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Fulltext A Review on Current Trends of Polymers in Orthodontics: BPA-Free and Smart Materials

Hassan R, Aslam Khan MU, Abdullah AM, Abd Razak SI

Polymers (Basel), 2021 Apr 27;13(9).
PMID: 33925332 DOI: 10.3390/polym13091409

Polymeric materials have always established an edge over other classes of materials due to their potential applications in various fields of biomedical engineering. Orthodontics is an emerging field in which polymers have attracted the enormous attention of researchers. In particular, thermoplastic materials have a great future utility in orthodontics, both as aligners and as retainer appliances. In recent years, the use of polycarbonate brackets and base monomers bisphenol A glycerolate dimethacrylate (bis-GMA) has been associated with the potential release of bisphenol A (BPA) in the oral environment. BPA is a toxic compound that acts as an endocrine disruptor that can affect human health. Therefore, there is a continuous search for non-BPA materials with satisfactory mechanical properties and an esthetic appearance as an alternative to polycarbonate brackets and conventional bis-GMA compounds. This study aims to review the recent developments of BPA-free monomers in the application of resin dental composites and adhesives. The most promising polymeric smart materials are also discussed for their relevance to future orthodontic applications.
Fulltext 1-(2,6-dihydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl) ethanone-induced cell cycle arrest in G₁/G₀ in HT-29 cells human colon adenocarcinoma cells

Lay MM, Karsani SA, Malek SN

Int J Mol Sci, 2014 Jan 02;15(1):468-83.
PMID: 24451128 DOI: 10.3390/ijms15010468

1-(2,6-Dihydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl) ethanone (DMHE) was isolated from the ethyl acetate fraction of Phaleria macrocarpa (Scheff.) Boerl fruits and the structure confirmed by GC-MS (gas chromatography-mass spectrometry) and NMR (nuclear magnetic resonance) analysis. This compound was tested on the HT-29 human colon adenocarcinoma cell line using MTT (method of transcriptional and translational) cell proliferation assay. The results of MTT assay showed that DMHE exhibited good cytotoxic effect on HT-29 cells in a dose- and time-dependent manner but no cytotoxic effect on the MRC-5 cell line after 72 h incubation. Morphological features of apoptotic cells upon treatment by DMHE, e.g., cell shrinkage and membrane blebbing, were examined by an inverted and phase microscope. Other features, such as chromatin condension and nuclear fragmentation were studied using acridine orange and propidium iodide staining under the fluorescence microscope. Future evidence of apoptosis/necrosis was provided by result fromannexin V-FITC/PI (fluorescein-isothiocyanate/propidium iodide) staining revealed the percentage of early apoptotic, late apoptotic, necrotic and live cells in a dose- and time-dependent manner using flow cytometry. Cell cycle analysis showed G0/G1 arrest in a time-dependent manner. A western blot analysis indicated that cell death might be associated with the up-regulation of the pro-apoptotic proteins Bax PUMA. However, the anit-apotptic proteins Bcl-2, Bcl-xL, and Mcl-1 were also found to increase in a time-dependent manner. The expression of the pro-apoptotic protein Bak was not observed.
Fulltext Induction of apoptosis and cell cycle blockade by helichrysetin in a549 human lung adenocarcinoma cells

Ho YF, Karsani SA, Yong WK, Abd Malek SN

Evid Based Complement Alternat Med, 2013;2013:857257.
PMID: 23533528 DOI: 10.1155/2013/857257

