Displaying publications 201 - 220 of 398 in total

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  1. Clinico-radiologic-pathologic conference. Abnormal findings on chest radiographs of an asymptomatic patient
    Staples CA, Brown MJ, Bai TR, Chan NH
    Can Assoc Radiol J, 1996 Apr;47(2):136-9.
    PMID: 8612087
  2. Factors Influencing Malaysian Men's Perceptions of Gender Equity in Family Planning
    Endut N, Bagheri R, Azmawati AA, Hashim I, Selamat NH, Mohajer L
    Malays Fam Physician, 2020;15(3):43-53.
    PMID: 33329862
    INTRODUCTION: Various factors influence men's perceptions regarding gender equity in family planning (FP). Identifying these factors can contribute to a deeper understanding of the roles that men play in family planning and ultimately leads to women's reproductive health outcomes.

    OBJECTIVES: This paper aims to investigate factors influencing Malaysian men's perceptions of gender equity in family planning. To achieve this, the effects of sociodemographic characteristics (age, education, and marital status), masculine traits, and attitudes towards domestic violence are investigated.

    METHODOLOGY: This is a cross-sectional study undertaken by administrating questionnaires to a sample of 168 men in Malaysia. The data are analyzed by applying partial least squares-structural equation modeling (PLS-SEM) and by using WarpPLS 6.0.

    RESULTS: The results confirmed the significant effects of masculine traits and attitudes supporting domestic violence on perceived gender equity in family planning. In other words, the results showed that men's masculine traits and attitudes supporting domestic violence negatively influenced gender equity in family planning. The hypothesized effects of sociodemographic characteristics on perceived gender equity in family planning could not be verified.

    CONCLUSIONS: This study suggests some practical implications for local authorities to implement interventions that take a gender transformative approach to reduce men's masculine traits and improve their attitudes towards domestic violence to enhance gender equity in family planning.

  3. Optimization of Culture Medium for the Growth of Candida sp. and Blastobotrys sp. as Starter Culture in Fermentation of Cocoa Beans (Theobroma cacao) Using Response Surface Methodology (RSM)
    Mahazar NH, Zakuan Z, Norhayati H, MeorHussin AS, Rukayadi Y
    Pak J Biol Sci, 2017;20(3):154-159.
    PMID: 29023007 DOI: 10.3923/pjbs.2017.154.159
    BACKGROUND AND OBJECTIVE: Inoculation of starter culture in cocoa bean fermentation produces consistent, predictable and high quality of fermented cocoa beans. It is important to produce healthy inoculum in cocoa bean fermentation for better fermented products. Inoculum could minimize the length of the lag phase in fermentation. The purpose of this study was to optimize the component of culture medium for the maximum cultivation of Candida sp. and Blastobotrys sp.

    MATERIALS AND METHODS: Molasses and yeast extract were chosen as medium composition and Response Surface Methodology (RSM) was then employed to optimize the molasses and yeast extract.

    RESULTS: Maximum growth of Candida sp. (7.63 log CFU mL-1) and Blastobotrys sp. (8.30 log CFU mL-1) were obtained from the fermentation. Optimum culture media for the growth of Candida sp., consist of 10% (w/v) molasses and 2% (w/v) yeast extract, while for Blastobotrys sp., were 1.94% (w/v) molasses and 2% (w/v) yeast extract.

    CONCLUSION: This study shows that culture medium consists of molasses and yeast extract were able to produce maximum growth of Candida sp. and Blastobotrys sp., as a starter culture for cocoa bean fermentation.

