Displaying publications 1 - 20 of 87 in total

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  1. Alginate-based matrix tablets for drug delivery
    Veronica N, Heng PWS, Liew CV
    Expert Opin Drug Deliv, 2023 Jan;20(1):115-130.
    PMID: 36503355 DOI: 10.1080/17425247.2023.2158183
    INTRODUCTION: As a nature-derived polymer with swelling and gelling properties, alginate has found wide biopharma-relevant applications. However, there is comparatively limited attention on alginate in tablet formulations. Therefore, this review aimed to provide an overview of the applications of alginate in solid dosage form formulations.

    AREAS COVERED: This review outlines the role of alginate for oral sustained release formulations. For better insights into its application in drug delivery, the mechanisms of drug release from alginate matrices are discussed alongside the alginate inherent properties and drug properties. Specifically, the influence of alginate properties and formulation components on the resultant alginate gel and subsequent drug release is reviewed. Modifications of the alginate to improve its properties in modulating drug release are also discussed.

    EXPERT OPINION: Alginate-based matrix tablets is useful for sustaining drug release. As a nature-derived polymer, batch consistency and stability raise some concerns about employing alginate in formulations. Furthermore, the alginate gel properties can be affected by formulation components, pH of the dissolution environment and the tablet matrix micro-environment pH. Conscientious efforts are pivotal to addressing these formulation challenges to increase the utilization of alginate in oral solid dosage forms.

    Matched MeSH terms: Hexuronic Acids/chemistry
  2. Eco-friendly encapsulation: Investigating plant-based protein-alginate shells for efficient delivery and digestion of hemp seed oil encapsulated via supercritical CO2 dispersion
    Gholivand S, Tan TB, Yusoff MM, Qoms MS, Wang Y, Liu Y, et al.
    Food Chem, 2025 Jan 15;463(Pt 4):141515.
    PMID: 39395350 DOI: 10.1016/j.foodchem.2024.141515
    In this study, supercritical carbon dioxide solution-enhanced dispersion (SEDS) was used to encapsulate hemp seed oil (HSO) within matrices of hemp seed protein isolate (HPI), pea protein (PPI) and soy protein (SPI) (0.5 % w/v) in complex with alginate (AL) (0.01 % w/v). The effects of different pH levels (3-9), NaCl concentrations (0-200 mmol/L) and simulated gastrointestinal conditions on HSO release and digestion patterns were analyzed. The findings revealed that SPI/AL microcapsules effectively maintained structural integrity and controlled oil release across diverse pH levels and salt concentrations. During gastrointestinal phases, minimal oil release was observed during oral digestion (<25 % for all samples), while significant (P 
    Matched MeSH terms: Hexuronic Acids/chemistry
  3. Fulltext Effect of microwave-assisted extraction on the yield and quality of apple pomace and lemon peel pectins
    Zarei, M., Ahmadi Zenouz, A., Saari, N., Ghanbari, R., Nikkhah, M., Vaziri, M.
    International Food Research Journal, 2017;24(6):2402-2407.
    MyJurnal
    Microwave assisted extraction treatments showed the higher pectin yields of 10.07% and 8.83% in pretreated samples by microwave and 9.4% and 8% in the extraction of dried after microwave treatment in lemon peel and apple pomace samples, respectively. Lemon peel pectin in pretreated samples by microwave and extraction of dried after microwave treatment showed the higher degree of esterification 71.8% and 70%, respectively, while apple pomace revealed 68% and 65.4% in same treatments. Furthermore, lemon peel pectin exhibited the highest galacturonic content of 74.5% in extraction of pretreated samples by microwave, while apple pomace pectin indicated the higher galacturonic acid content of 70.5% and 70% in both extraction of dried after microwave treatment and extraction of dried samples. Texture analysis of jellies prepared by various extracted pectin indicated the highest fracturability in the microwave-assisted drying treatment of 33 N and 32.5 N for apple pomace and lemon peel pectin, respectively.
    Matched MeSH terms: Hexuronic Acids
  4. Investigating metal removal potential by Effective Microorganisms (EM) in alginate-immobilized and free-cell forms
    Ting ASY, Rahman NHA, Isa MIHM, Tan WS
    Bioresour Technol, 2013 Nov;147:636-639.