Researchers are looking into the potential development of natural compounds for anticancer therapy. Previous studies have postulated the cytotoxic effect of helichrysetin towards different cancer cell lines. In this study, we investigated the cytotoxic effect of helichrysetin, a naturally occurring chalcone on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29, and further elucidated its biochemical and molecular mechanisms in human lung adenocarcinoma, A549. Helichrysetin showed the highest cytotoxic activity against Ca Ski followed by A549. Changes in the nuclear morphology of A549 cells such as chromatin condensation and nuclear fragmentation were observed in cells treated with helichrysetin. Further evidence of apoptosis includes the externalization of phosphatidylserine and the collapse of mitochondrial membrane potential which are both early signs of apoptosis. These signs of apoptosis are related to cell cycle blockade at the S checkpoint which suggests that the alteration of the cell cycle contributes to the induction of apoptosis in A549. These results suggest that helichrysetin has great potentials for development as an anticancer agent.
Angiomyolipoma during pregnancy: A forgotten risk factor for rupture and massive haemorrhage - A case report

Sayuti KA, Mat Rasid SA, Abdullah MS, Muhammad SJ

Malays Fam Physician, 2024;19:27.
PMID: 38725613 DOI: 10.51866/cr.399

Benign renal lesions are relatively rare. Angiomyolipoma (AML) is the most commonly encountered benign renal lesion. One of the complications of AML is rupture, which results in retroperitoneal haemorrhage with a mortality rate of up to 20%. Pregnancy poses a major risk for the rupture of AML. This is attributed to its hormonal effect, which causes the tumour to grow rapidly during pregnancy. The possibility of AML rupture should be considered when encountering pregnant patients with hypovolemic shock but with normal initial obstetric ultrasound findings. We present a case of a pregnant patient who was admitted with hypovolemic shock and CT scan confirmed rupture of AML.
Fulltext Cholesterol accumulation in ccRCC: the role of ccRCC-initiating VHL-HIFα pathway

Mohtar MA, Hasanah Mohd Yusuf SN, Syafruddin SE

EBioMedicine, 2024 May;103:105112.
PMID: 38599011 DOI: 10.1016/j.ebiom.2024.105112
Fulltext Prevalence and Sources of Stress among Universiti Sains Malaysia Medical Students

Yusoff MS, Abdul Rahim AF, Yaacob MJ

Malays J Med Sci, 2010 Jan;17(1):30-7.
PMID: 22135523 MyJurnal

Being in medical school has always been regarded as highly stressful. Excessive stress causes physical and mental health problems. Persistent stress can impair students' academic achievement and personal or professional development. The aim of this study is to explore the nature of stress among medical students by determining the prevalence, sources and pattern of stress and the factors affecting it.
Fulltext A Comparative Study between Supraorbital Keyhole and Pterional Approaches on Anterior Circulation Aneurysms

Genesan P, Haspani MSM, Noor SRM

Malays J Med Sci, 2018 Sep;25(5):59-67.
PMID: 30914863 MyJurnal DOI: 10.21315/mjms2018.25.5.6

Background: Many different conventional approaches such as the frontal and pterional approaches are used to access anterior circulation aneurysms. Recently, the supraorbital approach has been widely applied to the treatment of anterior circulation aneurysms. This study was done to evaluate which approach (pterional or supraorbital) has better outcomes in terms of residual neck post-clipping, cosmetic satisfaction, scar tenderness, complications and functional outcomes.
Methodology: A total of 123 patients were recruited into this study, comprising 82 patients who underwent a pterional approach and 41 patients who underwent a supraorbital approach. Computed tomography angiograms, the modified Rankin Scale, and the visual analogue scale were administered at 6 months to look for residual aneurysm, functional outcomes, scar tenderness, and cosmetic satisfaction. Complication data were collected from patients' case notes.
Results: The mean operating time for the pterional group was 226 min, compared to supraorbital group, which was 192 min (P = 0.07). Cosmetic satisfaction was significantly higher (P = 0.001) in the supraorbital group. There was no significant difference between the supraorbital and pterional groups' scar tenderness (P = 0.719), residual aneurysm (P = 0.719), or functional outcomes (P = 0.137), and there was no significant difference between the groups in terms of intra-operative and post-operative complications.
Conclusions: The supraorbital group had better cosmetic outcomes and shorter operating times compared to the pterional group.
Fulltext Hepatoprotective Effects of Zerumbone against Paracetamol-Induced Acute Hepatotoxicity in Rats