  4. Fulltext Hypertensive retinopathy and sensorineural hearing loss
    Tan TY, Rahmat O, Prepageran N, Fauzi A, Noran NH, Raman R
    Indian J Otolaryngol Head Neck Surg, 2009 Dec;61(4):275-9.
    PMID: 23120650 DOI: 10.1007/s12070-009-0082-9
    To determine the correlation between hypertensive retinopathy (which is the end-organ damage of the vessels due to chronic hypertension) with sensorineural hearing loss.
  5. Fulltext Quality changes of stabilizer-free natural peanut butter during storage
    Mohd Rozalli NH, Chin NL, Yusof YA, Mahyudin N
    J Food Sci Technol, 2016 Jan;53(1):694-702.
    PMID: 26787989 DOI: 10.1007/s13197-015-2006-x
    The storage stability of preservative-free peanut butter was evaluated for changes in physicochemical quality including moisture content and water activity, microbiological properties, oxidative stability and textural quality in terms of spreadability and firmness. The study was conducted for 16 weeks at storage temperature of 10, 25 and 35 °C on natural and pure peanut butter produced from two varieties of peanuts, the Virginia and Spanish TMV-2 varieties of China and India origin, respectively. The peanuts were ground using a high speed grinder for 2.5 and 3.0 min to produce peanut butter without addition of other ingredient. The natural peanut butter exhibited stability and had acceptable microbial count during storage. Storage at 10 °C gave similar textural quality with commercial product until week 8 and without appreciable loss in oxidative stability until week 12. At higher storage temperatures of 25 and 35 °C, oxidative stability was shortened to 4 weeks of storage. Among the factors of storage temperature and time, grinding time and peanut variety, storage temperature had the most significant effects on quality changes of natural peanut butter.
  6. Effects of various nonopioid receptor antagonists on the antinociceptive activity of Muntingia calabura extracts in mice
    Zakaria ZA, Hassan MH, Nurul Aqmar MN, Abd Ghani M, Mohd Zaid SN, Sulaiman MR, et al.
    Methods Find Exp Clin Pharmacol, 2007 Oct;29(8):515-20.
    PMID: 18040526
    This study was carried out in mice to determine the nonopioid receptor signaling pathway(s) that might modulate the antinociceptive activity of the aqueous and chloroform extracts of Muntingia calabura (M. calabura) leaves, using the hot-plate test. The leaves of M. calabura were sequentially soaked [1:2 (w/v); 72 h] in distilled water (dH(2)O) and chloroform. The 50% concentration extracts were selected for this study based on the plant's previously established antinociceptive profiles. The mice (n = 7) were pretreated (s.c.) for 10 min with the selected nonopioid receptor antagonists, followed by the (s.c.) administration of the respective extract. The latency of discomfort was recorded at the interval time of 0.5, 1, 2, 3, 4 and 5 h after the extract administration. The 5 mg/kg atropine, 10 mg/kg phenoxybenzamine, 10 mg/kg yohimbine, 10 mg/kg pindolol, 1 mg/kg haloperidol and 10 mg/kg bicuculline caused significant (p < 0.05) reduction in the aqueous extract-induced antinociceptive activity. The 10 mg/kg phenoxybenzamine, 10 mg/kg yohimbine, 10 mg/kg pindolol and 10 mg/kg bicuculline caused significant (p < 0.05) reduction in the chloroform extract-induced antinociceptive activity. In conclusion, the central antinociceptive activity of M. calabura leaves appears to be involved in the modulation of various nonopioid receptor signaling pathways. Its aqueous extract antinociceptive activity is mediated via modulation of the muscarinic, alpha(1)-adrenergic, alpha(2)-adrenergic, beta-adrenergic, dopaminergic and GABAergic receptors, while its chloroform extract activity is mediated via modulation of the alpha(1)-adrenergic, alpha(2)-adrenergic, beta-adrenergic and GABAergic receptors.
  7. Fulltext Length-weight relationship of six fish species from Sepang Besar River Estuary, Malaysia
    Ya, N. A., Singh, H. R., Samat, A., Mohd Rashid, H. N., Ramli, N. H., Makhtar, N., et al.
