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Exposed, but Not Protected: More Is Needed to Prevent Drug-Resistant Tuberculosis in Healthcare Workers and Students

von Delft A, Dramowski A, Sifumba Z, Mosidi T, Xun Ting T, von Delft D, et al.

Clin Infect Dis, 2016 05 15;62 Suppl 3:S275-80.
PMID: 27118858 DOI: 10.1093/cid/ciw037

"Occupational MDR-TB" … "XDR-TB" … "Treatment-induced hearing loss": 3 life-changing messages imparted over the phone. Three personal accounts are shared highlighting the false belief held by many healthcare workers (HCWs) and students in low-resource settings-that they are immune to tuberculosis despite high levels of occupational tuberculosis exposure. This misconception reflects a lack of awareness of tuberculosis transmission and disease risk, compounded by the absence of accurate occupational tuberculosis estimates. As the global problem of drug-resistant (DR) tuberculosis evolves, HCWs are increasingly infected and suffer considerable morbidity and mortality from occupational DR tuberculosis disease. Similarly, healthcare students are emerging as a vulnerable and unprotected group. There is an urgent need for improved detection, vaccines, preventive therapy, treatment, and support for affected HCWs and those they care for, as well as destigmatization of all forms of tuberculosis. Finally, efforts to protect HCWs and prevent DR tuberculosis transmission by universal implementation of tuberculosis infection control measures should be prioritized.

Matched MeSH terms: Hearing Loss, High-Frequency/etiology; Hearing Loss, High-Frequency/microbiology
Screening for gap junction protein beta-2 gene mutations in Malays with autosomal recessive, non-syndromic hearing loss, using denaturing high performance liquid chromatography

Aishah ZS, Khairi MD, Normastura AR, Zafarina Z, Zilfalil BA

J Laryngol Otol, 2008 Dec;122(12):1284-8.
PMID: 18353197 DOI: 10.1017/S0022215108002041

To determine the frequency and type of gap junction protein beta-2 gene mutations in Malay patients with autosomal recessive, non-syndromic hearing loss.

Matched MeSH terms: Hearing Loss/genetics*
Fulltext Reference-Free Assessment of Speech Intelligibility Using Bispectrum of an Auditory Neurogram

Hossain ME, Jassim WA, Zilany MS

PLoS One, 2016;11(3):e0150415.
PMID: 26967160 DOI: 10.1371/journal.pone.0150415

Sensorineural hearing loss occurs due to damage to the inner and outer hair cells of the peripheral auditory system. Hearing loss can cause decreases in audibility, dynamic range, frequency and temporal resolution of the auditory system, and all of these effects are known to affect speech intelligibility. In this study, a new reference-free speech intelligibility metric is proposed using 2-D neurograms constructed from the output of a computational model of the auditory periphery. The responses of the auditory-nerve fibers with a wide range of characteristic frequencies were simulated to construct neurograms. The features of the neurograms were extracted using third-order statistics referred to as bispectrum. The phase coupling of neurogram bispectrum provides a unique insight for the presence (or deficit) of supra-threshold nonlinearities beyond audibility for listeners with normal hearing (or hearing loss). The speech intelligibility scores predicted by the proposed method were compared to the behavioral scores for listeners with normal hearing and hearing loss both in quiet and under noisy background conditions. The results were also compared to the performance of some existing methods. The predicted results showed a good fit with a small error suggesting that the subjective scores can be estimated reliably using the proposed neural-response-based metric. The proposed metric also had a wide dynamic range, and the predicted scores were well-separated as a function of hearing loss. The proposed metric successfully captures the effects of hearing loss and supra-threshold nonlinearities on speech intelligibility. This metric could be applied to evaluate the performance of various speech-processing algorithms designed for hearing aids and cochlear implants.

Matched MeSH terms: Hearing Loss, Sensorineural/physiopathology*
Fulltext Noise measurement and awareness at construction site – A case study

Siti Nadia Mohd Bakhori, Mohamad Zaki Hassan, Feiruz Ab’lah, Aadil Nausherwan, Mohd Azlan Suhot, Mohd Yusof Daud, et al.