    PMID: 24001691 DOI: 10.1016/j.biortech.2013.08.064
    Metal removal potential of both alginate-immobilized and free-cells of Effective Microorganisms (EM-1™ Inoculant) was investigated in this study. Results revealed that removal of Cr(III), Cu(II) and Pb(II) followed a similar trend where alginate-immobilized EM were more efficient compared to free-cells of EM. For these metals, 0.940, 2.695 and 4.011 mg g(-1) of Cr(III), Cu(II) and Pb(II) were removed compared to only 0.160, 0.859 and 0.755 mg ml(-1) removed by free-cells, respectively. The higher efficiency of alginate-immobilized EM was primarily attributed to the alginate matrix. This was evident when both alginate-immobilized EM and plain alginate beads (without EM), were not significantly different in their removal efficacies. Presence of alginate also enhanced the use of the biosorbents as maximum metal sorption was achieved after 120 min as opposed to only 60 min for free-cells. EM per se in immobilized or free-cell forms did not enhance metal removal efficacy.
    Matched MeSH terms: Hexuronic Acids/chemistry
  5. Complete genome sequence of Planococcus donghaensis JH1T, a pectin-degrading bacterium
    See-Too WS, Chua KO, Lim YL, Chen JW, Convey P, Mohd Mohidin TB, et al.
    J Biotechnol, 2017 Jun 20;252:11-14.
    PMID: 28483443 DOI: 10.1016/j.jbiotec.2017.05.005
    The type strain Planococcus donghaensis JH1Tis a psychrotolerant and halotolerant bacterium with starch-degrading ability. Here, we determine the carbon utilization profile of P. donghaensis JH1Tand report the first complete genome of the strain. This study revealed the strain's ability to utilize pectin and d-galacturonic acid, and identified genes responsible for degradation of the polysaccharides. The genomic information provided may serve as a fundamental resource for full exploration of the biotechnological potential of P. donghaensis JH1T.
    Matched MeSH terms: Hexuronic Acids/metabolism
  6. Core-shell alginate-ghatti gum modified montmorillonite composite matrices for stomach-specific flurbiprofen delivery
    Bera H, Ippagunta SR, Kumar S, Vangala P
    Mater Sci Eng C Mater Biol Appl, 2017 Jul 01;76:715-726.
    PMID: 28482582 DOI: 10.1016/j.msec.2017.03.074
    Novel alginate-arabic gum (AG) gel membrane coated alginate-ghatti gum (GG) modified montmorillonite (MMT) composite matrices were developed for intragastric flurbiprofen (FLU) delivery by combining floating and mucoadhesion mechanisms. The clay-biopolymer composite matrices containing FLU as core were accomplished by ionic-gelation technique. Effects of polymer-blend (alginate:GG) ratios and crosslinker (CaCl2) concentrations on drug entrapment efficiency (DEE, %) and cumulative drug release after 8h (Q8h, %) were studied to optimize the core matrices by a 32factorial design. The optimized matrices (F-O) demonstrated DEE of 91.69±1.43% and Q8hof 74.96±1.56% with minimum errors in prediction. The alginate-AG gel membrane enveloped optimized matrices (F-O, coated) exhibited superior buoyancy, better ex vivo mucoadhesion and slower drug release rate. The drug release profile of FLU-loaded uncoated and coated optimized matrices was best fitted in Korsmeyer-Peppas model with anomalous diffusion and case-II transport driven mechanism, respectively. The uncoated and coated matrices containing FLU were also characterized for drug-excipients compatibility, drug crystallinity, thermal behaviour and surface morphology. Thus, the newly developed alginate-AG gel membrane coated alginate-GG modified MMT composite matrices are appropriate for intragastric delivery of FLU over an extended period of time with improved therapeutic benefits.
    Matched MeSH terms: Hexuronic Acids
  7. Advanced Dome cellulose/alginate/chitosan composite matrix design with gastric and intestinal co-targeting capacities
    Razali S, Bose A, Benetti C, Chong PW, Miller M, Colombo P, et al.
    Int J Pharm, 2022 Nov 25;628:122226.