Hamid A, Lee LS, Karim SR, Jufri NF

Malays J Med Sci, 2018 Mar;25(2):64-71.
PMID: 30918456 MyJurnal DOI: 10.21315/mjms2018.25.2.7

Background: Zerumbone (ZER) is a major bioactive compound of Zingiber zerumbet, a wild ginger plant that has been documented to have anti-proliferative, anti-inflammatory and anti-oxidant properties. To investigate its hepatoprotective potential, this study was designed to determine the treatment effects of ZER on acute hepatotoxicity induced by paracetamol (PCM) in rats.
Methods: The control group was administered with phosphate buffer solution (PBS) while the other two groups received PCM alone (1000 mg/kg) and PCM + 25 mg/kg ZER, respectively, at 0 h and 4 h after PCM injection. After 24 h, the blood and liver were collected for differential white blood cell count, liver histological observation and biochemical analysis including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total protein concentration in serum and liver.
Results: Treatment with ZER was found to significantly reduce ALT (P = 0.041), AST (P = 0.044) and total hepatic protein (P = 0.045) in comparison to PCM-induced rats. Rats treated with ZER exhibited the normal structure of hepatocytes with no vacuolisation or necrosis and showed significantly reduced neutrophil count (P = 0.037). This finding suggests its ability to suppress the inflammatory processes caused by PCM overdosage and decrease the hepatocytes tendency to go through necrotic processes.
Conclusion: ZER possessed protective activity against PCM-induced acute hepatotoxicity in a rat model.
Personalised learning in higher education for health sciences: a scoping review protocol

Ali M, Wahab IBA, Huri HZ, Yusoff MS

Syst Rev, 2024 Apr 02;13(1):99.
PMID: 38566190 DOI: 10.1186/s13643-024-02478-4

BACKGROUND: Personalised learning, an educational approach that tailors teaching and learning to individual needs and preferences, has gained attention in recent years, particularly in higher education. Advances in educational technology have facilitated the implementation of personalised learning in various contexts. Despite its potential benefits, the literature on personalised learning in health sciences higher education remains scattered and heterogeneous. This scoping review aims to identify and map the current literature on personalised learning in health sciences higher education and its definition, implementation strategies, benefits, and limitations.
METHODS: A comprehensive search of electronic databases, PubMed, Scopus, Google Scholar, Educational Research Complete, and Journal Storage (JSTOR), will be conducted to identify relevant articles. The search will be limited to articles published in the English language between 2000 and 2023. The search strategy will be designed and adapted for each database using a combination of keywords and subject headings related to personalised learning and health sciences higher education. Eligibility criteria will be applied to screen and select articles. Data extraction and quality assessment will be performed, and thematic synthesis will be used to analyse the extracted data.
DISCUSSION: The results of the scoping review will present a comprehensive and coherent overview of the literature on personalised learning in health sciences higher education. Key themes and topics related to personalised learning, its definitions, models, implementation strategies, benefits, and limitations, will be identified. The geographical and temporal distribution of research on personalised learning in health sciences higher education will also be described. This scoping review will provide a structured synthesis of the available evidence on personalised learning in health sciences higher education, highlighting potential gaps and areas for future research. The findings will contribute to ongoing scholarly and policy debates on personalised learning in higher education, informing the development of best practices, guidelines, and future research agendas.
Fulltext Physical and mechanical properties of cassava-bamboo composite lumber

Ros Syazmini Mohd Ghani, Razak Wahab, Noor Maisarah Che Musthafa, Nasihah Mokhtar, Mohamad Saiful Sulaiman, Lee, Man Djun

