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Fulltext Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach

Kundap UP, Kumari Y, Othman I, Shaikh MF

Front Pharmacol, 2017;8:515.
PMID: 28824436 DOI: 10.3389/fphar.2017.00515

Epilepsy is a neuronal disorder allied with distinct neurological and behavioral alterations characterized by recurrent spontaneous epileptic seizures. Impairment of the cognitive performances such as learning and memory is frequently observed in epileptic patients. Anti-epileptic drugs (AEDs) are efficient to the majority of patients. However, 30% of this population seems to be refractory to the drug treatment. These patients are not seizure-free and frequently they show impaired cognitive functions. Unfortunately, as a side effect, some AEDs could contribute to such impairment. The major problem associated with conducting studies on epilepsy-related cognitive function is the lack of easy, rapid, specific and sensitive in vivo testing models. However, by using a number of different techniques and parameters in the zebrafish, we can incorporate the unique feature of specific disorder to study the molecular and behavior basis of this disease. In the view of current literature, the goal of the study was to develop a zebrafish model of epilepsy induced cognitive dysfunction. In this study, the effect of AEDs on locomotor activity and seizure-like behavior was tested against the pentylenetetrazole (PTZ) induced seizures in zebrafish and epilepsy associated cognitive dysfunction was determined using T-maze test followed by neurotransmitter estimation and gene expression analysis. It was observed that all the AEDs significantly reversed PTZ induced seizure in zebrafish, but had a negative impact on cognitive functions of zebrafish. AEDs were found to modulate neurotransmitter levels, especially GABA, glutamate, and acetylcholine and gene expression in the drug treated zebrafish brains. Therefore, combination of behavioral, neurochemical and genenetic information, makes this model a useful tool for future research and discovery of newer and safer AEDs.

Matched MeSH terms: Memory
Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats

Tiang N, Ahad MA, Murugaiyah V, Hassan Z

J Pharm Pharmacol, 2020 Nov;72(11):1629-1644.
PMID: 32743849 DOI: 10.1111/jphp.13345

OBJECTIVES: Xanthones isolated from the pericarp of Garcinia mangostana has been reported to exhibit neuroprotective effect.
METHODS: In this study, the effect of xanthone-enriched fraction of Garcinia mangostana (XEFGM) and α-mangostin (α-MG) were investigated on cognitive functions of the chronic cerebral hypoperfusion (CCH) rats.
KEY FINDINGS: HPLC analysis revealed that XEFGM contained 55.84% of α-MG. Acute oral administration of XEFGM (25, 50 and 100 mg/kg) and α-MG (25 and 50 mg/kg) before locomotor activity and Morris water maze (MWM) tests showed no significant difference between the groups for locomotor activity.
CONCLUSIONS: However, α-MG (50 mg/kg) and XEFGM (100 mg/kg) reversed the cognitive impairment induced by CCH in MWM test. α-MG (50 mg/kg) was further tested upon sub-acute 14-day treatment in CCH rats. Cognitive improvement was shown in MWM test but not in long-term potentiation (LTP). BDNF but not CaMKII was found to be down-regulated in CCH rats; however, both parameters were not affected by α-MG. In conclusion, α-MG ameliorated learning and memory deficits in both acute and sub-acute treatments in CCH rats by improving the spatial learning but not hippocampal LTP. Hence, α-MG may be a promising lead compound for CCH-associated neurodegenerative diseases, including vascular dementia and Alzheimer's disease.

Matched MeSH terms: Memory/drug effects*
Fulltext Working memory load influence on control of attention among Malaysian undergraduates

Khairun Emylyana, Amin, Fitri Suraya, Mohamad

Journal of Cognitive Sciences & Human Development, 2021;7(1):0-0.
MyJurnal

The study investigates how working memory affects students' control of attention. A quasi-experimental research is conducted individually on 52 undergraduates of a public university in Malaysia, enrolled in various full-time undergraduate programmes, using Sternberg memory task and Task-switching tests. The reaction time is taken in milliseconds (ms) to differentiate the results for both tasks. The analysis revealed that when memory load was increased, reaction time also escalated. In the task-switching test, when one task was given at any one time, the reaction time was swift; however, when two or more tasks were integrated into one task, the reaction time would subsequently decelerated. Although the study also revealed that there is no significant difference between genders in terms of handling memory load and taskswitching. However, a significant relationship was observed in performances between memory load and task-switching. It is also evidenced in the study that when memory load increases, it compoundsthe reaction time for task-switching. Results from the study inform course instructors to be aware of cognitive load when chunking information and assigning tasks to students, as their decisions on content quantity bore an effect on what would be remembered when students learn.