    PMID: 36191818 DOI: 10.1016/j.ijpharm.2022.122226
    Dome matrix was designed with gastric and intestinal targeting capacities using melatonin and caffeine as model drugs, and alginate, chitosan and cellulose as composite materials. The melatonin, caffeine and intermediate hydroxypropylmethylcelluose-based dispersible modules were prepared through compaction. Caffeine piled module was capped at both ends with melatonin void modules via intermediate dispersible modules into Dome matrix. Dispersion of intermediate module detached melatonin module from Dome matrix and had it floated in stomach providing a more complete melatonin release due to favorable pH-pKa relationship of dissolution medium and drug. With reference to the caffeine module, the detachment of melatonin module facilitated its gastrointestinal transit as a reduced size matrix, with majority of caffeine delivered in colon. The dual site-targeted and -release Dome matrix is applicable as reference oral carrier for pharmaceutical, nutraceutical, functional food and veterinary medicine where a complex formulation and performancein vivoare required.
    Matched MeSH terms: Hexuronic Acids
  8. Aging and microwave effects on alginate/chitosan matrices
    Wong TW, Chan LW, Kho SB, Heng PW
    J Control Release, 2005 Jun 2;104(3):461-75.
    PMID: 15911046
    The influence of microwave irradiation on the drug release properties of freshly prepared and aged alginate, alginate-chitosan and chitosan beads was investigated. The beads were prepared by extrusion method with sulphathiazole as a model drug. The dried beads were subjected to microwave irradiation at 80 W for 10 min, 20 min or three consecutive cycles of 10 and 20 min, respectively. The profiles of drug dissolution, drug content, drug stability, drug polymorphism, drug-polymer interaction, polymer crosslinkage and complexation were determined by dissolution testing, drug content assay, differential scanning calorimetry and Fourier transform infra-red spectroscopy. The chemical stability of drug embedded in beads was unaffected by microwave conditions and length of storage time. The release property of drug was mainly governed by the extent of polymer interaction in beads. The aged alginate beads required intermittent cycles of microwave irradiation to induce drug release retarding effect in contrast to their freshly prepared samples. Unlike the alginate beads, the level of polymer interaction was higher in aged alginate-chitosan beads than the corresponding fresh beads. The drug release retarding property of aged alginate-chitosan beads could be significantly enhanced through subjecting the beads to microwave irradiation for 10 min. No further change in drug release from these beads was observed beyond 30 min of microwave irradiation. Unlike beads containing alginate, the rate and extent of drug released from the aged chitosan beads were higher upon treatment by microwave in spite of the higher degree of polymer interaction shown by the latter on prolonged storage. The observation suggested that the response of polymer matrix to microwave irradiation in induction of drug release retarding property was largely affected by the molecular arrangement of the polymer chains.
    Matched MeSH terms: Hexuronic Acids/radiation effects; Hexuronic Acids/chemistry
  9. Agarose- and alginate-based biopolymers for sample preparation: Excellent green extraction tools for this century
    Sanagi MM, Loh SH, Wan Ibrahim WN, Pourmand N, Salisu A, Wan Ibrahim WA, et al.
    J Sep Sci, 2016 Mar;39(6):1152-9.
    PMID: 27027592 DOI: 10.1002/jssc.201501207
    Recently, there has been considerable interest in the use of miniaturized sample preparation techniques before the chromatographic monitoring of the analytes in unknown complex compositions. The use of biopolymer-based sorbents in solid-phase microextraction techniques has achieved a good reputation. A great variety of polysaccharides can be extracted from marine plants or microorganisms. Seaweeds are the major sources of polysaccharides such as alginate, agar, agarose, as well as carrageenans. Agarose and alginate (green biopolymers) have been manipulated for different microextraction approaches. The present review is focused on the classification of biopolymer and their applications in multidisciplinary research. Besides, efforts have been made to discuss the state-of-the-art of the new microextraction techniques that utilize commercial biopolymer interfaces such as agarose in liquid-phase microextraction and solid-phase microextraction.
    Matched MeSH terms: Hexuronic Acids
  10. Fulltext Effects of different drying methods and hydrocolloids on quality properties of semi-dried catfish jerky
    Ishamri Ismail, Nur Husna Mohd Fauzi, Mastura Zahidi Baki, Ho, Lee Hoon
    Malaysian Journal of Applied Sciences, 2018;2(1):11-18.
    MyJurnal
    This study was carried out to evaluate the effects of different drying methods (sun drying, cabinet
    drying and convection oven) and hydrocolloids (carrageenan and alginate) on physicochemical
    properties of semi-dried catfish jerky. The concentration of hydrocolloids used was 1% and 2%.