Journal of Advanced Research Design, 2017;31(1):9-16.
MyJurnal

The construction industry is one of the major sectors in Malaysia. Apart from providing
facilities, services and goods it also offers employment opportunities to local and
foreign workers. In fact, the construction workers are exposed to high risk of noises
being generated from various sources including excavators, bulldozers, concrete mixer
and piling machines. Previous studies indicated that the piling and concrete work were
recorded as the main source that contributed to the highest level of noise among
others. Therefore, the aim of this study is to obtain the level of noise exposure during
piling process and to determine the awareness of workers against noise pollution at
the construction site. Initially, the reading of noise level was obtained at construction
site by using a digital sound level meter (SLM) and noise exposure to the workers was
mapped. Readings were taken from four different distances; 5, 10, 15 and 20 meters
from the piling machine. Furthermore, a set of questionnaire was also distributed to
assess the knowledge of regarding noise pollution at the construction site. The result
showed that the mean noise level at 5 meters distance was more than 90 dB, which
exceeded the recommended level. Although the level of awareness of regarding the
effect of noise pollution is satisfactory but majority of workers (90%) still did not wear
ear muffs during working periods. Therefore, the safety module guidelines related to
noise pollution controls should be implemented to provide a safe working environment
and prevent initial occupational hearing loss.

Matched MeSH terms: Hearing Loss, Noise-Induced
Fulltext The Prevalence of Sensorineural Hearing Loss in β-thalassaemia patient treated with Desferrioxamine

Kong MH, Goh BS, Hamidah A, Zarina AL

Med J Malaysia, 2014 Feb;69(1):9-12.
PMID: 24814621 MyJurnal

OBJECTIVE: This study aimed to evaluate the prevalence of sensorineural hearing loss (SNHL) in β-thalassaemia patients treated with Desferrioxamine (DFO) and determine the correlation of SNHL with average daily DFO dosage, serum ferritin level and Therapeutic index (T.I).

METHODS: This is a cross sectional descriptive study carried out for a period of 14 months and 54 patients were recruited. The recruited patients are transfusion dependant β- thalassaemia patient aged 3 years and above treated with DFO. An interview, clinical examination and hearing assessment, which included tympanogram, and Pure Tone Audiometry (PTA) or behaviour alaudiometry were performed. The data on age started on DFO, average daily DFO, duration of DFO intake, serum ferritin past 1 year and Therapeutic Index (T.I) were obtained from patients' case notes.

RESULTS: The prevalence of SNHL was 57.4% and majority has mild hearing loss (93.6%). Fourteen patients (25.9%) have bilateral ear involvement and as many as 17 patients (31.5%) have SNHL in either ear. A total of 23 patients (42.6%) have normal hearing level. Although the prevalence of SNHL was 57.4%, only a small percentage of the patient noticed and complained of hearing loss (11.1%). There is no association between age started on DFO, average daily DFO and duration of DFO intake with normal hearing group and those patients with SNHL. Positive correlation was seen between average daily DFO with 2000 and 4000Hz on PTA in the left ear and between serum ferritin level past 1 year with 4000 and 8000Hz in the right ear and 8000Hz in the left ear. No significant correlation was seen between T.I on PTA.

CONCLUSION: The prevalence of SNHL from hearing assessment is high in β-thalassaemia patients in this study. However, it is manifested clinically in a smaller percentage. We suggest a baseline hearing assessment should be carried on all β-thalassaemia patients prior to DFO chelation therapy.

Matched MeSH terms: Hearing Loss, Sensorineural; Hearing Loss
Screening of dental staff nurses for noise induced hearing loss

Daud MK, Noh NF, Sidek DS, Abd Rahman N, Abd Rani N, Zakaria MN

B-ENT, 2011;7(4):245-9.
PMID: 22338236

The effect of noise on employees of dental clinics is debatable. The purposes of this study were to determine the intensity and frequency components of dental instruments used by dental staff nurses and the prevalence of noise induced hearing loss.