    Journal of Advanced Research in Applied Sciences and Engineering Technology, 2015;1(1):27-35.
    MyJurnal
    Length-weight relationship (LWR) of six fish species from the Sepang Besar River estuary,
    Peninsular Malaysia were analyzes. A total of 594 individuals belonging to six species namely Arius
    sagor, Photopectoralis bindus, Plotosus lineatus, Toxotes chatareus, Toxotes jaculatrix, and Thryssa
    dussumieri collected from April 2014 to February 2015 were measured and weighed. Among them, four
    species showed positive allometric growth and the other two species showed negative allometric
    growth. The exponent b value of LWR ranged between 2.94 (Toxotes chatareus) and 3.50
    (Photopectoralis bindus). This outcome of the present study has contributed to the knowledge of basic
    information on the length–weight relationship of six most abundant species in Sepang Besar River
    estuary which is important for future ecological studies and assist in fishery management. Copyright
    © 2015 Penerbit Akademia Baru - All rights reserved.
  8. Fulltext Anti-cancer potential of pseuduvaria macrophylla in human cancer cell lines
    Taha, H., Mohebali, N., Chung, Y. L., Ismail, N. H., Aziz , A., Bakar, M. Z. A., et al.
    Journal of Advanced Research in Applied Sciences and Engineering Technology, 2016;4(1):1-11.
    MyJurnal
    his is a short report on the recent investigation on the anticancer and antioxidant potential
    of Pseuduvaria macrophylla stem bark and leaf extract on human breast cancer cell (MCF-7), human
    prostate cancer cell (PC-3) and human colon cancer cell (HT29). LCMS experiment was done to
    identify the chemical composition in the methanolic extracts while GCMS analysis was done to
    determine the chemical composition in the hexanolic extracts. For antioxidant activity, the most active
    extract was leaf methanolic with 69.22 % of DPPH inhibition. Additionally, the leaf methanolic extract
    inhibited the better proliferation especially on human breast cancer cell (MCF-7) compared to hexane
    crude extracts due to more than 90% of cancer cell death and lowest IC50 value at range of 80.70
    µg/mL ± 0.08 – 106.70 µg/mL ± 0.07. The major detected compounds were α-Cadinol, neophytadiene,
    palmitic acid, linoleic acid, oleic acid and isopolycerasoidal and isopolycerasoidal methyl ester. The
    findings of this study support the anti-cancer claims of Pseuduvaria macrophylla leaf. Copyright© 2016
    Penerbit Akademia Baru- All rights reserved.
  9. Fulltext Common type of turbines in power plant: a review
    Khattak, M. A., Mohd Ali, N. S., Zainal Abidin, N. H., Azhar, N. S., Omar, M. H.
    Journal of Advanced Research in Applied Sciences and Engineering Technology, 2016;3(1):77-100.
    MyJurnal
    Most conventional power plants require a turbine as conversion system from various
    working fluid like water, gas, steam and wind into mechanical energy that will be used to generate
    electricity. In future, the forecast energy usage is higher and thus, to compensate this, the power plant
    needs high efficiency of turbine to extract maximum quantity of energy from the working fluid.
    Therefore, various improvements on turbine technology has been done and studied. There are four
    common type of turbine which is hydraulic turbine, gas turbine, wind turbine and steam turbine that
    will reviewed in this paper. Each turbine was differentiating based on their working fluid and different
    type of turbine has their own efficiency. There is some parameter that affects the turbine efficiency like
    the turbine component, the characteristic of working fluid, materials used, cooling invention and many
    more. There is also some future development in progress to enhance the turbine efficiency and thus
    increase the amount of electricity produce. The aims for this review paper is to find out the common
    type of turbine used in power plant as different power plant needs different type of turbine. About 46