Journal of Engineering and Science Research, 2018;2(6):6-9.
MyJurnal

The study was carried out to determine the physical and mechanical properties of composite lumber made from cassava (Mahinot esculenta Crantz) and bamboo (Bambusa vulgaris) in different ratios which is 100% cassava with 0% bamboo, 75% cassava with 25% bamboo, 50% cassava with 50% bamboo, 25% cassava with 75% bamboo and 0% cassava with 100% bamboo. The tests samples for determining the strength properties were divided into two categories namely mechanical testing and physical testing. Basic density of the samples was carried out for physical testing. The lowest basic density was in samples with 100% cassava which is 0.49 g/cm3 and highest in samples with 100% bamboo which is 0.68 g/cm3. Two tests for the mechanical testing are bending test and compression test. In bending test, modulus of elasticity (MOE) and modulus of rupture (MOR) were both highest for samples with 100% bamboo which the reading of MOE was 16794.03 N/mm2 and 122.52 N/mm2 for MOR. Similar to the bending test, compression test is the highest for the samples with 100% bamboo which are 65.58 N/mm2. From statistical analysis, the basic density, static bending can compression strength give significant value at 95% confidence interval.
Fulltext Advanced Sacral Chordoma: A Multidisciplinary Team Approach

Kow Ren Yi, Saiful Azlan Kamisan, Goh Kian Liang, Asmah Hanim Hamdan, Ahmad Razali Md Ralib@Md Raghib

IIUM Medical Journal Malaysia, 2019;18(102):60-0.
MyJurnal

Sacral chordomas are rare, low-grade and slow growing malignant bone tumours arising from the sacral bone. They are locally aggressive with the tendency to metastasize to the lungs. Surgical resection remains the mainstay of treatment of sacral chordomas. However, most patients presented late with large tumours and intra-abdominal extension making en bloc resection highly challenging. Besides that, surgical resection poses risk of injury to the surrounding structures such as major blood vessels, bladder, ureters and rectum due to their proximity to the tumour. Therefore, multidisciplinary team approach is vital in ancipitating possible complications and preventing surgical morbidity. We present a case of advanced sacral chordoma which has been successfully resected with the assistance of pre-operative selective arterial embolization as a pre-emptive therapy. Case report: A 58-year-old lady presented with a large sacral chordoma (17.17 cm x 27.3 cm x 30.5 cm) with sacral erosion, infiltration to gluteus maximus, medius and minimus muscles and lung metastasis. A decision to perform a surgical resection was made to alleviate the pain secondary to sacral nerve compression. Anticipating massive bleeding intra-operatively, pre-operative arterial embolization was performed involving one branch of right internal iliac artery as well as five branches of left internal and external iliac arteries using endovascular coils. The tumour was resected with partial sacrectomy from S2 and below. Intra-operatively, 6 pints of packed cells were transfused with estimated blood loss of 4 litres. The patient recovered well after the surgery. She was pain-free post-operatively with no lower limb neurological deficit. Conclusion: Surgical resection remains the treatment of choice for sacral chordoma. Pre-operative selective arterial embolization can reduce intra-operative bleeding and avoid a potentially convoluted surgery.
Fulltext Properties of composite boards properties from elaeis guineensis empty fruit bunch

Razak Wahab, Mohamad Saiful Sulaiman, Ros Syazmini Mohd Ghani, Nasihah Mokhtar, Siti Marlia Mohd Don, Hashim W. Samsi

