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Fulltext Evidence in support of potential applications of lipid peroxidation products in cancer treatment

Erejuwa OO, Sulaiman SA, Ab Wahab MS

Oxid Med Cell Longev, 2013;2013:931251.
PMID: 24369491 DOI: 10.1155/2013/931251

Cancer cells generate reactive oxygen species (ROS) resulting from mitochondrial dysfunction, stimulation of oncogenes, abnormal metabolism, and aggravated inflammatory activities. Available evidence also suggests that cancer cells depend on intrinsic ROS level for proliferation and survival. Both physiological and pathophysiological roles have been ascribed to ROS which cause lipid peroxidation. In spite of their injurious effects, the ROS and the resulting lipid peroxidation products could be beneficial in cancer treatment. This review presents research findings suggesting that ROS and the resulting lipid peroxidation products could be utilized to inhibit cancer growth or induce cancer cell death. It also underscores the potential of lipid peroxidation products to potentiate the antitumor effect of other anticancer agents. The review also highlights evidence demonstrating other potential applications of lipid peroxidation products in cancer treatment. These include the prospect of lipid peroxidation products as a diagnostic tool to predict the chances of cancer recurrence, to monitor treatment progress or how well cancer patients respond to therapy. Further and detailed research is required on how best to successfully, effectively, and selectively target cancer cells in humans using lipid peroxidation products. This may prove to be an important strategy to complement current treatment regimens for cancer patients.

Matched MeSH terms: Lipid Peroxidation*
Fulltext Health Benefits of Palm Tocotrienol-Rich Fraction: A Systematic Review of Randomized Controlled Trials

Looi AD, Palanisamy UD, Moorthy M, Radhakrishnan AK

Nutr Rev, 2025 Feb 01;83(2):307-328.
PMID: 38916919 DOI: 10.1093/nutrit/nuae061

CONTEXT: Vitamin E, a well-known antioxidant with numerous positive effects on human health, encompasses tocotrienol-rich fraction (TRF), a natural variant abundant in palm oil.
OBJECTIVE: This systematic review analyzed findings from randomized controlled trials published until 2022 to evaluate the health impacts of palm TRF.
DATA SOURCES: A literature search was performed in Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, OVID Medline, SCOPUS, and Web of Science from inception until December 2022. Thirty studies involving 2646 patients, including both healthy individuals and those with underlying conditions, were identified.
RESULTS: This review shows palm TRF to be a promising natural supplement against inflammation and lipid peroxidation and that can significantly enhance overall health. Additionally, the study underscores the necessity for further research to ascertain the optimal dosage, formulation, and duration of supplementation, maximizing the potential health advantages.
CONCLUSION: This systematic review provides evidence supporting the health benefits associated with palm TRF.
SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42020204070.

Matched MeSH terms: Lipid Peroxidation/drug effects
Impact of plasticiser exposure on oyster Crassostrea (Magallana) saidii: assessing oxidative stress and biomarker responses

Ishak SA, Aris AZ, Law MC, Looi LJ, Abd Karim MM

Ecotoxicology, 2025 May;34(4):654-665.
PMID: 40074971 DOI: 10.1007/s10646-025-02866-z

Plasticisers are prevalent chemical contaminants that leach from plastics into aquatic ecosystems, posing potential risks to marine life. This study investigated the effects of alternative plasticisers [epoxidised methyl oleate (EMO), di-(2-ethylhexyl) adipate (DEHA), and diisononyl phthalate (DINP)] at 100 µg/L in oysters Crassostrea (Magallana) saidii over 21 days under controlled laboratory conditions. This study focused on changes in body weight, antioxidant enzyme activities such as superoxide dismutase (SOD) and catalase (CAT), non-enzymatic antioxidant reduced glutathione (GSH), lipid peroxidation (malondialdehyde (MDA) levels) after plasticisers exposure for 7, 14 and 21 days. The results indicated a decline in body weight in DINP-exposed oysters, indicating metabolic alterations. DEHA and DINP showed a pronounced increase in SOD activity at the end of the experiment, indicating elevated oxidative stress. CAT activity increased with EMO exposure, but decreased in oysters treated with DEHA and DINP. GSH levels were inversely proportional to CAT activity. Oysters exposed to DEHA and DINP exhibited higher MDA levels, indicating oxidative lipid damage associated with these plasticisers. Multi-biomarker data were integrated using the Integrated Biomarker Response (IBR) index, which ranked the plasticisers' oxidative stress potential as DEHA > DINP > EMO. The IBR analysis also suggested distinct modes of action among the plasticisers and provided insights into their toxicity mechanisms. Notably, EMO exhibited lower toxicity compared to DEHA and DINP, supporting its potential as a more friendly alternative to conventional plasticisers, albeit not exempt from toxic effects. These insights underscore the importance of environmental risk assessments in the future development of safer chemical alternatives.