    Samples without the addition of hydrocolloid served as the control group. The water activity of semidried catfish jerky decreased with the addition of hydrocolloids. For colour properties, lightness (L*)
    value of semi-dried catfish jerky increased with the increased concentration of hydrocolloids. The
    addition of 2% alginate (2%A) and 2% carrageenan (2%C) showed higher lightness (L*) than the
    controlled group for all drying methods, except for sun drying with carrageenan. Both carrageenan and
    alginate added into semi-dried catfish jerky increased the processing yields. The addition of 2%
    carrageenan (2%C) and 1% alginate (1%A) improved the product yields for all drying methods. This
    paper argues that the application of cabinet dryer gives better shelf stability due to the lower range of
    water activity than other drying methods while preserving colour quality and product yields.
    Matched MeSH terms: Hexuronic Acids
  11. Fabrication, Evaluation, In Vivo Pharmacokinetic and Toxicological Analysis of pH-Sensitive Eudragit S-100-Coated Hydrogel Beads: a Promising Strategy for Colon Targeting
    Rehman S, Ranjha NM, Shoukat H, Madni A, Ahmad F, Raza MR, et al.
    AAPS PharmSciTech, 2021 Jul 26;22(6):209.
    PMID: 34312763 DOI: 10.1208/s12249-021-02082-y
    The aim of present research aims to fabricate a system of enteric coating of hydrogel beads with pH-sensitive polymer, which shows solubility at pH > 7, and explore their potential to target the colon for drug delivery. Hydrogel beads were fabricated through the extrusion-dripping technique followed by ion gelation crosslinking. Moreover, freeze-thaw cycle was implemented for crosslinking of polyvinyl alcohol (PVA)/Ca-alginate blend beads. The oil-in-oil solvent evaporation method was adopted for the Eudragit coating of hydrogel beads using different coat: core ratios (4:1 or 8:1). Coated and uncoated hydrogel beads were evaluated by in vitro physicochemical properties, swelling and drug release behaviours, and in vivo pharmacokinetics, swelling, and toxicity evaluation. Diclofenac sodium was loaded as an experimental drug. Drug entrapment efficiency for the PVA/Ca-alginate beads was calculated as 98%, and for Ca-alginate beads, it came out to a maximum of 74%. Drug release study at various pH suggested that, unlike uncoated hydrogel beads, the coated beads delay the release of diclofenac sodium in low pH of the gastric and intestinal environment, thus targeting the colon for the drug release. It was concluded that Eudragit S-100-coated hydrogel beads could serve as a more promising and reliable way to target the colon for drug delivery.Graphical abstract.
    Matched MeSH terms: Hexuronic Acids
  12. Fulltext Development of seed treatments biofertilizer and nutrient uptake study using tracer technique for okra plants
    Hoe, Phua Choo Kwai, Khairuddin Abdul Rahim, Ahmad Nazrul Abd Wahid
    Jurnal Sains Nuklear Malaysia, 2013;25(1):16-23.
    MyJurnal
    Development of biofertilizer seed treatments for okra seeds were carried out by mixing phosphate
    solubilising bacteria (AP 3) and plant growth promoter (AP 2) with adhesives. The seeds were
    coated with inoculums and four types of adhesives namely, Gum Arabic; Polyethylene Glycol
    (PEG); Sodium Alginate and Methycellulose respectively. From eight seed treatments, all seed
    treatments significantly increased seed germinations except treatment T4 (Gum Arabic and AP3).
    In general, maximum germination rates and log of viable cells were observed when treated with
    polyethylene glycol 4000 (PEG) mixed with AP2 (T7) and AP3 (T8). These results show that using
    PEG as adhesive enhanced the germination rates and log of viable cells of AP2 and AP3. Thus,
    PEG could be a good adhesive for seed treatment. In greenhouse experiment, okra seeds treatment
    with AP2 and PEG (T1) showed the highest dry weight compared to other treatments. Seeds
    treatment with AP3 and PEG (T2) showed higher contribution of N compare to seeds treatment
    (T1). There were no significant different within seed treatments and urea treatment in okra yield.
    All treatments significantly increased yields compared with control
    Matched MeSH terms: Hexuronic Acids
  13. Progress and perspective on algal plastics - A critical review
    Zhang C, Show PL, Ho SH
    Bioresour Technol, 2019 Oct;289:121700.