Borneo Journal of Sciences and Technology, 2019;1(1):53-61.
MyJurnal

This study focussed on composite boards made from Elaeis guineesis empty fruit bunches (EFB). The EFB supplied by a smallholder oil palm planter in Kuala Krai, Kelantan. The fibre cutter and crusher were used in turning the EFB into smaller size particles. They were screened with four-tier sieve shaker used to remove the oversize particles and impurities present. Hardeners and wax added during the mixing process at 1% and 3%. Boards of three (3) different densities were produced using urea-formaldehyde as the bonding agent. The boards produced later conditioned in a chamber set at 20±2°C and 65% relative humidity. The testing procedure set by EN Standards and specifications were followed. The tests results showed the EFB composite boards possessed excellent physical and mechanical properties. The MOR, MOE and internal bonding of the boards were 22.91 N/mm2, 2059.56 N/mm2, and 0.98 N/mm2. The internal bonding for both edge and face screw withdrawal were 467.47 N/mm2, and 512.37 N/mm2 respectively. Boards with 700 g/cm3 density and 14% resin content met all the requirement needed according to standard exercised. Scanning electron microscope images of low-performance boards showed the resin and fibre in the board interacted closely, but voids appeared at the cross-section suggesting moisture penetrated the board via the open spaces and attacked the linkages existed, thus cause the board to have a low property. The thermal stability of the boards manufactured studied using the Thermogravimetric Analysis.
Fulltext ‘Batu reput’ used as raw material in fertilizer production

Mohd Nazry Salleh, Farizul Hafiz Kasim, Khairul Nizar Ismail, Che Mohd Ruzaidi Ghazali, Kamarudin Hussin, Saiful Azhar Saad, et al.

Journal of Nuclear and Related Technologies, 2007;2007(1):71-74.
MyJurnal

Batu Reput’ is primary sediment mineral and abundantly found in Perlis. Perlis is one of the major producers of ‘Batu Reput’ in Malaysia that content large deposit of high-purity dolomite [CaMg (CO3)2]. Pure samples of ‘Batu Reput’ recently explored in the Koperasi Rimba Mas Padang Besar Quarry were investigated for their physical, chemical and mineralogical composition. SEM and XRD analysis methods were applied. The potential of ‘Batu Reput’ as a raw material in fertilizer production was investigated in this paper.
Fulltext Betulinic acid was more cytotoxic towards the human breast cancer cell line MDA-MB-231 than the human promyelocytic leukaemia cell line HL-60

Latifah Saiful Yazan, Faujan Ahmad, Ooi, Choong Li, Raha Abdul Rahim, Hisyam Abdul Hamid, Lee, Pei Sze

Malaysian Journal of Pharmaceutical Science, 2009;7(1):23-37.
MyJurnal

Betulinic acid (BA) is a pentacyclic triterpene found in several botanical sources that has been shown to cause apoptosis in a number of cell lines. This study was undertaken to determine the in vitro cytotoxic properties of BA towards the human mammary carcinoma cell line MDA-MB-231 and the human promyelocytic leukaemia cell line HL-60 and the mode of the induced cell death. The cytotoxicity and mode of cell death of BA were determined using the MTT assay and DNA fragmentation analysis, respectively. In our study, the compound was found to be cytotoxic to MDA-MB-231 and HL-60 cells with IC50 values of 58 μg/mL and 134 μg/mL, respectively. Cells treated with high concentrations of BA exhibited features characteristic of apoptosis such as blebbing, shrinking and a number of small cytoplasm body masses when viewed under an inverted light microscope after 24h. The incidence of apoptosis in MDA-MB-231 was further confirmed by the DNA fragmentation analysis, with the formation of DNA fragments of oligonucleosomal size (180-200 base pairs), giving a ladder-like pattern on agarose gel electrophoresis. BA was more cytotoxic towards MDA-MB-231 than HL-60 cells, and induced apoptosis in MDA-MB-231 cells.
Fulltext Evaluation of medical students' perception towards the BigSib Programme in the School of Medical Sciences, USM

Muhamad Saiful Bahri Yusoff, Ahmad Fuad Abdul Rahim, Abdul Rahman Noor, Nor Azwany Yaacob, Zabidi Azhar Mohd Hussin

Education in Medicine Journal, 2010;2(1):2-11.
MyJurnal

Objective: BigSib Students' Peer-Group Mentoring Programme was implemented as an innovative, interactive and integrated instructional method in the Universiti Sains Malaysia medical school curriculum designed to enhance and strengthen medical students training in soft skills and professional development. This study was conducted to evaluate first- and second-year medical students’ perceptions of and attitudes towards the Programme.