    published studies (1939-2016) are reviewed in this paper. By reviewing others research studies
    worldwide, this review paper can be taken as a guideline in future regarding to common type of turbines
    used in power plant. Copyright © 2016 Penerbit Akademia Baru - All rights reserved.
  10. Fulltext Application of seaweed (Kappaphycus alvarezii) in Malaysian food products
    Mohammad, S. M., Mohd Razali, S. F., Mohamad Rozaiman, N. H. N., Laizani, A. N., Zawawi, N.
    International Food Research Journal, 2019;26(6):1677-1687.
    MyJurnal
    Kappaphycus alvarezii is a species of red algae, and one of the most important carrageenan
    sources for food, cosmetic, and pharmaceutical industries. It is commercially cultivated in the
    eastern part of Malaysia. Although K. alvarezii is rich in nutrients, it is limited in its integration
    into Malaysian food products. Therefore, the present work was conducted to investigate the
    quality characteristics, sensorial attributes, and antioxidant activity of K. alvarezii in Malaysian
    food products. Seaweed puree (SP) from K. alvarezii at 10%, 20% and 30% concentrations were
    prepared in the formulations of fish sausages, flat rice noodles and yellow alkaline noodles.
    Proximate analysis, physicochemical analysis, microbial count, total phenolic content (TPC),
    sensory evaluation, and consumer acceptance survey of the formulated food were conducted.
    The incorporation of K. alvarezii significantly increased the fibre, moisture, and ash content in
    formulated foods. In addition, the TPC content of K. alvarezii food also significantly increased
    up to 42 mg GAE/100 g. The presence of SP in food at higher concentration decreased the
    microbial counts. Sensory analysis confirmed that only fish sausages added with SP was
    overall acceptable as compared to control. Based on customer survey, functional foods that are
    “research proven” were the most preferred. In conclusion, K. alvarezii has the potential to be
    incorporated in Malaysian food products and developed as functional food.
  11. Fulltext Fixatives increase the efficacy of gel formulations containing piper aduncum linnaeus (piperales: piperaceae) essential oil as repellenty
    Mamood, S. N. H., Budin, S. B., Ahmad Rohi, G., Hidayatulfathi, O., Kalaivany, M., Zulfakar, M. H.
    Jurnal Sains Kesihatan Malaysia, 2019;17(1):9-15.
    MyJurnal
    Piper aduncum essential oil exhibit repellency activity and has a potential to be use as an alternative for synthetic repellent such as N,N-diethyl-3- methylbenzamide, (DEET). However, the volatility properties of the essential oil decrease their persistence as a topical repellent. Study has shown that formulation of the essential oil with some fixatives may increase their effectiveness. Therefore, this study was conduct to evaluate the effectiveness of gel formulation containing P. aduncum essential oil with two fixative; vanillin and paraffin oil. Gel formulations containing P. aduncum essential oil with 5% and 10% vanillin and 6% paraffin oil was prepared and tested against Aedes aegypti in laboratory using Standards and Industrial Research Institute of Malaysia (SIRIM) bioassay method. After 240 minute post-application, formulation containing 5% and 10% vanillin was able to provide >70% repellency percentage against mosquito while formulation containing 6% paraffin oil gives
  12. Fulltext Detection of α-thalassaemia in neonates on cord blood and dried blood spot samples by capillary electrophoresis
    Alauddin H, Langa M, Mohd Yusoff M, Raja Sabudin RZA, Ithnin A, Abdul Razak NF, et al.
    Malays J Pathol, 2017 Apr;39(1):17-23.
    PMID: 28413201 MyJurnal
    INTRODUCTION: Haemoglobin Bart's (Hb Bart's) level is associated with α-thalassaemia traits in neonates, enabling early diagnosis of α-thalassaemia. The study aimed to detect and quantify the Hb Bart's using Cord Blood (CB) and CE Neonat Fast Hb (NF) progammes on fresh and dried blood spot (DBS) specimen respectively by capillary electrophoresis (CE).