    PMID: 31262543 DOI: 10.1016/j.biortech.2019.121700
    There is a growing interest in developing bio-based biodegradable plastics to reduce the dependence on depleting fossil fuels and provide a sustainable alternative. Bio-based plastics can usually be produced from lipids, proteins or carbohydrates, which are major components of microalgae. Despite its potential for algal plastics, little information is available on strain selection, culture optimization and bioplastics fabrication mechanism. In this review, we summarized the recent developments in understanding the utilization of seaweed polysaccharides, such as alginate and carrageenan for bio-based plastics. In addition, a conceptual biorefinery framework for algal plastics through promising components (e.g., lipids, carbohydrates and proteins) from microalgae is comprehensively presented. Moreover, the reasons for variations in bioplastics performance and underlying mechanism of various algal biocomposites have been critically discussed. We believe this review can provide valuable information to accelerate the development of innovative green technologies for improving the commercial viability of algal plastics.
    Matched MeSH terms: Hexuronic Acids
  14. Effects of storage and yogurt matrix on the stability of tocotrienols encapsulated in chitosan-alginate microcapsules
    Tan PY, Tan TB, Chang HW, Tey BT, Chan ES, Lai OM, et al.
    Food Chem, 2018 Feb 15;241:79-85.
    PMID: 28958562 DOI: 10.1016/j.foodchem.2017.08.075
    Tocotrienol microcapsules (TM) were formed by firstly preparing Pickering emulsion containing tocotrienols, which was then gelled into microcapsules using alginate and chitosan. In this study, we examined the stability of TM during storage and when applied into a model food system, i.e. yogurt. During storage at 40°C, TM displayed remarkably lower tocotrienols loss (50.8%) as compared to non-encapsulated tocotrienols in bulk oil (87.5%). When the tocotrienols were incorporated into yogurt, the TM and bulk oil forms showed a loss of 23.5% and 81.0%, respectively. Generally, the tocotrienols were stable in the TM form and showed highest stability when these TM were added into yogurt. δ-Tocotrienol was the most stable isomer in both forms during storage and when incorporated into yogurt. The addition of TM into yogurt caused minimal changes in the yogurt's color and texture but slightly altered the yogurt's viscosity.
    Matched MeSH terms: Hexuronic Acids
  15. Fulltext Optimization of alginate and gellan-based edible coating formulations for fresh-cut pineapples
    Azarakhsh, N., Azizah, O., Ghazali H.M., Tan, C.P., Mohd Adzahan, N.
    International Food Research Journal, 2012;19(1):279-285.
    MyJurnal
    The effects of alginate-based [sodium alginate, 0-2% (w/v), glycerol, 0-2% (w/v) and sunflower oil 0.025% (w/v)] and gellan-based [gellan, 0-1% (w/v), glycerol, 0-1% (w/v) and sunflower oil 0.025% (w/v)] edible coatings on fresh-cut pineapple were evaluated by response surface methodology (RSM). Weight loss, firmness and respiration rate were considered as response variables. The results showed that for all response variables the RSM models were significantly (p0.05) difference between predicted and experimental values. The overall optimum region predicted by RSM indicated that alginate and gellan-based coatings containing 1.29% (w/v) sodium alginate, 1.16% (w/v) glycerol and 0.56% (w/v) gellan gum, 0.89% (w/v) glycerol were optimized formulations respectively.
    Matched MeSH terms: Hexuronic Acids
  16. Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing
    Rezvanian M, Amin MCIM, Ng SF
    Carbohydr Polym, 2016 Feb 10;137:295-304.
    PMID: 26686133 DOI: 10.1016/j.carbpol.2015.10.091
    Previously, studies have demonstrated that topical application of simvastatin can promote wound healing in diabetic mice via augmentation of angiogenesis and lymphangiogenesis. This study aimed to formulate and characterize simvastatin in alginate-based composite film wound dressings. Biopolymers used for composite films were sodium alginate blended with pectin or gelatin. The films were prepared and characterized based on their physical properties, surface morphology, mechanical strength and rheology. Then, in vitro drug releases from the films were investigated and, finally, the cell viability assay was performed to assess the cytotoxicity profile. From the pre-formulation studies, alginate/pectin composite film showed to possess desirable wound dressing properties and superior mechanical properties. The in vitro drug release profile revealed that alginate/pectin film produced a controlled release drug profile, and cell viability assay showed that the film was non-toxic. In summary, alginate/pectin composite film is suitable to be formulated with simvastatin as a potential wound dressing.