Methodology: A cross sectional study was carried on 314 medical students. Questionnaires assessing medical students' perceptions and attitudes towards the Programme were administered. Data were analysed by using SPSS version 12.

Results: 45.9 % of the students perceived the BigSib Students' Peer-Group Mentoring Programme as successful. More than 50% of the students are willing to participate in the Programme. About 60% of the students perceived it as an effective Programme in developing their soft skills and professionalism.

Conclusion: Medical students have positive attitudes toward the Programme and it is perceived as a successful and effective Programme in developing students' personal attributes. Similar peer-group mentoring programme may be considered relevant to be incorporated into the medical curriculum in the future.
Fulltext Construct validity of postgraduate conjoint assessment of master of surgery program of School of Medical Sciences at USM

Shahid Hassan, Ahmad Fuad Abdul Rahim, Mohamad Najib Mat Pa, Mohd Nor Gohar Rahman, Muhamad Saiful Bahri Yusoff

Education in Medicine Journal, 2012;4(2):65-79.
MyJurnal

Introduction: A clear concept and understanding about the measure and the measuring tools is essential for good practice of assessment. Assessors need to have information about the full range of assessment tools inclusive of psychometric validity and purpose of its use. Subjective inferences drawn from the readily available data as numbers of summative scores over the years and statistical evidences of reliability and validity of assessment tools used to measure student’s performance are good sources of feedback for competent assessment program. It also provides meaningful evaluation of learning and teaching in medical education. Method: A retrospective study of 119 candidates was carried out to analyze the summative assessment scores of their certifying examination of Masters of Surgery in School of Medical Sciences (SMS) at Universiti Sains Malaysia. Subjective judgment of raw data followed by internal consistency as reliability, convergent validity and discriminant validity as constructs of individual assessment tool was analyzed. Finally each assessment tool as a measure of written or clinical construct was evaluated against six aspects of Messick’s criteria for quality control. Result: The correlation coefficient for validity and Cronbach’s alpha for reliability was evaluated for clinical measures. However, the test of internal reliability was not possible for essay being the only measure in written construct of summative assessment in surgery. All measures of clinical construct were found highly reliable with Cronbach’s alpha between 0.962-0.979. Long case and the short cases have shown excellent correlations (r=0.959 at p
Fulltext Rethinking education environment: the clinical education environment framework

Nurhanis Syazni Roslan, Jamilah Al-Muhammady Mohammad, Mohd Al-Aarifin Ismail, Anisa Ahmad, Muhamad Saiful Bahri Yusof

Education in Medicine Journal, 2018;10(3):31-46.
MyJurnal

Educational environment is an important determinant of medical students’ behaviour. It impacts their
academic performance, motivation, and psychological well-being. Quantitative evidence have shown
that there is a decrease in the positive perception of clinical medical students towards the educational
environment. The primary focus on this study was to explore the clinical education environment
through the lived experience of clinical medical students during medical training. Using hermeneutic
phenomenology we aimed to interpret participants’ experience of personal clinical learning journey
through free text input. Thematic analysis was performed to analyse the written texts. Various
measures were taken to enhance the trustworthiness of the findings. A total of 154 (74.8%) fourth year
students and 144 (74.6%) final year students participated in the study. We identified six overarching
themes of education environment in clinical setting that are personal development, teaching and
learning, assessment for learning, facility, support and nurturing curriculum. The overlapping
relationship of the themes is illustrated in the Clinical Education Environment Framework. While
many themes were consistent with existing framework, our findings also proposed assessment as an
important component to influence perception on education environment. The themes in this study
finding conform to the definition of education environment which covers physical, social, and
psychological aspects of students learning. Medical schools should take active measures to incorporate
a nurturing education environment especially in clinical year where students struggle with the hidden
curriculum.
Fulltext Social media as an e-health communication channel: the use of (@MedTweetMYHQ) among students of UiTM Melaka