Matched MeSH terms: Lipid Peroxidation/drug effects
Fulltext Palm olein oil produces less lipid peroxidation products than soya bean oil

Zaiton Z, Merican Z, Khalid BA, Mohamed JB, Baharom S

Asia Pac J Clin Nutr, 1997 Jun;6(2):116-8.
PMID: 24394713

The soleus muscles of hyperthyroid rats were used to investigate the effect of palm olein oil and soya bean oil on the production of lipid peroxidation products. It was found that palm olein oil but not soya bean oil significantly decreased malonaldehyde and conjugated diene levels of the soleus muscles of hyperthyroid rats. These findings suggest that palm olein per se produces less lipid peroxidation products than soya bean oil. Such an assay method gives a composite net picture of the propensity of an oil to produce lipid peroxidation products.

Matched MeSH terms: Lipid Peroxidation
Fulltext Impact of sea-salt on morpho-physiological and biochemical responses in banana (Musa acuminata cv. Berangan)

Mazumdar P, Lau SE, Singh P, Takhtgahi HM, Harikrishna JA

Physiol Mol Biol Plants, 2019 May;25(3):713-726.
PMID: 31168234 DOI: 10.1007/s12298-019-00659-3

Banana is often grown in coastal-regions, and while known for its sensitivity towards seawater, little is documented on the effect of sea-salt on the growth, physiology and metal homeostasis. Here we report that banana plantlets exposed to sea-salt at extreme (average seawater concentration; 52.7 dS m-1), severe (28.5 dS m-1) or moderate (10.2 dS m-1) salinity levels had reduced root length (2.0-6.0-fold), plant height (1.2-1.6-fold), leaf number (2.0-2.3-fold) and leaf area (3.3-4.0-fold) compared to control plantlets. Degradation of pigments (total chlorophyll: 1.3-12.3-fold, chlorophyll a: 1.3-9.2-fold; chlorophyll b: 1.3-6.9-fold lower and carotenoids: 1.4-3.7-fold lower) reflected vulnerability of photosystems to salt stress. Relative water content showed a maximum decrease of 1.5-fold in salt stress. MDA analysis showed sea-salt exposure triggers 2.3-3.5-fold higher lipid peroxidation. Metal content analysis showed a 73-fold higher Na value from roots exposed to extreme salinity compared to control plantlets. While phenotype was clearly affected, moderate salinity showed no significant alteration of macro (N, P, K and Ca) and micro (Fe, Mn and Cu) metal content. The antioxidant enzymes: SOD (3.2-fold), CAT (1.7-fold) and GR (6-fold) showed higher activity at moderate salinity level compared to control plantlets but lower activity at severe (SOD: 1.3-fold; CAT: 1.5-fold; GR: 2-fold lower) and extreme seawater salinity (SOD: 1.5; CAT: 1.9; GR: 1.3-fold lower). Mild changes in growth and physiology at sea-salt levels equivalent to moderate seawater flooding, indicate that banana will survive such flooding, while extreme seawater inundation will be lethal. This data provides a reference for future salinity-mediated work in banana.

Matched MeSH terms: Lipid Peroxidation
Lipid peroxidation: Its effects on the formulation and use of pharmaceutical emulsions

Khanum R, Thevanayagam H

Asian J Pharm Sci, 2017 Sep;12(5):401-411.
PMID: 32104352 DOI: 10.1016/j.ajps.2017.05.003