Matched MeSH terms: Memory, Short-Term
Working memory and literacy as predictors of performance on algebraic word problems

Lee K, Ng SF, Ng EL, Lim ZY

J Exp Child Psychol, 2004 Oct;89(2):140-58.
PMID: 15388303 DOI: 10.1016/j.jecp.2004.07.001

Previous studies on individual differences in mathematical abilities have shown that working memory contributes to early arithmetic performance. In this study, we extended the investigation to algebraic word problem solving. A total of 151 10-year-olds were administered algebraic word problems and measures of working memory, intelligence quotient (IQ), and reading ability. Regression results were consistent with findings from the arithmetic literature showing that a literacy composite measure provided greater contribution than did executive function capacity. However, a series of path analyses showed that the overall contribution of executive function was comparable to that of literacy; the effect of executive function was mediated by that of literacy. Both the phonological loop and the visual spatial sketchpad failed to contribute directly; they contributed only indirectly by way of literacy and performance IQ, respectively.

Matched MeSH terms: Memory, Short-Term*
Fulltext Working Memory From the Psychological and Neurosciences Perspectives: A Review

Chai WJ, Abd Hamid AI, Abdullah JM

Front Psychol, 2018;9:401.
PMID: 29636715 DOI: 10.3389/fpsyg.2018.00401

Since the concept of working memory was introduced over 50 years ago, different schools of thought have offered different definitions for working memory based on the various cognitive domains that it encompasses. The general consensus regarding working memory supports the idea that working memory is extensively involved in goal-directed behaviors in which information must be retained and manipulated to ensure successful task execution. Before the emergence of other competing models, the concept of working memory was described by the multicomponent working memory model proposed by Baddeley and Hitch. In the present article, the authors provide an overview of several working memory-relevant studies in order to harmonize the findings of working memory from the neurosciences and psychological standpoints, especially after citing evidence from past studies of healthy, aging, diseased, and/or lesioned brains. In particular, the theoretical framework behind working memory, in which the related domains that are considered to play a part in different frameworks (such as memory's capacity limit and temporary storage) are presented and discussed. From the neuroscience perspective, it has been established that working memory activates the fronto-parietal brain regions, including the prefrontal, cingulate, and parietal cortices. Recent studies have subsequently implicated the roles of subcortical regions (such as the midbrain and cerebellum) in working memory. Aging also appears to have modulatory effects on working memory; age interactions with emotion, caffeine and hormones appear to affect working memory performances at the neurobiological level. Moreover, working memory deficits are apparent in older individuals, who are susceptible to cognitive deterioration. Another younger population with working memory impairment consists of those with mental, developmental, and/or neurological disorders such as major depressive disorder and others. A less coherent and organized neural pattern has been consistently reported in these disadvantaged groups. Working memory of patients with traumatic brain injury was similarly affected and shown to have unusual neural activity (hyper- or hypoactivation) as a general observation. Decoding the underlying neural mechanisms of working memory helps support the current theoretical understandings concerning working memory, and at the same time provides insights into rehabilitation programs that target working memory impairments from neurophysiological or psychological aspects.

Matched MeSH terms: Memory Disorders; Memory, Short-Term
What proteins are involved in learning and memory?