    METHODS: Capillarys Hemoglobin (E) Kit (for CB) and Capillarys Neonat Hb Kit (for NF) were used to detect and quantify Hb Bart's by CE in fresh cord blood and dried blood spot (DBS) specimens respectively. High performance liquid chromatography (HPLC) using the β-Thal Short Programme was also performed concurrently with CE analysis. Confirmation was obtained by multiplex ARMS Gap PCR.

    RESULTS: This study was performed on 600 neonates. 32/600 (5.3%) samples showed presence of Hb Bart's peak using the NF programme while 33/600 (5.5%) were positive with CB programme and HPLC methods. The range of Hb Bart's using NF programme and CB programme were (0.5-4.1%) and (0.5-7.1%), respectively. Molecular analysis confirmed all positive samples possessed α-thalassaemia genetic mutations, with 23/33 cases being αα/--SEA, four -α3.7/-α3.7, two αα/-α3.7 and three αα/ααCS. Fifty Hb Bart's negative samples were randomly tested for α-genotypes, three were also found to be positive for α-globin gene mutations. Thus, resulting in sensitivity of 91.7% and 88.9% and specificity of 100% for the Capillarys Cord Blood programme and Capillarys Neonat Fast programme respectively.

    CONCLUSION: Both CE programmes using fresh or dried cord blood were useful as a screening tool for α-thalassaemia in newborns. All methods show the same specificity (100%) with variable, but acceptable sensitivities in the detection of Hb Bart.
  13. Fatty acid profile from immobilised Chlorella vulgaris cells in different matrices
    Abu Sepian NR, Mat Yasin NH, Zainol N, Rushan NH, Ahmad AL
    Environ Technol, 2019 Apr;40(9):1110-1117.
    PMID: 29161985 DOI: 10.1080/09593330.2017.1408691
    The immobilisation of Chlorella vulgaris 211/11B entrapped in combinations of natural matrices to simplify the harvesting process was demonstrated in this study. Three combinations of matrices composed of calcium alginate (CA) and sodium alginate (SA), sodium carboxymethyl cellulose (CMC) and SA, and mixed matrices (SA, CA, and CMC) were investigated. The number of cells grown for each immobilised matrix to microalgae volume ratios (0.2:1-1:1) were explored and compared with using SA solely as a control. The optimum volume ratios obtained were 1:1 for SA, 0.3:1 for CA and SA, 1:1 for CMC and SA, and 0.3:1 for mixed matrices. The immobilised microalgae of mixed matrices exhibited the highest number of cells with 1.72 × 109 cells/mL at day 10 and 30.43% of oil extraction yield followed by CA and SA (24.29%), CMC and SA (13.00%), and SA (6.71%). Combining SA, CA, and CMC had formed a suitable structure which improved the growth of C. vulgaris and increased the lipid production compared to the immobilisation using single matrix. Besides, the fatty acids profile of the oil extracted indicates a high potential for biodiesel production.
  14. Fulltext Evaluation on physico-chemical properties of pink guava puree residue as bioresource
    Mhd Abd Kader, K. A., Ab. Aziz, N., Aziz, A., Talib, A. T., Ahmad, N. H., Tan, C. P., et al.
    International Food Research Journal, 2016;23(101):125-131.
    MyJurnal
    Pink Guava Puree (PGP) factory produces tons of residues from its unit operation [refiner (R),
    siever (S), and decanter (D)]. These residues represent a waste of nutrients and can contribute
    to environmental problem. However, it can benefit related industries if the properties of the
    residues are known. Thus, this research aims to determine the compositions of the residues
    from PGP processing factory in order to evaluate possible value-added by-product and energy
    sources. The residues from each unit operation were being tested for proximate composition,
    dietary fibre components, pH value, emulsifying activity (EA) and emulsifying stability (ES),
    carbon-to-nitrogen (C/N) ratio, and sugar analysis. The sugar content was analysed using High
    Performance Liquid Chromatography (HPLC-RI detector). Results showed that the residues
    have good composition of carbohydrate (11.82–12.18%), and thus potential as carbon source
    and can be a good substrate for fermentation. These residues may also benefit the food industry
    as a good source of dietary fibre (18.63–29.86%). The pH value for these PGP residues is 4;
    thus they were considered as acidic food by-product. The low pH value also contributed to the
    low EA and ES value other than the low content of protein in the sample. C/N ratio for PGP
    residue from R (46:1) is the lowest compared to the C/N ratio from S (84:1) and D (115:1). The
    amount of sugars detected in the PGP residues in descending order were fructose > glucose >
    sucrose.
  15. Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract
    Mediani A, Abas F, Maulidiani M, Khatib A, Tan CP, Ismail IS, et al.
    J Pharm Biomed Anal, 2016 Sep 05;128:302-312.
    PMID: 27318080 DOI: 10.1016/j.jpba.2016.06.003
    Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague-Dawley rats was achieved by a low dose of streptozotocin (STZ) (25mg/kgbw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500mg/kg bw) of P. niruri via metabolomics approach. The administration of 500mg/kgbw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus.
  16. Fulltext Urban governance and the systems approaches to health-environment co-benefits in cities
    Oliveira JA, Doll CN, Siri J, Dreyfus M, Farzaneh H, Capon A
    Cad Saude Publica, 2015 Nov;31 Suppl 1:25-38.
    PMID: 26648361 DOI: 10.1590/0102-311X00010015
    The term "co-benefits" refers to positive outcomes accruing from a policy beyond the intended outcome, often or usually in other sectors. In the urban context, policies implemented in particular sectors (such as transport, energy or waste) often generate multiple co-benefits in other areas. Such benefits may be related to the reduction of local or global environmental impacts and also extend into the area of public health. A key to identifying and realising co-benefits is the adoption of systems approaches to understand inter-sectoral linkages and, in particular, the translation of this understanding to improved sector-specific and city governance. This paper reviews a range of policies which can yield health and climate co-benefits across different urban sectors and illustrates, through a series of cases, how taking a systems approach can lead to innovations in urban governance which aid the development of healthy and sustainable cities.