Pharmaceutical delivery systems are developed to improve the physicochemical properties of therapeutic compounds. Emulsions are one of these drug delivering systems formulated using water, oils and lipids as main ingredients. Extensive data are usually generated on the physical and chemical characteristics of these oil-in-water and lipid emulsions. However, the oxidative tendency of emulsions is often overlooked. Oxidation impacts the overall quality and safety of these pharmaceutical emulsions. Additionally, introducing oxidatively unstable emulsions into biological systems further promotes oxidation in situ. Products of these reactions then continue to pose serious harm to cells and fuel other physiological oxidation reactions. Consequently, the increase of oxidation products leads to oxidative damage to biological systems. Thus, emulsions with lower lipid peroxidation are more stable and will reduce the negative effects of oxidation in situ. Preventive measures during the formulation of emulsions are important. Many naturally occurring and cost effective substances possess low oxidation tendencies and confer oxidative protection when used in emulsions. Additionally, certain preparatory methods should be employed to reduce or better control lipid peroxidation. Finally, emulsions must be evaluated for their oxidation susceptibility using the various techniques available. Careful attention to the preparation of emulsions and assessment of their oxidative stability will help produce safer emulsions without compromising efficacy.

Matched MeSH terms: Lipid Peroxidation
Effect of docosahexanoic acid on quality of frozen-thawed bull semen in BioXcell extender

Kaka A, Haron W, Yusoff R, Yimer N, Khumran AM, Sarsaifi K, et al.

Reprod Fertil Dev, 2017 Mar;29(3):490-495.
PMID: 28442061 DOI: 10.1071/RD15089

This study was conducted to investigate the effect of docosahexanoic acid (DHA) supplementation in BioXcell extender on the quality of frozen-thawed bull semen. Twenty-four ejaculates were collected from three bulls (eight from each bull). Ejaculates with motility ≥70% and normal morphology ≥80% were extended into BioXcell extender to which 0 (control), 3, 5, 10 or 15ngmL(-1) DHA was added. The supplemented semen samples were incubated at 37°C for 15min for DHA uptake by spermatozoa. Later, samples were cooled for 2h at 5°C and packaged into 0.25-mL straws, frozen in liquid nitrogen for 24h and subsequently thawed for evaluation. Results are presented as percentages ± s.e.m. Supplementation with DHA at 3ngmL(-1) significantly improved sperm functional parameters including sperm motility, normal morphology, viability, acrosome integrity and membrane integrity when compared with other supplemented groups and the control. Lipid peroxidation increased as the incorporation of DHA supplementation increased. In conclusion, 3ngmL(-1) concentration of DHA resulted in superior quality of frozen-thawed bull spermatozoa and is suggested as the optimum level of DHA to be added into BioXcell extender.

Matched MeSH terms: Lipid Peroxidation
Fulltext Effects of tocotrienol supplementation on hair growth in human volunteers

Beoy LA, Woei WJ, Hay YK

Trop Life Sci Res, 2010 Dec;21(2):91-9.
PMID: 24575202 MyJurnal

Studies have shown an association between oxidative stress and alopecia. Patients with alopecia generally exhibit lower levels of antioxidants in their scalp area as well as a higher lipid peroxidation index. Tocotrienols belong to the vitamin E family and are known to be potent antioxidants. Hence, a study was conducted to investigate the effect of tocotrienol supplementation on hair growth in volunteers suffering from hair loss. Twenty one volunteers were randomly assigned to orally receive 100 mg of mixed tocotrienols daily while 17 volunteers were assigned to receive placebo capsule orally. The volunteers were monitored for the number of hairs in a pre-determined scalp area as well as the weight of 20 strands of 1 cm length hair clippings at 0 (before supplementation), 4 and 8 months. The number of hairs of the volunteers in the tocotrienol supplementation group increased significantly as compared to the placebo group, with the former recording a 34.5% increase at the end of the 8-month supplementation as compared to a 0.1% decrease for the latter. Nevertheless, the cumulative weight of 20 strands of hair clippings did not differ much from the baseline for both supplementation groups at the end of the study period. In conclusion, this trial demonstrated that supplementation with tocotrienol capsules increases hair number in volunteers suffering from hair loss as compared to the placebo group. This observed effect was most likely to be due to the antioxidant activity of tocotrienols that helped to reduce lipid peroxidation and oxidative stress in the scalp, which are reported to be associated with alopecia.

