Ethnic differences of intraocular pressure and central corneal thickness: the Singapore Epidemiology of Eye Diseases study

Chua J 1 , Tham YC 2 , Liao J 2 , Zheng Y 1 , Aung T 2 , Wong TY 3 Show all authors , Cheng CY 4

Affiliations 

  • 1 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
  • 2 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore
  • 3 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore
  • 4 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore. Electronic address: ching-yu_cheng@nuhs.edu.sg
Ophthalmology, 2014 Oct;121(10):2013-22.
PMID: 24950592 DOI: 10.1016/j.ophtha.2014.04.041

Abstract

PURPOSE:
To determine the ethnic differences in the distribution of intraocular pressure (IOP) and central corneal thickness (CCT) in a multi-ethnic Asian population by self-reported ethnicity and genetic ancestry.
DESIGN:
Population-based, cross-sectional study.
PARTICIPANTS:
A total of 10 033 adults (3353 Chinese, 3280 Malays, and 3400 Indians) aged >40 years.
METHODS:
Participants underwent standardized systemic and ocular examinations and interviewer-administered questionnaires for risk factor assessment. The IOP readings were obtained by Goldmann applanation tonometry (Haag-Streit, Konig, Switzerland) before pupil dilation. The CCT was measured with ultrasound pachymetry. Genetic ancestry was derived using principal component (PC) analysis. Regression models were used to investigate the association of IOP and CCT with potential risk factors and genetic ancestry.
MAIN OUTCOME MEASURES:
Intraocular pressure and CCT.
RESULTS:
After excluding participants with a history of glaucoma surgery or medication, refractive surgery, corneal edema, or corneal dystrophy, IOP and CCT readings were available for 3251 Chinese, 3232 Malays, and 3317 Indians. The mean IOP readings in the Chinese, Malay, and Indian participants were 14.3±3.1, 15.3±3.7, and 15.8±2.9 mmHg, respectively (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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