  17. Fulltext Prenatal diagnosis of aneuploidies in amniotic fluid by multiple ligation-dependent probe amplification (MLPA) analysis
    Hamidah NH, Munirah AR, Hafiza A, Farisah AR, Shuhaila A, Norzilawati MN, et al.
    Malays J Pathol, 2014 Dec;36(3):163-8.
    PMID: 25500514 MyJurnal
    Prenatal diagnosis is essential in the new era of diagnosis and management of genetic diseases in obstetrics. Multiple ligation-dependent probe amplification (MLPA) is a recent technique for prenatal diagnosis for the relative quantification of 40 different nucleic acid sequences in one single reaction. We had utilized the MLPA technique in detecting aneuploidies in amniotic fluid samples from 25 pregnant women from the Obstetrics and Gynaecology Department UKMMC, versus the quantitative fluorescent polymerase chain reaction (QF-PCR) method. Conclusive results were obtained in 18 cases and all were concordant with that of the QF-PCR. All four cases of trisomies were correctly identified including one case with maternal cell contamination.
  18. Fulltext Magnitude and risk factors for postpartum symptoms: a literature review
    Norhayati MN, Hazlina NH, Asrenee AR, Emilin WM
    J Affect Disord, 2015 Apr 1;175:34-52.
    PMID: 25590764 DOI: 10.1016/j.jad.2014.12.041
    BACKGROUND: The prevalence of postpartum depression worldwide varies from 0.5% to 60.8% in the first 12 months postpartum using self-reported questionnaire. This review aims to update the current magnitude of postpartum depression based on self-reported questionnaire and clinical interview and explore its associated factors in developed and developing countries.
    METHODS: A literature search conducted between 2005 and 2014 identified 203 studies, of which 191 used self-reported questionnaire in 42 countries and 21 used structured clinical interview in 15 countries. Nine studies used a combination of self-reported questionnaire and clinical interview.
    RESULT: The prevalence of postpartum depression varies from 1.9% to 82.1% in developing countries and from 5.2% to 74.0% in developed countries using self-reported questionnaire. Structured clinical interview shows a much lower prevalence range from 0.1% in Finland to 26.3% in India. Antenatal depression and anxiety, previous psychiatric illness, poor marital relationship, stressful life events, negative attitude towards pregnancy, and lack of social support are significant contributors to postpartum depression.
    LIMITATION: All studies are included irrespective of the methodological quality, such as small sample size and their inclusion could affect the generalizability of the results.
    CONCLUSION: The current prevalence of postpartum depression is much higher than that previously reported, and similar risk factors are documented. A culturally sensitive cut-off score with adequate psychometric properties of the screening instruments should be available. In future studies, examining the physical, biological, and cultural factors in qualitative studies and in those with adequate methodological qualities is recommended.
    KEYWORDS:Epidemiology; Postpartum depression; Prevalence; Risk factors
  19. The prevalence and distribution of Brucella melitensis in goats in Malaysia from 2000 to 2009
    Bamaiyi PH, Hassan L, Khairani-Bejo S, ZainalAbidin M, Ramlan M, Adzhar A, et al.
    Prev Vet Med, 2015 May 1;119(3-4):232-6.
    PMID: 25746928 DOI: 10.1016/j.prevetmed.2015.02.001
    A study was conducted to describe the prevalence and distribution of zoonotic Brucella melitensis in goats in Peninsular Malaysia. Using serosurveillance data of the last decade (2000-2009) involving 119,799 goats and 3555 farms, the seroprevalence of brucellosis among goats was 0.91% (95% CI=0.86-0.96) and among farms was 7.09% (95% CI=6.27-7.98). The odds of brucellosis was significantly (P<0.05) higher in the later part of the decade, in larger herd size and among the states located in the peninsula as compared to eastern Malaysia. The infection was detected throughout Malaysia but at generally low seroprevalences with states like Perlis that border neighbouring countries having higher seroprevalence of brucellosis than other non-border states.
  20. Fulltext Homozygous familial hypercholesterolemia
    Alicezah MK, Razali R, Rahman T, Hoh BP, Suhana NH, Muid S, et al.
    Malays J Pathol, 2014 Aug;36(2):131-7.
    PMID: 25194536 MyJurnal
    We report a rare case of homozygous familial hypercholesterolemia (HoFH), a 22-year-old Malay woman who presented initially with minor soft tissue injury due to a cycling accident. She was then incidentally found to have severe xanthelasma and hypercholesterolemia (serum TC 15.3 mmol/L and LDL-C 13.9 mmol/L). She was referred to the Specialized Lipid Clinic and was diagnosed with familial hypercholesterolemia (FH) based on the Simon Broome (SB) diagnostic criteria. There was a family history of premature coronary heart disease (CHD) in that three siblings had sudden cardiac death, and of consanguineous marriage in that her parents are cousins. DNA screening of LDLR and APOB genes was done by Polymerase Chain Reaction (PCR), followed by Denaturing High Performance Liquid Chromatography (DHPLC). Homozygous mutation C255S in Exon 5 of her LDLR gene was found. There was no mutation was found in Exon 26 and Exon 29 of the APOB gene. This report is to emphasize the importance of identifying patients with FH and cascade screening through established diagnostic criteria and genetic studies in order to ensure early detection and early treatment intervention to minimize the risk of developing CHD and related complications.
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