Matched MeSH terms: Lipid Peroxidation
Ferroptosis as a potential target for cancer therapy

Chen Z, Wang W, Abdul Razak SR, Han T, Ahmad NH, Li X

Cell Death Dis, 2023 Jul 24;14(7):460.
PMID: 37488128 DOI: 10.1038/s41419-023-05930-w

Ferroptosis is a recently discovered essential type of cell death that is mainly characterized by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a double-edged sword in human cancer. However, the precise underlying molecular mechanisms and their differential roles in tumorigenesis are unclear. Therefore, in this review, we summarize and briefly present the key pathways of ferroptosis, paying special attention to the regulation of ferroptosis as well as its dual role as an oncogenic and as a tumor suppressor event in various human cancers. Moreover, multiple pharmacological ferroptosis activators are summarized, and the prospect of targeting ferroptosis in cancer therapy is further elucidated.

Matched MeSH terms: Lipid Peroxidation
Effect of oil circulation cycles on nutrient degradation and heterocyclic amine formation in crispy duck legs

Ma M, Sun Y, Mou Y, Pan D, Hu Y

Food Res Int, 2026 Dec 01;245(Pt 4):120883.
PMID: 42967709 DOI: 10.1016/j.foodres.2026.120883

The aim of this study was to investigate the effects of different numbers of oil recirculation cycles (0, 5, 10, 15 and 20) on the levels of four heterocyclic amines (HAAs) and their precursors, as well as the degree of fat and protein oxidation, in crispy duck legs. The results showed that the levels of four ACS-type HAAs increased with the number of oil circulation cycles, with norharman showing the greatest increase, rising from 0.45 ng/g to 21.60 ng/g, while L-tryptophan, as its primary precursor, increased by 79.11% after the oil been reused 20 times. Regarding lipid oxidation, both the peroxide value (POV) and thiobarbituric acid (TBARS) increased with the number of oil circulation cycles. In terms of protein oxidation, after the oil been reused 20 times, the carbonyl content and protein hydrolysis index (PI) increased significantly, while the total sulfhydryl content (T-SH) decreased significantly. Furthermore, electrophoresis results indicated that oil recirculation accelerates the breakdown of macromolecular proteins into smaller protein fragments, demonstrating that oil recirculation accelerates the oxidative degradation of proteins. Consequently, the reuse of oil leads to the deterioration of fats and proteins, causing the accumulation of heterocyclic amine precursors, and the production of greater quantities of heterocyclic amines. Therefore, the reuse of oil should be avoided as much as possible in production; this provides a scientific basis for the green production of crispy duck legs.

Matched MeSH terms: Lipid Peroxidation
Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: A review

Wong ZW, Thanikachalam PV, Ramamurthy S

Biomed Pharmacother, 2017 Oct;94:1145-1166.
PMID: 28826162 DOI: 10.1016/j.biopha.2017.08.009

Modern medicine has been used to treat myocardial infarction, a subset of cardiovascular diseases, and have been relatively effective but not without adverse effects. Consequently, this issue has stimulated interest in the use of natural products, which may be equally effective and better tolerated. Many studies have investigated the cardioprotective effect of natural products, such as plant-derived phytochemicals, against isoproterenol (ISO)-induced myocardial damage; these have produced promising results on the basis of their antioxidant, anti-atherosclerotic, anti-apoptotic and anti-inflammatory activities. This review briefly introduces the pathophysiology of myocardial infarction (MI) and then addresses the progress of natural product research towards its treatment. We highlight the promising applications and mechanisms of action of plant extracts, phytochemicals and polyherbal formulations towards the treatment of ISO-induced myocardial damage. Most of the products displayed elevated antioxidant levels with decreased oxidative stress and lipid peroxidation, along with restoration of ionic balance and lowered expression of myocardial injury markers, pro-inflammatory cytokines, and apoptotic parameters. Likewise, lipid profiles were positively altered and histopathological improvements could be seen from, for example, the better membrane integrity, decreased necrosis, edema, infarct size, and leukocyte infiltration. This review highlights promising results towards the amelioration of ISO-induced myocardial damage, which suggest the direction for future research on natural products that could be used to treat MI.