Matched MeSH terms: Hearing Loss, Noise-Induced/diagnosis; Hearing Loss, Noise-Induced/epidemiology*
Gender differences in coping skills of parents with hearing-impaired children

Md Daud MK, Noor SS, Yusoff MN, Abd Rahman N, Zakaria MN

B-ENT, 2013;9(4):319-23.
PMID: 24597108

To assess differences between the coping strategies of the mothers and fathers with hearing-impaired children.

Matched MeSH terms: Hearing Loss/psychology*
Statistical verification on the effect of hearing loss on speech-evoked auditory brainstem response

Zakaria MN

Int J Pediatr Otorhinolaryngol, 2017 10;101:264.
PMID: 28843698 DOI: 10.1016/j.ijporl.2017.08.016
Matched MeSH terms: Hearing Loss
Vancomycin administration in continuous ambulatory peritoneal dialysis: the risk of ototoxicity

Gendeh BS, Gibb AG, Aziz NS, Kong N, Zahir ZM

Otolaryngol Head Neck Surg, 1998 Apr;118(4):551-8.
PMID: 9560111

A prospective study was undertaken in 16 patients with chronic renal failure on continuous ambulatory peritoneal dialysis, with 22 episodes of peritonitis treated with vancomycin, a known ototoxic agent. Twelve patients had one episode each, and four had recurrent peritonitis. Each treatment course consisted of two infusions of vancomycin (30 mg/kg body weight) in 2 L of peritoneal dialysate administered at 6-day intervals. Serum vancomycin analyzed by enzyme immunoassay showed a mean trough level of 11.00 microg/ml on day 6 and mean serum levels of 33.8 and 38.6 microg/ml about 12 hours after administration on days 1 and 7, respectively. Similar levels, well within the therapeutic range, were encountered with repeated vancomycin therapy for recurrent episodes of peritonitis, suggesting that no changes occurred in the pharmacokinetic profile of the drug. Pure-tone audiometry, electronystagmography, and clinical assessment performed during each course of treatment showed no evidence of ototoxicity even on repeated courses of vancomycin therapy. The results suggest that vancomycin therapy when given in appropriate concentrations as a single therapeutic agent is both effective and safe. We believe, however, that vancomycin administered in combination with an aminoglycoside may produce ototoxic effects that may be greatly aggravated, possibly because of synergism.

Matched MeSH terms: Hearing Loss, Sensorineural/blood; Hearing Loss, Sensorineural/chemically induced*; Hearing Loss, Sensorineural/diagnosis
The impact of sensory impairment on cognitive performance, quality of life, depression, and loneliness in older adults

Harithasan D, Mukari SZS, Ishak WS, Shahar S, Yeong WL

Int J Geriatr Psychiatry, 2020 04;35(4):358-364.
PMID: 31736109 DOI: 10.1002/gps.5237

OBJECTIVES: The objective of this study was to evaluate the relationship between sensory impairment (hearing loss only, vision loss only, and dual sensory impairment [DSI]) and depression, loneliness, quality of life, and cognitive performance in older adults.
METHODS: A total of 229 community-dwelling older adults aged 60 years or older participated in this study. Variables were measured using the Geriatric Depression Scale (GDS-15), Revised University of California at Los Angeles Loneliness Scale (R-UCLA), Satisfaction with Life Scale (SWLS), and Mini-Mental State Examination (MMSE).
RESULTS: There was an independent association between DSI and quality of life (P < .05) and between DSI and hearing loss alone and cognitive function (P < .05) in older adults. In addition, higher education was associated with better quality of life and cognitive function.
CONCLUSIONS: DSI is a significant factor affecting the quality of life and cognitive function in older adults. Sociodemographic factors such as education play an important role in improving quality of life and cognitive function. Thus, increasing the awareness of this disability is important to ensure that older adults receive the necessary support services and rehabilitation to improve their level of independence.

