm), while medium- to high-concentration of CNC levels were calculated for G + ve (0.95 nm, 1.65 mm), respectively. Overall, (4%) Ag/CNC-doped CeO2 revealed significant antimicrobial activity against G-ve relative to G + ve at both concentrations, respectively. Furthermore, in silico molecular docking studies were performed against selected enzyme targets dihydrofolate reductase (DHFR), dihydropteroate synthase (DHPS), and DNA gyrase belonging to folate and nucleic acid biosynthetic pathway, respectively to rationalize possible mechanism behind bactericidal potential of CNC-CeO2 and Ag/CNC-CeO2.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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