Matched MeSH terms: Lipid Peroxidation/drug effects
Fulltext Antioxidative Potential of a Streptomyces sp. MUM292 Isolated from Mangrove Soil

Tan LT, Chan KG, Chan CK, Khan TM, Lee LH, Goh BH

Biomed Res Int, 2018;2018:4823126.
PMID: 29805975 DOI: 10.1155/2018/4823126

Mangrove derived microorganisms constitute a rich bioresource for bioprospecting of bioactive natural products. This study explored the antioxidant potentials of Streptomyces bacteria derived from mangrove soil. Based on 16S rRNA phylogenetic analysis, strain MUM292 was identified as the genus Streptomyces. Strain MUM292 showed the highest 16S rRNA gene sequence similarity of 99.54% with S. griseoruber NBRC12873T. Furthermore, strain MUM292 was also characterized and showed phenotypic characteristics consistent with Streptomyces bacteria. Fermentation and extraction were performed to obtain the MUM292 extract containing the secondary metabolites of strain MUM292. The extract displayed promising antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging and also metal-chelating activities. The process of lipid peroxidation in lipid-rich product was also retarded by MUM292 extract and resulted in reduced MDA production. The potential bioactive constituents of MUM292 extract were investigated using GC-MS and preliminary detection showed the presence of pyrazine, pyrrole, cyclic dipeptides, and phenolic compound in MUM292 extract. This work demonstrates that Streptomyces MUM292 can be a potential antioxidant resource for food and pharmaceutical industries.

Matched MeSH terms: Lipid Peroxidation/drug effects
Lipid peroxidation in the descending thoracic aorta of rats deprived of REM sleep using the inverted flowerpot technique

Nawi A, Eu KL, Faris ANA, Wan Ahmad WAN, Noordin L

Exp Physiol, 2020 08;105(8):1223-1231.
PMID: 32539237 DOI: 10.1113/EP088667

NEW FINDINGS: What is the central question of this study? Deprivation of rapid eye movement (REM) sleep is associated with increased oxidative stress, but its effects on the blood vessels are poorly documented. We investigated whether REM sleep deprivation induces oxidative stress and causes lipid peroxidation in the aorta. What is the main finding and its important? We demonstrate that REM sleep deprivation induces oxidative stress and mediates lipid peroxidation in the aorta. This can cause endothelial changes and increased blood pressure. These findings will contribute to the growing body of literature on the mechanism underlying the effects of sleep deprivation on cardiovascular disease.
ABSTRACT: Oxidative stress-mediated lipid peroxidation is a known cause of endothelial injury or dysfunction. Deprivation of rapid eye movement (REM) sleep is associated with oxidative stress. To date, the pathogenesis of increased blood pressure after sleep deprivation remains poorly understood, particularly in the REM sleep phase. Our aim was to investigate the effects of REM sleep deprivation on blood vessels in the REM sleep-deprived rat model. Twenty-eight male Sprague-Dawley rats were divided into four equal groups: free-moving control rats, rats deprived of REM sleep for 72 h (REMsd), tank control rats and 72 h sleep-recovered rats after 72 h of REM sleep deprivation. The rats were deprived of REM sleep using the inverted flowerpot technique. Food consumption, body weight gain and systolic blood pressure were monitored. At the end of the experiment, the descending thoracic aorta was isolated for the measurement of oxidative stress markers. Despite a significant increase in food consumption in the REMsd group compared with the other groups, there was a significant reduction in body weight gain. Systolic blood pressure also showed a significant increase in the REMsd group compared with the other groups. Superoxide dismutase activity was significantly lower and malondialdehyde concentrations significantly higher in the REMsd group compared with the other groups. Increased levels of malondialdehyde are suggestive of lipid peroxidation in the blood vessels, and oxidative stress may be attributed to the initiation of the process. The changes after REM sleep deprivation revert during sleep recovery. In conclusion, the findings of the present study provide convincing evidence that REM sleep deprivation induced lipid peroxidation, leading to endothelial damage.

Matched MeSH terms: Lipid Peroxidation*
Antibodies against malondialdehyde (MDA) in MRL/lpr/lpr mice: evidence for an autoimmune mechanism involving lipid peroxidation

Yahya MD, Pinnas JL, Meinke GC, Lung CC

J Autoimmun, 1996 Feb;9(1):3-9.
PMID: 8845052

Previous studies have shown that lipid peroxidative processes may play a role in disease pathogenesis in lupus-prone MRL/lpr mice. Studies were thus performed to determine if an immune response against malondialdehyde (MDA), a highly reactive byproduct of lipid peroxidation, was present in these mice. By using MDA-modified mouse serum albumin (MSA) as antigens in ELISA, we found that these mice produce high levels of MDA-specific antibodies in the complement-fixing IgG2a and IgG2b subclasses. Anti-MDA antibodies were also found in MRL/+ mice but in significantly lower levels. The specificity of these antibodies was verified by inhibition ELISA. MDA may contribute to disease pathogenesis in these mice by altering the immunogenicity of self molecules, eliciting an immune response and forming immune complexes that may deposit in tissues.