Matched MeSH terms: Hearing Loss/complications*; Hearing Loss/epidemiology; Hearing Loss/psychology
Fulltext Delayed Puberty and Anosmia in CHARGE Syndrome: A Case Report

Lee YL, Toh L, Yap F

J ASEAN Fed Endocr Soc, 2020;35(1):122-124.
PMID: 33442180 DOI: 10.15605/jafes.035.01.21

A 26-year-old female presented to the paediatric clinic at 11 years of age with poor growth. The detection of delayed puberty, anosmia, coloboma and hearing impairment led to a diagnosis of CHARGE syndrome. This was confirmed by a heterogenous de novo pathogenic variant c.6955C >T:p.(Arg2319Cys) detected in the CHD7 gene. Detailed assessment, including olfaction, ophthalmic and auditory examination should be part of the evaluation framework in children with delayed growth and puberty.

Matched MeSH terms: Hearing Loss
Fulltext Research on Hygiene Based on Fieldwork and Experimental Studies

Yajima I

Nihon Eiseigaku Zasshi, 2017;72(1):49-54.
PMID: 28154361 DOI: 10.1265/jjh.72.49

Several experimental studies on hygiene have recently been performed and fieldwork studies are also important and essential tools. However, the implementation of experimental studies is insufficient compared with that of fieldwork studies on hygiene. Here, we show our well-balanced implementation of both fieldwork and experimental studies of toxic-element-mediated diseases including skin cancer and hearing loss. Since the pollution of drinking well water by toxic elements induces various diseases including skin cancer, we performed both fieldwork and experimental studies to determine the levels of toxic elements and the mechanisms behind the development of toxic-element-related diseases and to develop a novel remediation system. Our fieldwork studies in several countries including Bangladesh, Vietnam and Malaysia demonstrated that drinking well water was polluted with high concentrations of several toxic elements including arsenic, barium, iron and manganese. Our experimental studies using the data from our fieldwork studies demonstrated that these toxic elements caused skin cancer and hearing loss. Further experimental studies resulted in the development of a novel remediation system that adsorbs toxic elements from polluted drinking water. A well-balanced implementation of both fieldwork and experimental studies is important for the prediction, prevention and therapy of toxic-element-mediated diseases.

Matched MeSH terms: Hearing Loss/etiology; Hearing Loss/prevention & control
Fulltext Review of an 11-year Experience in Retrosigmoid Approach for Treatment of Acoustic Neuromas

Lim SL, Wong SH

Med J Malaysia, 2013 Jun;68(3):253-8.
PMID: 23749017 MyJurnal

This study reviews surgery on acoustic neuromas by the second author using retrosigmoid approach from January 2000 to June 2010 in the state of Sarawak. There was a total of 32 patients in this study. The commonest presenting symptom was hearing loss (81.3%), followed by headache and tinnitus (each 37.5%), ataxia (34.4%) and facial numbness (21.9%). Twenty-seven patients (84.4%) had large tumor (≥ 3cm) while 5 patients (15.6%) had medium size tumor (1.5-2.9cm). The mean tumor size was 3.6 cm. Facial nerve outcome was good to moderate in 93.7% (House and Brackmann Grade I-IV). The most common complications were CSF leak with 3 patients(9.4%) and facial numbness with 2 patients(6.3%). All either resolved with treatment or improved. There was no mortality. Excision of acoustic neuromas using retrosigmoid approach could achieve acceptable facial nerve outcome with a low incidence of morbidity without mortality.