Wan Azfarozza Wan Athmar, Nur Azmina Ghazali, Muhammad Saiful Adli Mohd Nasir, Anis Athirah Zuhaizar, Farahani Mohd Asli

Journal of Academia Universiti Teknologi MARA Negeri Sembilan, 2018;6(1):129-138.
MyJurnal

Social media are now acknowledged as one of the platforms for engaging e-health that contributing to serious discussion and information regarding on medical and health issues. However, there are challenges and risks associated with social media in medical and health care which is misinformation. Misinformation can spread quickly on Twitter and each retweet is exposing to wider audiences. The aim of this paper is to identify the use of @MedTweetMYHQ among its’ users sepcifically among UiTM Melaka students. The researchers used in-depth interviews to five informants based on purposive sampling. The data was analysed using thematic analysis. Four themes emerged from the analysis which are the use of @MedTweetMYHQ to receive updated useful information on health, to share information on healthy lifestyle, to debunk health myths and as a platform for health discussions.
Differential protein expression in senescent human skin fibroblasts and stress induced premature senescence (SIPS) fibroblasts

Goon JA, Haryati Ahmad Hairi, Suzana Makpol, Mariati Abdul Rahman, Saiful Anuar Karsani, Wan Zurinah Wan Ngah

Sains Malaysiana, 2011;40:1247-1253.

Replicative senescence of human diploid fibroblasts (HDFs) occurs when cells lose their capacity to proliferate and enter a phase of irreversible growth arrest. Stress-induced premature senescence (SIPS) on the other hand is caused by subcytotoxic concentrations of various oxidants which trigger accelerated cellular senescence. In this study, a SIPS model was established by exposing human diploid fibroblasts (HDFs) to 20 μM H2O2 for 2 weeks. A proteomic comparison between young, senescent and SIPS cells was done using two dimensional gel electrophoresis (2DGE) to elucidate the changes in protein expression associated with cellular aging. Our analysis showed that 28 protein spots were differentially expressed in senescent cells whereas 10 protein spots were differentially expressed in SIPS as compared to young cells. Three similar protein spots were differentially expressed in both senescent and SIPS cells when compared to the young cells. These results indicate that a difference in protein expression exists between senescent cells and SIPS cells compared to young cells.
Psychological distress of first year medical students who underwent two different admission processes during a stressful period

Muhamad Saiful Bahri Yusoff, Ahmad Fuad Abdul Rahim, Abdul Aziz Baba, Shaiful Bahari Ismail, Hatta Sidi, Ab Rahman Esa

Sains Malaysiana, 2013;42:423-428.

The study of medicine is often regarded by students as a stressful environment particularly during examination period. Studies found a high percentage of medical students experience significant psychological distress during the examination period. This study compared percentage and level of psychological distress between two batches of first year medical students who underwent different selection admission processes during a stressful examination period. A comparative
cross-sectional study was done on two batches of first year medical students; one group selected based on academic merit (2008/2009 batch) and the other selected based on academic merit, psychometric tests and interview (2009/2010 batch). The psychological distress was measured by the 12-item general health questionnaire (GHQ-12). The data were collected right after the final examinations. A total of 99 (46.05%) medical students of the 2008/2009 batch and 196 (100%) medical students of the 2009/2010 batch participated. The percentage of medical students who had psychological distress of the 2008/2009 and the 2009/2010 batches were 58.59% and 42.3%, respectively. The mean GHQ-12 score and percentage of psychological distress were significantly different between the two batches (p< 0.01). The older batch had 2.01 times higher risk for developing psychological distress compared with the newer batch (p< 0.01). The newer batch
of medical students had better psychological health status and was less likely to develop psychological distress during the stressful period compared with older batch.

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