Matched MeSH terms: Lipid Peroxidation/immunology*
Effect of alpha-tocopherol on lipid peroxidation and total antioxidant status in spontaneously hypertensive rats

Newaz MA, Nawal NN

Am J Hypertens, 1998 Dec;11(12):1480-5.
PMID: 9880131

The aim of this study was to determine the effects of alpha-tocopherol on lipid peroxidation and total antioxidant status of spontaneously hypertensive rats (SHR), comparing them with normal Wistar-Kyoto (WKY) rats. SHR were divided into three groups and treated with different doses of alpha-tocopherol (alpha1, 17 mg/kg diet; alpha2, 34 mg/kg diet; and alpha3, 170 mg/kg diet). Normal WKY and untreated SHR were used as normal (N) and hypertensive control (HC). Blood pressures were recorded every 10 days for 3 months. At the end of the trial, animals were killed and measurement of plasma total antioxidant status, plasma superoxide dismutase (SOD) activity, and lipid peroxide levels in plasma and blood vessels was carried out following well-established methods. From our study it was found that lipid peroxides in thoracic aorta (N, 0.47 +/- 0.17; H, 0.96 +/- 0.37; P < .0001) and plasma (N, 0.06 +/- 0.01; H, 0.13 +/- 0.01) were significantly higher in hypertensives than in normal rats. SOD activity was significantly lower in hypertensive than normal rats (N, 172.93 +/- 46.91; H, 110.08 +/- 14.38; P < .005). Total antioxidant status was significantly higher in normal than hypertensive rats (N, 0.88 +/- 0.05; H, 0.83 +/- 0.02; P < .05). After the antioxidant trial, it was found that in the treated groups rise of blood pressure was prevented significantly (P < .001) and lipid peroxides in blood vessels were significantly reduced more than in the controls (P < .001). For plasma lipid peroxide it was only significant for groups alpha2 (P < .001) and alpha3 (P < .05). Although all three treated groups showed improved total antioxidant status, only groups alpha2 (0.87 +/- 0.04, P < .005) and alpha3 (1.20 +/- 0.18, P < .001) were statistically significant. All the three groups showed significant increases in their SOD activity (P < .001). Correlation studies showed that total antioxidant status and SOD were significantly negatively correlated with blood pressure in normal rats (P = .007; P = .008). Lipid peroxides in both blood vessel and plasma showed a positive correlation. In the treated groups, lipid peroxides in blood vessels maintained a significant positive correlation with blood pressure in all groups (alpha1, P = .021; alpha2, P = .019; alpha3, P = .002), whereas for plasma lipid peroxides the correlation was in groups alpha1 (P = .005) and alpha2 (P = .009). For SOD activity, significant negative correlations were found with blood pressure in the alpha2 (P = .017) and alpha3 (P = .025) groups. Total antioxidant status maintained a significant negative correlation with blood pressure in all three groups (alpha1, P = .012; alpha2, P = .044; alpha3, P = .014). In conclusion it was found that supplement of alpha-tocopherol may prevent development of increased blood pressure, reduce lipid peroxides in plasma and blood vessels, and enhance the total antioxidant status, including SOD activity.

Matched MeSH terms: Lipid Peroxidation/drug effects*
Fulltext Effect of single-session aerobic exercise with varying intensities on lipid peroxidation and muscle-damage markers in sedentary males

Moflehi D, Kok LY, Tengku-Kamalden TF, Amri S

Glob J Health Sci, 2012 Jul;4(4):48-54.
PMID: 22980341 DOI: 10.5539/gjhs.v4n4p48

This study was conducted to evaluate the effect of the different intensity levels of single-session aerobic exercise on serum levels of lipid peroxidation and muscle damage markers in sedentary males.

Matched MeSH terms: Lipid Peroxidation/physiology*
Antioxidant synergism between ethanolic Centella asiatica extracts and α-tocopherol in model systems

Thoo YY, Abas F, Lai OM, Ho CW, Yin J, Hedegaard RV, et al.