Perumal R, Tan I

IUBMB Life, 2007 Jul;59(7):465-8.
PMID: 17654123
Matched MeSH terms: Memory/physiology*
Fulltext Visual perceptual skills (non-motor) among adults in Selangor of Malaysia

Mohd Harimi, A.R., Sumithira N., Ashwini S., Mohd Fitri, H., K., Qiu-Ting

Medicine & Health, 2020;15(2):37-46.
MyJurnal

Kemahiran persepsi visual adalah penting bagi golongan dewasa untuk menjalankan aktiviti harian mereka seperti membaca, menulis dan memandu. Kajian ini dijalankan untuk menentukan kemahiran persepsi visual (bukan motor) dalam kalangan golongan dewasa di Selangor, Malaysia. Seramai 120 subjek dari Selangor yang berumur 20 hingga 59 tahun telah dipilih secara rawak dalam kajian keratan rentas ini. Kajian ini melibatkan pengukuran akuiti visual jauh dan dekat menggunakan carta Snellen dan carta penglihatan dekat Universiti Kebangsaan Malaysia (UKM), ujian saringan kognitif menggunakan soal selidik Mini Mental State Examination (MMSE) serta penilaian kemahiran persepsi visual (bukan motor) menggunakan Ujian Kemahiran Persepsi Visual (Bukan Motor)-Revised (TVPS-R). Purata umur subjek ialah 39.41+11.81 tahun. Keputusan menunjukkan purata skor TVPS-R bagi setiap sub-ujian iaitu Visual Discrimination (VD), Visual Memory (VM), Visual-Spatial Relationships (VSR), Visual Form Constancy (VFC), Visual Sequential Memory (VSM), Visual Figure-Ground (VFG) dan Visual Closure (VC) adalah 14.12+1.10, 13.42+1.58, 14.53+1.26, 12.47+1.03, 12.35+2.26, 13.67+1.64 dan 13.73+2.23. Analisis ANOVA menunjukkan skor VD, VM dan VSM dipengaruhi oleh tahap pendidikan (p

Matched MeSH terms: Memory
Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways

Rahim NS, Lim SM, Mani V, Hazalin NAMN, Majeed ABA, Ramasamy K

J Diet Suppl, 2020 Oct 14.
PMID: 33962540 DOI: 10.1080/19390211.2020.1830223

Neuroinflammation is associated with neuronal cell death and could lead to chronic neurodegeneration. This study investigated the neuroprotective potential of virgin coconut oil (VCO) against lipopolysaccharide (LPS)-induced cytotoxicity of neuroblastoma SK-N-SH cells. The findings were validated using Wistar rats, which were fed with 1-10 g/kg VCO for 31 days, exposed to LPS (0.25 mg/kg) and subjected to the Morris Water Maze Test. Brain homogenate was subjected to biochemical analyses and gene expression studies. α-Tocopherol (α-T; 150 mg/kg) served as the positive control. VCO (100 µg/mL) significantly (p

Matched MeSH terms: Spatial Memory
Views on Memory and Treatment of Cognitive Impairment in 17th-Century Spain: Juan Gutiérrez de Godoy's Work

Palma JA, Palma F

Neurology, 2022 Sep 05;99(10):424-427.
PMID: 35794022 DOI: 10.1212/WNL.0000000000201025

Memory and its care were significant sociocultural and scientific topics in early modern Spain. Although a major interest in memory was related to its legal and rhetorical implications, medical treatises discussing memory, cognitive impairment, and its treatment began to appear in the 16th and 17th century. Among these treatises, Disputationes phylosophicæ ac medicæ super libros Aristotelis de memoria, et reminiscentia (Philosophical and medical arguments on Aristotle's "De memoria et reminiscentia"), published in 1629 by the physician Juan Gutiérrez de Godoy, is unique in that it is entirely devoted to the medical aspects of memory. Although many of its concepts are now superseded, the treatise is valuable to understand the views on memory and cognitive impairment in 17th-century Spain and their sources, as Gutiérrez quoted many classical, medieval, and contemporary scholars and physicians. The book, written in Latin, is exclusively devoted to memory from a physiologic and medical point of view, with chapters on the classification of memory loss, a description of its causes (including old age, something not widely recognized before), and several chapters on its prevention and treatment, with a fascinating emphasis on confectio anacardina, or anacardium, an intranasal concoction made with the "marking nut," the fruit of the Semecarpus anacardium tree (also known as Malacca bean), with alleged memory-enhancing properties. We review Gutiérrez's Disputationes phylosophicæ, putting it into the wider intellectual and social context in the Europe of its time, and discuss the relevance and purported neuropharmacologic effects of anacardina.