Matched MeSH terms: Hearing Loss
Fulltext Acoustic neuroma with orofacial paresthesia: description of an atypical presentation

Lim CC, Misron K, Liew YT, Wong EHC

BMJ Case Rep, 2019 Nov 04;12(11).
PMID: 31690691 DOI: 10.1136/bcr-2019-232275

Acoustic neuroma (AN) usually manifests with asymmetric hearing loss, tinnitus, dizziness and sense of disequilibrium. About 10% of patients complain of atypical symptoms, which include facial numbness or pain and sudden onset of hearing loss. Patients with atypical symptoms also tend to have larger tumours due to the delay in investigation. We report a particularly interesting case of a patient presented to us with numbness over her right hemifacial region after a dental procedure without significant acoustic and vestibular symptoms. Physical examination and pure tone audiometry revealed no significant findings but further imaging revealed a cerebellopontine angle mass. The changing trends with easier access to further imaging indicate that the presentation of patients with AN are also changing. Atypical symptoms which are persistent should raise clinical suspicion of this pathology among clinicians.

Matched MeSH terms: Hearing Loss/etiology; Hearing Loss/physiopathology*
Letter to the editor regarding "A questionnaire-based study on parental satisfaction with a universal newborn hearing screening program in Kuala Lumpur, Malaysia"

Wiwanitkit V

Int J Pediatr Otorhinolaryngol, 2014 Apr;78(4):710.
PMID: 24565116 DOI: 10.1016/j.ijporl.2014.01.037
Matched MeSH terms: Hearing Loss/diagnosis*
Fulltext Auditory neuropathy: three cases among a group with sensorineural hearing loss

Mohd Khairi MD, Normastura AR, Wan Zaharah AW

Singapore Med J, 2009 Sep;50(9):e324-5.
PMID: 19787161

The prevalence of auditory neuropathy is not known, although the majority of cases are felt to lie within the population of neonatal intensive care unit graduates. We report three cases of auditory neuropathy, out of 211 children with sensorineural hearing loss, seen at our audiology clinic from April 1, 1999 to December 31, 2003. Two patients did not have a risk factor for hearing impairment. Screening policies based solely on transient evoked otoacoustic emissions testing will not detect auditory neuropathy effectively, and may falsely reassure parents and professionals unaware of this condition.
Study site: Audiology clinic, Hospital Universiti Sains Malaysia, Kelantan, Malaysia

Matched MeSH terms: Hearing Loss, Sensorineural/diagnosis*; Hearing Loss, Sensorineural/etiology*
Fulltext Cervical vestibular evoked myogenic potential (cVEMP) findings in adults with sensorineural hearing loss (SNHL): comparisons between 500 Hz tone burst and narrowband CE-Chirp stimuli

Zakaria MN, Salim R, Abdul Wahat NH, Md Daud MK, Wan Mohamad WN

Sci Rep, 2023 Dec 21;13(1):22842.
PMID: 38129442 DOI: 10.1038/s41598-023-48810-1

There has been a growing interest in studying the usefulness of chirp stimuli in recording cervical vestibular evoked myogenic potential (cVEMP) waveforms. Nevertheless, the study outcomes are debatable and require verification. In view of this, the aim of the present study was to compare cVEMP results when elicited by 500 Hz tone burst and narrowband (NB) CE-Chirp stimuli in adults with sensorineural hearing loss (SNHL). Fifty adults with bilateral SNHL (aged 20-65 years) underwent the cVEMP testing based on the established protocol. The 500 Hz tone burst and NB CE-Chirp (centred at 500 Hz) stimuli were presented to each ear at an intensity level of 120.5 dB peSPL. P1 latency, N1 latency, and P1-N1 amplitude values were analysed accordingly. The NB CE-Chirp stimulus produced significantly shorter P1 and N1 latencies (p 0.80). In contrast, both stimuli elicited cVEMP responses with P1-N1 amplitude values that were not statistically different from one another (p = 0.157, d = 0.15). Additionally, age and hearing level were found to be significantly correlated (r = 0.56, p

Matched MeSH terms: Hearing Loss, Bilateral; Hearing Loss, Sensorineural*
Self-Perceived Hearing Loss, Hearing-Help Seeking and Hearing Aid Adoption Among Older Adults in Malaysia

Mukari SZMS, Wan Hashim WF

Ann Otol Rhinol Laryngol, 2018 Nov;127(11):798-805.
PMID: 30139270 DOI: 10.1177/0003489418795982