    Matched MeSH terms: Hexuronic Acids/chemistry
  17. Polygalacturonase production by calcium alginate immobilized Enterobacter aerogenes NBO2 cells
    Darah I, Nisha M, Lim SH
    Appl Biochem Biotechnol, 2015 Mar;175(5):2629-36.
    PMID: 25547814 DOI: 10.1007/s12010-014-1447-4
    Bacterial cells of Enterobacter aerogenes NBO2 were entrapped in calcium alginate beads in order to enhance polygalacturonase production compared to free cells. The optimized condition of 5 % (w/v) sodium alginate concentration, agitation speed of 250 rpm, and 15 beads of calcium alginate with inoculum size of 4 % (v/v; 5.4 × 10(7) cells/ml) produced 23.48 U/mL of polygalacturonase compared to free cells of 18.54 U/ml. There was about 26.6 % increment in polygalaturonase production. However, in this study, there was 296.6 % of increment in polygalacturonase production after improvement parameters compared to before improvement parameters of calcium alginate bead immobilization cells (5.92 U/ml). This research has indicated that optimized physical parameters of calcium alginate bead immobilization cells have significantly enhanced the production of polygalacturonase.
    Matched MeSH terms: Hexuronic Acids/chemistry
  18. Alginate-based emulsion template containing high oil loading stabilized by nonionic surfactants
    Ong WD, Tey BT, Quek SY, Tang SY, Chan ES
    J Food Sci, 2015 Jan;80(1):E93-E100.
    PMID: 25529579 DOI: 10.1111/1750-3841.12729
    Oil-in-water (O/W) emulsion-gel systems containing high oil payloads are of increasing interest for food applications because of the reduction in encapsulation cost, consumption frequency or volume of food products. This study shows a facile approach to prepare stable alginate-based O/W emulsions at high oil loading using a mixture of nonionic surfactants (Tween 80 and Span 20) as a template to form gelled-emulsions. The synergistic effects of alginate and surfactants on the O/W emulsion properties were evaluated in terms of oil droplet size and emulsion stability. At 2% (w/v) of alginate and 1% (w/v) of surfactants, the size distribution of oil droplets was narrow and monomodal, even at an oil loading of 70% (v/v). The emulsions formed were stable against phase separation. The oil droplet size could be further reduced to below 1 μm using a high-shear homogenizer. The emulsions formed could be easily molded and gelled into solids of different shapes via ionic gelation. The findings of this study create possible avenues for applications in food industries.
    Matched MeSH terms: Hexuronic Acids/chemistry
  19. Alginate-immobilized bentonite clay: adsorption efficacy and reusability for Cu(II) removal from aqueous solution
    Tan WS, Ting AS
    Bioresour Technol, 2014 May;160:115-8.
    PMID: 24405651 DOI: 10.1016/j.biortech.2013.12.056
    This study evaluated the use of alginate-immobilized bentonite to remove Cu(II) as an alternative to mitigate clogging problems. The adsorption efficacy (under the influence of time, pH and initial Cu(II) concentration) and reusability of immobilized-bentonite (1% w/v bentonite) was tested against plain alginate beads. Results revealed that immobilized bentonite demonstrated significantly higher sorption efficacy compared to plain alginate beads with 114.70 and 94.04 mg Cu(II) adsorbed g(-1) adsorbent, respectively. Both sorbents were comparable in other aspects where sorption equilibrium was achieved within 6 h, with optimum pH between pH 4 and 5 for adsorption, displayed maximum adsorption capacity at initial Cu(II) concentrations of 400 mg l(-1), and demonstrated excellent reusability potential with desorption greater than 90% throughout three consecutive adsorption-desorption cycles. Both sorbents also conformed to Langmuir isotherm and pseudo-second order kinetic model. Immobilized bentonite is therefore recommended for use in water treatments to remove Cu(II) without clogging the system.
    Matched MeSH terms: Hexuronic Acids/chemistry
  20. In vitro evaluation of chitosan coated- and uncoated-calcium alginate beads containing methyl salicylate-lactose physical mixture
    Tamilvanan S, Karmegam S
    Pharm Dev Technol, 2012 Jul-Aug;17(4):494-501.
    PMID: 21609308 DOI: 10.3109/10837450.2010.550622
    Methyl salicylate-lactose physical mixture (1:1 and 1:1.5 ratios) was incorporated into calcium alginate beads by a coacervation method involving an ionotropic gelation/polyelectrolyte complexation approach.
    Matched MeSH terms: Hexuronic Acids/chemistry
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