Matched MeSH terms: Memory Disorders/therapy
Fulltext Verbal working memory in schizophrenia: relationship to cigarette smoking and psychopathology

Hazura, H., Wan Norhaida, W.A., Zahiruddin, O., Ruzita, J.

Malaysian Journal of Psychiatry, 2012;21(1):0-0.
MyJurnal

Introduction: A number of researches suggest smoking serves as a form of self-medication to reduce the side effects of antipsychotic medications, to alleviate negative symptoms, and/or to ameliorate a number of cognitive deficits associated with schizophrenia. Objective: The aim of this study was to investigate the association of cigarette smoking with verbal working memory and psychopathology of patients with schizophrenia. Methods: Fifty-three patients with schizophrenia were assessed by a single rater using the Malay Version of Auditory Verbal Learning Test (MVAVLT) and Positive and Negative Syndrome Scale (PANSS). Smokers (n=30) were compared with nonsmokers (n=23) on socio-demographic, clinical, psychopathology and verbal memory variables. Single linear and multiple regression analysis were performed to determine factors associated with verbal memory performance.
Results: Verbal working memory performance is associated with lower number of admission to ward, lesser severity of the negative symptoms or general psychopathology of schizophrenia and use of atypical antipsychotics in all schizophrenic subjects. Smokers with schizophrenia scored higher than non- smoker in measures that reflect immediate memory, delayed recall and recognition memory. However, the association between verbal working
memory performance and smoking status was found to be not significant. Conclusion: Verbal working memory performance is associated with negative symptoms but not positive symptoms. This study failed to detect association of smoking on verbal working memory.

Matched MeSH terms: Memory, Short-Term
Fulltext Verbal memory test performance in patients with bipolar I disorder attending a psychiatric clinic of a university hospital in Kuala Lumpur, Malaysia.

Abdul Hamid Abdul Rahman, Shamsul Azhar Shah, Normala Ibrahim

ASEAN Journal of Psychiatry, 2009;10(2):157-168.
MyJurnal

Objective: The study aims to determine pattern of verbal memory and learning impairment and its associated factors among patients with bipolar I disorder in a psychiatric clinic of a university hospital. Methods: A case control study comparing verbal memory test
performance in 40 patients with bipolar I disorder to that of 40 healthy normal subjects using Rey Auditory Verbal Learning Test (RAVLT). The association between demographic, clinical
characteristics and poor verbal memory performance were examined. Results: Up to 92% of patients with bipolar I disorder have impaired short term working memory in this hospital-based study. They also recalled fewer words in all the RAVLT trials and had difficulties
learning the word list in comparison to that of normal healthy individuals. Verbal memory and learning impairment are observed in bipolar illness in the absence of active mood symptoms while duration and severity of illness are not found to have any effect on verbal memory and learning. Conclusion: There is consistent verbal memory and learning problems in individuals with bipolar I disorder and their presence in the absence of mania, depression and mixed symptoms during the course of the illness suggests a trait related deficit.

Study site: Psychiatric Clinic, Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)

Matched MeSH terms: Memory Disorders; Memory, Short-Term
Fulltext Validation of the Malay version of auditory verbal learning test (MVAVLT) among schizophrenia patients in Hospital Universiti Sains Malaysia (HUSM), Malaysia

Zahiruddin Othman, Muhammad Najib Muhammad Alwi, Kamarul Imran Musa, Muhammad Najib Muhammad Alwi, Ruzita Jamaluddin