INTRODUCTION: The aims of this study were to examine the validity of self-perceived hearing loss in detecting hearing loss and factors associated with self-perceived hearing loss and hearing-help seeking and to report hearing aid adoption among a group of community-dwelling older adults in Malaysia.
METHODS: A total of 301 older adults (⩾60 years of age) participating in a study on aging had their hearing tested using pure-tone audiometry. Self-perceived hearing loss was assessed using a single question. Sociodemographic profile, otologic history, and general cognitive status were also obtained.
RESULTS: A single question had low sensitivity in detecting actual hearing loss: 31.3% for 4-frequency average > 25 dBHL and 48.8% for 4-frequency average > 40 dBHL. Besides hearing level, history of otorrhea and tinnitus were factors that were associated with self-perceived hearing loss among older adults with at least mild hearing loss. Hearing-help-seeking behavior was not associated with any of the tested variables. The hearing aid adoption rate was 2.7% and 7.3% among participants with 4-frequency averages > 25 dBHL and > 40 dBHL, respectively.
CONCLUSION: The underestimation of hearing loss in the majority of older adults in this study poses a potential barrier to hearing loss intervention.

Matched MeSH terms: Hearing Loss
A Preliminary Study Investigating the Association Between Hearing Acuity and a Screening Cognitive Tool

Mukari SZS, Ishak WS, Maamor N, Wan Hashim WF

Ann Otol Rhinol Laryngol, 2017 Oct;126(10):697-705.
PMID: 28845678 DOI: 10.1177/0003489417727547

OBJECTIVES: Studies in cognitive aging demonstrated inconsistent association between hearing and cognition in older adults. Furthermore, it is still unclear if hearing loss at high frequencies, which is the earliest to be affected, is associated with cognitive functioning. This study aimed to determine the association between global cognitive status and pure tone average (PTA) at 0.5, 1, and 2 kHz (PTA low) and PTA at 4 and 8 kHz (PTA high).
METHODS: This study involved 307 adults aged 60 years and older. Participants had their hearing and cognition measured using pure tone audiometry and Mini Mental State Examination (MMSE), respectively.
RESULTS: Pure tone average (low) accounted for significant but minimal amount of variance in measure of MMSE. Multiple regression analyses were also performed on normal and impaired hearing cohorts and cohorts with younger (60-69 years) and older (≥70 years) groups. The results revealed a significant relationship between PTA (low) and MMSE only in the younger age group. In contrast, no significant relationship was found between PTA (high) and cognition in any of the cohorts.
CONCLUSION: Pure tone average (low) is significantly but minimally related to measure of general cognitive status. Similar relationship is not observed between high-frequency hearing and cognition. Further research using a more comprehensive cognitive test battery is needed to confirm the lack of association between high-frequency hearing and cognition.

Matched MeSH terms: Hearing Loss/diagnosis*
Fulltext Factors associated with the parents’ intention in bringing their child to the audiologist

Nur Najihah Najwa Jamil, Masnira Jusoh, Wan Aslynn Wan Ahmad

International Journal of Allied Health Sciences, 2018;2(3):468-474.
MyJurnal

This study was designed to examine the relationship between attitude, subjective norms and perceived behavioral control towards parents’ intention in sending their child to the audiologist. A sample of 76 parents with hearing impaired child all over the Peninsular of Malaysia was involved in this research. A set of questionnaires was used for data collection. The theory of planned behavioral (TPB) was able to explain the link between human intention and their behavior. In this study, the researcher looked at parents’ behavior in bringing their child to Audiologist. In order to achieve this a set of questionnaires was adapted from Jusoh (2011) and was administered to a group of parents with hearing loss (HL) children. The result showed that there were correlations between attitude, subjective norms as well as perceived behavioral control and parents’ intention in sending their child to the audiologist. However, there was no correlation between intentions and behavior towards the same intention.

Matched MeSH terms: Hearing Loss

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