Food Chem, 2013 Jun 1;138(2-3):1215-9.
PMID: 23411234 DOI: 10.1016/j.foodchem.2012.11.013

The synergistic antioxidant effects of ethanolic extracts of Centella asiatica (CE), and α-tocopherol have been studied. The types of interactions exhibited by CE and α-tocopherol combined at different ratios were measured using three assays: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical-scavenging capacity, the β-carotene bleaching system and liposome peroxidation assays. Fixed-fraction isobolographic analysis was used to detect any inducement of the antioxidant activity compared with the individual activities of CE and α-tocopherol. Of all synergistic combinations of CE and α-tocopherol, only fraction 2/3 showed the synergistic combination that fits well in three different assays and can be explained by the regeneration of α-tocopherol by CE despite the interaction effect of β-carotene present in the analytical assay. This phenomenon involved complex interactions between CE and α-tocopherol to exhibit different degrees of interactions that eventually increased antioxidant activity.

Matched MeSH terms: Lipid Peroxidation/drug effects
Fulltext Antioxidant and hepatoprotective effects of Murdannia bracteata methanol extract

Yam MF, Ang LF, Lim CP, Ameer OZ, Salman IM, Ahmad M, et al.

J Acupunct Meridian Stud, 2010 Sep;3(3):197-202.
PMID: 20869021 DOI: 10.1016/S2005-2901(10)60036-2

Murdannia bracteata (C. B. Clarke) is a local plant that is widely used in Malaysia as a traditional remedy for various diseases of the kidney and liver, including inflammation and cancer. In the present study, we investigated the antioxidant and hepatoprotective activities of M. bracteata methanol extract (MB). 2,2'-diphenyl-1-picrylhydrazyl radical scavenging activity, lipid peroxidation inhibition and trolox equivalent antioxidant capacity of MB were determined. The hepatoprotective activity of MB was studied using a CCl(4)-induced liver toxicity model in rats. The hepatoprotective effect was assessed by monitoring the plasma malondialdehyde level and serum alanine transaminase and aspartate transaminase activities. Histopathological changes of hepatic tissue were also investigated. The results indicated that MB possessed potential antioxidant, lipid peroxidation inhibition and free radical scavenging activities. Pretreatment of rats with MB (500 mg/kg and 1000 mg/kg per os) before induction of CCl(4)-induced hepatotoxicity showed a dose-dependent reduction in the necrotic changes in hepatic tissue. The increases in plasma malondialdehyde level, serum alanine transaminase and aspartate transaminase activities were also significantly inhibited by MB. The total phenolic content of MB determined using Folin-Ciocalteu assay was found to be 10%. The results of the present study indicated that the hepatoprotective effect of MB is most likely due to its antioxidant and free radical scavenging properties.

Matched MeSH terms: Lipid Peroxidation/drug effects
Fulltext Biomedical studies on lipid peroxidation and erythrocyte fragility during the process of aging

Kumar A

Asian Pac J Trop Biomed, 2011 Jan;1(1):6-7.
PMID: 23569715 DOI: 10.1016/S2221-1691(11)60058-0

To investigate oxidative stress, hemoglobin percentage and erythrocyte osmotic fragility in various aging groups.

Matched MeSH terms: Lipid Peroxidation/physiology*
The potential role of honey and its polyphenols in preventing heart diseases: a review

Khalil MI, Sulaiman SA

Afr J Tradit Complement Altern Med, 2010;7(4):315-21.
PMID: 21731163

Honey is rich in phenolic compounds, which act as natural antioxidants and are becoming increasingly popular because of their potential role in contributing to human health. A wide range of phenolic constituents is present in honey like quercetin, caffeic acid phenethyl ester (CAPE), acacetin, kaempferol, galangin which have promising effect in the treatment of cardiovascular diseases. Many epidemiological studies have shown that regular intake of phenolic compounds is associated with reduced risk of heart diseases. In coronary heart disease, the protective effects of phenolic compounds include mainly antithrombotic, anti-ischemic, anti-oxidant, and vasorelaxant. It is suggested that flavonoids decrease the risk of coronary heart disease by three major actions: improving coronary vasodilatation, decreasing the ability of platelets in the blood to clot, and preventing low-density lipoproteins (LDLs) from oxidizing. In this review paper, we discussed the preventive role of polyphenols of honey against cardiovascular diseases.

Matched MeSH terms: Lipid Peroxidation/drug effects

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