ASEAN Journal of Psychiatry, 2009;10(1):54-74.
MyJurnal

Objective: Many studies have emphasized the significance of verbal memory for the functional outcome in schizophrenia. A preserved capability to encode and recall verbal information is essential for the long-term efficacy of psychoeducational programs and other
psychological intervention to ensure the successful transfer of newly acquired skills or knowledge into everyday life. Aims of this study aimed to validate the MVALT among schizophrenia patients in HUSM. Methods: The subjects were 15 schizophrenia patients
conveniently selected from the patients that attended follow up at the psychiatry clinic in HUSM or inpatients who have been admitted during the study period and 15 healthy control subjects as a comparison. Reliability and validity of the MVAVLT were analyzed. Results: The validation study showed that the Malay version Auditory Verbal Learning Test (MVAVLT) had a good validity (factor analysis 0.66 to 0.98) and test-retest reliability (pearson correlation ranged from 0.24 to 0.84) and has been shown to be sensitive in
discriminating between normal and schizophrenia patients. In line with the previous research, the schizophrenia patients performed significantly worse than healthy control in all indexes measured in MVAVLT. Conclusion: The screening of deficits in verbal learning
and memory among the schizophrenia patients is important, for early detection and treatment since it can be helpful for clinicians and psychologists in their counseling sessions. Subsequently, it helps patients to reduce such cognitive difficulties and their impact by using specific rehabilitation with the usage of newer antipsychotic agents.

Matched MeSH terms: Memory
Fulltext Understanding the reminiscence bump: A systematic review

Munawar K, Kuhn SK, Haque S

PLoS One, 2018;13(12):e0208595.
PMID: 30533033 DOI: 10.1371/journal.pone.0208595

One of the most consistently observed phenomena in autobiographical memory research is the reminiscence bump: a tendency for middle-aged and elderly people to access more personal memories from approximately 10-30 years of age. This systematic review (PROSPERO 2017:CRD42017076695) aimed to synthesize peer-reviewed literature pertaining to the reminiscence bump. The researchers conducted searches in nine databases for studies published between the date of inception of each database and the year 2017. Keywords used included: reminiscence, bump, peak, surge, blip, reminiscence effect, and reminiscence component. Sixty-eight quantitative studies, out of 523, met the inclusion criteria. The researchers implemented a thematic analytic technique for data extraction. Four main themes were generated: methods of memory activation/instruction for life scripts, types of memory/life scripts recalled, location of the reminiscence bump, and theoretical accounts for the bump. The two prevailing methods of memory activation implemented were the cuing method and important memories method. Three types of memories/life scripts were recalled: personal/autobiographical memory, memories for public events, and life script events. The findings illustrate differing temporal periods for the bump: approximately 10-30 years for memories for important events, approximately 5-30 years for memories that were induced by word cues, and 6-39 years for studies using life scripts. In explaining the bump, the narrative/identity account and cultural life script account received the most support.

Matched MeSH terms: Memory, Episodic*
Fulltext Tuning attention based long-short term memory neural networks for Parkinson's disease detection using modified metaheuristics

Cuk A, Bezdan T, Jovanovic L, Antonijevic M, Stankovic M, Simic V, et al.

Sci Rep, 2024 Feb 21;14(1):4309.
PMID: 38383690 DOI: 10.1038/s41598-024-54680-y

Parkinson's disease (PD) is a progressively debilitating neurodegenerative disorder that primarily affects the dopaminergic system in the basal ganglia, impacting millions of individuals globally. The clinical manifestations of the disease include resting tremors, muscle rigidity, bradykinesia, and postural instability. Diagnosis relies mainly on clinical evaluation, lacking reliable diagnostic tests and being inherently imprecise and subjective. Early detection of PD is crucial for initiating treatments that, while unable to cure the chronic condition, can enhance the life quality of patients and alleviate symptoms. This study explores the potential of utilizing long-short term memory neural networks (LSTM) with attention mechanisms to detect Parkinson's disease based on dual-task walking test data. Given that the performance of networks is significantly inductance by architecture and training parameter choices, a modified version of the recently introduced crayfish optimization algorithm (COA) is proposed, specifically tailored to the requirements of this investigation. The proposed optimizer is assessed on a publicly accessible real-world clinical gait in Parkinson's disease dataset, and the results demonstrate its promise, achieving an accuracy of 87.4187 % for the best-constructed models.

Matched MeSH terms: Memory, Short-Term
Fulltext Tualang honey supplementation as cognitive enhancer in patients with schizophrenia

Yahaya R, Zahary MN, Othman Z, Ismail R, Nik Him NAS, Abd Aziz A, et al.

Heliyon, 2020 May;6(5):e03948.
PMID: 32426546 DOI: 10.1016/j.heliyon.2020.e03948

Introduction: Schizophrenia is a chronic mental illness with clusters of symptoms, including cognitive impairment. This study aimed to explore the effect of Tualang Honey (TH) on cognitive domains, especially as it pertained to the verbal memory of schizophrenia patients.
Method: This was a cross-sectional study involved 80 individuals, diagnosed with schizophrenia. The Malay Version Auditory Verbal Learning Test (MVAVLT) was used. Data were analysed using SPSS 20.0 software. Intention to treat analysis was applied.
Result: A comparison of the total learning score at eight weeks between the two groups based on time effect and time-treatment interaction favoured TH group.
Conclusion: This study concludes that by supplementing schizophrenia patients with 8-week of TH did improve total learning performance across domains in the immediate memory among patients with schizophrenia.

Matched MeSH terms: Memory, Short-Term
Tualang honey supplement improves memory performance and hippocampal morphology in stressed ovariectomized rats

Al-Rahbi B, Zakaria R, Othman Z, Hassan A, Mohd Ismail ZI, Muthuraju S

Acta Histochem, 2014 Jan;116(1):79-88.
PMID: 23810156 DOI: 10.1016/j.acthis.2013.05.004

Recently, our research team has reported that Tualang honey was able to improve immediate memory in postmenopausal women comparable with that of estrogen progestin therapy. Therefore the aim of the present study was to examine the effects of Tualang honey supplement on hippocampal morphology and memory performance in ovariectomized (OVX) rats exposed to social instability stress. Female Sprague-Dawley rats were divided into six groups: (i) sham-operated controls, (ii) stressed sham-operated controls, (iii) OVX rats, (iv) stressed OVX rats, (v) stressed OVX rats treated with 17β-estradiol (E2), and (vi) stressed OVX rats treated with Tualang honey. These rats were subjected to social instability stress procedure followed by novel object recognition (NOR) test. Right brain hemispheres were subjected to Nissl staining. The number and arrangement of pyramidal neurons in regions of CA1, CA2, CA3 and the dentate gyrus (DG) were recorded. Two-way ANOVA analyses showed significant interactions between stress and OVX in both STM and LTM test as well as number of Nissl-positive cells in all hippocampal regions. Both E2 and Tualang honey treatments improved both short-term and long-term memory and enhanced the neuronal proliferation of hippocampal CA2, CA3 and DG regions compared to that of untreated stressed OVX rats.

Matched MeSH terms: Memory, Short-Term*
Fulltext Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress

Azman KF, Zakaria R, AbdAziz C, Othman Z, Al-Rahbi B

Noise Health, 2015 Mar-Apr;17(75):83-9.
PMID: 25774610 DOI: 10.4103/1463-1741.153388

Recent evidence has exhibited dietary influence on the manifestation of different types of behavior induced by stressor tasks. The present study examined the effects of Tualang honey supplement administered with the goal of preventing or attenuating the occurrence of stress-related behaviors in male rats subjected to noise stress. Forty-eight adult male rats were randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey. The supplement was given once daily via oral gavage at 0.2 g/kg body weight. Two types of behavioral tests were performed, namely, the novel object recognition test to evaluate working memory and the forced swimming test to evaluate depressive-like behavior. Data were analyzed by a two-way analysis of variance (ANOVA) using IBM SPSS 18.0. It was observed that the rats subjected to noise stress expressed higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats. In addition, our results indicated that the supplementation regimen successfully counteracted the effects of noise stress. The forced swimming test indicated that climbing and swimming times were significantly increased and immobility times significantly decreased in honey-supplemented rats, thereby demonstrating an antidepressant-like effect. Furthermore, cognitive function was shown to be intensely affected by noise stress, but the effects were counteracted by the honey supplement. These findings suggest that subchronic exposure to noise stress induces depressive-like behavior and reduces cognitive functions, and that these effects can be attenuated by Tualang honey supplementation. This warrants further studies to examine the role of Tulang honey in mediating such effects.

Matched MeSH terms: Memory; Memory, Short-Term*
Tualang honey consumption enhanced hippocampal pyramidal count and spatial memory performance of adult male rats

Mohd Amiruddin Kamarulzaidi, Zulkifli Mohd. Yusoff MY, Abdul Majid Mohamed, Durriyyah Sharifah Hasan Adli

Sains Malaysiana, 2016;45:215-220.

As a natural anti-oxidant source, Tualang honey, produced by wild bees nesting on the Tualang tree (Koompassia excelsa) is expected to have positive influence on health, including memory. This study investigated the effect of Tualang honey on the cell count of memory formation related hippocampal pyramidal neuron and on spatial memory performance (SMP) of rats using the radial arm maze (RAM). Sprague Dawley male rats (n=24), 7-8 weeks old were divided into two groups; experimental group group force-fed 1 mL/100 g body weight with 70% honey (HG); and the control group with 0.9% saline (CG) for 12 weeks. Nissl staining technique (with cresyl violet) was employed for neurohistological analysis of the hippocampal tissue. Six randomly selected rats from each group were used for the neuronal soma counting of pyramidal cell layer CA1, CA3a and CA3c regions. Two-way ANOVA analysis showed positively significant differences between treatment and control groups for SMP comparison of working memory and reference memory components, as well as the number of pyramidal neurons. Hence, this positive effects of Tualang honey, as demonstrated behaviorally and neurohistologically, supported report that Tualang honey could improve memory and deter hippocampal morphological impairments; possibly due to its high anti-oxidant properties.

Matched MeSH terms: Memory, Short-Term; Spatial Memory
Fulltext Tualang Honey Improves Memory and Prevents Hippocampal Changes in Prenatally Stressed Rats

Abd Aziz CB, Hasim H, Zakaria R, Ahmad AH

Turk J Pharm Sci, 2020 Dec 23;17(6):620-625.
PMID: 33389951 DOI: 10.4274/tjps.galenos.2019.21548

Objectives: This study investigated whether the alterations in memory and hippocampus morphology and levels of malondialdehyde (MDA) and N-methyl-D-aspartate (NMDA) receptor in the hippocampus of adult rats after prenatal stress could be prevented by administration of Tualang honey (TH).
Materials and Methods: Twenty-four pregnant rats were randomly grouped into a control group (C), a stress group (S), and a stress group treated with TH. Eight male pups from each group were randomly chosen and they were sacrificed at eight or ten weeks of age following the novel object recognition test. Their brains were removed and histological changes and levels of MDA and NMDA receptors in the hippocampus were determined.
Results: The offspring from TH group showed significantly increased preference index (p<0.05) with higher neuronal number compared to S group. A significantly lower level of MDA and NMDA receptors were shown in TH group (P<0.01; P<0.05 respectively) compared to S group. The parameters investigated were not significantly different between C and TH groups.
Conclusion: The study has shown that memory alteration, changes in hippocampus histology, MDA and NMDA receptor levels could be prevented by TH administration during prenatal stress. The results suggest the beneficial effects of Tualang honey in prenatally stressed rat offspring.

Matched MeSH terms: Memory
Try to Remember: Interplay between Memory and Substance Use Disorder

Mohamed RMP, Kumar J, Yap E, Mohamed IN, Sidi H, Adam RL, et al.

Curr Drug Targets, 2019;20(2):158-165.
PMID: 28641520 DOI: 10.2174/1389450118666170622092824

Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insights that suggest memories associated with substance use disorder may follow unique neurobiological pathways that render them more accessible to pharmacological intervention. In parallel to this, research in neurochemistry has identified several potential candidate molecules that could influence the formation and maintenance of long-term memory. Drugs that target these molecules (blebbistatin, isradipine and zeta inhibitory peptide) have shown promise at the preclinical stage. In this review, we shall provide an overview of the evolving understanding on the biochemical mechanisms involved in memory formation and expound on the premise that substance use disorder is a learning disorder.

Matched MeSH terms: Memory, Long-Term/drug effects*

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